Statins for aortic stenosis? Still waiting for answers
Catherine M Otto
Correspondence Division of Cardiology, University of Washington, Box 356422, HSB Room AA522, 1959 NE Pacific Street, Seattle, WA 98195, USA
Email cmotto@u.washington.edu
This article has no abstract so we have provided the first paragraph of the full text.
Until recently, valvular AS was thought of as a purely mechanical problem involving valve function with no wider implications, treatable only by valve surgery at symptom onset. Accumulating scientific data, however, support the concept that calcific AS is the final stage of an active disease process, rather than an inevitable consequence of aging.1, 2 At the cellular and molecular level, there are many similarities between AS and atherosclerosis—both are associated with endothelial disruption, lipid accumulation, and inflammation.1, 2 These observations have led to the broad hypothesis that targeted medical therapy might slow disease progression, improve clinical outcomes in adults with AS and, ultimately, prevent the need for valve replacement.
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