Sophisticated technology is not a substitute for cognitive cardiology

Robert A O'Rourke and Valentin Fuster

doi:10.1038/ncpcardio1007 | Full Text | PDF (94K)

Elderly patients should not be denied fibrinolytic therapy

Cheuk-Kit Wong and Harvey D White

The number of elderly patients with cardiac conditions in the US is increasing, but these individuals receive fewer evidence-based therapies than their younger counterparts. Fibrinolytic therapy, in particular, is underused in the elderly and is commonly withheld on the basis of advanced age alone. In this Viewpoint, Cheuk-Kit Wong and Harvey D White seek to redress this situation by reviewing the evidence for fibrinolytic therapy in elderly patients and advocating that this treatment should not be denied unless there are clear contraindications.

doi:10.1038/ncpcardio0980 | Full Text | PDF (141K)

Successful coronary scaffolding achieved with bioabsorbable stents

doi:10.1038/ncpcardio0954 | Full Text | PDF (130K)

Epoprostenol suitable for treatment of severe pulmonary hypertension in children

doi:10.1038/ncpcardio0955 | Full Text | PDF (101K)

Rosiglitazone and the risk of myocardial infarction: interim analysis of the RECORD trial

doi:10.1038/ncpcardio0968 | Full Text | PDF (113K)

Chronic kidney disease components associated with risk of cardiovascular disease

doi:10.1038/ncpcardio0969 | Full Text | PDF (130K)

Systematic review of techniques for assessing lower limb peripheral arterial disease

doi:10.1038/ncpcardio0970 | Full Text | PDF (113K)

Benefits of cardiac resynchronization therapy in heart failure

doi:10.1038/ncpcardio0971 | Full Text | PDF (130K)

Reperfusion in patients with STEMI: further results of the ExTRACT-TIMI 25 trial

doi:10.1038/ncpcardio0972 | Full Text | PDF (113K)

Use of ICDs for primary prevention following acute MI

doi:10.1038/ncpcardio0974 | Full Text | PDF (130K)

OPERA registry provides support for the widened ESC/ACC definition of MI

doi:10.1038/ncpcardio0975 | Full Text | PDF (141K)

Heart failure in very elderly patients: clinical characteristics, treatment and outcomes

doi:10.1038/ncpcardio0958 | Full Text | PDF (130K)

Increased antithrombotic use puts the over 75s at risk for stroke

doi:10.1038/ncpneuro0548 | Full Text | PDF (113K)

Myocardial injury predicts poor outcome in patients with acute liver failure

doi:10.1038/ncpgasthep0882 | Full Text | PDF (103K)

Trimetazidine reduces risk of contrast-induced nephropathy after coronary procedures

doi:10.1038/ncpneph0557 | Full Text | PDF (131K)

Is enoxaparin superior to unfractionated heparin for the prevention of thromboembolism after ischemic stroke?

Harold P Adams Jr

doi:10.1038/ncpcardio0961 | Full Text | PDF (140K)

The global burden of atherosclerotic vascular disease

Gregg C Fonarow

doi:10.1038/ncpcardio0940 | Full Text | PDF (136K)

Does treatment with eicosapentaenoic acid prevent major coronary events in patients with hypercholesterolemia?

William S Harris

doi:10.1038/ncpcardio0967 | Full Text | PDF (135K)

Can percutaneous coronary intervention be performed safely as an outpatient procedure?

Mark W Sheldon and Cindy L Grines

doi:10.1038/ncpcardio0963 | Full Text | PDF (138K)

Does early abciximab improve angiographic outcome and left ventricular function in patients with acute MI?

Maarten L Simoons

doi:10.1038/ncpcardio0962 | Full Text | PDF (140K)

Prehypertension

William J Elliott and Henry R Black

Four years on from JNC 7, William Elliott and Henry Black examine the epidemiology and attendant risks of prehypertension, and discuss the controversial issue of drug treatment for individuals with blood pressures in the prehypertensive range.

doi:10.1038/ncpcardio0989 | Full Text | PDF (365K)

Mechanisms of Disease: intracrine physiology in the cardiovascular system

Richard N Re and Julia L Cook

Hormones, growth factors, DNA-binding proteins and enzymes can all display intracrine functionality. Here Richard Re and Julia Cook examine the role intracrines have in the heart and vasculature, and argue that understanding the principles of intracrine physiology could help the development of more-effective therapeutic interventions in cardiovascular disease.

doi:10.1038/ncpcardio0985 | Full Text | PDF (328K)