Advance online publication
The latest papers brought to you ahead of print publication by Nature Clinical Practice. Advance online publication papers are listed below.
About advance online publication
Viewpoint
Etiology of cognitive change after CABG surgery: more than just the pump?
There is much debate surrounding the etiology of cognitive decline following CABG surgery. In this Viewpoint, Neuropsychologist Ola Selnes postulates that this worrying complication is likely to be attributable to patient-related factors, such as the extent of pre-existing cerebrovascular disease, rather than to cardiopulmonary bypass.
Published online:
22 April 2008
doi:10.1038/ncpcardio1193 |
Full Text | PDF (174K)
Practice Points
Long-term outcomes after Fontan surgery
Published online:
13 May 2008
doi:10.1038/ncpcardio1220 |
Full Text | PDF (174K)
What are the risk factors for progression of coronary artery calcification in patients with type 2 diabetes?
Published online:
13 May 2008
doi:10.1038/ncpcardio1208 |
Full Text | PDF (175K)
Sirolimus as primary immunosuppression is effective in attenuating progression of cardiac-allograft vasculopathy
Published online:
06 May 2008
doi:10.1038/ncpcardio1213 |
Full Text | PDF (172K)
What are the effects of patient age and blood pressure on the cholesterol-related risk of vascular mortality?
Published online:
29 April 2008
doi:10.1038/ncpcardio1209 |
Full Text | PDF (176K)
Solving the paradox of self blood-pressure measurement
Published online:
29 April 2008
doi:10.1038/ncpcardio1207 |
Full Text | PDF (172K)
Anacetrapib: new hope for cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia
Published online:
22 April 2008
doi:10.1038/ncpcardio1190 |
Full Text | PDF (179K)
Early intervention in acute coronary syndrome: is bivalirudin monotherapy an effective antithrombotic strategy?
Published online:
15 April 2008
doi:10.1038/ncpcardio1187 |
Full Text | PDF (176K)
Should patients with implantable cardioverter-defibrillators refrain from driving?
Published online:
08 April 2008
doi:10.1038/ncpcardio1188 |
Full Text | PDF (173K)
Do nondiabetic patients with acute coronary syndromes and hyperglycemia benefit from insulin therapy?
Published online:
18 March 2008
doi:10.1038/ncpcardio1156 |
Full Text | PDF (178K)
Is it time to discard the apo B:apo A-I ratio as a predictor of cardiovascular disease?
Published online:
06 November 2007
doi:10.1038/ncpcardio1040 |
Full Text | PDF (161K)
OPTIMIZE-ing treatment for patients with heart failure
Published online:
30 October 2007
doi:10.1038/ncpcardio1037 |
Full Text | PDF (168K)
Outpatient venous thromboembolism: the importance of optimum prophylaxis
Published online:
23 October 2007
doi:10.1038/ncpcardio1036 |
Full Text | PDF (165K)
Does trimetazidine prevent myocardial injury after percutaneous coronary intervention?
Published online:
16 October 2007
doi:10.1038/ncpcardio1013 |
Full Text | PDF (159K)
Do preoperative anemia and polycythemia affect clinical outcome in patients undergoing major surgery?
Published online:
16 October 2007
doi:10.1038/ncpcardio1033 |
Full Text | PDF (167K)
How can the bleeding risk associated with warfarin therapy be reduced?
Published online:
16 October 2007
doi:10.1038/ncpcardio1034 |
Full Text | PDF (162K)
Reviews
Molecular MRI of hematopoietic stem-progenitor cells: in vivo monitoring of gene therapy and atherosclerosis
Noninvasive in vivo imaging to monitor the trafficking or homing of hematopoietic progenitor cells to vascular lesions is essential for both basic research and clinical practice. Here Qiu and Yang examine molecular MRI of stem-progenitor cells in atherosclerosis. They discuss advanced techniques for magnetic labeling of stem-progenitor cells, and how this modality could be used to monitor stem-progenitor cells migrating to injured arteries and vascular gene therapy mediated by stem-progenitor cells.
Published online:
13 May 2008
doi:10.1038/ncpcardio1217 |
Full Text | PDF (960K)
Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
Förstermann reviews oxidative stress—the enzymes responsible for generating reactive oxygen species and the enzymatic and nonprotein systems designed to protect from vascular disease. He discusses how oxidative stress is involved in endothelial dysfunction, how it contributes to vascular disease, and by what therapeutic approaches it could be prevented.
Published online:
06 May 2008
doi:10.1038/ncpcardio1211 |
Full Text | PDF (531K)
Spotlight on HDL-raising therapies: insights from the torcetrapib trials
The premature termination of the torcetrapib trial in December 2006 was widely publicized. A year on, Anatol Kontush, Maryse Guérin and M John Chapman revisit cholesteryl ester transfer protein inhibition as a potential therapeutic target and review recent developments in HDL-raising therapy with a focus on torcetrapib trials.
Published online:
22 April 2008
doi:10.1038/ncpcardio1191 |
Full Text | PDF (366K)
Safety of drug-eluting stents
In light of the recent furore over late stent thrombosis and drug-eluting stents, Drs Stephan Windecker and Peter Jüni present their thorough review of the benefits and risks of first-generation sirolimus-eluting and paclitaxel-eluting stents, providing practical advice on the use of these devices in different patient groups.
Published online:
15 April 2008
doi:10.1038/ncpcardio1189 |
Full Text | PDF (535K)
Case Study
Papillary fibroelastoma of the aortic valve and coronary artery disease visualized by 64-slice CT
In this month's Case Study, De Visser and colleagues present a 75-year-old male patient with a recent history of transient ischemic attack who underwent routine cardiological evaluation before a cystectomy. He was found to have coronary artery disease and an aortic valve papillary fibroelastoma—a rare, benign cardiac tumor. Multislice CT was successfully used to visualize the tumor and coronary arteries, before the patient underwent surgical excision of the tumor and an end-to-side anastomosis of the left internal mammary artery and the left anterior descending coronary artery.
Published online:
29 April 2008
doi:10.1038/ncpcardio1212 |
Full Text | PDF (571K)
Clinical Image
Right atrial thrombus attached to the defibrillator lead
Published online:
29 April 2008
doi:10.1038/ncpcardio1210 |
Full Text | PDF (286K)
Clinical research
Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population
Leptin may be a key regulator of C-reactive protein (CRP) levels, which in turn, is a marker of systemic inflammation. Both leptin and CRP are predictors of cardiovascular disease (CVD). High leptin levels are independently associated with CVD even after adjustment for CRP; elevated CRP levels are not associated with CVD after adjustment for leptin. However, subjects with increased leptin and CRP are at the highest risk for CVD.
Published online:
22 April 2008
doi:10.1038/ncpcardio1218 |
Full Text | PDF (390K)
Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia
The custom microenvironment "vascular niche" is a potential therapeutic target for several pathophysiological conditions. Osteoblasts act as regulators of the hematopoietic stem cell niche, and activation of the parathyroid hormone (PTH) receptor may increase the number of cells mobilized into the bloodstream. The authors demonstrate that PTH may enhance the efficiency of hematopoietic stem cell-based therapy in a recognized model of peripheral ischemia.
Published online:
15 April 2008
doi:10.1038/ncpcardio1214 |
Full Text | PDF (614K)
Evaluation of a screening protocol using auscultation and portable echocardiography to detect asymptomatic rheumatic heart disease in Tongan schoolchildren
Rheumatic heart disease is an important problem in developing countries but many cases are detected only when the disease has progressed to cardiac failure. Screening can detect cases earlier, but there are no screening guidelines. In this paper the authors describe a novel screening protocol and report a high echocardiographically confirmed prevalence of rheumatic heart disease among Tongan schoolchildren.
Published online:
08 April 2008
doi:10.1038/ncpcardio1185 |
Full Text | PDF (300K)
See also: Clinical Context by Poole-Wilson & Seth
Clinical Context
Rheumatic fever: the potential advantages of technology
Clinical Context commentary on Carapetis et al. This article sets out the clinical context of the research presented by Carapetis et al. in an accompanying article in this issue. No screening guidelines exist for early detection of rheumatic heart disease (RHD). The lack of agreed diagnostic criteria is one of the reasons why large proportions of cases in resource poor nations go untreated and are detected only when the disease has progressed to cardiac failure. Here, Poole-Wilson and Seth discuss the study carried out by Jonathan Carapetis and colleagues—a cross-sectional screening protocol in Tongan primary school children. The protocol designed by Carapetis et al. identified the highest echocardiographically confirmed prevalence of RHD reported to date. Poole-Wilson and Seth explore how modern technology, in the shape of portable echocardiography, can help to move the focus on rheumatic heart disease away from epidemiology and crude preventive programs, and towards screening programs that can effectively identify people who should receive treatment before cardiac failure occurs.
Published online:
15 April 2008
doi:10.1038/ncpcardio1216 |
Full Text | PDF (174K)
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Until print versions of AOP papers are published, they should be cited in the style "Authorname A et al. (year) Title of article. Nat Clin Pract Cardiovasc Med, advance online publication, day month year [doi:10.1038/ncpcardioxxxx]". Once the print version (identical to the AOP) is published, it should be cited as follows: "Authorname A et al. (year) Title of article. Nat Clin Pract Cardiovasc Med Vol: xxx–xxx, advance online publication, [doi:10.1038/ncpcardioxxxx]".
