Latest Research

  • Article | | open

    The resolution limitations when using the ubiquitous algorithms that process images obtained using modern techniques are not straightforward to define. Here, the authors examine the performance of localization algorithms and use spatial statistics to provide a metric for assessing the resolution limit of such algorithms.

    • Edward A. K. Cohen
    • , Anish V. Abraham
    • , Sreevidhya Ramakrishnan
    •  & Raimund J. Ober
  • Article | | open

    PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins and increased virulence.

    • Mariya I. Goncheva
    • , Ronald S. Flannagan
    • , Brigid E. Sterling
    • , Holly A. Laakso
    • , Nancy C. Friedrich
    • , Julienne C. Kaiser
    • , David W. Watson
    • , Christy H. Wilson
    • , Jessica R. Sheldon
    • , Martin J. McGavin
    • , Patti K. Kiser
    •  & David E. Heinrichs
  • Article | | open

    SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection.

    • Lara M. Myers
    • , Michal Caspi Tal
    • , Laughing Bear Torrez Dulgeroff
    • , Aaron B. Carmody
    • , Ronald J. Messer
    • , Gunsagar Gulati
    • , Ying Ying Yiu
    • , Matthew M. Staron
    • , Cesar Lopez Angel
    • , Rahul Sinha
    • , Maxim Markovic
    • , Edward A. Pham
    • , Benjamin Fram
    • , Aijaz Ahmed
    • , Aaron M. Newman
    • , Jeffrey S. Glenn
    • , Mark M. Davis
    • , Susan M. Kaech
    • , Irving L. Weissman
    •  & Kim J. Hasenkrug
  • Article | | open

    Simple, fast, and accurate detection of food freshness has great significance to food safety and business. Here, the authors develop cellulose-based ratiometric fluorescent materials with superior amine-response, which can be used for visual monitoring the freshness of shrimp and crab.

    • Ruonan Jia
    • , Weiguo Tian
    • , Haotian Bai
    • , Jinming Zhang
    • , Shu Wang
    •  & Jun Zhang
  • Article | | open

    Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here authors reveal the role played by a single residue in the second transmembrane domain of vertebrate and invertebrate two-pore domain potassium channels.

    • Ismail Ben Soussia
    • , Sonia El Mouridi
    • , Dawon Kang
    • , Alice Leclercq-Blondel
    • , Lamyaa Khoubza
    • , Philippe Tardy
    • , Nora Zariohi
    • , Marie Gendrel
    • , Florian Lesage
    • , Eun-Jin Kim
    • , Delphine Bichet
    • , Olga Andrini
    •  & Thomas Boulin
  • Article | | open

    Triple negative breast cancers (TNBC) disseminate and metastasise, but the clonal relationship of metastases to primary tumours is poorly understood. Here, the authors use cellular barcoding of TNBC patient-derived xenografts and track the fate of barcoded clones in primary tumours and their metastases, including after resection or chemotherapy.

    • D. Merino
    • , T. S. Weber
    • , A. Serrano
    • , F. Vaillant
    • , K. Liu
    • , B. Pal
    • , L. Di Stefano
    • , J. Schreuder
    • , D. Lin
    • , Y. Chen
    • , M. L. Asselin-Labat
    • , T. N. Schumacher
    • , D. Cameron
    • , G. K. Smyth
    • , A. T. Papenfuss
    • , G. J. Lindeman
    • , J. E. Visvader
    •  & S. H. Naik
  • Article | | open

    Meiotic crossover (CO) landscape differs inter- and intra-species, as well as between sexes. Here, the authors show that male meiosis produces more COs than female in maize and detect CO maturation inefficiency in some genetic backgrounds, which may help to improve breeding efficiency.

    • Cheng Luo
    • , Xiang Li
    • , Qinghua Zhang
    •  & Jianbing Yan
  • Article | | open

    Molecular motion has attracted a wide range of interest for different applications. Here, the authors develop nanoparticles with internal molecular motion upon near infrared absorption and use the nanoparticles for photoacoustic imaging and demonstrate this application in vivo.

    • Zheng Zhao
    • , Chao Chen
    • , Wenting Wu
    • , Fenfen Wang
    • , Lili Du
    • , Xiaoyan Zhang
    • , Yu Xiong
    • , Xuewen He
    • , Yuanjing Cai
    • , Ryan T. K. Kwok
    • , Jacky W. Y. Lam
    • , Xike Gao
    • , Pingchuan Sun
    • , David Lee Phillips
    • , Dan Ding
    •  & Ben Zhong Tang
  • Article | | open

    Group membership can inform individuals’ decisions on whether to cooperate. Here, the authors show how cooperative groups themselves can emerge and change due to use of reputation heuristics (such as “the enemy of a friend is an enemy”), and how this destabilizes cooperation over time.

    • Jörg Gross
    •  & Carsten K. W. De Dreu
  • Article | | open

    Membrane elongation is fundamental to autophagy and is controlled by an ubiquitin-conjugating cascade orchestrated by ATG16L1. Here, the authors identify that the E3 ligase Gigaxonin regulates autophagosome formation by controlling ATG16L1 turnover.

    • Aurora Scrivo
    • , Patrice Codogno
    •  & Pascale Bomont
  • Article | | open

    FXR1P is a RNA binding protein involved in muscle development. Here, the authors show that mutations in FXR1 exon 15, which is alternatively spliced in muscle, cause multi-minicore myopathy in humans and in mouse models.

    • María Cristina Estañ
    • , Elisa Fernández-Núñez
    • , Maha S. Zaki
    • , María Isabel Esteban
    • , Sandra Donkervoort
    • , Cynthia Hawkins
    • , José A. Caparros-Martin
    • , Dimah Saade
    • , Ying Hu
    • , Véronique Bolduc
    • , Katherine Ru-Yui Chao
    • , Julián Nevado
    • , Ana Lamuedra
    • , Raquel Largo
    • , Gabriel Herrero-Beaumont
    • , Javier Regadera
    • , Concepción Hernandez-Chico
    • , Eduardo F. Tizzano
    • , Victor Martinez-Glez
    • , Jaime J. Carvajal
    • , Ruiting Zong
    • , David L. Nelson
    • , Ghada A. Otaify
    • , Samia Temtamy
    • , Mona Aglan
    • , Mahmoud Issa
    • , Carsten G. Bönnemann
    • , Pablo Lapunzina
    • , Grace Yoon
    •  & Victor L. Ruiz-Perez
  • Author Correction | | open

    • Lot Snijders Blok
    • , Justine Rousseau
    • , Joanna Twist
    • , Sophie Ehresmann
    • , Motoki Takaku
    • , Hanka Venselaar
    • , Lance H. Rodan
    • , Catherine B. Nowak
    • , Jessica Douglas
    • , Kathryn J. Swoboda
    • , Marcie A. Steeves
    • , Inderneel Sahai
    • , Connie T. R. M. Stumpel
    • , Alexander P. A. Stegmann
    • , Patricia Wheeler
    • , Marcia Willing
    • , Elise Fiala
    • , Aaina Kochhar
    • , William T. Gibson
    • , Ana S. A. Cohen
    • , Ruky Agbahovbe
    • , A. Micheil Innes
    • , P. Y. Billie Au
    • , Julia Rankin
    • , Ilse J. Anderson
    • , Steven A. Skinner
    • , Raymond J. Louie
    • , Hannah E. Warren
    • , Alexandra Afenjar
    • , Boris Keren
    • , Caroline Nava
    • , Julien Buratti
    • , Arnaud Isapof
    • , Diana Rodriguez
    • , Raymond Lewandowski
    • , Jennifer Propst
    • , Ton van Essen
    • , Murim Choi
    • , Sangmoon Lee
    • , Jong H. Chae
    • , Susan Price
    • , Rhonda E. Schnur
    • , Ganka Douglas
    • , Ingrid M. Wentzensen
    • , Christiane Zweier
    • , André Reis
    • , Martin G. Bialer
    • , Christine Moore
    • , Marije Koopmans
    • , Eva H. Brilstra
    • , Glen R. Monroe
    • , Koen L. I. van Gassen
    • , Ellen van Binsbergen
    • , Ruth Newbury-Ecob
    • , Lucy Bownass
    • , Ingrid Bader
    • , Johannes A. Mayr
    • , Saskia B. Wortmann
    • , Kathy J. Jakielski
    • , Edythe A. Strand
    • , Katja Kloth
    • , Tatjana Bierhals
    • , Jeremy F. McRae
    • , Stephen Clayton
    • , Tomas W. Fitzgerald
    • , Joanna Kaplanis
    • , Elena Prigmore
    • , Diana Rajan
    • , Alejandro Sifrim
    • , Stuart Aitken
    • , Nadia Akawi
    • , Mohsan Alvi
    • , Kirsty Ambridge
    • , Daniel M. Barrett
    • , Tanya Bayzetinova
    • , Philip Jones
    • , Wendy D. Jones
    • , Daniel King
    • , Netravathi Krishnappa
    • , Laura E. Mason
    • , Tarjinder Singh
    • , Adrian R. Tivey
    • , Munaza Ahmed
    • , Uruj Anjum
    • , Hayley Archer
    • , Ruth Armstrong
    • , Jana Awada
    • , Meena Balasubramanian
    • , Siddharth Banka
    • , Diana Baralle
    • , Angela Barnicoat
    • , Paul Batstone
    • , David Baty
    • , Chris Bennett
    • , Jonathan Berg
    • , Birgitta Bernhard
    • , A. Paul Bevan
    • , Maria Bitner-Glindzicz
    • , Edward Blair
    • , Moira Blyth
    • , David Bohanna
    • , Louise Bourdon
    • , David Bourn
    • , Lisa Bradley
    • , Angela Brady
    • , Simon Brent
    • , Carole Brewer
    • , Kate Brunstrom
    • , David J. Bunyan
    • , John Burn
    • , Natalie Canham
    • , Bruce Castle
    • , Kate Chandler
    • , Elena Chatzimichali
    • , Deirdre Cilliers
    • , Angus Clarke
    • , Susan Clasper
    • , Jill Clayton-Smith
    • , Virginia Clowes
    • , Andrea Coates
    • , Trevor Cole
    • , Irina Colgiu
    • , Amanda Collins
    • , Morag N. Collinson
    • , Fiona Connell
    • , Nicola Cooper
    • , Helen Cox
    • , Lara Cresswell
    • , Gareth Cross
    • , Jill Clayton-Smith
    • , Virginia Clowes
    • , Andrea Coates
    • , Trevor Cole
    • , Irina Colgiu
    • , Amanda Collins
    • , Morag N. Collinson
    • , Fiona Connell
    • , Nicola Cooper
    • , Helen Cox
    • , Lara Cresswell
    • , Gareth Cross
    • , Yanick Crow
    • , Mariella D’Alessandro
    • , Tabib Dabir
    • , Rosemarie Davidson
    • , Sally Davies
    • , Dylan de Vries
    • , John Dean
    • , Charu Deshpande
    • , Gemma Devlin
    • , Abhijit Dixit
    • , Angus Dobbie
    • , Alan Donaldson
    • , Dian Donnai
    • , Deirdre Donnelly
    • , Carina Donnelly
    • , Angela Douglas
    • , Sofia Douzgou
    • , Alexis Duncan
    • , Jacqueline Eason
    • , Sian Ellard
    • , Ian Ellis
    • , Frances Elmslie
    • , Karenza Evans
    • , Sarah Everest
    • , Tina Fendick
    • , Richard Fisher
    • , Frances Flinter
    • , Nicola Foulds
    • , Andrew Fry
    • , Alan Fryer
    • , Carol Gardiner
    • , Lorraine Gaunt
    • , Neeti Ghali
    • , Richard Gibbons
    • , Harinder Gill
    • , Judith Goodship
    • , David Goudie
    • , Emma Gray
    • , Andrew Green
    • , Philip Greene
    • , Lynn Greenhalgh
    • , Susan Gribble
    • , Rachel Harrison
    • , Lucy Harrison
    • , Victoria Harrison
    • , Rose Hawkins
    • , Liu He
    • , Stephen Hellens
    • , Alex Henderson
    • , Sarah Hewitt
    • , Lucy Hildyard
    • , Emma Hobson
    • , Simon Holden
    • , Muriel Holder
    • , Susan Holder
    • , Georgina Hollingsworth
    • , Tessa Homfray
    • , Mervyn Humphreys
    • , Jane Hurst
    • , Ben Hutton
    • , Stuart Ingram
    • , Melita Irving
    • , Lily Islam
    • , Andrew Jackson
    • , Joanna Jarvis
    • , Lucy Jenkins
    • , Diana Johnson
    • , Elizabeth Jones
    • , Dragana Josifova
    • , Shelagh Joss
    • , Beckie Kaemba
    • , Sandra Kazembe
    • , Rosemary Kelsell
    • , Bronwyn Kerr
    • , Helen Kingston
    • , Usha Kini
    • , Esther Kinning
    • , Gail Kirby
    • , Claire Kirk
    • , Emma Kivuva
    • , Alison Kraus
    • , Dhavendra Kumar
    • , V. K. Ajith Kumar
    • , Katherine Lachlan
    • , Wayne Lam
    • , Anne Lampe
    • , Caroline Langman
    • , Melissa Lees
    • , Derek Lim
    • , Cheryl Longman
    • , Gordon Lowther
    • , Sally A. Lynch
    • , Alex Magee
    • , Eddy Maher
    • , Alison Male
    • , Sahar Mansour
    • , Karen Marks
    • , Katherine Martin
    • , Una Maye
    • , Emma McCann
    • , Vivienne McConnell
    • , Meriel McEntagart
    • , Ruth McGowan
    • , Kirsten McKay
    • , Shane McKee
    • , Dominic J. McMullan
    • , Susan McNerlan
    • , Catherine McWilliam
    • , Sarju Mehta
    • , Kay Metcalfe
    • , Anna Middleton
    • , Zosia Miedzybrodzka
    • , Emma Miles
    • , Shehla Mohammed
    • , Tara Montgomery
    • , David Moore
    • , Sian Morgan
    • , Jenny Morton
    • , Hood Mugalaasi
    • , Victoria Murday
    • , Helen Murphy
    • , Swati Naik
    • , Andrea Nemeth
    • , Louise Nevitt
    • , Andrew Norman
    • , Rosie O’Shea
    • , Caroline Ogilvie
    • , Kai-Ren Ong
    • , Soo-Mi Park
    • , Michael J. Parker
    • , Chirag Patel
    • , Joan Paterson
    • , Stewart Payne
    • , Daniel Perrett
    • , Julie Phipps
    • , Daniela T. Pilz
    • , Martin Pollard
    • , Caroline Pottinger
    • , Joanna Poulton
    • , Norman Pratt
    • , Katrina Prescott
    • , Abigail Pridham
    • , Annie Procter
    • , Hellen Purnell
    • , Oliver Quarrell
    • , Nicola Ragge
    • , Raheleh Rahbari
    • , Josh Randall
    • , Lucy Raymond
    • , Debbie Rice
    • , Leema Robert
    • , Eileen Roberts
    • , Jonathan Roberts
    • , Paul Roberts
    • , Gillian Roberts
    • , Alison Ross
    • , Elisabeth Rosser
    • , Anand Saggar
    • , Shalaka Samant
    • , Julian Sampson
    • , Richard Sandford
    • , Ajoy Sarkar
    • , Susann Schweiger
    • , Richard Scott
    • , Ingrid Scurr
    • , Ann Selby
    • , Anneke Seller
    • , Cheryl Sequeira
    • , Nora Shannon
    • , Saba Sharif
    • , Charles Shaw-Smith
    • , Emma Shearing
    • , Debbie Shears
    • , Eamonn Sheridan
    • , Ingrid Simonic
    • , Roldan Singzon
    • , Zara Skitt
    • , Audrey Smith
    • , Kath Smith
    • , Sarah Smithson
    • , Linda Sneddon
    • , Miranda Splitt
    • , Miranda Squires
    • , Fiona Stewart
    • , Helen Stewart
    • , Volker Straub
    • , Mohnish Suri
    • , Vivienne Sutton
    • , Ganesh Jawahar Swaminathan
    • , Elizabeth Sweeney
    • , Kate Tatton-Brown
    • , Cat Taylor
    • , Rohan Taylor
    • , Mark Tein
    • , I. Karen Temple
    • , Jenny Thomson
    • , Marc Tischkowitz
    • , Susan Tomkins
    • , Audrey Torokwa
    • , Becky Treacy
    • , Claire Turner
    • , Peter Turnpenny
    • , Carolyn Tysoe
    • , Anthony Vandersteen
    • , Vinod Varghese
    • , Pradeep Vasudevan
    • , Parthiban Vijayarangakannan
    • , Julie Vogt
    • , Emma Wakeling
    • , Sarah Wallwark
    • , Jonathon Waters
    • , Astrid Weber
    • , Diana Wellesley
    • , Margo Whiteford
    • , Sara Widaa
    • , Sarah Wilcox
    • , Emily Wilkinson
    • , Denise Williams
    • , Nicola Williams
    • , Louise Wilson
    • , Geoff Woods
    • , Christopher Wragg
    • , Michael Wright
    • , Laura Yates
    • , Michael Yau
    • , Chris Nellåker
    • , Michael Parker
    • , Helen V. Firth
    • , Caroline F. Wright
    • , David R. FitzPatrick
    • , Jeffrey C. Barrett
    • , Matthew E. Hurles
    • , John D. Roberts
    • , Robert M. Petrovich
    • , Shinichi Machida
    • , Hitoshi Kurumizaka
    • , Stefan Lelieveld
    • , Rolph Pfundt
    • , Sandra Jansen
    • , Pelagia Deriziotis
    • , Laurence Faivre
    • , Julien Thevenon
    • , Mirna Assoum
    • , Lawrence Shriberg
    • , Tjitske Kleefstra
    • , Han G. Brunner
    • , Paul A. Wade
    • , Simon E. Fisher
    •  & Philippe M. Campeau
  • Article | | open

    Large-scale deletions of mitochondrial DNA (mtDNA) are associated with different human mitochondrial diseases and normal human ageing. Here the authors present a model for mtDNA formation based on generation sequencing analysis of patients samples and in vitro reconstituted mtDNA deletion using purified proteins.

    • Örjan Persson
    • , Yazh Muthukumar
    • , Swaraj Basu
    • , Louise Jenninger
    • , Jay P. Uhler
    • , Anna-Karin Berglund
    • , Robert McFarland
    • , Robert W. Taylor
    • , Claes M. Gustafsson
    • , Erik Larsson
    •  & Maria Falkenberg
  • Article | | open

    Wide application of quantum dot light emitting diodes (QLED) in display technology is hindered by the poor lifetime of the blue QLEDs. Here, the degradation mechanism is shown to originate from space charge accumulation in the electron-transporting layer enabling improvements in blue QLED lifetimes.

    • Song Chen
    • , Weiran Cao
    • , Taili Liu
    • , Sai-Wing Tsang
    • , Yixing Yang
    • , Xiaolin Yan
    •  & Lei Qian
  • Article | | open

    The photofixation and utilization of CO2 is considered to be a clean and green way to produce high-value-added commodity chemicals, but production of long chain chemicals through this process remains a challenge. Here, the authors develop a practical way for the photofixation of CO2 to long-chain chemicals via defect engineering.

    • Shichuan Chen
    • , Hui Wang
    • , Zhixiong Kang
    • , Sen Jin
    • , Xiaodong Zhang
    • , Xusheng Zheng
    • , Zeming Qi
    • , Junfa Zhu
    • , Bicai Pan
    •  & Yi Xie
  • Article | | open

    Here, the authors explore the relationship between socioeconomic position (SEP) across the life course and inflammation in a multi-cohort study and show that educational attainment is most strongly related to inflammation, suggesting that socioeconomic disadvantage in young adulthood is independently associated with later life inflammation.

    • Eloïse Berger
    • , Raphaële Castagné
    • , Marc Chadeau-Hyam
    • , Murielle Bochud
    • , Angelo d’Errico
    • , Martina Gandini
    • , Maryam Karimi
    • , Mika Kivimäki
    • , Vittorio Krogh
    • , Michael Marmot
    • , Salvatore Panico
    • , Martin Preisig
    • , Fulvio Ricceri
    • , Carlotta Sacerdote
    • , Andrew Steptoe
    • , Silvia Stringhini
    • , Rosario Tumino
    • , Paolo Vineis
    • , Cyrille Delpierre
    •  & Michelle Kelly-Irving
  • Article | | open

    Radiomics—the quantification of features within tumor images—has shown prognostic potential in cancer. Here, the authors use a machine learning approach to develop a radiomic-based small set of descriptors to predict ovarian cancer patient survival based on CT scans acquired pre-operatively in 364 patients.

    • Haonan Lu
    • , Mubarik Arshad
    • , Andrew Thornton
    • , Giacomo Avesani
    • , Paula Cunnea
    • , Ed Curry
    • , Fahdi Kanavati
    • , Jack Liang
    • , Katherine Nixon
    • , Sophie T. Williams
    • , Mona Ali Hassan
    • , David D. L. Bowtell
    • , Hani Gabra
    • , Christina Fotopoulou
    • , Andrea Rockall
    •  & Eric O. Aboagye
  • Article | | open

    Investigation of a reaction scope usually starts with the optimization for a model substrate. Here, the authors apply a time-efficient multi-substrate screening approach to identify a general organocatalyst for the Diels–Alder reaction of cyclopentadiene with α,β-unsaturated aldehydes.

    • Hyejin Kim
    • , Gabriela Gerosa
    • , Jonas Aronow
    • , Pinar Kasaplar
    • , Jie Ouyang
    • , Julia B. Lingnau
    • , Paul Guerry
    • , Christophe Farès
    •  & Benjamin List
  • Article | | open

    Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.

    • Maik Luu
    • , Sabine Pautz
    • , Vanessa Kohl
    • , Rajeev Singh
    • , Rossana Romero
    • , Sébastien Lucas
    • , Jörg Hofmann
    • , Hartmann Raifer
    • , Niyati Vachharajani
    • , Lucia Campos Carrascosa
    • , Boris Lamp
    • , Andrea Nist
    • , Thorsten Stiewe
    • , Yoav Shaul
    • , Till Adhikary
    • , Mario M. Zaiss
    • , Matthias Lauth
    • , Ulrich Steinhoff
    •  & Alexander Visekruna
  • Article | | open

    The mechanism of enhanced superconducting transition temperature (Tc) at the FeSe/SrTiO3 interface remains enigmatic. Here, Song and Yu et al. reveal the evidence of cooperation between intrinsic pairing interaction in FeSe and interfacial electron–phonon coupling to enhance the Tc at the FeSe/SrTiO3 interface.

    • Q. Song
    • , T. L. Yu
    • , X. Lou
    • , B. P. Xie
    • , H. C. Xu
    • , C. H. P. Wen
    • , Q. Yao
    • , S. Y. Zhang
    • , X. T. Zhu
    • , J. D. Guo
    • , R. Peng
    •  & D. L. Feng
  • Article | | open

    Infection of a cell with influenza B virus (IBV) often results in cell death and the role of surviving cells in pathogenesis is unclear. Here, Dumm et al. generate a recombinant IBV that activates a host-cell reporter to permanently label infected cells, and show that surviving cells are important to preserve epithelial barrier function.

    • Rebekah E. Dumm
    • , Jessica K. Fiege
    • , Barbara M. Waring
    • , Chay T. Kuo
    • , Ryan A. Langlois
    •  & Nicholas S. Heaton
  • Article | | open

    Heavy-fermion materials have unusual electronic behavior due to a dual localized-itinerant character of 4f electrons. Here, by studying divalent EuRh2Si2, the authors gain insight into the electronic states of the trivalent heavy fermion system YbRh2Si2 and show that it experimentally demonstrates Luttinger’s theorem.

    • M. Güttler
    • , A. Generalov
    • , S. I. Fujimori
    • , K. Kummer
    • , A. Chikina
    • , S. Seiro
    • , S. Danzenbächer
    • , Yu. M. Koroteev
    • , E. V. Chulkov
    • , M. Radovic
    • , M. Shi
    • , N. C. Plumb
    • , C. Laubschat
    • , J. W. Allen
    • , C. Krellner
    • , C. Geibel
    •  & D. V. Vyalikh
  • Article | | open

    Defect tolerance is important in order to ensure the mechanical integrity of synthetic materials and biological tissues. Here the authors demonstrate that toughening mechanisms provide soft collagenous tissues with high defect tolerance, with important implications for biomedical applications.

    • Kevin Bircher
    • , Manuel Zündel
    • , Marco Pensalfini
    • , Alexander E. Ehret
    •  & Edoardo Mazza
  • Article | | open

    SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in complex with the C-terminal ChAD (chaperone addiction) extension of the antitoxin HigA1.

    • Valérie Guillet
    • , Patricia Bordes
    • , Cécile Bon
    • , Julien Marcoux
    • , Virginie Gervais
    • , Ambre Julie Sala
    • , Suzana Dos Reis
    • , Nawel Slama
    • , Israel Mares-Mejía
    • , Anne-Marie Cirinesi
    • , Laurent Maveyraud
    • , Pierre Genevaux
    •  & Lionel Mourey
  • Article | | open

    Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex and explain how ASPP2 can distinguish between PP1 isoforms.

    • M. Teresa Bertran
    • , Stéphane Mouilleron
    • , Yanxiang Zhou
    • , Rakhi Bajaj
    • , Federico Uliana
    • , Ganesan Senthil Kumar
    • , Audrey van Drogen
    • , Rebecca Lee
    • , Jennifer J. Banerjee
    • , Simon Hauri
    • , Nicola O’Reilly
    • , Matthias Gstaiger
    • , Rebecca Page
    • , Wolfgang Peti
    •  & Nicolas Tapon
  • Article | | open

    Phyllosilicate minerals are critical components of seismogenic fault, shear and subduction zones. Here, the authors provide a new deformation mechanism for phyllosilicates, based on newly discovered crystallographic defects in biotite (ripplocations), affecting our understanding of fault zone processes.

    • Joe Aslin
    • , Elisabetta Mariani
    • , Karl Dawson
    •  & Michel W. Barsoum
  • Article | | open

    SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal tissues, but not the testis.

    • Fu-Ping Zhang
    • , Marjo Malinen
    • , Arfa Mehmood
    • , Tiina Lehtiniemi
    • , Tiina Jääskeläinen
    • , Einari A. Niskanen
    • , Hanna Korhonen
    • , Asta Laiho
    • , Laura L. Elo
    • , Claes Ohlsson
    • , Noora Kotaja
    • , Matti Poutanen
    • , Petra Sipilä
    •  & Jorma J. Palvimo
  • Article | | open

    Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.

    • Armin P. Schoech
    • , Daniel M. Jordan
    • , Po-Ru Loh
    • , Steven Gazal
    • , Luke J. O’Connor
    • , Daniel J. Balick
    • , Pier F. Palamara
    • , Hilary K. Finucane
    • , Shamil R. Sunyaev
    •  & Alkes L. Price
  • Article | | open

    The amount of carbon stored in closed hidden reservoirs is unknown. Here the authors use a computational approach to study the evolution of carbon species and observe polymerization of carbon atoms at high pressures, illustrating the potential for a significant carbon reservoir in the Earth’s deep interior.

    • Natalia V. Solomatova
    • , Razvan Caracas
    •  & Craig E. Manning
  • Article | | open

    Pseudomonas aeruginosa releases redox-active metabolites called phenazines. Here, the authors use metabolic imaging by stimulated Raman scattering microscopy to show that phenazines antagonize the effects of antibiotics on P. aeruginosa biofilms by modulating bacterial metabolism.

    • Konstanze T. Schiessl
    • , Fanghao Hu
    • , Jeanyoung Jo
    • , Sakila Z. Nazia
    • , Bryan Wang
    • , Alexa Price-Whelan
    • , Wei Min
    •  & Lars E. P. Dietrich
  • Article | | open

    The fusion peptide (FP) of HIV envelope (Env) is critical in the cell entry process. Here, Kumar et al. present crystal structures of B41 SOSIP.664 Env trimer and show the dynamic nature of the FP and proximal region, which likely relates to conformational rearrangements required for membrane fusion.

    • Sonu Kumar
    • , Anita Sarkar
    • , Pavel Pugach
    • , Rogier W. Sanders
    • , John P. Moore
    • , Andrew B. Ward
    •  & Ian A. Wilson
  • Article | | open

    Objects with varied mechanical properties can be produced by additive manufacturing, but multimaterial control along all three axes of printing is still limited. Here the authors use wavelength control during vat polymerization and demonstrate printing of objects with spatial control of the composition and stiffness.

    • J. J. Schwartz
    •  & A. J. Boydston
  • Article | | open

    Organic cocrystals have interesting properties owing to synergistic effects of the individual components but development of effective growth methods for molecular cocrystals is still in its primary stage. Here the authors demonstrate a sublimation method which allows growing organic cocrystals with controlled morphology.

    • Xin Ye
    • , Yang Liu
    • , Qing Guo
    • , Quanxiang Han
    • , Chao Ge
    • , Shuangyue Cui
    • , Leilei Zhang
    •  & Xutang Tao
  • Article | | open

    Perylenediimide (PDI) radical anions show promise as photothermal agents for phototherapy, but are typically very unstable. Here the authors fabricate a PDI-based metal-organic framework where the PDI units become stable radical anions upon incorporation of amine vapors.

    • Baozhong Lü
    • , Yifa Chen
    • , Pengyu Li
    • , Bo Wang
    • , Klaus Müllen
    •  & Meizhen Yin
  • Article | | open

    CC and TIR-domain type NLR receptors trigger plant immunity in response to pathogen effectors. Here, Bhandari et al. show that the EP-domain surface of EDS1 heterodimers signals downstream of both receptor types and ensures a rapid transcriptional response in TIR-NLR immunity to bacteria.

    • Deepak D. Bhandari
    • , Dmitry Lapin
    • , Barbara Kracher
    • , Patrick von Born
    • , Jaqueline Bautor
    • , Karsten Niefind
    •  & Jane E. Parker
  • Article | | open

    Rydberg atoms can be created from photoexcitation of molecules using intense ultrafast laser pulses. Here the authors use a coincidence detection of electrons, ion and excited Rydberg atoms and their energy sharing to reveal the general mechanism of Rydberg state excitation in a dissociating H2 molecule.

    • Wenbin Zhang
    • , Xiaochun Gong
    • , Hui Li
    • , Peifen Lu
    • , Fenghao Sun
    • , Qinying Ji
    • , Kang Lin
    • , Junyang Ma
    • , Hanxiao Li
    • , Junjie Qiang
    • , Feng He
    •  & Jian Wu
  • Article | | open

    Viruses can encode genes that regulate the host's translational machinery to their advantage. Here, the authors show that viruses encode ribosomal proteins that can be incorporated into the host’s ribosome and may affect translation.

    • Carolina M. Mizuno
    • , Charlotte Guyomar
    • , Simon Roux
    • , Régis Lavigne
    • , Francisco Rodriguez-Valera
    • , Matthew B. Sullivan
    • , Reynald Gillet
    • , Patrick Forterre
    •  & Mart Krupovic
  • Article | | open

    To realize efficient optoelectronic devices based on two-dimensional (2D) organic crystals, optimizing the photoelectrical response and growth of these materials at the 2D limit is vital. Here, the authors report enhanced internal photoresponse in large-area 2D crystals using a novel growth method.

    • Min Cao
    • , Cong Zhang
    • , Zhi Cai
    • , Chengcheng Xiao
    • , Xiaosong Chen
    • , Kongyang Yi
    • , Yingguo Yang
    • , Yunhao Lu
    •  & Dacheng Wei
  • Article | | open

    It is not clear how the public views the acceptability of bioenergy with carbon capture and storage (BECCS). Here the authors explored public perceptions of BECCS by situating the technology in three policy scenarios and found that the policy instrument used to incentivise BECCS significantly affects the degree of public support for the technology.

    • Rob Bellamy
    • , Javier Lezaun
    •  & James Palmer
  • Article | | open

    Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeutic target.

    • Lin Wang
    • , Yilong Zhou
    • , Zijuan Chen
    • , Lei Sun
    • , Juehui Wu
    • , Haohao Li
    • , Feng Liu
    • , Fei Wang
    • , Chunfu Yang
    • , Juhao Yang
    • , Qibin Leng
    • , Qingli Zhang
    • , Ajing Xu
    • , Lisong Shen
    • , Jinqiao Sun
    • , Dianqing Wu
    • , Caiyun Fang
    • , Haojie Lu
    • , Dapeng Yan
    •  & Baoxue Ge
  • Article | | open

    Using seismic data and numerical modelling, here, the authors characterize the three-month period of unrest occurring prior to the 2017 Agung eruption (Bali, Indonesia). They observe a large uplift signal located at ~5 km from Agung summit corresponding to the emplacement of a 10 km deep magma intrusion between Agung edifice and Batur caldera, suggesting a potential magmatic connection between the two volcanic systems.

    • Fabien Albino
    • , Juliet Biggs
    •  & Devy Kamil Syahbana
  • Article | | open

    Coccolithophores are one of the most abundant phytoplankton and calcifying organisms, well-known to produce intricate calcareous exoskeletons made of coccoliths. Here the authors show, by using X-ray nanotomography, the dependence of the grid size on the calcite nucleation site number and on the mass of coccoliths.

    • T. Beuvier
    • , I. Probert
    • , L. Beaufort
    • , B. Suchéras-Marx
    • , Y. Chushkin
    • , F. Zontone
    •  & A. Gibaud
  • Article | | open

    It is unclear whether CO2-stimulation of photosynthesis can propagate through slower ecosystem processes and lead to long-term increases in terrestrial carbon. Here the authors show that CO2-stimulation of photosynthesis leads to a 30% increase in forest regrowth over a decade of CO2 enrichment.

    • Anthony P. Walker
    • , Martin G. De Kauwe
    • , Belinda E. Medlyn
    • , Sönke Zaehle
    • , Colleen M. Iversen
    • , Shinichi Asao
    • , Bertrand Guenet
    • , Anna Harper
    • , Thomas Hickler
    • , Bruce A. Hungate
    • , Atul K. Jain
    • , Yiqi Luo
    • , Xingjie Lu
    • , Meng Lu
    • , Kristina Luus
    • , J. Patrick Megonigal
    • , Ram Oren
    • , Edmund Ryan
    • , Shijie Shu
    • , Alan Talhelm
    • , Ying-Ping Wang
    • , Jeffrey M. Warren
    • , Christian Werner
    • , Jianyang Xia
    • , Bai Yang
    • , Donald R. Zak
    •  & Richard J. Norby
  • Article | | open

    Various physical mechanisms are proposed to explain the heating observed in turbulent astrophysical plasmas. Here, Chen et al. find a signature consistent with one of these mechanisms, electron Landau damping, by applying a field-particle correlation technique to in situ spacecraft data of turbulence in the Earth’s magnetosheath.

    • C. H. K. Chen
    • , K. G. Klein
    •  & G. G. Howes