TABLE 2 Linkage studies of myocardial infarction and coronary artery disease.
From the following article:
Mechanisms of Disease: the genetic basis of coronary heart disease
Iftikhar J Kullo and Keyue Ding
BACK TO ARTICLE| Study | Population | Study sample (number of participants) | Ascertainment | Locus or loci | Peak LOD | Candidate gene(s) | Confirmed by fine mapping |
|---|---|---|---|---|---|---|---|
aIncluded: 2.3% African American, 0.8% Asian or Pacific Islander, 91.7% White, 1.4% Hispanic, 1.7% Native American or Alaskan, 0.8% mixed ethnicity, and 1.3% unknown ethnicity. Abbreviations: ACSM3, acyl-CoA synthetase medium-chain family member 3; AGTR2, angiotensin II receptor, type 2; ALOX5AP, arachidonate 5-lipoxygenase-activating protein; CAD, coronary artery disease; CHD, coronary heart disease; GJA4, gap junction protein, alpha 4; IL1A, interleukin 1 alpha; IL1B, interleukin 1 beta; LOD, logarithm of odds of linkage; MEF2A, MADS box transcription enhancer factor 2, polypeptide A; MI, myocardial infarction; PROC, protein C; SOCS1, suppressor of cytokine signaling 1. | |||||||
| Wang et al.88 | Americana | 428 multiplex families (1,613) | Each family in the cohort had at least two affected siblings with premature CAD or MI, and most families also had one unaffected sibling | 1p36 | 11.7 | GJA4 | No |
| Francke et al.89 | Indo-Mauritian | 99 sibships (535) | Proband with CHD before 52 years of age and additional siblings with MI or diabetes | 16p13.3 | 3.1 | SOCS1, ACSM3 | No |
| Helgadottir et al.19 | Icelandic | 296 multiplex families (713 cases; 1,741 first-degree relatives) | On the basis of MI | 13q12–13 | 2.5 | ALOX5AP | Yes |
| Broeckel et al.90 | German | 513 sibships (1,406) | At least two siblings with MI or CAD affected at  59 years of age | 14q32 | 3.9 | Unknown | Unknown |
| Wang et al.21 | European-Americans | 1 family (25; 13 patients) | Proband with MI | 15q26 | 4.2 | MEF2A | Yes |
| Samani et al.17 | British | 1,933 sibships (4,175) | Each sibship had at least two available siblings with CAD or MI | 2q14.3–21.2 | 1.98 | IL1A, IL1B, PROC | No |
| Hauser et al.91 | Predominantly European-Americans | 438 sibships (1,168) | Affected sibling pairs with onset of CAD at <51 years of age for men and <56 years of age for women | 3q13 | 3.5 | Unknown | Unknown |
| Pajukanta et al.92 | Finnish | 156 sibships (526) | Each sibship had at least two siblings with premature CAD (>50% stenosis of at least two coronary arteries) | Xq25 | 3.5 | AGTR2 | No |
