Nature Clinical Practice Endocrinology & Metabolism Nature Clinical Practice Endocrinology & Metabolism provides physicians with authoritative and timely interpretations of key developments in the field, translating the latest findings into clinical practice. http://www.nature.com/ncpendmet/current_issue/ Nature Publishing Group en © 2008 Nature Publishing Group Nature Clinical Practice Endocrinology & Metabolism 1745-8366 1745-8374 © 2008 Nature Publishing Group permissions@nature.com Nature Clinical Practice Endocrinology & Metabolism http://www.nature.com/includes/rj_globnavimages/ncpendmet_logo.gif http://www.nature.com/ncpendmet/ Gastric banding to treat obesity: band-aid or breakthrough? http://dx.doi.org/10.1038/ncpendmet0889 Gastric banding to treat obesity: band-aid or breakthrough?

Nature Clinical Practice Endocrinology & Metabolism 4, 421 (2008). doi:10.1038/ncpendmet0889

Authors: Kenneth S Polonsky & Samuel Klein

]]> Gastric banding to treat obesity: band-aid or breakthrough? Kenneth S Polonsky Samuel Klein doi:10.1038/ncpendmet0889 Nature Clinical Practice Endocrinology & Metabolism 4, 421 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Editorial 421 421 Serum adiponectin levels predict progression from diabetic nephropathy to ESRD http://dx.doi.org/10.1038/ncpendmet0873 Serum adiponectin levels predict progression from diabetic nephropathy to ESRD

Nature Clinical Practice Endocrinology & Metabolism 4, 422 (2008). doi:10.1038/ncpendmet0873

]]> Serum adiponectin levels predict progression from diabetic nephropathy to ESRD doi:10.1038/ncpendmet0873 Nature Clinical Practice Endocrinology & Metabolism 4, 422 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 422 422 Hyperthyroidism linked with increased ectopic supraventricular heart activity http://dx.doi.org/10.1038/ncpendmet0874 Hyperthyroidism linked with increased ectopic supraventricular heart activity

Nature Clinical Practice Endocrinology & Metabolism 4, 422 (2008). doi:10.1038/ncpendmet0874

]]> Hyperthyroidism linked with increased ectopic supraventricular heart activity doi:10.1038/ncpendmet0874 Nature Clinical Practice Endocrinology & Metabolism 4, 422 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 422 422 LRP5 polymorphisms influence BMD and fracture risk http://dx.doi.org/10.1038/ncpendmet0875 LRP5 polymorphisms influence BMD and fracture risk

Nature Clinical Practice Endocrinology & Metabolism 4, 422 (2008). doi:10.1038/ncpendmet0875

]]> LRP5 polymorphisms influence BMD and fracture risk doi:10.1038/ncpendmet0875 Nature Clinical Practice Endocrinology & Metabolism 4, 422 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 422 423 Effects of growth hormone therapy in children with PWS http://dx.doi.org/10.1038/ncpendmet0876 Effects of growth hormone therapy in children with PWS

Nature Clinical Practice Endocrinology & Metabolism 4, 423 (2008). doi:10.1038/ncpendmet0876

]]> Effects of growth hormone therapy in children with PWS doi:10.1038/ncpendmet0876 Nature Clinical Practice Endocrinology & Metabolism 4, 423 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 423 423 Beneficial effects of GHRT in women with hypopituitarism http://dx.doi.org/10.1038/ncpendmet0877 Beneficial effects of GHRT in women with hypopituitarism

Nature Clinical Practice Endocrinology & Metabolism 4, 423 (2008). doi:10.1038/ncpendmet0877

]]> Beneficial effects of GHRT in women with hypopituitarism doi:10.1038/ncpendmet0877 Nature Clinical Practice Endocrinology & Metabolism 4, 423 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 423 424 Use of both IGF and collagen markers could improve detection of GH abuse http://dx.doi.org/10.1038/ncpendmet0878 Use of both IGF and collagen markers could improve detection of GH abuse

Nature Clinical Practice Endocrinology & Metabolism 4, 424 (2008). doi:10.1038/ncpendmet0878

]]> Use of both IGF and collagen markers could improve detection of GH abuse doi:10.1038/ncpendmet0878 Nature Clinical Practice Endocrinology & Metabolism 4, 424 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 424 424 Different vitamin D therapeutic regimens are equally effective in young children http://dx.doi.org/10.1038/ncpendmet0879 Different vitamin D therapeutic regimens are equally effective in young children

Nature Clinical Practice Endocrinology & Metabolism 4, 424 (2008). doi:10.1038/ncpendmet0879

]]> Different vitamin D therapeutic regimens are equally effective in young children doi:10.1038/ncpendmet0879 Nature Clinical Practice Endocrinology & Metabolism 4, 424 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 424 424 T3 thyrotoxicosis in patients with massively metastatic thyroid carcinoma http://dx.doi.org/10.1038/ncpendmet0880 T3 thyrotoxicosis in patients with massively metastatic thyroid carcinoma

Nature Clinical Practice Endocrinology & Metabolism 4, 425 (2008). doi:10.1038/ncpendmet0880

]]> T3 thyrotoxicosis in patients with massively metastatic thyroid carcinoma doi:10.1038/ncpendmet0880 Nature Clinical Practice Endocrinology & Metabolism 4, 425 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 425 425 Effects of childhood exposure to Chernobyl fallout on thyroid function http://dx.doi.org/10.1038/ncpendmet0881 Effects of childhood exposure to Chernobyl fallout on thyroid function

Nature Clinical Practice Endocrinology & Metabolism 4, 425 (2008). doi:10.1038/ncpendmet0881

]]> Effects of childhood exposure to Chernobyl fallout on thyroid function doi:10.1038/ncpendmet0881 Nature Clinical Practice Endocrinology & Metabolism 4, 425 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 425 425 CKD severity in patients with diabetes affects the risk of foot ulcer http://dx.doi.org/10.1038/ncpendmet0882 CKD severity in patients with diabetes affects the risk of foot ulcer

Nature Clinical Practice Endocrinology & Metabolism 4, 425 (2008). doi:10.1038/ncpendmet0882

]]> CKD severity in patients with diabetes affects the risk of foot ulcer doi:10.1038/ncpendmet0882 Nature Clinical Practice Endocrinology & Metabolism 4, 425 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 425 426 Effects of lowered LDL and blood pressure targets on atherosclerosis and CVD events http://dx.doi.org/10.1038/ncpendmet0883 Effects of lowered LDL and blood pressure targets on atherosclerosis and CVD events

Nature Clinical Practice Endocrinology & Metabolism 4, 426 (2008). doi:10.1038/ncpendmet0883

]]> Effects of lowered LDL and blood pressure targets on atherosclerosis and CVD events doi:10.1038/ncpendmet0883 Nature Clinical Practice Endocrinology & Metabolism 4, 426 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 426 426 Bisphosphonate use does not increase the risk of atrial fibrillation and flutter http://dx.doi.org/10.1038/ncpendmet0884 Bisphosphonate use does not increase the risk of atrial fibrillation and flutter

Nature Clinical Practice Endocrinology & Metabolism 4, 426 (2008). doi:10.1038/ncpendmet0884

]]> Bisphosphonate use does not increase the risk of atrial fibrillation and flutter doi:10.1038/ncpendmet0884 Nature Clinical Practice Endocrinology & Metabolism 4, 426 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 426 427 Effects of metformin or repaglinide therapy for diabetes on serum markers for CVD http://dx.doi.org/10.1038/ncpendmet0885 Effects of metformin or repaglinide therapy for diabetes on serum markers for CVD

Nature Clinical Practice Endocrinology & Metabolism 4, 427 (2008). doi:10.1038/ncpendmet0885

]]> Effects of metformin or repaglinide therapy for diabetes on serum markers for CVD doi:10.1038/ncpendmet0885 Nature Clinical Practice Endocrinology & Metabolism 4, 427 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 427 427 Central obesity in middle age increases the risk of dementia later in life http://dx.doi.org/10.1038/ncpneuro0814 Central obesity in middle age increases the risk of dementia later in life

Nature Clinical Practice Endocrinology & Metabolism 4, 427 (2008). doi:10.1038/ncpneuro0814

]]> Central obesity in middle age increases the risk of dementia later in life doi:10.1038/ncpneuro0814 Nature Clinical Practice Endocrinology & Metabolism 4, 427 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 8 Research Highlights 427 427 Can calcitonin and carcinoembryonic antigen doubling times predict progression of thyroid carcinoma? http://dx.doi.org/10.1038/ncpendmet0865 Can calcitonin and carcinoembryonic antigen doubling times predict progression of thyroid carcinoma?

Nature Clinical Practice Endocrinology & Metabolism 4, 428 (2008). doi:10.1038/ncpendmet0865

Authors: Joshua Klopper & Bryan Haugen

]]> Can calcitonin and carcinoembryonic antigen doubling times predict progression of thyroid carcinoma? Joshua Klopper Bryan Haugen doi:10.1038/ncpendmet0865 Nature Clinical Practice Endocrinology & Metabolism 4, 428 (2008) 2008-06-10 Nature Clinical Practice Endocrinology & Metabolism 2008-06-10 4 8 Practice Point 428 429 Dietary glycemic index and glycemic load in diabetes prevention—what can we learn from observational studies? http://dx.doi.org/10.1038/ncpendmet0867 Dietary glycemic index and glycemic load in diabetes prevention—what can we learn from observational studies?

Nature Clinical Practice Endocrinology & Metabolism 4, 430 (2008). doi:10.1038/ncpendmet0867

Author: Mark A Pereira

]]> Dietary glycemic index and glycemic load in diabetes prevention—what can we learn from observational studies? Mark A Pereira doi:10.1038/ncpendmet0867 Nature Clinical Practice Endocrinology & Metabolism 4, 430 (2008) 2008-06-10 Nature Clinical Practice Endocrinology & Metabolism 2008-06-10 4 8 Practice Point 430 431 Is somatic RET mutation a prognostic factor for sporadic medullary thyroid carcinoma? http://dx.doi.org/10.1038/ncpendmet0866 Is somatic RET mutation a prognostic factor for sporadic medullary thyroid carcinoma?

Nature Clinical Practice Endocrinology & Metabolism 4, 432 (2008). doi:10.1038/ncpendmet0866

Author: Jan Zedenius

]]> Is somatic RET mutation a prognostic factor for sporadic medullary thyroid carcinoma? Jan Zedenius doi:10.1038/ncpendmet0866 Nature Clinical Practice Endocrinology & Metabolism 4, 432 (2008) 2008-06-10 Nature Clinical Practice Endocrinology & Metabolism 2008-06-10 4 8 Practice Point 432 433 Does an intensive multifactorial intervention reduce mortality in type 2 diabetes mellitus? http://dx.doi.org/10.1038/ncpendmet0868 Does an intensive multifactorial intervention reduce mortality in type 2 diabetes mellitus?

Nature Clinical Practice Endocrinology & Metabolism 4, 434 (2008). doi:10.1038/ncpendmet0868

Author: Bernard Zinman

]]> Does an intensive multifactorial intervention reduce mortality in type 2 diabetes mellitus? Bernard Zinman doi:10.1038/ncpendmet0868 Nature Clinical Practice Endocrinology & Metabolism 4, 434 (2008) 2008-06-24 Nature Clinical Practice Endocrinology & Metabolism 2008-06-24 4 8 Practice Point 434 435 Prognostic role of undetectable ablation thyroglobulin and follow-up thyroglobulin in patients with thyroid cancer http://dx.doi.org/10.1038/ncpendmet0864 Prognostic role of undetectable ablation thyroglobulin and follow-up thyroglobulin in patients with thyroid cancer

Nature Clinical Practice Endocrinology & Metabolism 4, 436 (2008). doi:10.1038/ncpendmet0864

Author: Sophie Leboulleux

]]> Prognostic role of undetectable ablation thyroglobulin and follow-up thyroglobulin in patients with thyroid cancer Sophie Leboulleux doi:10.1038/ncpendmet0864 Nature Clinical Practice Endocrinology & Metabolism 4, 436 (2008) 2008-06-24 Nature Clinical Practice Endocrinology & Metabolism 2008-06-24 4 8 Practice Point 436 437 The cutting edge in diabetes treatment—is weight-loss surgery an effective therapeutic strategy? http://dx.doi.org/10.1038/ncpendmet0893 The cutting edge in diabetes treatment—is weight-loss surgery an effective therapeutic strategy?

Nature Clinical Practice Endocrinology & Metabolism 4, 438 (2008). doi:10.1038/ncpendmet0893

Authors: Lee M Kaplan & Nadia N Ahmad

]]> The cutting edge in diabetes treatment—is weight-loss surgery an effective therapeutic strategy? Lee M Kaplan Nadia N Ahmad doi:10.1038/ncpendmet0893 Nature Clinical Practice Endocrinology & Metabolism 4, 438 (2008) 2008-07-01 Nature Clinical Practice Endocrinology & Metabolism 2008-07-01 4 8 Practice Point 438 439 Are prescribing patterns of antidiabetic medications influenced by fears of litigation? http://dx.doi.org/10.1038/ncpendmet0869 Management of diabetes mellitus is occasionally confounded by lack of understanding on the part of physicians and patients of issues surrounding the risks and benefits of antidiabetic drugs. The need for adequately powered outcome studies that minimize the effects of the unknown on prescribing habits in diabetes care is debated. Are prescribing patterns of antidiabetic medications influenced by fears of litigation?

Nature Clinical Practice Endocrinology & Metabolism 4, 440 (2008). doi:10.1038/ncpendmet0869

Author: John B Buse

]]> Are prescribing patterns of antidiabetic medications influenced by fears of litigation? John B Buse doi:10.1038/ncpendmet0869 Nature Clinical Practice Endocrinology & Metabolism 4, 440 (2008) 2008-06-17 Nature Clinical Practice Endocrinology & Metabolism 2008-06-17 4 8 Viewpoint 440 441 Dehydroepiandrosterone replacement therapy—panacea, snake oil, or a bit of both? http://dx.doi.org/10.1038/ncpendmet0870 Age-related declines in dehydroepiandrosterone sulfate concentration parallel the physical and cognitive changes of aging. This observation suggests that these events are causally related and that replacement therapy might have beneficial effects in the elderly. The authors of this Viewpoint consider the evidence for, and against, such an approach. Dehydroepiandrosterone replacement therapy—panacea, snake oil, or a bit of both?

Nature Clinical Practice Endocrinology & Metabolism 4, 442 (2008). doi:10.1038/ncpendmet0870

Authors: Alice Y Chang, Hans K Ghayee & Richard J Auchus

]]> Dehydroepiandrosterone replacement therapy—panacea, snake oil, or a bit of both? Alice Y Chang Hans K Ghayee Richard J Auchus doi:10.1038/ncpendmet0870 Nature Clinical Practice Endocrinology & Metabolism 4, 442 (2008) 2008-06-17 Nature Clinical Practice Endocrinology & Metabolism 2008-06-17 4 8 Viewpoint 442 443 The pathogenesis of diabetic nephropathy http://dx.doi.org/10.1038/ncpendmet0894 Between 20% and 40% of patients with diabetes ultimately develop nephropathy. The bank of data on the multiple and complex mechanisms, disease markers and disease progression continues to grow. This article provides an overview of the current status of findings relating to underlying mechanisms and genetic susceptibility. The pathogenesis of diabetic nephropathy

Nature Clinical Practice Endocrinology & Metabolism 4, 444 (2008). doi:10.1038/ncpendmet0894

Authors: Suma Dronavalli, Irena Duka & George L Bakris

]]> The pathogenesis of diabetic nephropathy Suma Dronavalli Irena Duka George L Bakris doi:10.1038/ncpendmet0894 Nature Clinical Practice Endocrinology & Metabolism 4, 444 (2008) 2008-07-08 Nature Clinical Practice Endocrinology & Metabolism 2008-07-08 4 8 Review 444 452 Environmental factors and autoimmune thyroiditis http://dx.doi.org/10.1038/ncpendmet0896 Autoimmune thyroiditis, which manifests as Hashimoto thyroiditis and Graves disease among other forms, is an inflammatory disorder of the thyroid gland. Various environmental factors interact with susceptibility genes and seem to be associated with disease initiation and to influence duration and severity. This Review summarizes the currently available information and highlights the areas that urgently require further study. Environmental factors and autoimmune thyroiditis

Nature Clinical Practice Endocrinology & Metabolism 4, 454 (2008). doi:10.1038/ncpendmet0896

Author: Leonidas H Duntas

]]> Environmental factors and autoimmune thyroiditis Leonidas H Duntas doi:10.1038/ncpendmet0896 Nature Clinical Practice Endocrinology & Metabolism 4, 454 (2008) 2008-07-08 Nature Clinical Practice Endocrinology & Metabolism 2008-07-08 4 8 Review 454 460 Techniques to quantify TSH receptor antibodies http://dx.doi.org/10.1038/ncpendmet0886 Thyroid stimulation in Graves disease is caused by antibodies to the TSH receptor that have thyroid-stimulating or thyroid-blocking activity. Antibody detection can aid diagnosis and prediction of outcomes of the disease, as well as prediction of the course of associated ophthalmology. In this Review, Ajjan and Weetman describe the different measurement techniques available and their clinical applications. Techniques to quantify TSH receptor antibodies

Nature Clinical Practice Endocrinology & Metabolism 4, 461 (2008). doi:10.1038/ncpendmet0886

Authors: RA Ajjan & AP Weetman

]]> Techniques to quantify TSH receptor antibodies RA Ajjan AP Weetman doi:10.1038/ncpendmet0886 Nature Clinical Practice Endocrinology & Metabolism 4, 461 (2008) 2008-06-24 Nature Clinical Practice Endocrinology & Metabolism 2008-06-24 4 8 Review 461 468 Malignant struma ovarii http://dx.doi.org/10.1038/ncpendmet0887 Struma ovarii is a rare tumor, characterized by the presence of thyroid tissue in an ovarian teratoma. In this article Yassa et al. describe a patient who presented to her gynecologist with a pelvic mass, which was found to be a malignant struma ovarii. The investigations and treatment options for this tumor are described. Malignant struma ovarii

Nature Clinical Practice Endocrinology & Metabolism 4, 469 (2008). doi:10.1038/ncpendmet0887

Authors: Leila Yassa, Peter Sadow & Ellen Marqusee

]]> Malignant struma ovarii Leila Yassa Peter Sadow Ellen Marqusee doi:10.1038/ncpendmet0887 Nature Clinical Practice Endocrinology & Metabolism 4, 469 (2008) 2008-06-17 Nature Clinical Practice Endocrinology & Metabolism 2008-06-17 4 8 Case Study 469 472