Mechanisms of Disease: ion channel remodeling in the failing ventricle
Robert D Nass, Takeshi Aiba, Gordon F Tomaselli and Fadi G Akar*
Correspondence *Cardiovascular Research Centre, Mount Sinai School of Medicine, Box 1030, One Gustave L Levy Place, New York, NY 10029, USA
Email fadi.akar@mssm.edu
Elucidating arrhythmia mechanisms in heart failure at the basic ionic level will facilitate the design of novel therapeutic approaches. In this Review, Nass and colleagues examine some of the important changes in ventricular ion channels and calcium-handling proteins that underlie electrical remodeling.
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