Table of contents
June 2008 Volume 5 No 6
Editorial
Research Highlights
Emotional stress from watching soccer can increase the risk of cardiac events
296Adverse events cluster after cessation of clopidogrel therapy
296Thrombus aspiration during PCI improves myocardial reperfusion
296Statin therapy reduces the risk of incidence or recurrence of atrial fibrillation
297Intensive intervention reduces cardiovascular mortality in patients with diabetes
297Myocardial infarction and hyperglycemia are associated with future angiographic events
298High prevalence of CAD detected by multislice CT in patients with diabetes
299Practice Points
Sirolimus as primary immunosuppression is effective in attenuating progression of cardiac-allograft vasculopathy
300Anacetrapib: new hope for cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia
302Should patients with implantable cardioverter-defibrillators refrain from driving?
304Solving the paradox of self blood-pressure measurement
306Early intervention in acute coronary syndrome: is bivalirudin monotherapy an effective antithrombotic strategy?
308What are the effects of patient age and blood pressure on the cholesterol-related risk of vascular mortality?
310Viewpoint
Etiology of cognitive change after CABG surgery: more than just the pump?
314There is much debate surrounding the etiology of cognitive decline following CABG surgery. In this Viewpoint, Neuropsychologist Ola Selnes postulates that this worrying complication is likely to be attributable to patient-related factors, such as the extent of pre-existing cerebrovascular disease, rather than to cardiopulmonary bypass.
Reviews
Safety of drug-eluting stents
316In light of the recent furore over late stent thrombosis and drug-eluting stents, Drs Stephan Windecker and Peter Jüni present their thorough review of the benefits and risks of first-generation sirolimus-eluting and paclitaxel-eluting stents, providing practical advice on the use of these devices in different patient groups.
doi:10.1038/ncpcardio1189 | Full Text | PDF (251K)
Spotlight on HDL-raising therapies: insights from the torcetrapib trials
329The premature termination of the torcetrapib trial in December 2006 was widely publicized. A year on, Anatol Kontush, Maryse Guérin and M John Chapman revisit cholesteryl ester transfer protein inhibition as a potential therapeutic target and review recent developments in HDL-raising therapy with a focus on torcetrapib trials.
doi:10.1038/ncpcardio1191 | Full Text | PDF (166K)
Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
338Förstermann reviews oxidative stress—the enzymes responsible for generating reactive oxygen species and the enzymatic and nonprotein systems designed to protect from vascular disease. He discusses how oxidative stress is involved in endothelial dysfunction, how it contributes to vascular disease, and by what therapeutic approaches it could be prevented.
doi:10.1038/ncpcardio1211 | Full Text | PDF (251K)
Case Study
Papillary fibroelastoma of the aortic valve and coronary artery disease visualized by 64-slice CT
350In this month's Case Study, De Visser and colleagues present a 75-year-old male patient with a recent history of transient ischemic attack who underwent routine cardiological evaluation before a cystectomy. He was found to have coronary artery disease and an aortic valve papillary fibroelastoma—a rare, benign cardiac tumor. Multislice CT was successfully used to visualize the tumor and coronary arteries, before the patient underwent surgical excision of the tumor and an end-to-side anastomosis of the left internal mammary artery and the left anterior descending coronary artery.
doi:10.1038/ncpcardio1212 | Full Text | PDF (427K)
Clinical Image
Right atrial thrombus attached to the defibrillator lead
354doi:10.1038/ncpcardio1210 | Full Text | PDF (203K)
Article Responses
Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning
E1doi:10.1038/ncpcardio1235 | Full Text
Authors' response to "Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning"
E2doi:10.1038/ncpcardio1236 | Full Text
