Browse Articles

  • Article | | open

    Sesame seeds contain phenylpropanoid-derived lignans that are potentially beneficial to human health. Here, the authors clone a cytochrome P450 enzyme that is responsible for the last steps of sesame lignan biosynthesis and show that it acts through a novel oxidative rearrangement mechanism.

    • Jun Murata
    • , Eiichiro Ono
    • , Seigo Yoroizuka
    • , Hiromi Toyonaga
    • , Akira Shiraishi
    • , Shoko Mori
    • , Masayuki Tera
    • , Toshiaki Azuma
    • , Atsushi J. Nagano
    • , Masaru Nakayasu
    • , Masaharu Mizutani
    • , Tatsuya Wakasugi
    • , Masayuki P. Yamamoto
    •  & Manabu Horikawa
  • Article | | open

    Iron-based superconductors exhibit complex couplings between different electronic degrees of freedom, leading to unusual correlated phases. Ok et al. show that Sr2VO3FeAs develops a hidden order state due to frustrated interactions between the magnetic fluctuations of its SrVO3 and SrFeAs layers.

    • Jong Mok Ok
    • , S.-H. Baek
    • , C. Hoch
    • , R. K. Kremer
    • , S. Y. Park
    • , Sungdae Ji
    • , B. Büchner
    • , J.-H. Park
    • , S. I. Hyun
    • , J. H. Shim
    • , Yunkyu Bang
    • , E. G. Moon
    • , I. I. Mazin
    •  & Jun Sung Kim
  • Article | | open

    NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.

    • Yu Zhang
    • , Xian Guo
    • , Wanyao Yan
    • , Yan Chen
    • , Mengxiang Ke
    • , Cheng Cheng
    • , Xiuqin Zhu
    • , Weili Xue
    • , Qiaoqiao Zhou
    • , Ling Zheng
    • , Shun Wang
    • , Bin Wu
    • , Xinran Liu
    • , Liang Ma
    • , Lianqi Huang
    •  & Kun Huang
  • Article | | open

    Improving the safety and efficacy of chemotherapeutics will help to enhance their effects. Here, the authors show that intraperitoneal delivery of nanoparticle conjugates of a potent toxin prolongs tumor inhibition and survival as compared to cisplatin in advanced-stage and platinum-resistant ovarian cancer mouse models.

    • Ruogu Qi
    • , Yongheng Wang
    • , Peter M. Bruno
    • , Haihua Xiao
    • , Yu Yingjie
    • , Ting Li
    • , Sam Lauffer
    • , Wei Wei
    • , Qixian Chen
    • , Xiang Kang
    • , Haiqin Song
    • , Xi Yang
    • , Xing Huang
    • , Alexandre Detappe
    • , Ursula Matulonis
    • , David Pepin
    • , Michael T. Hemann
    • , Michael J. Birrer
    •  & P. Peter Ghoroghchian
  • Article | | open

    Optical imaging deep in biological tissue is difficult due to multiple scattering and specimen induced aberrations of both the incident and reflected light. Here, Kang et al. develop an adaptive closed-loop algorithm to correct tissue aberrations in the presence of multiple scattering for deep tissue imaging.

    • Sungsam Kang
    • , Pilsung Kang
    • , Seungwon Jeong
    • , Yongwoo Kwon
    • , Taeseok D. Yang
    • , Jin Hee Hong
    • , Moonseok Kim
    • , Kyung–Deok Song
    • , Jin Hyoung Park
    • , Jun Ho Lee
    • , Myoung Joon Kim
    • , Ki Hean Kim
    •  & Wonshik Choi
  • Article | | open

    Plant pathogens translocate type III effector (T3E) proteins that may be recognized by plants to trigger immunity. Here, the authors show that the Xanthomonas T3E XopH possesses a novel 1-phytase activity that is required for XopH-mediated immunity of plants carrying the Bs7 resistance gene.

    • Doreen Blüher
    • , Debabrata Laha
    • , Sabine Thieme
    • , Alexandre Hofer
    • , Lennart Eschen-Lippold
    • , Antonia Masch
    • , Gerd Balcke
    • , Igor Pavlovic
    • , Oliver Nagel
    • , Antje Schonsky
    • , Rahel Hinkelmann
    • , Jakob Wörner
    • , Nargis Parvin
    • , Ralf Greiner
    • , Stefan Weber
    • , Alain Tissier
    • , Mike Schutkowski
    • , Justin Lee
    • , Henning Jessen
    • , Gabriel Schaaf
    •  & Ulla Bonas
  • Article | | open

    Two dimensional monolayer transition metal ditellurides and their alloys are interesting but their growth has been difficult. Herein, Yun et al. demonstrate the use of sodium salts to convert transition metal disulfide to ditelluride and alloys in tellurium vapor at low temperature.

    • Seok Joon Yun
    • , Gang Hee Han
    • , Hyun Kim
    • , Dinh Loc Duong
    • , Bong Gyu Shin
    • , Jiong Zhao
    • , Quoc An Vu
    • , Jubok Lee
    • , Seung Mi Lee
    •  & Young Hee Lee
  • Article | | open

    Eukaryotes often silence transposable elements (TEs) via DNA methylation. Here, the authors show that evolution of VANC, an Arabidopsis anti-silencing factor, and its target motifs allows sequence-specific demethylation, suggesting a way TEs can proliferate while minimizing damage to the host genome.

    • Aoi Hosaka
    • , Raku Saito
    • , Kazuya Takashima
    • , Taku Sasaki
    • , Yu Fu
    • , Akira Kawabe
    • , Tasuku Ito
    • , Atsushi Toyoda
    • , Asao Fujiyama
    • , Yoshiaki Tarutani
    •  & Tetsuji Kakutani
  • Article | | open

    Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain oxidative stress sensitivity and epigenetic changes.

    • Christopher R. S. Banerji
    • , Maryna Panamarova
    • , Husam Hebaishi
    • , Robert B. White
    • , Frédéric Relaix
    • , Simone Severini
    •  & Peter S. Zammit
  • Article | | open

    Human and environmental water needs can come into conflict in dam-regulated river systems. Here, Chen and Olden investigate the potential for the use of fish–flow modeling to make recommendations for the management of native and nonnative fish species whilst providing water for society.

    • William Chen
    •  & Julian D. Olden
  • Article | | open

    The yeast and human RNA exosome is structurally related to prokaryotic phosphorylases but degrades RNA only via associated hydrolytic activities. Here the authors show that the RNA exosome of plants, and likely those of a few basal eukaryotes, combines phosphorolytic and hydrolytic activities to degrade RNA.

    • Natalia Sikorska
    • , Hélène Zuber
    • , Anthony Gobert
    • , Heike Lange
    •  & Dominique Gagliardi
  • Article | | open

    The NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here the authors show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the mitochondria and preventing release of proinflammatory mitochondrial DNA and ROS.

    • Wenjie Guo
    • , Wen Liu
    • , Zhen Chen
    • , Yanhong Gu
    • , Shuang Peng
    • , Lihong Shen
    • , Yan Shen
    • , Xingqi Wang
    • , Gen-Sheng Feng
    • , Yang Sun
    •  & Qiang Xu
  • Article | | open

    Ligand-induced biased signaling is thought to result in part from ligand-specific receptor conformations that cause the engagement of distinct effectors. Here the authors trace and evaluate the impact of mutations of the β2–adrenergic receptor on multiple signaling outputs to provide structural-level insight into the determinants of GPCR functional selectivity.

    • Anne-Marie Schönegge
    • , Jonathan Gallion
    • , Louis-Philippe Picard
    • , Angela D. Wilkins
    • , Christian Le Gouill
    • , Martin Audet
    • , Wayne Stallaert
    • , Martin J. Lohse
    • , Marek Kimmel
    • , Olivier Lichtarge
    •  & Michel Bouvier
  • Article | | open

    Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics.

    • Michael Tong
    • , Jeff G. Pelton
    • , Michelle L. Gill
    • , Weibing Zhang
    • , Francis Picart
    •  & Markus A. Seeliger
  • Article | | open

    Longitudinal imaging of bone marrow would shed insight into long-term cellular dynamics within this compartment. Here, the authors develop a multi-photon imaging approach for the mouse femur and reveal extensive vascular plasticity within the bone marrow during bone healing and steady-state homeostasis.

    • David Reismann
    • , Jonathan Stefanowski
    • , Robert Günther
    • , Asylkhan Rakhymzhan
    • , Romano Matthys
    • , Reto Nützi
    • , Sandra Zehentmeier
    • , Katharina Schmidt-Bleek
    • , Georg Petkau
    • , Hyun-Dong Chang
    • , Sandra Naundorf
    • , York Winter
    • , Fritz Melchers
    • , Georg Duda
    • , Anja E. Hauser
    •  & Raluca A. Niesner
  • Review Article | | open

    Advances in multi-neuron recordings and optogenetic manipulation have resulted in an interrogation of the function of specific cortical cell types in auditory cortex during sound processing. Here, the authors review this literature and discuss the merits of integrating computational approaches from dynamic network science.

    • Jennifer M. Blackwell
    •  & Maria N. Geffen
  • Article | | open

    It has been suggested that the magnetic properties of metal layers using reversible redox reactions could form the basis of memory devices but this requires fast electric control to be practical. Here the authors demonstrate this on sub-millisecond timescales in a metal–oxide heterostructure.

    • Hao-Bo Li
    • , Nianpeng Lu
    • , Qinghua Zhang
    • , Yujia Wang
    • , Deqiang Feng
    • , Tianzhe Chen
    • , Shuzhen Yang
    • , Zheng Duan
    • , Zhuolu Li
    • , Yujun Shi
    • , Weichao Wang
    • , Wei-Hua Wang
    • , Kui Jin
    • , Hui Liu
    • , Jing Ma
    • , Lin Gu
    • , Cewen Nan
    •  & Pu Yu
  • Article | | open

    Translesion synthesis (TLS) enables cells to tolerate damaged DNA encountered during replication. Here the authors use super-resolution photoactivation localization microscopy to reveal a lesion type dependent mechanism of recruitment of the TLS polymerase Pol IV following DNA damage.

    • Elizabeth S. Thrall
    • , James E. Kath
    • , Seungwoo Chang
    •  & Joseph J. Loparo
  • Article | | open

    The role of frontal lobes in speech perception is controversial. Here, the authors show that neurodegeneration of frontal speech regions delays prediction reconciliation in temporal cortex and results in inflexible prior expectations, indicating that fronto-temporal interactions determine predictive processes in speech.

    • Thomas E. Cope
    • , E. Sohoglu
    • , W. Sedley
    • , K. Patterson
    • , P. S. Jones
    • , J. Wiggins
    • , C. Dawson
    • , M. Grube
    • , R. P. Carlyon
    • , T. D. Griffiths
    • , Matthew H. Davis
    •  & James B. Rowe
  • Article | | open

    Single-molecule magnets typically only retain information in the presence of an applied magnetic field and at very low temperatures. Here, Demir, Long and co-workers design N2 3– radical-bridged dilanthanide complexes that exhibit giant coercivities and 100-s magnetic blocking temperatures of up to 20 K.

    • Selvan Demir
    • , Miguel I. Gonzalez
    • , Lucy E. Darago
    • , William J. Evans
    •  & Jeffrey R. Long
  • Article | | open

    Dynein is a microtubule motor the motility of which is affected by the microtubule-associated protein She1. Here, the authors show that She1 alters dynein stepping behavior and increases its microtubule affinity through simultaneous interactions with the microtubule and dynein microtubule binding domain.

    • Kari H. Ecklund
    • , Tatsuya Morisaki
    • , Lindsay G. Lammers
    • , Matthew G. Marzo
    • , Timothy J. Stasevich
    •  & Steven M. Markus
  • Article | | open

    Twin nucleation in face-centered cubic metals with high twin-fault energies should theoretically be unfavourable, but instead twinning is very often observed. Here, the authors report a new twinning route in nanocrystalline platinum that bypasses the high twin-fault energy barrier using closely spaced partial dislocations.

    • Lihua Wang
    • , Pengfei Guan
    • , Jiao Teng
    • , Pan Liu
    • , Dengke Chen
    • , Weiyu Xie
    • , Deli Kong
    • , Shengbai Zhang
    • , Ting Zhu
    • , Ze Zhang
    • , Evan Ma
    • , Mingwei Chen
    •  & Xiaodong Han
  • Article | | open

    Catalytic acceptorless dehydrogenation reactions provide a sustainable route to valuable products and hydrogen fuel. Here, the authors show a recyclable iron catalyst that is highly active in the acceptorless dehydrogenation of a wide range of N-heterocycles and alcohols.

    • Garima Jaiswal
    • , Vinod G. Landge
    • , Dinesh Jagadeesan
    •  & Ekambaram Balaraman
  • Article | | open

    New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to  specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arrest and enabling arterial gene expression.

    • Jennifer S. Fang
    • , Brian G. Coon
    • , Noelle Gillis
    • , Zehua Chen
    • , Jingyao Qiu
    • , Thomas W. Chittenden
    • , Janis M. Burt
    • , Martin A. Schwartz
    •  & Karen K. Hirschi
  • Article | | open

    Realisation of large-scale quantum computation requires both error correction capability and a large number of qubits. Here, the authors propose to use a CMOS-compatible architecture featuring a spin qubit surface code and individual qubit control via floating memory gate electrodes.

    • M. Veldhorst
    • , H. G. J. Eenink
    • , C. H. Yang
    •  & A. S. Dzurak