Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population
Abel Romero-Corral, Justo Sierra-Johnson, Francisco Lopez-Jimenez, Randal J Thomas, Prachi Singh, Michal Hoffmann, Aynur Okcay, Josef Korinek, Robert Wolk and Virend K Somers*
Correspondence *Division of Cardiovascular Diseases, Domitillia 4-350, 200 First Street SW, Rochester, MN 55905, USA
Tel: +1 507 255 1144
Email somers.virend@mayo.edu
Leptin may be a key regulator of C-reactive protein (CRP) levels, which in turn, is a marker of systemic inflammation. Both leptin and CRP are predictors of cardiovascular disease (CVD). High leptin levels are independently associated with CVD even after adjustment for CRP; elevated CRP levels are not associated with CVD after adjustment for leptin. However, subjects with increased leptin and CRP are at the highest risk for CVD.
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