Figures and Tables

From the following article:

Mechanisms of Disease: molecular genetics of arrhythmogenic right ventricular dysplasia/cardiomyopathy

Mark M Awad, Hugh Calkins and Daniel P Judge

Nature Clinical Practice Cardiovascular Medicine (2008) 5, 258-267
doi:10.1038/ncpcardio1182

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Figure 1

The cardiac desmosome and proposed roles of the desmosome in (A) supporting structural stability through cell–cell adhesion, (B) regulating transcription of genes involved in adipogenesis and apoptosis, and maintaining proper electrical conductivity through regulation of (C) gap junctions and (D) calcium homeostasis.

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Figure 2

Schematic of the five desmosomal proteins in which ARVD/C mutations have been identified and published.

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Figure 3

Tallies of the types of unique mutations found in each of the five desmosomal genes mutated in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

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Table 1

Arrhythmogenic right ventricular dysplasia/cardiomyopathy diagnostic criteria. To confirm diagnosis, individuals must fulfill two major criteria, or one major and two minor criteria, or four minor criteria, with each criterion coming from a different group.

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