A polypill for secondary prevention: time to move from intellectual debate to action
Valentin Fuster and Gines Sanz
This article has no abstract so we have provided the first paragraph of the full text.
The concept of a fixed-dose combination pill—or 'polypill'—for cardiovascular disease prevention was first proposed by Wald and Law in 2003. Using data from published trials and their own meta-analysis, they claimed that a six-component polypill administered to every individual older than 55 years could reduce the incidence of cardiovascular disease by more than 80%. Since then, a storm of controversy has surrounded this idea.
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