Macrophage immunolocalization could aid noninvasive imaging of atherosclerosis
This article has no abstract so we have provided the first paragraph of the full text.
Macrophages are widely implicated in the pathogenesis of atherosclerosis, the major cause of death in Western countries. Amirbekian and colleagues investigated the potential of MRI for the detection and quantification of macrophages in vivo, using a mouse model of atherosclerosis. Immunomicelles labeled with gadolinium and targeted to a macrophage-specific receptor were injected into apolipoprotein E knockout and wild-type mice. The intensity of the MRI signal generated by immunomicelles in the animals' aortas was expressed as the normalized enhancement ratio (NER).
Full text of this article is available with one of the following:
- Personal subscription Purchase your own personal subscription to this journal. Already a subscriber? Please log in for immediate access.
- 7 day single article pass for US$18 In order to purchase this article you must be a registered user. Please register or log in.
- Site licence Learn more about institutional site licences
Current Subscribers
Please log in to access the full text article using the login box at the top of the page.
