Diabetes and hypertension: inextricably linked

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The treatment of diabetes and hypertension has become one of the greatest challenges for medical professionals today. It is estimated that by 2025 some 1.56 billion people will have hypertension and by 2030 around 366 million will have diabetes. From October 22nd 2007, Nature Clinical Practice will be presenting a selection of articles from a variety of Nature Publishing Group journals that will focus on these conditions.

Featured Article

Featured Article 1

Diabetes and hypertension

Rodrigo M Lago, Premranjan P Singh and Richard W Nesto

Diabetes and hypertension are inexorably bound together, and require early diagnosis and aggressive treatment to prevent the development of further complications, such as coronary artery and chronic kidney disease. In this Editorial, Drs Lago, Singh and Nesto examine the growing epidemic and introduce this free collection of articles from the Nature Publishing Group.

Featured Article

Featured Article 2

Lessons learnt from the ABCD trial

Robert W Schrier, Raymond O Estacio, Philip S Mehler and William R Hiatt

In recent years, the focus of treatment for type 2 diabetes mellitus has expanded to include blood pressure control, not just blood glucose control. Here, Schrier et al. review the ABCD studies, which highlighted the important role of aggressive blood pressure control in reducing the burden of complications caused by type 2 diabetes mellitus, in both both hypertensive and normotensive patients.

Featured Article

Featured Article 3

How important is screening angiography for CAS in diabetic patients awaiting transplant? A cardiologist's view

Michael E Farkouh

In this Practice Point, cardiologist Michael Farkouh examines the recent paper by Witczak et al. demonstrating the efficacy of routine invasive screening for significant coronary artery disease in patients with diabetic nephropathy. He argues that noninvasive testing is preferable to angiography for identifying coronary ischemia in diabetic patients before they undergo renal transplantation.

Featured Article

Featured Article 4

Are antihypertensive drugs associated with an increased risk of incident type 2 diabetes?

Pantelis A Sarafidis and George L Bakris

Here, Drs Sarafidis and Bakris, two leaders in the field of diabetes and hypertension, discuss the findings of a prospective study by Taylor et al., which found that the use of certain antihypertensive drugs was associated with an increased incidence of type 2 diabetes mellitus.

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Editorials

Diabetes and hypertension

Rodrigo M Lago, Premranjan P Singh and Richard W Nesto

Nature Clinical Practice Endocrinology & Metabolism 3, In press (01 Oct 2007)

doi:10.1038/ncpendmet0638 | Full Text | PDF

Diabetes and residual risk of coronary heart disease

Richard W Nesto and Premranjan P Singh

Nature Clinical Practice Endocrinology & Metabolism 3, 71 (01 Feb 2007)

doi:10.1038/ncpendmet0398 | Full Text | PDF

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Viewpoint

Should patients with type 2 diabetes asymptomatic for coronary artery disease undergo testing for myocardial ischemia?

Robert A O'Rourke

Nature Clinical Practice Cardiovascular Medicine 2, 492-493 (01 Oct 2005)

doi:10.1038/ncpcardio0326 | Full Text | PDF

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Practice Points

Increasing telmisartan vs amlodipine dose in patients with hypertension, type 2 diabetes and microalbuminuria

Julia Lewis

Nature Clinical Practice Nephrology 3, 476-477 (24 Aug 2007)

doi:10.1038/ncpneph0562 | Full Text | PDF

Can a network meta-analysis be used to determine the effect of antihypertensive drugs on the risk of incident diabetes?

Finlay A McAlister

Nature Clinical Practice Endocrinology & Metabolism 3, 516-517 (01 Jul 2007)

doi:10.1038/ncpendmet0537 | Full Text | PDF

Intensive versus moderate blood-pressure control in normotensive patients with type 2 diabetes

Josephine Briggs

Nature Clinical Practice Nephrology 3, 304-305 (01 Jun 2007)

doi:10.1038/ncpneph0478 | Full Text | PDF

Does pioglitazone reduce carotid intima–media thickness in patients with type 2 diabetes mellitus?

Cyrus Desouza

Nature Clinical Practice Endocrinology & Metabolism 3, 394-395 (01 May 2007)

doi:10.1038/ncpendmet0482 | Full Text | PDF

How important is screening angiography for CAS in diabetic patients awaiting transplant? A cardiologist's view

Michael E Farkouh

Nature Clinical Practice Cardiovascular Medicine 4, 132-133 (01 Mar 2007)

doi:10.1038/ncpcardio0801 | Full Text | PDF

How important is screening angiography for CAS in diabetic patients awaiting transplant? A nephrologist's view

Jonathan A Winston

Nature Clinical Practice Cardiovascular Medicine 4, 134-135 (01 Mar 2007)

doi:10.1038/ncpcardio0802 | Full Text | PDF

Are antihypertensive drugs associated with an increased risk of incident type 2 diabetes?

Pantelis A Sarafidis and George L Bakris

Nature Clinical Practice Endocrinology & Metabolism 3, 8-9 (01 Jan 2007)

doi:10.1038/ncpendmet0315 | Full Text | PDF

How prevalent are diabetes-related complications in patients with youth-onset type 2 diabetes mellitus?

Jennifer Miller and Janet Silverstein

Nature Clinical Practice Endocrinology & Metabolism 3, 12-13 (01 Jan 2007)

doi:10.1038/ncpendmet0356 | Full Text | PDF

Does the risk of developing diabetes in hypertensive kidney disease vary with different antihypertensive agents?

Karin Jandeleit-Dahm

Nature Clinical Practice Nephrology 2, 612-613 (01 Nov 2006)

doi:10.1038/ncpneph0312 | Full Text | PDF

What is the impact of blood-pressure control on cardiovascular events in patients with diabetic nephropathy?

Guiseppe Mancia

Nature Clinical Practice Nephrology 2, 132-133 (01 Mar 2006)

doi:10.1038/ncpneph0127 | Full Text | PDF

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Reviews

Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial

Robert W Schrier, Raymond O Estacio, Philip S Mehler and William R Hiatt

Nature Clinical Practice Nephrology 3, 428-438 (01 Aug 2007)

doi:10.1038/ncpneph0559 | Full Text | PDF

The changing costs and benefits of screening for asymptomatic coronary heart disease in patients with diabetes

Martin K Rutter and Richard W Nesto

Nature Clinical Practice Endocrinology & Metabolism 3, 26-35 (01 Jan 2007)

doi:10.1038/ncpendmet0352 | Full Text | PDF

Hypertension and antihypertensive treatment of diabetic nephropathy

Eberhard Ritz and Ralf Dikow

Nature Clinical Practice Nephrology 2, 562-567 (01 Oct 2006)

doi:10.1038/ncpneph0298 | Full Text | PDF

Therapy Insight: peripheral arterial disease and diabetes—from pathogenesis to treatment guidelines

Emile R Mohler III

Nature Clinical Practice Cardiovascular Medicine 4, 151-162 (01 Mar 2007)

doi:10.1038/ncpcardio0823 | Full Text | PDF

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Original Research

Blood pressure, antihypertensive treatment and factors associated with good blood pressure control in hypertensive diabetics: the Tarmidas study

P de Pablos-Velasco, O Gonzalez-Albarran, V Estopiñan and A Khanbhai in representation of the TARMIDAS Group

Journal of Human Hypertension 21, 664-672 (01 Aug 2007; published online 26 Apr 2007)

doi:10.1038/sj.jhh.1002214 | Full Text | PDF

The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension

S Tekes and A S Cikim

Journal of Human Hypertension 21, 546-550 (01 Jul 2007; published online 29 Mar 2007)

doi:10.1038/sj.jhh.1002194 | Full Text | PDF

Risk of diabetes in a real-world setting among patients initiating antihypertensive therapy with valsartan or amlodipine

D Weycker, J Edelsberg, G Vincze, S E Kjeldsen, K Jamerson, Z M Khan and G Oster

Journal of Human Hypertension 21, 374-380 (01 May 2007; published online 22 Feb 2007)

doi:10.1038/sj.jhh.1002159 | Full Text | PDF

Usefulness of ambulatory blood pressure monitoring in predicting the presence of autonomic neuropathy in type I diabetic patients

V Spallone, M R Maiello, R Morganti, S Mandica and G Frajese

Journal of Human Hypertension 21, 381-386 (01 May 2007; published online 15 Feb 2007)

doi:10.1038/sj.jhh.1002162 | Full Text | PDF

Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation

A Onat, G Can, G Hergenç, M Yazi nodotci nodot, A Karabulut and S Albayrak

International Journal of Obesity 31, 1119-1125 (01 Jul 2007; published online 13 Feb 2007)

doi:10.1038/sj.ijo.0803552 | Full Text | PDF

Effect of nifedipine on adiponectin in hypertensive patients with type 2 diabetes mellitus

S Nomura, N Inami, Y Kimura, S Omoto, A Shouzu, M Nishikawa and T Iwasaka

Journal of Human Hypertension 21, 38-44 (01 Jan 2007; published online 19 Oct 2006)

doi:10.1038/sj.jhh.1002100 | Full Text | PDF

Improved insulin sensitivity with the angiotensin II-receptor blocker losartan in patients with hypertension and other cardiovascular risk factors

T A Aksnes, H M Reims, S Guptha, A Moan, I Os and S E Kjeldsen

Journal of Human Hypertension 20, 860-866 (01 Nov 2006; published online 21 Sep 2006)

doi:10.1038/sj.jhh.1002087 | Full Text | PDF

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