Genetic determinants of plasma lipoproteins
Rebecca L Pollex and Robert A Hegele*
Correspondence *Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, Room 406, 100 Perth Drive, London, ON N6A 5K8, Canada
Email hegele@robarts.ca
In addition to environmental factors, genetic variation exerts a sizeable, complex influence on lipoprotein phenotypes. Rebecca Pollex and Robert Hegele review recent progress on genomic variants and cholesterol metabolism, focusing on key, well-characterized genes that are determinants of plasma lipoproteins and have shown consistent results over the years, and discuss their potential utility in clinical cardiology.
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