Nature Clinical Practice Endocrinology & Metabolism Nature Clinical Practice Endocrinology & Metabolism provides physicians with authoritative and timely interpretations of key developments in the field, translating the latest findings into clinical practice. http://www.nature.com/ncpendmet/current_issue/ Nature Publishing Group en © 2008 Nature Publishing Group Nature Clinical Practice Endocrinology & Metabolism 1745-8366 1745-8374 © 2008 Nature Publishing Group permissions@nature.com Nature Clinical Practice Endocrinology & Metabolism http://www.nature.com/includes/rj_globnavimages/ncpendmet_logo.gif http://www.nature.com/ncpendmet/ Dr Joseph Edward Rall http://dx.doi.org/10.1038/ncpendmet0871 Dr Joseph Edward Rall

Nature Clinical Practice Endocrinology & Metabolism 4, 359 (2008). doi:10.1038/ncpendmet0871

Authors: Jan Wolff & P Reed Larsen

]]> Dr Joseph Edward Rall Jan Wolff P Reed Larsen doi:10.1038/ncpendmet0871 Nature Clinical Practice Endocrinology & Metabolism 4, 359 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Editorial 359 359 A TNFRS11B mutation is associated with BMD and risk of hip fracture http://dx.doi.org/10.1038/ncpendmet0847 A TNFRS11B mutation is associated with BMD and risk of hip fracture

Nature Clinical Practice Endocrinology & Metabolism 4, 360 (2008). doi:10.1038/ncpendmet0847

]]> A TNFRS11B mutation is associated with BMD and risk of hip fracture doi:10.1038/ncpendmet0847 Nature Clinical Practice Endocrinology & Metabolism 4, 360 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 360 360 Low testosterone levels are associated with insulin resistance in men with diabetes http://dx.doi.org/10.1038/ncpendmet0848 Low testosterone levels are associated with insulin resistance in men with diabetes

Nature Clinical Practice Endocrinology & Metabolism 4, 360 (2008). doi:10.1038/ncpendmet0848

]]> Low testosterone levels are associated with insulin resistance in men with diabetes doi:10.1038/ncpendmet0848 Nature Clinical Practice Endocrinology & Metabolism 4, 360 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 360 360 Elevated sex-hormone-binding globulin level is an independent risk factor for hip fracture http://dx.doi.org/10.1038/ncpendmet0849 Elevated sex-hormone-binding globulin level is an independent risk factor for hip fracture

Nature Clinical Practice Endocrinology & Metabolism 4, 360 (2008). doi:10.1038/ncpendmet0849

]]> Elevated sex-hormone-binding globulin level is an independent risk factor for hip fracture doi:10.1038/ncpendmet0849 Nature Clinical Practice Endocrinology & Metabolism 4, 360 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 360 361 Results of testosterone-doping test depend on UGT2B17 genotype http://dx.doi.org/10.1038/ncpendmet0850 Results of testosterone-doping test depend on UGT2B17 genotype

Nature Clinical Practice Endocrinology & Metabolism 4, 361 (2008). doi:10.1038/ncpendmet0850

]]> Results of testosterone-doping test depend on UGT2B17 genotype doi:10.1038/ncpendmet0850 Nature Clinical Practice Endocrinology & Metabolism 4, 361 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 361 361 Health risks and benefits change after withdrawal of estrogen plus progestin therapy http://dx.doi.org/10.1038/ncpendmet0851 Health risks and benefits change after withdrawal of estrogen plus progestin therapy

Nature Clinical Practice Endocrinology & Metabolism 4, 361 (2008). doi:10.1038/ncpendmet0851

]]> Health risks and benefits change after withdrawal of estrogen plus progestin therapy doi:10.1038/ncpendmet0851 Nature Clinical Practice Endocrinology & Metabolism 4, 361 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 361 362 Genotype influences lipid profile and incident cardiovascular disease risk http://dx.doi.org/10.1038/ncpendmet0852 Genotype influences lipid profile and incident cardiovascular disease risk

Nature Clinical Practice Endocrinology & Metabolism 4, 362 (2008). doi:10.1038/ncpendmet0852

]]> Genotype influences lipid profile and incident cardiovascular disease risk doi:10.1038/ncpendmet0852 Nature Clinical Practice Endocrinology & Metabolism 4, 362 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 362 362 Growth-hormone therapy might not improve exercise capacity http://dx.doi.org/10.1038/ncpendmet0853 Growth-hormone therapy might not improve exercise capacity

Nature Clinical Practice Endocrinology & Metabolism 4, 362 (2008). doi:10.1038/ncpendmet0853

]]> Growth-hormone therapy might not improve exercise capacity doi:10.1038/ncpendmet0853 Nature Clinical Practice Endocrinology & Metabolism 4, 362 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 362 362 CTGF might have a role in vascular and renal disease associated with type 1 diabetes http://dx.doi.org/10.1038/ncpendmet0854 CTGF might have a role in vascular and renal disease associated with type 1 diabetes

Nature Clinical Practice Endocrinology & Metabolism 4, 363 (2008). doi:10.1038/ncpendmet0854

]]> CTGF might have a role in vascular and renal disease associated with type 1 diabetes doi:10.1038/ncpendmet0854 Nature Clinical Practice Endocrinology & Metabolism 4, 363 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 363 363 Lipid-lowering therapy could protect against peripheral neuropathy http://dx.doi.org/10.1038/ncpendmet0855 Lipid-lowering therapy could protect against peripheral neuropathy

Nature Clinical Practice Endocrinology & Metabolism 4, 363 (2008). doi:10.1038/ncpendmet0855

]]> Lipid-lowering therapy could protect against peripheral neuropathy doi:10.1038/ncpendmet0855 Nature Clinical Practice Endocrinology & Metabolism 4, 363 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 363 363 Metformin benefits low-birth-weight girls with precocious pubarche http://dx.doi.org/10.1038/ncpendmet0856 Metformin benefits low-birth-weight girls with precocious pubarche

Nature Clinical Practice Endocrinology & Metabolism 4, 363 (2008). doi:10.1038/ncpendmet0856

]]> Metformin benefits low-birth-weight girls with precocious pubarche doi:10.1038/ncpendmet0856 Nature Clinical Practice Endocrinology & Metabolism 4, 363 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 363 364 Daily rhPTH1–84 injections could be avoided in osteoporosis treatment http://dx.doi.org/10.1038/ncpendmet0857 Daily rhPTH1–84 injections could be avoided in osteoporosis treatment

Nature Clinical Practice Endocrinology & Metabolism 4, 364 (2008). doi:10.1038/ncpendmet0857

]]> Daily rhPTH1–84 injections could be avoided in osteoporosis treatment doi:10.1038/ncpendmet0857 Nature Clinical Practice Endocrinology & Metabolism 4, 364 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 364 364 Pioglitazone treatment decreases BMD even in estrogen-replete women http://dx.doi.org/10.1038/ncpendmet0858 Pioglitazone treatment decreases BMD even in estrogen-replete women

Nature Clinical Practice Endocrinology & Metabolism 4, 364 (2008). doi:10.1038/ncpendmet0858

]]> Pioglitazone treatment decreases BMD even in estrogen-replete women doi:10.1038/ncpendmet0858 Nature Clinical Practice Endocrinology & Metabolism 4, 364 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 364 365 Identification of a serum biomarker profile that could aid early diagnosis of osteoporosis http://dx.doi.org/10.1038/ncpendmet0859 Identification of a serum biomarker profile that could aid early diagnosis of osteoporosis

Nature Clinical Practice Endocrinology & Metabolism 4, 365 (2008). doi:10.1038/ncpendmet0859

]]> Identification of a serum biomarker profile that could aid early diagnosis of osteoporosis doi:10.1038/ncpendmet0859 Nature Clinical Practice Endocrinology & Metabolism 4, 365 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 365 365 Patients with MEN1-associated ZES have a severe form of hyperparathyroidism http://dx.doi.org/10.1038/ncpendmet0860 Patients with MEN1-associated ZES have a severe form of hyperparathyroidism

Nature Clinical Practice Endocrinology & Metabolism 4, 365 (2008). doi:10.1038/ncpendmet0860

]]> Patients with MEN1-associated ZES have a severe form of hyperparathyroidism doi:10.1038/ncpendmet0860 Nature Clinical Practice Endocrinology & Metabolism 4, 365 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Research Highlights 365 365 Can serum pentosidine levels predict risk of vertebral fracture in patients with type 2 diabetes mellitus? http://dx.doi.org/10.1038/ncpendmet0835 Can serum pentosidine levels predict risk of vertebral fracture in patients with type 2 diabetes mellitus?

Nature Clinical Practice Endocrinology & Metabolism 4, 366 (2008). doi:10.1038/ncpendmet0835

Author: Karl Insogna

]]> Can serum pentosidine levels predict risk of vertebral fracture in patients with type 2 diabetes mellitus? Karl Insogna doi:10.1038/ncpendmet0835 Nature Clinical Practice Endocrinology & Metabolism 4, 366 (2008) 2008-05-06 Nature Clinical Practice Endocrinology & Metabolism 2008-05-06 4 7 Practice Point 366 367 Is hydrocortisone an effective treatment for septic shock? http://dx.doi.org/10.1038/ncpendmet0836 Is hydrocortisone an effective treatment for septic shock?

Nature Clinical Practice Endocrinology & Metabolism 4, 368 (2008). doi:10.1038/ncpendmet0836

Author: Mark S Cooper

]]> Is hydrocortisone an effective treatment for septic shock? Mark S Cooper doi:10.1038/ncpendmet0836 Nature Clinical Practice Endocrinology & Metabolism 4, 368 (2008) 2008-05-06 Nature Clinical Practice Endocrinology & Metabolism 2008-05-06 4 7 Practice Point 368 369 Should the upper limit of the normal reference range for TSH be lowered? http://dx.doi.org/10.1038/ncpendmet0841 Should the upper limit of the normal reference range for TSH be lowered?

Nature Clinical Practice Endocrinology & Metabolism 4, 370 (2008). doi:10.1038/ncpendmet0841

Author: Martin I Surks

]]> Should the upper limit of the normal reference range for TSH be lowered? Martin I Surks doi:10.1038/ncpendmet0841 Nature Clinical Practice Endocrinology & Metabolism 4, 370 (2008) 2008-05-20 Nature Clinical Practice Endocrinology & Metabolism 2008-05-20 4 7 Practice Point 370 371 How does teriparatide compare with alendronate for the treatment of glucocorticoid-induced osteoporosis? http://dx.doi.org/10.1038/ncpendmet0838 How does teriparatide compare with alendronate for the treatment of glucocorticoid-induced osteoporosis?

Nature Clinical Practice Endocrinology & Metabolism 4, 372 (2008). doi:10.1038/ncpendmet0838

Author: René Rizzoli

]]> How does teriparatide compare with alendronate for the treatment of glucocorticoid-induced osteoporosis? René Rizzoli doi:10.1038/ncpendmet0838 Nature Clinical Practice Endocrinology & Metabolism 4, 372 (2008) 2008-05-13 Nature Clinical Practice Endocrinology & Metabolism 2008-05-13 4 7 Practice Point 372 373 Does testosterone supplementation improve health and function in elderly men? http://dx.doi.org/10.1038/ncpendmet0840 Does testosterone supplementation improve health and function in elderly men?

Nature Clinical Practice Endocrinology & Metabolism 4, 374 (2008). doi:10.1038/ncpendmet0840

Authors: Stephanie T Page, John K Amory & Alvin M Matsumoto

]]> Does testosterone supplementation improve health and function in elderly men? Stephanie T Page John K Amory Alvin M Matsumoto doi:10.1038/ncpendmet0840 Nature Clinical Practice Endocrinology & Metabolism 4, 374 (2008) 2008-05-20 Nature Clinical Practice Endocrinology & Metabolism 2008-05-20 4 7 Practice Point 374 375 Is denosumab a safe and effective treatment for postmenopausal osteoporosis? http://dx.doi.org/10.1038/ncpendmet0845 Is denosumab a safe and effective treatment for postmenopausal osteoporosis?

Nature Clinical Practice Endocrinology & Metabolism 4, 376 (2008). doi:10.1038/ncpendmet0845

Author: Kathryn E Ackerman

]]> Is denosumab a safe and effective treatment for postmenopausal osteoporosis? Kathryn E Ackerman doi:10.1038/ncpendmet0845 Nature Clinical Practice Endocrinology & Metabolism 4, 376 (2008) 2008-05-27 Nature Clinical Practice Endocrinology & Metabolism 2008-05-27 4 7 Practice Point 376 377 The role of energy and nutritional support in the intensive care unit http://dx.doi.org/10.1038/ncpendmet0839 Malnutrition is common in critically ill, hospitalized patients and so represents a major problem for intensive care. Nutritional support can be beneficial in such cases and may help preserve vital organ and immune function. Energy requirements, route of delivery and potential complications of nutritional support are discussed in this Viewpoint. The role of energy and nutritional support in the intensive care unit

Nature Clinical Practice Endocrinology & Metabolism 4, 378 (2008). doi:10.1038/ncpendmet0839

Authors: Mette M Berger & René L Chioléro

]]> The role of energy and nutritional support in the intensive care unit Mette M Berger René L Chioléro doi:10.1038/ncpendmet0839 Nature Clinical Practice Endocrinology & Metabolism 4, 378 (2008) 2008-05-13 Nature Clinical Practice Endocrinology & Metabolism 2008-05-13 4 7 Viewpoint 378 379 Pharmacologic treatment options for prediabetes http://dx.doi.org/10.1038/ncpendmet0842 Identification and subsequent treatment of individuals with prediabetes can prevent progression to type 2 diabetes mellitus. Although lifestyle changes are critical in this setting, the question of whether pharmacotherapy should also be used remains unanswered. The authors of this Viewpoint, therefore, discuss potential strategies for pharmacologic intervention. Pharmacologic treatment options for prediabetes

Nature Clinical Practice Endocrinology & Metabolism 4, 380 (2008). doi:10.1038/ncpendmet0842

Authors: Willa A Hsueh & Yehuda Handelsman

]]> Pharmacologic treatment options for prediabetes Willa A Hsueh Yehuda Handelsman doi:10.1038/ncpendmet0842 Nature Clinical Practice Endocrinology & Metabolism 4, 380 (2008) 2008-06-03 Nature Clinical Practice Endocrinology & Metabolism 2008-06-03 4 7 Viewpoint 380 381 The prevention of type 2 diabetes http://dx.doi.org/10.1038/ncpendmet0843 Prediabetic states that involve impairments of insulin secretion and action can be identified. Medical therapy and lifestyle modifications can be used in people with these disorders to delay or prevent the onset of type 2 diabetes. In this Review, the data on development and evaluation of diabetes-prevention strategies are discussed and some recommendations for practice are provided. The prevention of type 2 diabetes

Nature Clinical Practice Endocrinology & Metabolism 4, 382 (2008). doi:10.1038/ncpendmet0843

Authors: Jill P Crandall, William C Knowler, Steven E Kahn, David Marrero, Jose C Florez, George A Bray, Steven M Haffner, Mary Hoskin & David M Nathan

]]> The prevention of type 2 diabetes Jill P Crandall William C Knowler Steven E Kahn David Marrero Jose C Florez George A Bray Steven M Haffner Mary Hoskin David M Nathan doi:10.1038/ncpendmet0843 Nature Clinical Practice Endocrinology & Metabolism 4, 382 (2008) 2008-05-20 Nature Clinical Practice Endocrinology & Metabolism 2008-05-20 4 7 Review 382 393 The role of thyroid autoimmunity in fertility and pregnancy http://dx.doi.org/10.1038/ncpendmet0846 The thyroid gland and thyroid hormones have important roles in fertility and throughout pregnancy. In fertile and infertile women with thyroid disorders, such as hypothyroidism or thyroid autoimmunity, therapy might enable conception, but a host of problems can arise. Poppe et al. present an overview of the interactions between thyroid disorders and spontaneous and assisted pregnancies. The role of thyroid autoimmunity in fertility and pregnancy

Nature Clinical Practice Endocrinology & Metabolism 4, 394 (2008). doi:10.1038/ncpendmet0846

Authors: Kris Poppe, Brigitte Velkeniers & Daniel Glinoer

]]> The role of thyroid autoimmunity in fertility and pregnancy Kris Poppe Brigitte Velkeniers Daniel Glinoer doi:10.1038/ncpendmet0846 Nature Clinical Practice Endocrinology & Metabolism 4, 394 (2008) 2008-05-27 Nature Clinical Practice Endocrinology & Metabolism 2008-05-27 4 7 Review 394 405 Endocrine abnormalities in anorexia nervosa http://dx.doi.org/10.1038/ncpendmet0872 Various endocrine abnormalities arise in anorexia nervosa. Most are related to the body's adaptation to starvation, but some might relate to susceptibility to recurrence, as they persist after recovery. Lawson and Klibanski summarize the main endocrine alterations in girls and women, concentrating particularly on bone loss. Endocrine abnormalities in anorexia nervosa

Nature Clinical Practice Endocrinology & Metabolism 4, 407 (2008). doi:10.1038/ncpendmet0872

Authors: Elizabeth A Lawson & Anne Klibanski

]]> Endocrine abnormalities in anorexia nervosa Elizabeth A Lawson Anne Klibanski doi:10.1038/ncpendmet0872 Nature Clinical Practice Endocrinology & Metabolism 4, 407 (2008) 2008-06-10 Nature Clinical Practice Endocrinology & Metabolism 2008-06-10 4 7 Review 407 414 Treatment of male infertility secondary to morbid obesity http://dx.doi.org/10.1038/ncpendmet0844 Obesity can be a cause of secondary hypogonadism. This article describes a male patient with infertility in the setting of obesity, who was successfully treated with the aromatase inhibitor anastrozole. The authors illustrate the connections between adiposity, aromatase expression, testosterone and estradiol levels, and the suppression of gonadotropin release and spermatogenesis. Treatment of male infertility secondary to morbid obesity

Nature Clinical Practice Endocrinology & Metabolism 4, 415 (2008). doi:10.1038/ncpendmet0844

Authors: Mara Y Roth, John K Amory & Stephanie T Page

]]> Treatment of male infertility secondary to morbid obesity Mara Y Roth John K Amory Stephanie T Page doi:10.1038/ncpendmet0844 Nature Clinical Practice Endocrinology & Metabolism 4, 415 (2008) 2008-06-03 Nature Clinical Practice Endocrinology & Metabolism 2008-06-03 4 7 Case Study 415 419 A patient with MEN1-associated hyperparathyroidism, responsive to cinacalcet http://dx.doi.org/10.1038/ncpendmet0888 A patient with MEN1-associated hyperparathyroidism, responsive to cinacalcet

Nature Clinical Practice Endocrinology & Metabolism 4, 420 (2008). doi:10.1038/ncpendmet0888

Authors: Alberto Falchetti, Antonio Cilotti, Luca Vagelli, Laura Masi, Antonietta Amedei, Federica Cioppi, Francesco Tonelli & Maria Luisa Brandi

]]> A patient with MEN1-associated hyperparathyroidism, responsive to cinacalcet Alberto Falchetti Antonio Cilotti Luca Vagelli Laura Masi Antonietta Amedei Federica Cioppi Francesco Tonelli Maria Luisa Brandi doi:10.1038/ncpendmet0888 Nature Clinical Practice Endocrinology & Metabolism 4, 420 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 7 Corrigendum 420 420