Is elevated cystatin C a predictor of cardiovascular risk in elderly people without chronic kidney disease?
Wolfgang Koenig
Correspondence Department of Internal Medicine II—Cardiology, University of Ulm Medical Center, Robert-Koch Stra
e 8, D—89081 Ulm, Germany
Email wolfgang.koenig@uniklinik-ulm.de
This article has no abstract so we have provided the first paragraph of the full text.
CKD is becoming an increasing burden in the general population and is associated with poor outcomes, including end-stage renal disease, and cardiovascular morbidity and mortality. Despite this situation, CKD is often under-recognized or is inadequately treated. Early identification of patients with CKD is, therefore, vitally important so that renoprotective measures can be initiated. In clinical practice, GFR is measured either by serum or plasma creatinine concentration or by creatinine clearance rate. Serum creatinine concentration is of limited value in the early detection of CKD, however, because of considerable inter-individual variability. Furthermore, the 24-hour creatinine clearance rate can overestimate the true GFR, because creatinine is not only filtered by the glomeruli but also secreted by the tubules.1
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