Latest Research

  • Article | | open

    Single-molecule magnets typically only retain information in the presence of an applied magnetic field and at very low temperatures. Here, Demir, Long and co-workers design N2 3– radical-bridged dilanthanide complexes that exhibit giant coercivities and 100-s magnetic blocking temperatures of up to 20 K.

    • Selvan Demir
    • , Miguel I. Gonzalez
    • , Lucy E. Darago
    • , William J. Evans
    •  & Jeffrey R. Long
  • Article | | open

    Dynein is a microtubule motor the motility of which is affected by the microtubule-associated protein She1. Here, the authors show that She1 alters dynein stepping behavior and increases its microtubule affinity through simultaneous interactions with the microtubule and dynein microtubule binding domain.

    • Kari H. Ecklund
    • , Tatsuya Morisaki
    • , Lindsay G. Lammers
    • , Matthew G. Marzo
    • , Timothy J. Stasevich
    •  & Steven M. Markus
  • Article | | open

    Twin nucleation in face-centered cubic metals with high twin-fault energies should theoretically be unfavourable, but instead twinning is very often observed. Here, the authors report a new twinning route in nanocrystalline platinum that bypasses the high twin-fault energy barrier using closely spaced partial dislocations.

    • Lihua Wang
    • , Pengfei Guan
    • , Jiao Teng
    • , Pan Liu
    • , Dengke Chen
    • , Weiyu Xie
    • , Deli Kong
    • , Shengbai Zhang
    • , Ting Zhu
    • , Ze Zhang
    • , Evan Ma
    • , Mingwei Chen
    •  & Xiaodong Han
  • Article | | open

    Catalytic acceptorless dehydrogenation reactions provide a sustainable route to valuable products and hydrogen fuel. Here, the authors show a recyclable iron catalyst that is highly active in the acceptorless dehydrogenation of a wide range of N-heterocycles and alcohols.

    • Garima Jaiswal
    • , Vinod G. Landge
    • , Dinesh Jagadeesan
    •  & Ekambaram Balaraman
  • Article | | open

    New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to  specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arrest and enabling arterial gene expression.

    • Jennifer S. Fang
    • , Brian G. Coon
    • , Noelle Gillis
    • , Zehua Chen
    • , Jingyao Qiu
    • , Thomas W. Chittenden
    • , Janis M. Burt
    • , Martin A. Schwartz
    •  & Karen K. Hirschi
  • Article | | open

    Realisation of large-scale quantum computation requires both error correction capability and a large number of qubits. Here, the authors propose to use a CMOS-compatible architecture featuring a spin qubit surface code and individual qubit control via floating memory gate electrodes.

    • M. Veldhorst
    • , H. G. J. Eenink
    • , C. H. Yang
    •  & A. S. Dzurak
  • Article | | open

    Perception can be explained by predictive coding, but it is unclear how this theory applies at the single-neuron level. Here, authors describe how auditory patterns are encoded and detected by single neurons along the auditory pathway, demonstrating that prediction error exists in single auditory neurons.

    • Gloria G. Parras
    • , Javier Nieto-Diego
    • , Guillermo V. Carbajal
    • , Catalina Valdés-Baizabal
    • , Carles Escera
    •  & Manuel S. Malmierca
  • Article | | open

    Large-scale changes in continental water storage have been shown to have an impact on seismicity. Here, the authors show that variation in the rate of microearthquakes in the New Madrid Seismic Zone coincides with hydrological loading in the Mississippi embayment at both annual and multi-annual timescales.

    • Timothy J. Craig
    • , Kristel Chanard
    •  & Eric Calais
  • Article | | open

    The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its downregulation ameliorates pathology in mice.

    • Young-Ok Son
    • , Seulki Park
    • , Ji-Sun Kwak
    • , Yoonkyung Won
    • , Wan-Su Choi
    • , Jinseol Rhee
    • , Churl-Hong Chun
    • , Je-Hwang Ryu
    • , Don-Kyu Kim
    • , Hueng-Sik Choi
    •  & Jang-Soo Chun
  • Article | | open

    Photoactive and semiconducting metal-organic frameworks are desirable for electrical and photoelectrical devices, but remain rare. Here Demets and co-workers design a naphthalene diimide and cobalt based MOF with anisotropic electrical semiconductivity and a high responsivity of 2.5 × 105 A W−1.

    • Evandro Castaldelli
    • , K. D. G. Imalka Jayawardena
    • , David C. Cox
    • , Guy J. Clarkson
    • , Richard I. Walton
    • , Long Le-Quang
    • , Jerôme Chauvin
    • , S. Ravi P. Silva
    •  & Grégoire Jean-François Demets
  • Article | | open

    Multiplexing of quantum memories could boost the efficiency of photon state preparation. Here, the authors use a cold atomic ensemble and a single-photon resolving camera to exploit emission multiplexing of Raman photons from 665 different angular modes, confirming nonclassical photon-number correlations.

    • Michał Parniak
    • , Michał Dąbrowski
    • , Mateusz Mazelanik
    • , Adam Leszczyński
    • , Michał Lipka
    •  & Wojciech Wasilewski
  • Article | | open

    Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies.

    • Benjamin J. Burwitz
    • , Jochen M. Wettengel
    • , Martin A. Mück-Häusl
    • , Marc Ringelhan
    • , Chunkyu Ko
    • , Marvin M. Festag
    • , Katherine B. Hammond
    • , Mina Northrup
    • , Benjamin N. Bimber
    • , Thomas Jacob
    • , Jason S. Reed
    • , Reed Norris
    • , Byung Park
    • , Sven Moller-Tank
    • , Knud Esser
    • , Justin M. Greene
    • , Helen L. Wu
    • , Shaheed Abdulhaqq
    • , Gabriela Webb
    • , William F. Sutton
    • , Alex Klug
    • , Tonya Swanson
    • , Alfred W. Legasse
    • , Tania Q. Vu
    • , Aravind Asokan
    • , Nancy L. Haigwood
    • , Ulrike Protzer
    •  & Jonah B. Sacha
  • Article | | open

    It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent manner.

    • Amit Ron
    • , Evren U. Azeloglu
    • , Rhodora C. Calizo
    • , Mufeng Hu
    • , Smiti Bhattacharya
    • , Yibang Chen
    • , Gomathi Jayaraman
    • , Sunwoo Lee
    • , Susana R. Neves-Zaph
    • , Hong Li
    • , Ronald E. Gordon
    • , John C. He
    • , James C. Hone
    •  & Ravi Iyengar
  • Article | | open

    Exotic transport properties of type-II Weyl semimetals have been predicted but are yet to be experimentally evidenced. Here, Li et al. report evidences of an anisotropy of negative magnetoresistance and a quantum oscillation arising from the predicted Weyl orbit in the type-II Weyl semimetal WTe2.

    • Peng Li
    • , Yan Wen
    • , Xin He
    • , Qiang Zhang
    • , Chuan Xia
    • , Zhi-Ming Yu
    • , Shengyuan A. Yang
    • , Zhiyong Zhu
    • , Husam N. Alshareef
    •  & Xi-Xiang Zhang
  • Article | | open

    Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.

    • Yu-Hsiu Wang
    • , Anushya Hariharan
    • , Giulia Bastianello
    • , Yusuke Toyama
    • , G. V. Shivashankar
    • , Marco Foiani
    •  & Michael P. Sheetz
  • Article | | open

    The intrinsic properties of atomically thin MoS2 are believed to be strongly affected by the presence of structural defects; however, the underlying physical mechanism of such link is not fully understood. Here, the authors combine noise-current analysis with atomic force microscopy to explore the relationship between point defects and the anomalous physical properties of MoS2 monolayers.

    • Seung Hyun Song
    • , Min-Kyu Joo
    • , Michael Neumann
    • , Hyun Kim
    •  & Young Hee Lee
  • Article | | open

    Regeneration capable flatworms have emerged as powerful models for studying stem cell biology and patterning, however their study has been hindered by the lack of transgenesis methods. Here, the authors describe a transgenesis method for Macrostomum lignano, as well as a new annotated genome sequence.

    • Jakub Wudarski
    • , Daniil Simanov
    • , Kirill Ustyantsev
    • , Katrien de Mulder
    • , Margriet Grelling
    • , Magda Grudniewska
    • , Frank Beltman
    • , Lisa Glazenburg
    • , Turan Demircan
    • , Julia Wunderer
    • , Weihong Qi
    • , Dita B. Vizoso
    • , Philipp M. Weissert
    • , Daniel Olivieri
    • , Stijn Mouton
    • , Victor Guryev
    • , Aziz Aboobaker
    • , Lukas Schärer
    • , Peter Ladurner
    •  & Eugene Berezikov
  • Article | | open

    Noisy gene expression can cause stochasticity in the expression of plant traits. Here, Araújo et al. use a dual reporter system of protein expression in Arabidopsis to show that expression noise is lowest in stomata relative to other tissues and that leaf cells are coupled with respect to noise.

    • Ilka Schultheiß Araújo
    • , Jessica Magdalena Pietsch
    • , Emma Mathilde Keizer
    • , Bettina Greese
    • , Rachappa Balkunde
    • , Christian Fleck
    •  & Martin Hülskamp
  • Article | | open

    Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.

    • Filippo Veglia
    • , Vladimir A. Tyurin
    • , Dariush Mohammadyani
    • , Maria Blasi
    • , Elizabeth K. Duperret
    • , Laxminarasimha Donthireddy
    • , Ayumi Hashimoto
    • , Alexandr Kapralov
    • , Andrew Amoscato
    • , Roberto Angelini
    • , Sima Patel
    • , Kevin Alicea-Torres
    • , David Weiner
    • , Maureen E. Murphy
    • , Judith Klein-Seetharaman
    • , Esteban Celis
    • , Valerian E. Kagan
    •  & Dmitry I. Gabrilovich
  • Article | | open

    Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions.

    • Sebastian G. Wicha
    • , Chunli Chen
    • , Oskar Clewe
    •  & Ulrika S. H. Simonsson
  • Article | | open

    An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.

    • Jeong-Ki Kim
    • , Arghavan Louhghalam
    • , Geonhui Lee
    • , Benjamin W. Schafer
    • , Denis Wirtz
    •  & Dong-Hwee Kim