Browse Articles

  • Article | | open

    Countering the optical network ‘capacity crunch’ requires developments in optical fibres. Here, the authors report a hollow-core fibre with conjoined tubes in the cladding and a negative-curvature core shape. It exhibits a transmission loss of 2 dB/km at 1512 nm and less than 16 dB/km bandwidth in the 1302–1637 nm range.

    • Shou-fei Gao
    • , Ying-ying Wang
    • , Wei Ding
    • , Dong-liang Jiang
    • , Shuai Gu
    • , Xin Zhang
    •  & Pu Wang
  • Article | | open

    The human CST complex (CTC1-STN1-TEN1) is essential for telomere homeostasis. Here the authors dissect the roles of individual CST subunits in telomere length maintenance through regulation of telomerase-mediated G-strand synthesis and DNA polymerase-mediated C-strand synthesis in colon cancer cells.

    • Xuyang Feng
    • , Shih-Jui Hsu
    • , Anukana Bhattacharjee
    • , Yongyao Wang
    • , Jiajie Diao
    •  & Carolyn M. Price
  • Article | | open

    Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senescence.

    • Joana Catarina Macedo
    • , Sara Vaz
    • , Bjorn Bakker
    • , Rui Ribeiro
    • , Petra Lammigje Bakker
    • , Jose Miguel Escandell
    • , Miguel Godinho Ferreira
    • , René Medema
    • , Floris Foijer
    •  & Elsa Logarinho
  • Article | | open

    HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L-selectin reduces HIV infection and release.

    • Joseph Kononchik
    • , Joanna Ireland
    • , Zhongcheng Zou
    • , Jason Segura
    • , Genevieve Holzapfel
    • , Ashley Chastain
    • , Ruipeng Wang
    • , Matthew Spencer
    • , Biao He
    • , Nicole Stutzman
    • , Daiji Kano
    • , James Arthos
    • , Elizabeth Fischer
    • , Tae-Wook Chun
    • , Susan Moir
    •  & Peter Sun
  • Article | | open

    The phylum of archaea Aigarchaeota is poorly characterized due to limited genomic sampling. Here, Hua and colleagues use genome-resolved metagenome sequencing to reconstruct six hot spring strains of Aigarchaeota and then infer their metabolism and evolutionary history.

    • Zheng-Shuang Hua
    • , Yan-Ni Qu
    • , Qiyun Zhu
    • , En-Min Zhou
    • , Yan-Ling Qi
    • , Yi-Rui Yin
    • , Yang-Zhi Rao
    • , Ye Tian
    • , Yu-Xian Li
    • , Lan Liu
    • , Cindy J. Castelle
    • , Brian P. Hedlund
    • , Wen-Sheng Shu
    • , Rob Knight
    •  & Wen-Jun Li
  • Article | | open

    NifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the formation of the final iron-sulfur cluster.

    • Lee A. Rettberg
    • , Jarett Wilcoxen
    • , Chi Chung Lee
    • , Martin T. Stiebritz
    • , Kazuki Tanifuji
    • , R. David Britt
    •  & Yilin Hu
  • Article | | open

    Chemical transformation of amides is normally occurring under harsh conditions. Here, the authors report a mild iridium-catalyzed reductive Ugi-type coupling of tertiary amides, isocyanides and (thio)acetic acid or trimethylsilyl azide to give homologous, bioactive amine products.

    • Lan-Gui Xie
    •  & Darren J. Dixon
  • Article | | open

    In the mammalian cerebellum, surplus synapses between climbing fibers (CF) and Purkinje cells (PC) are developmentally pruned. Here, Nakayama and colleagues show that ablation of microglia impairs pruning of CF-PC synapses because of dysfunction of GABAergic inhibition prerequisite for pruning.

    • Hisako Nakayama
    • , Manabu Abe
    • , Chie Morimoto
    • , Tadatsune Iida
    • , Shigeo Okabe
    • , Kenji Sakimura
    •  & Kouichi Hashimoto
  • Article | | open

    Suspensions appear in a wide range of industrial settings, and dispersing particles in a uniform manner throughout a fluid remains challenging for applications. Wang et al. obtain hyperuniform mixtures without fine tuning by harnessing self-organized criticality due to slow sedimentation and shear.

    • Jikai Wang
    • , J. M. Schwarz
    •  & Joseph D. Paulsen
  • Article | | open

    There is increasing urgency to understand the spatiotemporal dynamics of dengue in non-endemic regions. Here, the authors reconstruct likely dengue transmission chains in the city of Porto Alegre based on geo-located cases only, and find that most transmission events occur over short-distances.

    • Giorgio Guzzetta
    • , Cecilia A. Marques-Toledo
    • , Roberto Rosà
    • , Mauro Teixeira
    •  & Stefano Merler
  • Article | | open

    Superconductor–semiconductor hybrid systems can bring together physical properties that are promising for fast and coherent quantum technology. Here, Hendrickx et al. realize such a system in planar germanium heterostructures demonstrating excellent quantum dots and tunable Josephson supercurrents.

    • N. W. Hendrickx
    • , D. P. Franke
    • , A. Sammak
    • , M. Kouwenhoven
    • , D. Sabbagh
    • , L. Yeoh
    • , R. Li
    • , M. L. V. Tagliaferri
    • , M. Virgilio
    • , G. Capellini
    • , G. Scappucci
    •  & M. Veldhorst
  • Article | | open

    Nanopores are an emerging powerful single-molecule method of DNA sequencing. Here the authors map the structure of aerolysin for use as a nanopore and show detection of modified and unmodified nucleobases.

    • Chan Cao
    • , Meng-Yin Li
    • , Nuria Cirauqui
    • , Ya-Qian Wang
    • , Matteo Dal Peraro
    • , He Tian
    •  & Yi-Tao Long
  • Article | | open

    The noradrenergic system plays numerous physiological roles but tools to study it are scarce. Here the authors develop a fluorescent analogue of norepinephrine that can be used to label noradrenergic neurons and the synaptic vesicles, and use it to measure single synaptic vesicle release sites in living mice.

    • Matthew Dunn
    • , Adam Henke
    • , Samuel Clark
    • , Yekaterina Kovalyova
    • , Kimberly A. Kempadoo
    • , Richard J. Karpowicz Jr.
    • , Eric R. Kandel
    • , David Sulzer
    •  & Dalibor Sames
  • Article | | open

    Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the transcription factor PDX1 and has stem cell capacity.

    • Hue M. La
    • , Juho-Antti Mäkelä
    • , Ai-Leen Chan
    • , Fernando J. Rossello
    • , Christian M. Nefzger
    • , Julien M. D. Legrand
    • , Mia De Seram
    • , Jose M. Polo
    •  & Robin M. Hobbs
  • Article | | open

    Disrupted dopamine neuron firing is thought to contribute to cognitive dysfunction in psychiatric disorders. Here the authors show that mice overexpressing D2R in the striatum, commonly seen in schizophrenia, are also impaired in recruitment of dopamine neurons during working memory performance.

    • Sevil Duvarci
    • , Eleanor H. Simpson
    • , Gaby Schneider
    • , Eric R. Kandel
    • , Jochen Roeper
    •  & Torfi Sigurdsson
  • Article | | open

    Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.

    • Shinji Kishimoto
    • , Kodai Hara
    • , Hiroshi Hashimoto
    • , Yuichiro Hirayama
    • , Pier Alexandre Champagne
    • , Kendall N. Houk
    • , Yi Tang
    •  & Kenji Watanabe
  • Article | | open

    Data sharing is recognized as a way to promote scientific collaboration and reproducibility, but some are concerned over whether research based on shared data can achieve high impact. Here, the authors show that neuroimaging papers using shared data are no less likely to appear in top-ranked journals.

    • Michael P. Milham
    • , R. Cameron Craddock
    • , Jake J. Son
    • , Michael Fleischmann
    • , Jon Clucas
    • , Helen Xu
    • , Bonhwang Koo
    • , Anirudh Krishnakumar
    • , Bharat B. Biswal
    • , F. Xavier Castellanos
    • , Stan Colcombe
    • , Adriana Di Martino
    • , Xi-Nian Zuo
    •  & Arno Klein
  • Article | | open

    Tracheal development arises due to tube morphogenesis but how this is regulated is unclear. Here, the authors identify polarization of smooth muscle progenitors as controlling murine tracheal development, activating noncanonical Wnt signaling followed by subepithelial morphogenesis and ring cartilage development.

    • Keishi Kishimoto
    • , Masaru Tamura
    • , Michiru Nishita
    • , Yasuhiro Minami
    • , Akira Yamaoka
    • , Takaya Abe
    • , Mayo Shigeta
    •  & Mitsuru Morimoto
  • Article | | open

    The disease dynamics of bovine tuberculosis have been of interest given the pathogen’s effect on wild animal and livestock health. Here, the authors show that a brief cessation of testing for bovine tuberculosis in 2001 altered the population synchrony of the disease dynamics across regions of Great Britain.

    • Aristides Moustakas
    • , Matthew R. Evans
    • , Ioannis N. Daliakopoulos
    •  & Yannis Markonis
  • Article | | open

    Molecules can change their electronic properties when they are adsorbed on substrates, which can be useful for sensing and catalysis. Here, the authors use atomic force microscopy to show that the spin state of an iron complex can be changed upon displacing the molecule to different sites of a nitrogen-doped graphene

    • Bruno de la Torre
    • , Martin Švec
    • , Prokop Hapala
    • , Jesus Redondo
    • , Ondřej Krejčí
    • , Rabindranath Lo
    • , Debashree Manna
    • , Amrit Sarmah
    • , Dana Nachtigallová
    • , Jiří Tuček
    • , Piotr Błoński
    • , Michal Otyepka
    • , Radek Zbořil
    • , Pavel Hobza
    •  & Pavel Jelínek
  • Article | | open

    Myelin-forming cells derive from oligodendrocyte progenitors. Here the authors identify histone arginine methyl-transferase PRMT5 as critical for developmental myelination by modulating the cross-talk between histone arginine methylation and lysine acetylation, to favor differentiation.

    • Antonella Scaglione
    • , Julia Patzig
    • , Jialiang Liang
    • , Rebecca Frawley
    • , Jabez Bok
    • , Angeliki Mela
    • , Camila Yattah
    • , Jingxian Zhang
    • , Shun Xie Teo
    • , Ting Zhou
    • , Shuibing Chen
    • , Emily Bernstein
    • , Peter Canoll
    • , Ernesto Guccione
    •  & Patrizia Casaccia
  • Article | | open

    Armadillo (ARM) family proteins can act as oncogenes or tumor suppressors. Here, the authors show that a new ARM protein (ARMC12) is upregulated in neuroblastoma, binds the PRC2 component RBBP4, and inhibits transcription of tumor suppressive genes.

    • Dan Li
    • , Huajie Song
    • , Hong Mei
    • , Erhu Fang
    • , Xiaojing Wang
    • , Feng Yang
    • , Huanhuan Li
    • , Yajun Chen
    • , Kai Huang
    • , Liduan Zheng
    •  & Qiangsong Tong
  • Article | | open

    SP7/Osterix is a transcription factor involved in osteoblast differentiation. Here, the authors show that Sirtuin 7 activates Osterix posttranslationally by regulating its lysine acylation, and that mice lacking Sirtuin 7 in osteoblasts show reduced bone formation.

    • Masatoshi Fukuda
    • , Tatsuya Yoshizawa
    • , Md. Fazlul Karim
    • , Shihab U. Sobuz
    • , Wataru Korogi
    • , Daiki Kobayasi
    • , Hiroki Okanishi
    • , Masayoshi Tasaki
    • , Katsuhiko Ono
    • , Tomohiro Sawa
    • , Yoshifumi Sato
    • , Mami Chirifu
    • , Takeshi Masuda
    • , Teruya Nakamura
    • , Hironori Tanoue
    • , Kazuhisa Nakashima
    • , Yoshihiro Kobashigawa
    • , Hiroshi Morioka
    • , Eva Bober
    • , Sumio Ohtsuki
    • , Yuriko Yamagata
    • , Yukio Ando
    • , Yuichi Oike
    • , Norie Araki
    • , Shu Takeda
    • , Hiroshi Mizuta
    •  & Kazuya Yamagata