Trimetazidine reduces risk of contrast-induced nephropathy after coronary procedures
This article has no abstract so we have provided the first paragraph of the full text.
Contrast-induced nephropathy (CIN), a serious complication of coronary angiography, is particularly common in patients with renal insufficiency. Hydration with isotonic saline is the only generally accepted way of preventing CIN at present. As formation of oxygen free radicals and renal medullar ischemia are thought to be involved in the pathogenesis of CIN, Onbasili et al. investigated whether administration of trimetazidine, an agent with anti-ischemic and antioxidant properties, might be a useful adjunct to isotonic saline.
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