Multipotent embryonic cardiac progenitor cells implicated in cardiogenesis

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There are two distinct populations of cardiac progenitor cells; one of these populations, which contributes to the formation of the outflow tract, right ventricle, portions of the left ventricle and the atria, is characterized by the expression of the transcription factor islet-1 (isl1). Whether different cardiovascular cell types arise from distinct precursor cells or from a single lineage of multipotent stem cells has been unclear. Moretti et al. have now identified a subset of multipotent isl1⁺ cardiovascular progenitor (MICP) cells that can give rise to cardiac muscle, smooth muscle or endothelial cells during embryonic heart development in mice.

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