Articles

  • Article | | open

    While direct N2 reduction using electrochemistry offers an appealing method to obtain usable nitrogen, materials typically show poor activities and efficiencies. Here, authors demonstrate a single-atom catalyst, iron on N-doped carbon, to have dramatically enhanced N2 reduction efficiencies.

    • Mengfan Wang
    • , Sisi Liu
    • , Tao Qian
    • , Jie Liu
    • , Jinqiu Zhou
    • , Haoqing Ji
    • , Jie Xiong
    • , Jun Zhong
    •  & Chenglin Yan
  • Article | | open

    Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical study that targeting the MR pathway may provide clinical benefits in nAMD patiens.

    • Min Zhao
    • , Irmela Mantel
    • , Emmanuelle Gelize
    • , Xinxin Li
    • , Xiaoyue Xie
    • , Alejandro Arboleda
    • , Marie Seminel
    • , Rinath Levy-Boukris
    • , Marilyn Dernigoghossian
    • , Andrea Prunotto
    • , Charlotte Andrieu-Soler
    • , Carlo Rivolta
    • , Jérémie Canonica
    • , Marie-Christine Naud
    • , Sebastian Lechner
    • , Nicolette Farman
    • , Irene Bravo-Osuna
    • , Rocio Herrero-Vanrell
    • , Frederic Jaisser
    •  & Francine Behar-Cohen
  • Article | | open

    The mid-Pleistocene transition is recognized as a shift in paleoclimatic periodicity from 41- to 100-kyr cycles. Here the authors present a unique mid-Pleistocene transition of coupled monsoon-vegetation changes from 23- to 100-kyr cycles, which indicates varied sensitivity of past climate to astronomical and ice/CO2 forcing.

    • Youbin Sun
    • , Qiuzhen Yin
    • , Michel Crucifix
    • , Steven C. Clemens
    • , Pablo Araya-Melo
    • , Weiguo Liu
    • , Xiaoke Qiang
    • , Qingsong Liu
    • , Hui Zhao
    • , Lianji Liang
    • , Hongyun Chen
    • , Ying Li
    • , Li Zhang
    • , Guocheng Dong
    • , Ming Li
    • , Weijian Zhou
    • , Andre Berger
    •  & Zhisheng An
  • Article | | open

    Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.

    • Nicola Fenderico
    • , Revina C. van Scherpenzeel
    • , Michael Goldflam
    • , Davide Proverbio
    • , Ingrid Jordens
    • , Tomica Kralj
    • , Sarah Stryeck
    • , Tarek Z. Bass
    • , Guy Hermans
    • , Christopher Ullman
    • , Teodor Aastrup
    • , Piet Gros
    •  & Madelon M. Maurice
  • Article | | open

    Obesity and the distribution of fat within the body are risk factors for cardiometabolic diseases. Here, Rask-Andersen et al. perform GWAS for bio-electrical impedance measurements in UK Biobank participants and identify 29 novel independent loci for fat distribution and a high degree of sex-heterogeneity.

    • Mathias Rask-Andersen
    • , Torgny Karlsson
    • , Weronica E. Ek
    •  & Åsa Johansson
  • Article | | open

    Electron correlation normally makes electrons less mobile, but it is still not clear when correlation becomes very strong in Dirac semimetals. Here, Fujioka et al. report a very high electron mobility exceeding 60,000 cm2V−1s−1 in correlated Dirac semimetal of perovskite CaIrO3, due to the enhanced electron correlation nearby the Mott transition.

    • J. Fujioka
    • , R. Yamada
    • , M. Kawamura
    • , S. Sakai
    • , M. Hirayama
    • , R. Arita
    • , T. Okawa
    • , D. Hashizume
    • , M. Hoshino
    •  & Y. Tokura
  • Article | | open

    Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.

    • Simon Haworth
    • , Chin Yang Shapland
    • , Caroline Hayward
    • , Bram P. Prins
    • , Janine F. Felix
    • , Carolina Medina-Gomez
    • , Fernando Rivadeneira
    • , Carol Wang
    • , Tarunveer S. Ahluwalia
    • , Martine Vrijheid
    • , Mònica Guxens
    • , Jordi Sunyer
    • , Ioanna Tachmazidou
    • , Klaudia Walter
    • , Valentina Iotchkova
    • , Andrew Jackson
    • , Louise Cleal
    • , Jennifer Huffmann
    • , Josine L. Min
    • , Lærke Sass
    • , Paul R. H. J. Timmers
    • , Saeed Al Turki
    • , Carl A. Anderson
    • , Richard Anney
    • , Dinu Antony
    • , María Soler Artigas
    • , Muhammad Ayub
    • , Senduran Bala
    • , Jeffrey C. Barrett
    • , Inês Barroso
    • , Phil Beales
    • , Jamie Bentham
    • , Shoumo Bhattacharya
    • , Ewan Birney
    • , Douglas Blackwood
    • , Martin Bobrow
    • , Elena Bochukova
    • , Patrick F. Bolton
    • , Rebecca Bounds
    • , Chris Boustred
    • , Gerome Breen
    • , Mattia Calissano
    • , Keren Carss
    • , Ruth Charlton
    • , Krishna Chatterjee
    • , Lu Chen
    • , Antonio Ciampi
    • , Sebahattin Cirak
    • , Peter Clapham
    • , Gail Clement
    • , Guy Coates
    • , Massimiliano Cocca
    • , David A. Collier
    • , Catherine Cosgrove
    • , Tony Cox
    • , Nick Craddock
    • , Lucy Crooks
    • , Sarah Curran
    • , David Curtis
    • , Allan Daly
    • , Petr Danecek
    • , Ian N. M. Day
    • , Aaron Day-Williams
    • , Anna Dominiczak
    • , Thomas Down
    • , Yuanping Du
    • , Ian Dunham
    • , Richard Durbin
    • , Sarah Edkins
    • , Rosemary Ekong
    • , Peter Ellis
    • , David M. Evans
    • , I. Sadaf Farooqi
    • , David R. Fitzpatrick
    • , Paul Flicek
    • , James Floyd
    • , A. Reghan Foley
    • , Christopher S. Franklin
    • , Marta Futema
    • , Louise Gallagher
    • , Tom R. Gaunt
    • , Matthias Geihs
    • , Daniel Geschwind
    • , Celia M. T. Greenwood
    • , Heather Griffin
    • , Detelina Grozeva
    • , Xiaosen Guo
    • , Xueqin Guo
    • , Hugh Gurling
    • , Deborah Hart
    • , Audrey E. Hendricks
    • , Peter Holmans
    • , Bryan Howie
    • , Jie Huang
    • , Liren Huang
    • , Tim Hubbard
    • , Steve E. Humphries
    • , Matthew E. Hurles
    • , Pirro Hysi
    • , David K. Jackson
    • , Yalda Jamshidi
    • , Chris Joyce
    • , Konrad J. Karczewski
    • , Jane Kaye
    • , Thomas Keane
    • , John P. Kemp
    • , Karen Kennedy
    • , Alastair Kent
    • , Julia Keogh
    • , Farrah Khawaja
    • , Margriet van Kogelenberg
    • , Anja Kolb-Kokocinski
    • , Genevieve Lachance
    • , Cordelia Langford
    • , Daniel Lawson
    • , Irene Lee
    • , Monkol Lek
    • , Rui Li
    • , Yingrui Li
    • , Jieqin Liang
    • , Hong Lin
    • , Ryan Liu
    • , Jouko Lönnqvist
    • , Luis R. Lopes
    • , Margarida Lopes
    • , Daniel G. MacArthur
    • , Massimo Mangino
    • , Jonathan Marchini
    • , Gaëlle Marenne
    • , John Maslen
    • , Iain Mathieson
    • , Shane McCarthy
    • , Peter McGuffin
    • , Andrew M. McIntosh
    • , Andrew G. McKechanie
    • , Andrew McQuillin
    • , Yasin Memari
    • , Sarah Metrustry
    • , Nicola Migone
    • , Hannah M. Mitchison
    • , Alireza Moayyeri
    • , Andrew Morris
    • , James Morris
    • , Dawn Muddyman
    • , Francesco Muntoni
    • , Kate Northstone
    • , Michael C. O’Donovan
    • , Stephen O’Rahilly
    • , Alexandros Onoufriadis
    • , Karim Oualkacha
    • , Michael J. Owen
    • , Aarno Palotie
    • , Kalliope Panoutsopoulou
    • , Victoria Parker
    • , Jeremy R. Parr
    • , Lavinia Paternoster
    • , Tiina Paunio
    • , Felicity Payne
    • , Stewart J. Payne
    • , John R. B. Perry
    • , Olli Pietilainen
    • , Vincent Plagnol
    • , Rebecca C. Pollitt
    • , David J. Porteous
    • , Sue Povey
    • , Michael A. Quail
    • , Lydia Quaye
    • , F. Lucy Raymond
    • , Karola Rehnström
    • , J. Brent Richards
    • , Cheryl K. Ridout
    • , Susan Ring
    • , Graham R. S. Ritchie
    • , Nicola Roberts
    • , Rachel L. Robinson
    • , David B. Savage
    • , Peter Scambler
    • , Stephan Schiffels
    • , Miriam Schmidts
    • , Nadia Schoenmakers
    • , Richard H. Scott
    • , Robert K. Semple
    • , Eva Serra
    • , Sally I. Sharp
    • , Adam Shaw
    • , Hashem A. Shihab
    • , So-Youn Shin
    • , David Skuse
    • , Kerrin S. Small
    • , Carol Smee
    • , Blair H. Smith
    • , Nicole Soranzo
    • , Lorraine Southam
    • , Olivera Spasic-Boskovic
    • , Timothy D. Spector
    • , David St Clair
    • , Jim Stalker
    • , Elizabeth Stevens
    • , Jianping Sun
    • , Gabriela Surdulescu
    • , Jaana Suvisaari
    • , Petros Syrris
    • , Rohan Taylor
    • , Jing Tian
    • , Martin D. Tobin
    • , Ana M. Valdes
    • , Anthony M. Vandersteen
    • , Parthiban Vijayarangakannan
    • , Peter M. Visscher
    • , Louise V. Wain
    • , James T. R. Walters
    • , Guangbiao Wang
    • , Jun Wang
    • , Yu Wang
    • , Kirsten Ward
    • , Eleanor Wheeler
    • , Tamieka Whyte
    • , Hywel J. Williams
    • , Kathleen A. Williamson
    • , Crispian Wilson
    • , Scott G. Wilson
    • , Kim Wong
    • , ChangJiang Xu
    • , Jian Yang
    • , Feng Zhang
    • , Pingbo Zhang
    • , Hou-Feng Zheng
    • , George Davey Smith
    • , Simon E. Fisher
    • , James F. Wilson
    • , Tim J. Cole
    • , Dietmar Fernandez-Orth
    • , Klaus Bønnelykke
    • , Hans Bisgaard
    • , Craig E. Pennell
    • , Vincent W. V. Jaddoe
    • , George Dedoussis
    • , Nicholas Timpson
    • , Eleftheria Zeggini
    • , Veronique Vitart
    •  & Beate St Pourcain
  • Article | | open

    Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3.

    • Florian Haller
    • , Matthias Bieg
    • , Rainer Will
    • , Cindy Körner
    • , Dieter Weichenhan
    • , Alexander Bott
    • , Naveed Ishaque
    • , Pavlo Lutsik
    • , Evgeny A. Moskalev
    • , Sarina K. Mueller
    • , Marion Bähr
    • , Angelika Woerner
    • , Birgit Kaiser
    • , Claudia Scherl
    • , Marlen Haderlein
    • , Kortine Kleinheinz
    • , Rainer Fietkau
    • , Heinrich Iro
    • , Roland Eils
    • , Arndt Hartmann
    • , Christoph Plass
    • , Stefan Wiemann
    •  & Abbas Agaimy
  • Article | | open

    Thermonuclear fusion of nuclei of deuterium and tritium may provide the energy for the future and spin polarization is a potential mechanism for enhancing the nuclear reaction. Here the authors predict the enhanced DT fusion rate using chiral effective field theory and ab initio calculations.

    • Guillaume Hupin
    • , Sofia Quaglioni
    •  & Petr Navrátil
  • Article | | open

    The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-specific deficiency of OGT leading to severe autoimmunity.

    • Bing Liu
    • , Oscar C. Salgado
    • , Sangya Singh
    • , Keli L. Hippen
    • , Jason C. Maynard
    • , Alma L. Burlingame
    • , Lauren E. Ball
    • , Bruce R. Blazar
    • , Michael A. Farrar
    • , Kristin A. Hogquist
    •  & Hai-Bin Ruan
  • Article | | open

    In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.

    • Antoine Campagne
    • , Ming-Kang Lee
    • , Dina Zielinski
    • , Audrey Michaud
    • , Stéphanie Le Corre
    • , Florent Dingli
    • , Hong Chen
    • , Lara Z. Shahidian
    • , Ivaylo Vassilev
    • , Nicolas Servant
    • , Damarys Loew
    • , Eric Pasmant
    • , Sophie Postel-Vinay
    • , Michel Wassef
    •  & Raphaël Margueron
  • Article | | open

    Pigmentation variation in humans is influenced by complex genetic architecture in different populations. Here, the authors perform a genome-wide association analysis involving > 6,000 Latin Americans for pigmentation of skin and eyes, and identify known and novel genetic associations.

    • Kaustubh Adhikari
    • , Javier Mendoza-Revilla
    • , Anood Sohail
    • , Macarena Fuentes-Guajardo
    • , Jodie Lampert
    • , Juan Camilo Chacón-Duque
    • , Malena Hurtado
    • , Valeria Villegas
    • , Vanessa Granja
    • , Victor Acuña-Alonzo
    • , Claudia Jaramillo
    • , William Arias
    • , Rodrigo Barquera Lozano
    • , Paola Everardo
    • , Jorge Gómez-Valdés
    • , Hugo Villamil-Ramírez
    • , Caio C. Silva de Cerqueira
    • , Tábita Hunemeier
    • , Virginia Ramallo
    • , Lavinia Schuler-Faccini
    • , Francisco M. Salzano
    • , Rolando Gonzalez-José
    • , Maria-Cátira Bortolini
    • , Samuel Canizales-Quinteros
    • , Carla Gallo
    • , Giovanni Poletti
    • , Gabriel Bedoya
    • , Francisco Rothhammer
    • , Desmond J. Tobin
    • , Matteo Fumagalli
    • , David Balding
    •  & Andrés Ruiz-Linares
  • Article | | open

    Polarization-insensitive metasurfaces implies limiting the choice of constituent elements to isotropic nanostructures. Here, the authors demonstrate a polarization-insensitive metalens using anisotropic nanofins, allowing achromatic and polarization-insensitive behaviour across the entire visible.

    • Wei Ting Chen
    • , Alexander Y. Zhu
    • , Jared Sisler
    • , Zameer Bharwani
    •  & Federico Capasso
  • Article | | open

    While the Chern number is used to characterize topological states in both electronic and photonic systems, its direct physical meaning in photonics has not yet been established. Here, Silveirinha shows that the photonic Chern number can be understood as a quantum of the optical angular momentum.

    • Mário G. Silveirinha
  • Article | | open

    Mucosal melanoma is a rare melanoma subtype that is poorly characterised. Here, the authors sequenced human, canine, and equine melanoma samples and performed a cross-species analysis, which revealed candidate driver genes, recurrent copy number alterations in regions syntenic between species, extensive intra-tumour heterogeneity and potential germline predisposing alleles

    • Kim Wong
    • , Louise van der Weyden
    • , Courtney R. Schott
    • , Alastair Foote
    • , Fernando Constantino-Casas
    • , Sionagh Smith
    • , Jane M. Dobson
    • , Elizabeth P. Murchison
    • , Hong Wu
    • , Iwei Yeh
    • , Douglas R. Fullen
    • , Nancy Joseph
    • , Boris C. Bastian
    • , Rajiv M. Patel
    • , Inigo Martincorena
    • , Carla Daniela Robles-Espinoza
    • , Vivek Iyer
    • , Marieke L. Kuijjer
    • , Mark J. Arends
    • , Thomas Brenn
    • , Paul W. Harms
    • , Geoffrey A. Wood
    •  & David J. Adams
  • Article | | open

    Cells divide within a given size range and can scale across differing cell sizes but mechanisms and function remain unclear. Here the authors show, despite the current dogma of fission yeast maintaining constant width, some fission yeast can scale their width and length, impacting the positioning of the cell division site.

    • Ying Gu
    •  & Snezhana Oliferenko
  • Article | | open

    Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage dysplasia.

    • Yuanbin Song
    • , Anthony Rongvaux
    • , Ashley Taylor
    • , Tingting Jiang
    • , Toma Tebaldi
    • , Kunthavai Balasubramanian
    • , Arun Bagale
    • , Yunus Kasim Terzi
    • , Rana Gbyli
    • , Xiaman Wang
    • , Xiaoying Fu
    • , Yimeng Gao
    • , Jun Zhao
    • , Nikolai Podoltsev
    • , Mina Xu
    • , Natalia Neparidze
    • , Ellice Wong
    • , Richard Torres
    • , Emanuela M. Bruscia
    • , Yuval Kluger
    • , Markus G. Manz
    • , Richard A. Flavell
    •  & Stephanie Halene
  • Article | | open

    Single-cell transcriptomic profiling allows the exploration of cellular heterogeneity but commonly focuses on the 3′-end of the transcript. Here the authors introduce C1 CAGE, which detects the 5′ transcript end in a multiplexed microfluidic system.

    • Tsukasa Kouno
    • , Jonathan Moody
    • , Andrew Tae-Jun Kwon
    • , Youtaro Shibayama
    • , Sachi Kato
    • , Yi Huang
    • , Michael Böttcher
    • , Efthymios Motakis
    • , Mickaël Mendez
    • , Jessica Severin
    • , Joachim Luginbühl
    • , Imad Abugessaisa
    • , Akira Hasegawa
    • , Satoshi Takizawa
    • , Takahiro Arakawa
    • , Masaaki Furuno
    • , Naveen Ramalingam
    • , Jay West
    • , Harukazu Suzuki
    • , Takeya Kasukawa
    • , Timo Lassmann
    • , Chung-Chau Hon
    • , Erik Arner
    • , Piero Carninci
    • , Charles Plessy
    •  & Jay W. Shin
  • Article | | open

    Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility and transcriptome landscapes for human pre-implantation embryos.

    • Longqi Liu
    • , Lizhi Leng
    • , Chuanyu Liu
    • , Changfu Lu
    • , Yue Yuan
    • , Liang Wu
    • , Fei Gong
    • , Shuoping Zhang
    • , Xiaoyu Wei
    • , Mingyue Wang
    • , Lei Zhao
    • , Liang Hu
    • , Jian Wang
    • , Huanming Yang
    • , Shida Zhu
    • , Fang Chen
    • , Guangxiu Lu
    • , Zhouchun Shang
    •  & Ge Lin
  • Article | | open

    Plant-inspired osmotic actuation has been proposed as a competitive actuation strategy yet reversibility is still an open issue hampering its implementation in soft robotics. Here the authors show a low input voltage reversible osmotic actuation strategy based on the electrosorption of ions on flexible electrodes.

    • Indrek Must
    • , Edoardo Sinibaldi
    •  & Barbara Mazzolai
  • Article | | open

    The architecture of functional TNTs is still under debate. Here, the authors combine correlative FIB-SEM, light- and cryo-electron microscopy approaches to elucidate the structure of TNTs in neuronal cells, showing that they form structures that are distinct form other membrane protrusions.

    • Anna Sartori-Rupp
    • , Diégo Cordero Cervantes
    • , Anna Pepe
    • , Karine Gousset
    • , Elise Delage
    • , Simon Corroyer-Dulmont
    • , Christine Schmitt
    • , Jacomina Krijnse-Locker
    •  & Chiara Zurzolo
  • Article | | open

    The Pacific white shrimp Litopenaeus vannamei is an important aquaculture species and a promising model for crustacean biology. Here, the authors provide a reference genome assembly, and show that gene expansion is involved in the regulation of frequent molting as well as benthic adaptation of the shrimp.

    • Xiaojun Zhang
    • , Jianbo Yuan
    • , Yamin Sun
    • , Shihao Li
    • , Yi Gao
    • , Yang Yu
    • , Chengzhang Liu
    • , Quanchao Wang
    • , Xinjia Lv
    • , Xiaoxi Zhang
    • , Ka Yan Ma
    • , Xiaobo Wang
    • , Wenchao Lin
    • , Long Wang
    • , Xueli Zhu
    • , Chengsong Zhang
    • , Jiquan Zhang
    • , Songjun Jin
    • , Kuijie Yu
    • , Jie Kong
    • , Peng Xu
    • , Jack Chen
    • , Hongbin Zhang
    • , Patrick Sorgeloos
    • , Amir Sagi
    • , Acacia Alcivar-Warren
    • , Zhanjiang Liu
    • , Lei Wang
    • , Jue Ruan
    • , Ka Hou Chu
    • , Bin Liu
    • , Fuhua Li
    •  & Jianhai Xiang
  • Article | | open

    Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for oral administration.

    • Marianela C. Serradell
    • , Lucía L. Rupil
    • , Román A. Martino
    • , César G. Prucca
    • , Pedro G. Carranza
    • , Alicia Saura
    • , Elmer A. Fernández
    • , Pablo R. Gargantini
    • , Albano H. Tenaglia
    • , Juan P. Petiti
    • , Renata R. Tonelli
    • , Nicolás Reinoso-Vizcaino
    • , José Echenique
    • , Luciana Berod
    • , Eliane Piaggio
    • , Bertrand Bellier
    • , Tim Sparwasser
    • , David Klatzmann
    •  & Hugo D. Luján
  • Article | | open

    Prion-forming proteins have been found in animals, plants, fungi, and bacteria. Here, Nan et al. report that a baculovirus-encoded protein behaves as prion in a yeast system and forms aggregates at high multiplicity of infection in insect cells that affect baculovirus replication.

    • Hao Nan
    • , Hongying Chen
    • , Mick F. Tuite
    •  & Xiaodong Xu
  • Article | | open

    Exploring the ground state of two-dimensional (2D) magnetic systems enriches the fundamental understanding of magnetism and boosts the applications. The authors here show the suppression of magnetic order and 2D XY behavior in XXZ-type antiferromagnet NiPS3 when approaching the monolayer limit by Raman spectroscopy.

    • Kangwon Kim
    • , Soo Yeon Lim
    • , Jae-Ung Lee
    • , Sungmin Lee
    • , Tae Yun Kim
    • , Kisoo Park
    • , Gun Sang Jeon
    • , Cheol-Hwan Park
    • , Je-Geun Park
    •  & Hyeonsik Cheong
  • Article | | open

    Serotonin is released throughout the brain from diverse projections of neurons in the dorsal raphe nucleus. Here, the authors use optogenetics and fMRI mediated mapping of the mouse brain-wide serotonin network in response to acute stress and treatment with SSRI.

    • Joanes Grandjean
    • , Alberto Corcoba
    • , Martin C. Kahn
    • , A. Louise Upton
    • , Evan S. Deneris
    • , Erich Seifritz
    • , Fritjof Helmchen
    • , Edward O. Mann
    • , Markus Rudin
    •  & Bechara J. Saab
  • Article | | open

    Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and side effect profile of opioid analgesics.

    • A. Kliewer
    • , F. Schmiedel
    • , S. Sianati
    • , A. Bailey
    • , J. T. Bateman
    • , E. S. Levitt
    • , J. T. Williams
    • , M. J. Christie
    •  & S. Schulz
  • Article | | open

    While many processes in biological cells can be understood in terms of molecular logic gates that process information sequentially and combinationally, the design and construction of such devices in the laboratory are unknown. Here the authors achieve this by the reversibly-controlled capture and release of guest molecules from host containers.

    • Brian Daly
    • , Thomas S. Moody
    • , Allen J. M. Huxley
    • , Chaoyi Yao
    • , Benjamin Schazmann
    • , Andre Alves-Areias
    • , John F. Malone
    • , H. Q. Nimal Gunaratne
    • , Peter Nockemann
    •  & A. Prasanna de Silva
  • Article | | open

    Label-free, spatio-temporal imaging of cellular physiological responses is challenging. Here the authors combine digital holographic microscopy with a millifluidic chip and mathematical modelling to quantify cell volume, mass and cell uptake under changing environmental conditions.

    • Daniel Midtvedt
    • , Erik Olsén
    • , Fredrik Höök
    •  & Gavin D. M. Jeffries
  • Article | | open

    The interactions of lignin with polysaccharides in plant secondary cell walls are not well understood. Here the authors employ solid-state NMR measurements to analyse intact stems of maize, Arabidopsis, switchgrass and rice and observe that lignin self-aggregates and forms highly hydrophobic microdomains that make extensive surface contacts to xylan.

    • Xue Kang
    • , Alex Kirui
    • , Malitha C. Dickwella Widanage
    • , Frederic Mentink-Vigier
    • , Daniel J. Cosgrove
    •  & Tuo Wang
  • Article | | open

    Understanding the structural dynamics of flexible metal-organic frameworks at a thin-film level is key if they are to be implemented in devices. Here, Fischer and colleagues anchor flexible MOF crystallites onto substrates and identify a structural responsiveness that is distinct to that of the bulk.

    • Suttipong Wannapaiboon
    • , Andreas Schneemann
    • , Inke Hante
    • , Min Tu
    • , Konstantin Epp
    • , Anna Lisa Semrau
    • , Christian Sternemann
    • , Michael Paulus
    • , Samuel J. Baxter
    • , Gregor Kieslich
    •  & Roland A. Fischer
  • Article | | open

    There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.

    • Lei Xiong
    • , Feng Wu
    • , Qiong Wu
    • , Liangliang Xu
    • , Otto K. Cheung
    • , Wei Kang
    • , Myth T. Mok
    • , Lemuel L. M. Szeto
    • , Cheuk-Yin Lun
    • , Raymond W. Lung
    • , Jinglin Zhang
    • , Ken H. Yu
    • , Sau-Dan Lee
    • , Guangcun Huang
    • , Chiou-Miin Wang
    • , Joseph Liu
    • , Zhuo Yu
    • , Dae-Yeul Yu
    • , Jian-Liang Chou
    • , Wan-Hong Huang
    • , Bo Feng
    • , Yue-Sun Cheung
    • , Paul B. Lai
    • , Patrick Tan
    • , Nathalie Wong
    • , Michael W. Chan
    • , Tim H. Huang
    • , Kevin Y. Yip
    • , Alfred S. Cheng
    •  & Ka-Fai To
  • Article | | open

    Immune recognition of Influenza B virus (IBV) is poorly understood. Here, Liu et al. use flow cytometry to characterize IBV-specific memory B cell responses following seasonal vaccination and show that elicited cross-reactive antibodies can protect against infection, providing a platform for vaccine design.

    • Yi Liu
    • , Hyon-Xhi Tan
    • , Marios Koutsakos
    • , Sinthujan Jegaskanda
    • , Robyn Esterbauer
    • , Danielle Tilmanis
    • , Malet Aban
    • , Katherine Kedzierska
    • , Aeron C. Hurt
    • , Stephen J. Kent
    •  & Adam K. Wheatley
  • Article | | open

    Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.

    • Catherine Lee
    • , Vasilisa A. Rudneva
    • , Serap Erkek
    • , Marc Zapatka
    • , Lianne Q. Chau
    • , Silvia K. Tacheva-Grigorova
    • , Alexandra Garancher
    • , Jessica M. Rusert
    • , Ozlem Aksoy
    • , Robin Lea
    • , Helai P. Mohammad
    • , Jianxun Wang
    • , William A. Weiss
    • , H. Leighton Grimes
    • , Stefan M. Pfister
    • , Paul A. Northcott
    •  & Robert J. Wechsler-Reya
  • Article | | open

    Beta II protein kinase C (βIIPKC) activation contributes to heart failure. Here the authors show, in a rat model of myocardial infarction, that heart failure outcome can be improved by selectively inhibiting the interaction between βIIPKC and its downstream mitochondrial target Mitofusin-1, and that this strategy is superior to global βIIPKC inhibition.

    • Julio C. B. Ferreira
    • , Juliane C. Campos
    • , Nir Qvit
    • , Xin Qi
    • , Luiz H. M. Bozi
    • , Luiz R. G. Bechara
    • , Vanessa M. Lima
    • , Bruno B. Queliconi
    • , Marie-Helene Disatnik
    • , Paulo M. M. Dourado
    • , Alicia J. Kowaltowski
    •  & Daria Mochly-Rosen
  • Article | | open

    Spatial proteomics allows studying cellular protein localisations at system-wide scale. Here, the authors show that combining the previously developed hyperLOPIT method with differential centrifugation yields protein localisation maps at suborganellar resolution while reducing analysis time and input material.

    • Aikaterini Geladaki
    • , Nina Kočevar Britovšek
    • , Lisa M. Breckels
    • , Tom S. Smith
    • , Owen L. Vennard
    • , Claire M. Mulvey
    • , Oliver M. Crook
    • , Laurent Gatto
    •  & Kathryn S. Lilley
  • Article | | open

    Gain of function methods based on gene overexpression are not easily applied to high-throughput screening across different experimental conditions. Here, the authors present Dub-seq, which separates overexpression library characterization from functional screening and uses random DNA barcodes to increase the experimental throughput.

    • Vivek K. Mutalik
    • , Pavel S. Novichkov
    • , Morgan N. Price
    • , Trenton K. Owens
    • , Mark Callaghan
    • , Sean Carim
    • , Adam M. Deutschbauer
    •  & Adam P. Arkin
  • Article | | open

    Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglycemia and hepatic steatosis in response to GCs.

    • M. Charlotte Hemmer
    • , Michael Wierer
    • , Kristina Schachtrup
    • , Michael Downes
    • , Norbert Hübner
    • , Ronald M. Evans
    •  & N. Henriette Uhlenhaut
  • Article | | open

    To increase transparency in science, some scholarly journals have begun publishing peer review reports. Here, the authors show how this policy shift affects reviewer behavior by analyzing data from five journals piloting open peer review.

    • Giangiacomo Bravo
    • , Francisco Grimaldo
    • , Emilia López-Iñesta
    • , Bahar Mehmani
    •  & Flaminio Squazzoni
  • Article | | open

    Context-dependent inhibition of NMDA receptors has important therapeutic implications for treatment of neurological diseases. Here, the authors use structural biology and biophysics to describe the basis for pH-dependent inhibition for a class of allosteric NMDAR inhibitors, called the 93-series.

    • Michael C. Regan
    • , Zongjian Zhu
    • , Hongjie Yuan
    • , Scott J. Myers
    • , Dave S. Menaldino
    • , Yesim A. Tahirovic
    • , Dennis C. Liotta
    • , Stephen F. Traynelis
    •  & Hiro Furukawa
  • Article | | open

    Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulating both its enzymatic activity and RNA-binding capacity.

    • Silvia Galván-Peña
    • , Richard G. Carroll
    • , Carla Newman
    • , Elizabeth C. Hinchy
    • , Eva Palsson-McDermott
    • , Elektra K. Robinson
    • , Sergio Covarrubias
    • , Alan Nadin
    • , Andrew M. James
    • , Moritz Haneklaus
    • , Susan Carpenter
    • , Vincent P. Kelly
    • , Michael P. Murphy
    • , Louise K. Modis
    •  & Luke A. O’Neill
  • Article | | open

    Agouti-related peptide (AgRP) producing neurons regulate food intake and metabolic processes in peripheral organs. Here, the authors show that hypothalamic AgRP neurons alter whole body substrate utilization to favour carbohydrate usage and lipid storage.

    • João Paulo Cavalcanti-de-Albuquerque
    • , Jeremy Bober
    • , Marcelo R. Zimmer
    •  & Marcelo O. Dietrich
  • Article | | open

    Thanks to their versatile redox behaviors, octahedral molecular sieves show promise in a range of electrochemical applications. Here the authors report a hexagonal polymorph of tungsten trioxide, an octahedral molecular sieve that exhibits fast proton (de)insertion for electrochromic devices.

    • Julie Besnardiere
    • , Binghua Ma
    • , Almudena Torres-Pardo
    • , Gilles Wallez
    • , Houria Kabbour
    • , José M. González-Calbet
    • , Hans Jürgen Von Bardeleben
    • , Benoit Fleury
    • , Valérie Buissette
    • , Clément Sanchez
    • , Thierry Le Mercier
    • , Sophie Cassaignon
    •  & David Portehault
  • Article | | open

    DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.

    • Sara A. Grimm
    • , Takashi Shimbo
    • , Motoki Takaku
    • , James W. Thomas
    • , Scott Auerbach
    • , Brian D. Bennett
    • , John R. Bucher
    • , Adam B. Burkholder
    • , Frank Day
    • , Ying Du
    • , Christopher G. Duncan
    • , John E. French
    • , Julie F. Foley
    • , Jianying Li
    • , B. Alex Merrick
    • , Raymond R. Tice
    • , Tianyuan Wang
    • , Xiaojiang Xu
    • , Beatrice B. Barnabas
    • , Gerard G. Bouffard
    • , Shelise Y. Brooks
    • , Holly Coleman
    • , Lyudmila Dekhtyar
    • , Xiaobin Guan
    • , Joel Han
    • , Shi-ling Ho
    • , Richelle Legaspi
    • , Quino L. Maduro
    • , Catherine A. Masiello
    • , Jennifer C. McDowell
    • , Cassandra Montemayor
    • , Morgan Park
    • , Nancy L. Riebow
    • , Karen Schandler
    • , Chanthra Scharer
    • , Brian Schmidt
    • , Christina Sison
    • , Sirintorn Stantripop
    • , Pamela J. Thomas
    • , Meghana Vemulapalli
    • , Alice C. Young
    • , Pierre R. Bushel
    • , David C. Fargo
    • , James C. Mullikin
    •  & Paul A. Wade
  • Article | | open

    Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.

    • Quanbo Ji
    • , Xiaojie Xu
    • , Lei Kang
    • , Yameng Xu
    • , Jingbo Xiao
    • , Stuart B. Goodman
    • , Xiang Zhu
    • , Wenchao Li
    • , Juan Liu
    • , Xu Gao
    • , Zhifeng Yan
    • , Yuxuan Zheng
    • , Zheng Wang
    • , William J. Maloney
    • , Qinong Ye
    •  & Yan Wang
  • Article | | open

    The evolution of resistance to an antibiotic can render bacteria more susceptible, or more resistant, to a second antibiotic. Here, Nichol et al. provide evidence that the final outcome can be fairly stochastic and depends on the shape of the evolutionary fitness landscape.

    • Daniel Nichol
    • , Joseph Rutter
    • , Christopher Bryant
    • , Andrea M. Hujer
    • , Sai Lek
    • , Mark D. Adams
    • , Peter Jeavons
    • , Alexander R. A. Anderson
    • , Robert A. Bonomo
    •  & Jacob G. Scott
  • Article | | open

    The gut microbiota can impact the bioavailability of therapeutic drugs. Here, the authors show that bacterial tyrosine decarboxylases (TDC) decrease the levels of levodopa, the primary treatment in Parkinson’s disease, by conversion to dopamine, and suggest TDC as a potential predictive biomarker for treatment.

    • Sebastiaan P. van Kessel
    • , Alexandra K. Frye
    • , Ahmed O. El-Gendy
    • , Maria Castejon
    • , Ali Keshavarzian
    • , Gertjan van Dijk
    •  & Sahar El Aidy
  • Article | | open

    Hydra regenerate various body parts on amputation by activation of the appropriate organiser, but how head formation is controlled is unclear. Here, the authors identify the transcription factor Sp5 as restricting head formation, by being activated by beta-catenin and then acting as a repressor of Wnt3.

    • Matthias C. Vogg
    • , Leonardo Beccari
    • , Laura Iglesias Ollé
    • , Christine Rampon
    • , Sophie Vriz
    • , Chrystelle Perruchoud
    • , Yvan Wenger
    •  & Brigitte Galliot
  • Article | | open

    It has proven difficult to measure the release of neurotransmitters, such as dopamine, in the human brain. Here, the authors introduce and validate a new method that infers dopamine release based on minute-by-minute fluctuations of the positron emission tomography (PET) radioligand [11C]raclopride.

    • Rachel N. Lippert
    • , Anna Lena Cremer
    • , Sharmili Edwin Thanarajah
    • , Clio Korn
    • , Thomas Jahans-Price
    • , Lauren M. Burgeno
    • , Marc Tittgemeyer
    • , Jens C. Brüning
    • , Mark E. Walton
    •  & Heiko Backes
  • Article | | open

    Researchers can make use of a variety of computational tools to prioritize genetic variants and predict their pathogenicity. Here, the authors evaluate the performance of six of these tools in three typical biological tasks and find generally low concordance of predictions and experimental confirmation.

    • Li Liu
    • , Maxwell D. Sanderford
    • , Ravi Patel
    • , Pramod Chandrashekar
    • , Greg Gibson
    •  & Sudhir Kumar