Latest Research

  • Article | | open

    It is known that full-term pregnancies can reduce a woman’s breast cancer risk. Here, the authors interrogate data from 2.3 million Danish women, showing that this protective effect arises at precisely the 34th week of the pregnancy, and replicated this finding in 1.6 million women from Norway.

    • Anders Husby
    • , Jan Wohlfahrt
    • , Nina Øyen
    •  & Mads Melbye
  • Article | | open

    Mutations in pantotenate kinase (PANK) cause neurodegneration. Here the authors carry out achemical screen and identify a PANK activator that is orally available, crosses the blood brain barrierand show that it effecttive in improving pathology and life span in a mouse model of the disease.

    • Lalit Kumar Sharma
    • , Chitra Subramanian
    • , Mi-Kyung Yun
    • , Matthew W. Frank
    • , Stephen W. White
    • , Charles O. Rock
    • , Richard E. Lee
    •  & Suzanne Jackowski
  • Article | | open

    TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated neurodegeneration through the Ell transcriptional elongation complexes LEC and SEC.

    • Chia-Yu Chung
    • , Amit Berson
    • , Jason R. Kennerdell
    • , Ashley Sartoris
    • , Travis Unger
    • , Sílvia Porta
    • , Hyung-Jun Kim
    • , Edwin R. Smith
    • , Ali Shilatifard
    • , Vivianna Van Deerlin
    • , Virginia M.-Y. Lee
    • , Alice Chen-Plotkin
    •  & Nancy M. Bonini
  • Article | | open

    Understanding how one metal nanocluster transforms into another is of synthetic and fundamental importance. Here, the authors use mass spectrometry to reveal an acid-induced structural transformation between two Ag clusters that proceeds via a breakage-growth-reassembly mechanism.

    • Zhi Wang
    • , Hai-Feng Su
    • , Chen-Ho Tung
    • , Di Sun
    •  & Lan-Sun Zheng
  • Article | | open

    Organic electrode materials could enable novelty chemistry required by the new generation of batteries. Here the authors show the synthesis and electrochemical performance of Mg(Li2)-p-DHT as a lithiated cathode material that cycles at 3.4 V due to the presence of a spectator cation in the host structure.

    • Alia Jouhara
    • , Nicolas Dupré
    • , Anne-Claire Gaillot
    • , Dominique Guyomard
    • , Franck Dolhem
    •  & Philippe Poizot
  • Article | | open

    Short-tandem repeats (STR), similar to single nucleotide polymorphisms (SNP), contribute to complex traits, but their ascertainment by next-generation sequencing is costly. Here, Saini et al. provide a SNP+STR haplotype reference panel that allows imputation of STRs from SNP array data.

    • Shubham Saini
    • , Ileena Mitra
    • , Nima Mousavi
    • , Stephanie Feupe Fotsing
    •  & Melissa Gymrek
  • Article | | open

    Metal ions at the active site of an enzyme act as cofactors and their dynamic fluctuations might influence enzyme activity. Here authors use single-molecule FRET to study λ-exonuclease and find that metal-ion-coordination is correlated with enzymatic reaction-steps.

    • Wonseok Hwang
    • , Jungmin Yoo
    • , Yuno Lee
    • , Suyeon Park
    • , Phuong Lien Hoang
    • , HyeokJin Cho
    • , Jeongmin Yu
    • , Thi Minh Hoa Vo
    • , Minsang Shin
    • , Mi Sun Jin
    • , Daeho Park
    • , Changbong Hyeon
    •  & Gwangrog Lee
  • Article | | open

    Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.

    • Jeffrey A. Schneider
    • , Timothy W. Craven
    • , Amanda C. Kasper
    • , Chi Yun
    • , Michael Haugbro
    • , Erica M. Briggs
    • , Vladimir Svetlov
    • , Evgeny Nudler
    • , Holger Knaut
    • , Richard Bonneau
    • , Michael J. Garabedian
    • , Kent Kirshenbaum
    •  & Susan K. Logan
  • Article | | open

    The transcription factor DAF-16/FOXO is a downstream effector of insulin/insulin-like growth factor signaling and plays an important role in stress resistance and longevity. Here, the authors show that DAF-16/FOXO can form a complex with HLH-30/TFEB to synergistically regulate transcription of target genes in response to certain stress stimuli.

    • Xin-Xuan Lin
    • , Ilke Sen
    • , Georges E. Janssens
    • , Xin Zhou
    • , Bryan R. Fonslow
    • , Daniel Edgar
    • , Nicholas Stroustrup
    • , Peter Swoboda
    • , John R. Yates 3rd
    • , Gary Ruvkun
    •  & Christian G. Riedel
  • Article | | open

    Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.

    • Vishnu Modur
    • , Navneet Singh
    • , Vakul Mohanty
    • , Eunah Chung
    • , Belal Muhammad
    • , Kwangmin Choi
    • , Xiaoting Chen
    • , Kashish Chetal
    • , Nancy Ratner
    • , Nathan Salomonis
    • , Matthew T. Weirauch
    • , Susan Waltz
    • , Gang Huang
    • , Lisa Privette-Vinnedge
    • , Joo-Seop Park
    • , Edith M. Janssen
    •  & Kakajan Komurov
  • Article | | open

    Peripheral nerves have a complex physiology and it is therefore difficult to measure axonal activity in vitro. Here the authors make a nerve-on-a-chip platform to align peripheral nerves and permit measurement of conduction amplitude and velocity along several axons in a single experiment.

    • Sandra Gribi
    • , Sophie du Bois de Dunilac
    • , Diego Ghezzi
    •  & Stéphanie P. Lacour
  • Article | | open

    On-chip spectrometers typically have limited spectral channels and low signal to noise ratios. Here the authors introduce a digital architecture that uses switches to change the interferometer path lengths, enabling exponentially more spectral channels per circuit element and lower noise by leveraging a machine learning reconstruction algorithm.

    • Derek M. Kita
    • , Brando Miranda
    • , David Favela
    • , David Bono
    • , Jérôme Michon
    • , Hongtao Lin
    • , Tian Gu
    •  & Juejun Hu
  • Article | | open

    “Diffusing diffusivity” concept has been recently put forward to account for rapid structural rearrangements in soft matter and biological systems. Here the authors propose a general mathematical framework to compute the distribution of first-passage times in a dynamically heterogeneous medium.

    • Yann Lanoiselée
    • , Nicolas Moutal
    •  & Denis S. Grebenkov
  • Article | | open

    Though the Preisach model successfully describes hysteretic switching in ferroelectrics, the physical reality of the model remains elusive. Here, the authors explained the origin of the experimental Preisach distribution and its effect on switching kinetics and materials’ potential applications

    • Indrė Urbanavičiūtė
    • , Tim D. Cornelissen
    • , Xiao Meng
    • , Rint P. Sijbesma
    •  & Martijn Kemerink
  • Article | | open

    Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice.

    • Christoffer Clemmensen
    • , Sigrid Jall
    • , Maximilian Kleinert
    • , Carmelo Quarta
    • , Tim Gruber
    • , Josefine Reber
    • , Stephan Sachs
    • , Katrin Fischer
    • , Annette Feuchtinger
    • , Angelos Karlas
    • , Stephanie E. Simonds
    • , Gerald Grandl
    • , Daniela Loher
    • , Eva Sanchez-Quant
    • , Susanne Keipert
    • , Martin Jastroch
    • , Susanna M. Hofmann
    • , Emmani B. M. Nascimento
    • , Patrick Schrauwen
    • , Vasilis Ntziachristos
    • , Michael A. Cowley
    • , Brian Finan
    • , Timo D. Müller
    •  & Matthias H. Tschöp
  • Article | | open

    In this work, the authors recorded single neurons and field potentials from the human medial temporal lobe (MTL) and show indistinguishable responses to associated stimuli. This coding mechanism provides a simple and flexible way of encoding memories in the human MTL.

    • Hernan G. Rey
    • , Emanuela De Falco
    • , Matias J. Ison
    • , Antonio Valentin
    • , Gonzalo Alarcon
    • , Richard Selway
    • , Mark P. Richardson
    •  & Rodrigo Quian Quiroga
  • Article | | open

    Self-renewal and pluripotency of human embryonic stem cells (hESCs) depends upon the function of the transcription factor OCT4. Here, the authors identified proteins associated with the OCT4 enhancer, notably ZNF207 that maintains both pluripotency and differentiation towards ectoderm through isoform switching.

    • Fang Fang
    • , Ninuo Xia
    • , Benjamin Angulo
    • , Joseph Carey
    • , Zackery Cady
    • , Jens Durruthy-Durruthy
    • , Theo Bennett
    • , Vittorio Sebastiano
    •  & Renee A. Reijo Pera
  • Article | | open

    Identifying phosphors with good thermal stability and quantum efficiency is a prerequisite to improve the performance of white LED light sources. Here, a combined machine learning and density functional theory method is introduced to identify next generation inorganic phosphors.

    • Ya Zhuo
    • , Aria Mansouri Tehrani
    • , Anton O. Oliynyk
    • , Anna C. Duke
    •  & Jakoah Brgoch
  • Article | | open

    The long-term evolution of the sulfur budget in the lithosphere is poorly constrained. Here, using mass independent isotope fractionation as an indelible tracer, the authors track the pathway of sulfur from the Earth’s surface to punctuated episodes of granitoid magmatism during collisional orogenesis.

    • Crystal LaFlamme
    • , Marco L. Fiorentini
    • , Mark D. Lindsay
    •  & Thi Hao Bui
  • Article | | open

    Heterozygous loss of chromosome 17p is a common genomic event in castration-resistant prostate cancers (CRPC). Here, the authors use CRISPR-based screen to identify RBX1 as a target gene for CRPC with 17p loss and targeting RBX1 sensitizes CRPC to the treatment of α-amanitin antibody conjugates.

    • Yujing Li
    • , Yunhua Liu
    • , Hanchen Xu
    • , Guanglong Jiang
    • , Kevin Van der Jeught
    • , Yuanzhang Fang
    • , Zhuolong Zhou
    • , Lu Zhang
    • , Michael Frieden
    • , Lifei Wang
    • , Zhenhua Luo
    • , Milan Radovich
    • , Bryan P. Schneider
    • , Yibin Deng
    • , Yunlong Liu
    • , Kun Huang
    • , Bin He
    • , Jin Wang
    • , Xiaoming He
    • , Xinna Zhang
    • , Guang Ji
    •  & Xiongbin Lu
  • Article | | open

    Transformation of strong C-F bonds into C-Si bonds is an extremely useful strategy for further derivatization of organic molecules. Here, the authors report a nickel-catalyzed strategy to convert aryl fluorides into sylylated arenes while defluorosilylation of alkyl fluorides is achieved under metal-free conditions.

    • Benqiang Cui
    • , Shichong Jia
    • , Etsuko Tokunaga
    •  & Norio Shibata
  • Article | | open

    Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that BAP1 promotes DEUBAD monoubiquitination of ASXL2, which in turn stimulates BAP1 DUB activity.

    • Salima Daou
    • , Haithem Barbour
    • , Oumaima Ahmed
    • , Louis Masclef
    • , Caroline Baril
    • , Nadine Sen Nkwe
    • , Daméhan Tchelougou
    • , Maxime Uriarte
    • , Eric Bonneil
    • , Derek Ceccarelli
    • , Nazar Mashtalir
    • , Mika Tanji
    • , Jean-Yves Masson
    • , Pierre Thibault
    • , Frank Sicheri
    • , Haining Yang
    • , Michele Carbone
    • , Marc Therrien
    •  & El Bachir Affar
  • Article | | open

    Storm runoff extremes dominate flash flood formation and generation, posing a grand threat to ecosystems and communities across the world. Here the authors show that current projected response of these storm runoff extremes to climate and anthropogenic changes are underestimated.

    • Jiabo Yin
    • , Pierre Gentine
    • , Sha Zhou
    • , Sylvia C. Sullivan
    • , Ren Wang
    • , Yao Zhang
    •  & Shenglian Guo
  • Article | | open

    The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerization and macroautophagy.

    • Yi Zhang
    • , Su Ran Mun
    • , Juan F. Linares
    • , JaeWoo Ahn
    • , Christina G. Towers
    • , Chang Hoon Ji
    • , Brent E. Fitzwalter
    • , Michael R. Holden
    • , Wenyi Mi
    • , Xiaobing Shi
    • , Jorge Moscat
    • , Andrew Thorburn
    • , Maria T. Diaz-Meco
    • , Yong Tae Kwon
    •  & Tatiana G. Kutateladze
  • Article | | open

    There are many proposals for new forms of quantum matter in frustrated magnets but in practice disorder prevents the realisation of theoretically-tractable idealised models. Kimchi et al. show that recently observed scaling behavior common to several disordered quantum magnets can be understood as the emergence of a universal random-singlet regime.

    • Itamar Kimchi
    • , John P. Sheckelton
    • , Tyrel M. McQueen
    •  & Patrick A. Lee
  • Article | | open

    The Drosophila ventral nerve cord (VNC) is functionally equivalent to the vertebrate spinal cord. This study reports a 2-photon imaging approach for recording neural activity in the VNC of walking and grooming adult flies.

    • Chin-Lin Chen
    • , Laura Hermans
    • , Meera C. Viswanathan
    • , Denis Fortun
    • , Florian Aymanns
    • , Michael Unser
    • , Anthony Cammarato
    • , Michael H. Dickinson
    •  & Pavan Ramdya
  • Article | | open

    Nano-contact-based spin wave generation may enable high-frequency magnonic devices but has been limited to long wavelengths and weak signal strengths. Here the authors demonstrate high-order short-wavelength propagating spin waves with increased transmission rates and propagation lengths in magnetic tunnel junction stacks.

    • A. Houshang
    • , R. Khymyn
    • , H. Fulara
    • , A. Gangwar
    • , M. Haidar
    • , S. R. Etesami
    • , R. Ferreira
    • , P. P. Freitas
    • , M. Dvornik
    • , R. K. Dumas
    •  & J. Åkerman
  • Article | | open

    Spherical neutron polarimetry (SNP) experiment in conjunction with high pressure condition faces many experimental difficulties. Here the authors report development of SNP with nonmagnetic hybrid anvil high pressure cell and application to the magnetoelectric multiferroic delafossite CuFeO2 system.

    • Noriki Terada
    • , Navid Qureshi
    • , Laurent C. Chapon
    •  & Toyotaka Osakabe
  • Article | | open

    Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory stimuli.

    • Chunjie Sheng
    • , Chen Yao
    • , Ziyang Wang
    • , Hongyuan Chen
    • , Yu Zhao
    • , Dazhi Xu
    • , Haojie Huang
    • , Wenlin Huang
    •  & Shuai Chen
  • Article | | open

    LncRNAs modulate diverse physiological cellular processes, however, their involvement in heme-dependent processes are not yet clear. Here the authors reveal the role of lncRNA UCA1 in erythroid cell development.

    • Jinhua Liu
    • , Yapu Li
    • , Jingyuan Tong
    • , Jie Gao
    • , Qing Guo
    • , Lingling Zhang
    • , Bingrui Wang
    • , Hui Zhao
    • , Hongtao Wang
    • , Erlie Jiang
    • , Ryo Kurita
    • , Yukio Nakamura
    • , Osamu Tanabe
    • , James Douglas Engel
    • , Emery H. Bresnick
    • , Jiaxi Zhou
    •  & Lihong Shi
  • Article | | open

    Protein NEDDylation increases upon proteotoxic stress but the function of this response remains to be elucidated. Here, the authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregation and protecting the ubiquitin proteasome system.

    • Chantal M. Maghames
    • , Sofia Lobato-Gil
    • , Aurelien Perrin
    • , Helene Trauchessec
    • , Manuel S. Rodriguez
    • , Serge Urbach
    • , Philippe Marin
    •  & Dimitris P. Xirodimas
  • Article | | open

    Clear understanding of the influence from material inhomogeneities and defects is one of the keys to achieve reliable Skyrmion based devices. Here the authors report their first principles studies on the interaction of single skyrmions with single-atom impurities and reveal its universal shape originated from the defect’s electron filling.

    • Imara Lima Fernandes
    • , Juba Bouaziz
    • , Stefan Blügel
    •  & Samir Lounis
  • Article | | open

    The development of single cell RNA sequencing technologies has been instrumental in advancing our understanding of tissue biology. Here, MacParland et al. performed single cell RNA sequencing of human liver samples, and identify distinct populations of intrahepatic macrophages that may play specific roles in liver disease.

    • Sonya A. MacParland
    • , Jeff C. Liu
    • , Xue-Zhong Ma
    • , Brendan T. Innes
    • , Agata M. Bartczak
    • , Blair K. Gage
    • , Justin Manuel
    • , Nicholas Khuu
    • , Juan Echeverri
    • , Ivan Linares
    • , Rahul Gupta
    • , Michael L. Cheng
    • , Lewis Y. Liu
    • , Damra Camat
    • , Sai W. Chung
    • , Rebecca K. Seliga
    • , Zigong Shao
    • , Elizabeth Lee
    • , Shinichiro Ogawa
    • , Mina Ogawa
    • , Michael D. Wilson
    • , Jason E. Fish
    • , Markus Selzner
    • , Anand Ghanekar
    • , David Grant
    • , Paul Greig
    • , Gonzalo Sapisochin
    • , Nazia Selzner
    • , Neil Winegarden
    • , Oyedele Adeyi
    • , Gordon Keller
    • , Gary D. Bader
    •  & Ian D. McGilvray
  • Article | | open

    T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essential to mount these responses against autoantigens.

    • Seung-Chul Choi
    • , Anton A. Titov
    • , Georges Abboud
    • , Howard R. Seay
    • , Todd M. Brusko
    • , Derry C. Roopenian
    • , Shahram Salek-Ardakani
    •  & Laurence Morel
  • Article | | open

    Attention affects stimulus response gain, but its impact without sensory drive is less known. Here, the authors show that attention is coded diversely in a population and is distinct between unstimulated and stimulated contexts, providing a contrast to normalized gain models of attention.

    • Adam C. Snyder
    • , Byron M. Yu
    •  & Matthew A. Smith
  • Article | | open

    Self-renewal of spermatogonial stem cells (SSC) is necessary for spermatogenesis and male fertility. Here the authors identify testicular endothelial cells (TECs) as a source of 5 key growth factors for self-renewal and expansion of human and mouse SSCs.

    • Dong Ha Bhang
    • , Bang-Jin Kim
    • , Byung Gak Kim
    • , Keri Schadler
    • , Kwan-Hyuck Baek
    • , Yong Hee Kim
    • , Wayland Hsiao
    • , Bi-Sen Ding
    • , Shahin Rafii
    • , Mitchell J. Weiss
    • , Stella T. Chou
    • , Thomas F. Kolon
    • , Jill P. Ginsberg
    • , Buom-Yong Ryu
    •  & Sandra Ryeom
  • Article | | open

    Here, the authors demonstrate that the dispersion of hyperbolic phonon polaritons can be controlled using the permittivity changes inherent in the different phases of phase change materials. This enables direct launching, reflection, transmission and refraction at the phase change material domain boundaries.

    • T. G. Folland
    • , A. Fali
    • , S. T. White
    • , J. R. Matson
    • , S. Liu
    • , N. A. Aghamiri
    • , J. H. Edgar
    • , R. F. Haglund Jr.
    • , Y. Abate
    •  & J. D. Caldwell
  • Article | | open

    RNA-encoded regulatory circuits are desirable because they do not integrate in the host and are less immunogenic, but the availability of regulatory devices is limited. Here the authors develop viral protease RNA-binding proteins and protease–protease genetic circuits that ultimately regulate mRNA translation.

    • Federica Cella
    • , Liliana Wroblewska
    • , Ron Weiss
    •  & Velia Siciliano
  • Article | | open

    The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is associated with an increased burden of tau pathology in postmortem human brains with progressive supranuclear palsy.

    • Na Zhao
    • , Chia-Chen Liu
    • , Alexandra J. Van Ingelgom
    • , Cynthia Linares
    • , Aishe Kurti
    • , Joshua A. Knight
    • , Michael G. Heckman
    • , Nancy N. Diehl
    • , Mitsuru Shinohara
    • , Yuka A. Martens
    • , Olivia N. Attrebi
    • , Leonard Petrucelli
    • , John D. Fryer
    • , Zbigniew K. Wszolek
    • , Neill R. Graff-Radford
    • , Richard J. Caselli
    • , Monica Y. Sanchez-Contreras
    • , Rosa Rademakers
    • , Melissa E. Murray
    • , Shunsuke Koga
    • , Dennis W. Dickson
    • , Owen A. Ross
    •  & Guojun Bu
  • Article | | open

    Investment in watershed services programs is growing, however the factors that contribute to sustainability of such programs are unclear. Here the authors use a large database of cities around the world to show that payment schemes are more likely to be present in watersheds with more agricultural land and less protected areas.

    • Chelsie L. Romulo
    • , Stephen Posner
    • , Stella Cousins
    • , Jenn Hoyle Fair
    • , Drew E. Bennett
    • , Heidi Huber-Stearns
    • , Ryan C. Richards
    •  & Robert I. McDonald
  • Article | | open

    Gels filtering particles by interactions are a goal of nanotechnology; this is difficult when particles are larger than the mesh of the gel. Here, the authors present an equilibrium mechanism where binding dynamics of crosslinks are affected by interacting particles so that particles experience enhanced diffusion.

    • Carl P. Goodrich
    • , Michael P. Brenner
    •  & Katharina Ribbeck
  • Article | | open

    Dynamics in cold atomic ensembles involve complex many-body interactions that are hard to treat analytically. Here, the authors use machine learning to optimise the cooling and trapping of neutral atoms, showing an improvement in the resulting resonant optical depth compared to more traditional solutions.

    • A. D. Tranter
    • , H. J. Slatyer
    • , M. R. Hush
    • , A. C. Leung
    • , J. L. Everett
    • , K. V. Paul
    • , P. Vernaz-Gris
    • , P. K. Lam
    • , B. C. Buchler
    •  & G. T. Campbell
  • Article | | open

    Manipulating the assembly of π-conjugated organic molecules into alloys to control composition and shape remains a largely unsolved problem. Here the authors show the co-assembly of two structurally similar organic semiconductors into two-component helices by control of their growth kinetics as well as the molar ratio of the building blocks.

    • Yilong Lei
    • , Yanqiu Sun
    • , Yi Zhang
    • , Hongyang Zhang
    • , Haihua Zhang
    • , Zhengong Meng
    • , Wai-Yeung Wong
    • , Jiannian Yao
    •  & Hongbing Fu
  • Article | | open

    The mitotic checkpoint complex (MCC) is assembled during both mitosis and interphase. Here, the authors use auxin-inducible degron tags to rapidly degrade TRIP13 and find that mitotic exit requires MCC disassembly by TRIP13-catalyzed removal of Mad2 or APC1-driven ubiquitination of Cdc20.

    • Dong Hyun Kim
    • , Joo Seok Han
    • , Peter Ly
    • , Qiaozhen Ye
    • , Moira A. McMahon
    • , Kyungjae Myung
    • , Kevin D. Corbett
    •  & Don W. Cleveland
  • Article | | open

    Climate change may impact forest disturbances, though local variability is high. Here, Sommerfeld et al. show that disturbance patterns across the temperate biome vary with agents and tree traits, yet large disturbances are consistently linked to warmer and drier than average conditions.

    • Andreas Sommerfeld
    • , Cornelius Senf
    • , Brian Buma
    • , Anthony W. D’Amato
    • , Tiphaine Després
    • , Ignacio Díaz-Hormazábal
    • , Shawn Fraver
    • , Lee E. Frelich
    • , Álvaro G. Gutiérrez
    • , Sarah J. Hart
    • , Brian J. Harvey
    • , Hong S. He
    • , Tomáš Hlásny
    • , Andrés Holz
    • , Thomas Kitzberger
    • , Dominik Kulakowski
    • , David Lindenmayer
    • , Akira S. Mori
    • , Jörg Müller
    • , Juan Paritsis
    • , George L. W. Perry
    • , Scott L. Stephens
    • , Miroslav Svoboda
    • , Monica G. Turner
    • , Thomas T. Veblen
    •  & Rupert Seidl