Screening for familial hypercholesterolemia: what is the most effective strategy?
Stephen R Daniels
Correspondence Department of Pediatrics, University of Colorado School of Medicine, The Children's Hospital, B065, 13123 East 16th Avenue, Aurora, CO 80045, USA
Email daniels.stephen@tchden.org
This article has no abstract so we have provided the first paragraph of the full text.
The process of atherosclerosis begins in childhood. Studies in pathology have demonstrated that elevated total cholesterol and LDL cholesterol, and low HDL cholesterol, are associated with the development of fibrous plaques in the aorta and coronary arteries of young individuals.1 These findings raise important questions about how to identify children at high risk of atherosclerotic cardiovascular disease (CVD). Which children should undergo routine measurement of lipids and lipoproteins? At what age should children be screened? Is one set of cutoff values acceptable for all ages or should these values reflect the changes in cholesterol levels observed with age, sex, and maturation?2
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