Practice Point

Nature Clinical Practice Endocrinology & Metabolism (2007) 3, 8-9
doi:10.1038/ncpendmet0315  
Received 25 June 2006 | Accepted 15 August 2006

Are antihypertensive drugs associated with an increased risk of incident type 2 diabetes?

Pantelis A Sarafidis* and George L Bakris

Correspondence *Hypertension/Clinical Research Center, Department of Preventive Medicine, Rush University Medical Center, 1700 West Van Buren, Suite 470, Chicago, IL 60612, USA

Email
 psarafidis11@yahoo.gr

This article has no abstract so we have provided the first paragraph of the full text.

Over the past 25 years, numerous studies have demonstrated a spectrum of effects of the various classes of antihypertensive agents on carbohydrate metabolism. In general, thiazide diuretics and beta-blockers worsen insulin sensitivity and glycemic control, whereas ACE inhibitors, angiotensin II receptor blockers, CCBs, and alpha-blockers have neutral or beneficial effects. It must be noted, however, that not all drugs within a given class have similar effects on these parameters. For example, vasodilating beta-blockers have metabolic effects distinct from those of conventional beta-blockers.1

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