Browse Articles

  • Article | | open

    Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.

    • Ewa Bielska
    • , Marta Arch Sisquella
    • , Maha Aldeieg
    • , Charlotte Birch
    • , Eloise J. O’Donoghue
    •  & Robin C. May
  • Article | | open

    Exploring the magnetism in the van der Waals materials facilitates two dimensional spintronic devices. Here the authors demonstrate the evolution of magnetic behavior, strong perpendicular magnetic anisotropy and existence of magnetic coupling between atomic layers in Fe3GeTe2 nanoflakes by varying the layer thickness.

    • Cheng Tan
    • , Jinhwan Lee
    • , Soon-Gil Jung
    • , Tuson Park
    • , Sultan Albarakati
    • , James Partridge
    • , Matthew R. Field
    • , Dougal G. McCulloch
    • , Lan Wang
    •  & Changgu Lee
  • Article | | open

    The female bladder seems to harbor a poorly characterized indigenous microbiota. Here, the authors isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women, generating a culture collection representing two thirds of the bacterial diversity within the samples.

    • Krystal Thomas-White
    • , Samuel C. Forster
    • , Nitin Kumar
    • , Michelle Van Kuiken
    • , Catherine Putonti
    • , Mark D. Stares
    • , Evann E. Hilt
    • , Travis K. Price
    • , Alan J. Wolfe
    •  & Trevor D. Lawley
  • Article | | open

    Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-STAT pathway, revealing potential ANKL therapeutic targets.

    • Olli Dufva
    • , Matti Kankainen
    • , Tiina Kelkka
    • , Nodoka Sekiguchi
    • , Shady Adnan Awad
    • , Samuli Eldfors
    • , Bhagwan Yadav
    • , Heikki Kuusanmäki
    • , Disha Malani
    • , Emma I Andersson
    • , Paavo Pietarinen
    • , Leena Saikko
    • , Panu E. Kovanen
    • , Teija Ojala
    • , Dean A. Lee
    • , Thomas P. Loughran Jr.
    • , Hideyuki Nakazawa
    • , Junji Suzumiya
    • , Ritsuro Suzuki
    • , Young Hyeh Ko
    • , Won Seog Kim
    • , Shih-Sung Chuang
    • , Tero Aittokallio
    • , Wing C. Chan
    • , Koichi Ohshima
    • , Fumihiro Ishida
    •  & Satu Mustjoki
  • Article | | open

    Extant representatives of the earliest land plant lineages adapt to various terrestrial habitats with structural and physiological innovations. Here the authors show a dual-coding gene in the moss Physcomitrella patens evolved from a hemerythrin gene, with effects on oil body biogenesis and dehydration resistance.

    • Yanlong Guan
    • , Li Liu
    • , Qia Wang
    • , Jinjie Zhao
    • , Ping Li
    • , Jinyong Hu
    • , Zefeng Yang
    • , Mark P. Running
    • , Hang Sun
    •  & Jinling Huang
  • Article | | open

    The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome priming by inducing NLRP3 ubiquitination and by targeting IRAK1.

    • Fiachra Humphries
    • , Ronan Bergin
    • , Ruaidhri Jackson
    • , Nezira Delagic
    • , Bingwei Wang
    • , Shuo Yang
    • , Alice V. Dubois
    • , Rebecca J. Ingram
    •  & Paul N. Moynagh
  • Article | | open

    The stereoselective synthesis of polyesters has been achieved via various methods; however, all routes show limited side-chain group functionality. Here the authors synthesize stereoblock polyesters by photoredox ring-opening polymerization of racemic O-carboxyanhydrides that have abundant side-chain functionality.

    • Quanyou Feng
    • , Lei Yang
    • , Yongliang Zhong
    • , Dong Guo
    • , Guoliang Liu
    • , Linghai Xie
    • , Wei Huang
    •  & Rong Tong
  • Article | | open

    As a circadian organ, liver functions are regulated by circadian clock. Here, the authors present a comprehensive proteomics landscape of the mouse liver, including transcription factor binding profiles, phosphorylation and ubiquitylation patterns, nuclear and whole proteome, and the transcriptome.

    • Yunzhi Wang
    • , Lei Song
    • , Mingwei Liu
    • , Rui Ge
    • , Quan Zhou
    • , Wanlin Liu
    • , Ruiyang Li
    • , Jingbo Qie
    • , Bei Zhen
    • , Yi Wang
    • , Fuchu He
    • , Jun Qin
    •  & Chen Ding
  • Article | | open

    Filamentous anoxygenic phototrophs (FAPs) are phylogenetically distant from other anoxygenic photosynthetic bacteria. Here the authors present the 4.1 Å cryo-EM structure of the photosynthetic core complex from the FAP Roseiflexus castenholzii and propose a model for energy and electron transfer.

    • Yueyong Xin
    • , Yang Shi
    • , Tongxin Niu
    • , Qingqiang Wang
    • , Wanqiang Niu
    • , Xiaojun Huang
    • , Wei Ding
    • , Lei Yang
    • , Robert E. Blankenship
    • , Xiaoling Xu
    •  & Fei Sun
  • Article | | open

    Conventional reconstruction methods used in cryo-EM single particle analysis do not take the depth of field effect into account. Here the authors present a block-based reconstruction method to deal with the depth of field effect and show that this approach can improve the resolution of cryo-EM virus structures.

    • Dongjie Zhu
    • , Xiangxi Wang
    • , Qianglin Fang
    • , James L Van Etten
    • , Michael G Rossmann
    • , Zihe Rao
    •  & Xinzheng Zhang
  • Article | | open

    Reactions in aqueous microdroplets can significantly differ from those in bulk. Here, the authors report microdroplets that not only accelerate gold nanoparticle formation by several orders of magnitude but also promote spontaneous nanostructure formation with no reducing agents or template.

    • Jae Kyoo Lee
    • , Devleena Samanta
    • , Hong Gil Nam
    •  & Richard N. Zare
  • Article | | open

    Demonstrations of sensing devices using nitrogen vacancy centres have shown significantly improved sensitivity compared to traditional methods. Here the authors demonstrate an approach for performing nanoscale electron spin resonance without magnetic fields in order to achieve better spectral resolution.

    • Fei Kong
    • , Pengju Zhao
    • , Xiangyu Ye
    • , Zhecheng Wang
    • , Zhuoyang Qin
    • , Pei Yu
    • , Jihu Su
    • , Fazhan Shi
    •  & Jiangfeng Du
  • Article | | open

    Surface-enhanced Raman spectroscopy (SERS) visualizes fingerprints of intermolecular vibrations of many metabolites. Here the authors report a SERS imaging technique that enables the visualization of metabolites distribution and automated extraction of tumour boundaries in frozen tissues.

    • Megumi Shiota
    • , Masayuki Naya
    • , Takehiro Yamamoto
    • , Takako Hishiki
    • , Takeharu Tani
    • , Hiroyuki Takahashi
    • , Akiko Kubo
    • , Daisuke Koike
    • , Mai Itoh
    • , Mitsuyo Ohmura
    • , Yasuaki Kabe
    • , Yuki Sugiura
    • , Nobuyoshi Hiraoka
    • , Takayuki Morikawa
    • , Keiyo Takubo
    • , Kentaro Suina
    • , Hideaki Nagashima
    • , Oltea Sampetrean
    • , Osamu Nagano
    • , Hideyuki Saya
    • , Shogo Yamazoe
    • , Hiroyuki Watanabe
    •  & Makoto Suematsu
  • Article | | open

    JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation.

    • Yohei Abe
    • , Yosuke Fujiwara
    • , Hiroki Takahashi
    • , Yoshihiro Matsumura
    • , Tomonobu Sawada
    • , Shuying Jiang
    • , Ryo Nakaki
    • , Aoi Uchida
    • , Noriko Nagao
    • , Makoto Naito
    • , Shingo Kajimura
    • , Hiroshi Kimura
    • , Timothy F. Osborne
    • , Hiroyuki Aburatani
    • , Tatsuhiko Kodama
    • , Takeshi Inagaki
    •  & Juro Sakai
  • Article | | open

    The role of orbital degrees of freedom in determining the electronic structure remains obscured. Here, Walkup et al. report strain-induced band structure changes in a topological crystalline insulator SnTe, whose surprising behavior reflects the  orbital nature of bands.

    • Daniel Walkup
    • , Badih A. Assaf
    • , Kane L. Scipioni
    • , R. Sankar
    • , Fangcheng Chou
    • , Guoqing Chang
    • , Hsin Lin
    • , Ilija Zeljkovic
    •  & Vidya Madhavan
  • Article | | open

    M1-like polarization of macrophages is thought to control adipose inflammation and associated insulin resistance and metabolic syndrome. Here the authors show that macrophage-specific deletion of the OxPhos-related gene Crif1 results in an M1-like phenotype in mice, and that the effects can be reversed by recombinant GDF15.

    • Saet-Byel Jung
    • , Min Jeong Choi
    • , Dongryeol Ryu
    • , Hyon-Seung Yi
    • , Seong Eun Lee
    • , Joon Young Chang
    • , Hyo Kyun Chung
    • , Yong Kyung Kim
    • , Seul Gi Kang
    • , Ju Hee Lee
    • , Koon Soon Kim
    • , Hyun Jin Kim
    • , Cuk-Seong Kim
    • , Chul-Ho Lee
    • , Robert W. Williams
    • , Hail Kim
    • , Heung Kyu Lee
    • , Johan Auwerx
    •  & Minho Shong
  • Article | | open

    Radiation and conduction are generally considered as the main energy transport mechanisms for the evolution of early supernova remnants. Here the authors experimentally show the role of electron heat transfer on the growth of Rayleigh–Taylor instability in young supernova remnants.

    • C. C. Kuranz
    • , H.-S. Park
    • , C. M. Huntington
    • , A. R. Miles
    • , B. A. Remington
    • , T. Plewa
    • , M. R. Trantham
    • , H. F. Robey
    • , D. Shvarts
    • , A. Shimony
    • , K. Raman
    • , S. MacLaren
    • , W. C. Wan
    • , F. W. Doss
    • , J. Kline
    • , K. A. Flippo
    • , G. Malamud
    • , T. A. Handy
    • , S. Prisbrey
    • , C. M. Krauland
    • , S. R. Klein
    • , E. C. Harding
    • , R. Wallace
    • , M. J. Grosskopf
    • , D. C. Marion
    • , D. Kalantar
    • , E. Giraldez
    •  & R. P. Drake
  • Article | | open

    The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solutions to RNA recognition.

    • Pooja Kumari
    • , Florian Aeschimann
    • , Dimos Gaidatzis
    • , Jeremy J. Keusch
    • , Pritha Ghosh
    • , Anca Neagu
    • , Katarzyna Pachulska-Wieczorek
    • , Janusz M. Bujnicki
    • , Heinz Gut
    • , Helge Großhans
    •  & Rafal Ciosk
  • Article | | open

    Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOCS1.

    • Nicholas P. D. Liau
    • , Artem Laktyushin
    • , Isabelle S. Lucet
    • , James M. Murphy
    • , Shenggen Yao
    • , Eden Whitlock
    • , Kimberley Callaghan
    • , Nicos A. Nicola
    • , Nadia J. Kershaw
    •  & Jeffrey J. Babon
  • Article | | open

    Long non-coding RNA TERRAs are essential for telomere protection and telomere length maintenance. Here the authors report a role for TERRAs in telomeric heterochromatin formation by recruiting Polycomb Repressive Complex 2 to telomeres.

    • Juan J. Montero
    • , Isabel López-Silanes
    • , Diego Megías
    • , Mario F. Fraga
    • , Álvaro Castells-García
    •  & Maria A. Blasco
  • Article | | open

    The mid-infrared technologies are essential to various applications but suffer from limited materials with suitable bandgap. Here the authors demonstrate that two-dimensional atomically thin PtSe2 with variable bandgaps in the mid-infrared via layer and defect engineering is highly promising for mid-infrared optoelectronics.

    • Xuechao Yu
    • , Peng Yu
    • , Di Wu
    • , Bahadur Singh
    • , Qingsheng Zeng
    • , Hsin Lin
    • , Wu Zhou
    • , Junhao Lin
    • , Kazu Suenaga
    • , Zheng Liu
    •  & Qi Jie Wang
  • Article | | open

    The improvement of photostability of Au clusters on metal-support interface remains challenging. Here, the authors report a joint strategy via interfacial modification and composition manipulation to enhance the photostability and activity of glutathione-protected Au clusters.

    • Bo Weng
    • , Kang-Qiang Lu
    • , Zichao Tang
    • , Hao Ming Chen
    •  & Yi-Jun Xu
  • Article | | open

    Population coding, where populations of artificial neurons process information collectively can facilitate robust data processing, but require high circuit overheads. Here, the authors realize this approach with reduced circuit area and power consumption, by utilizing superparamagnetic tunnel junction based neurons.

    • Alice Mizrahi
    • , Tifenn Hirtzlin
    • , Akio Fukushima
    • , Hitoshi Kubota
    • , Shinji Yuasa
    • , Julie Grollier
    •  & Damien Querlioz
  • Article | | open

    Histone variant H3.3 is incorporated at transcriptionally active genes and is associated with active marks. Here, the authors investigate H3.3 deposition during reprogramming and find that initially H3.3 helps maintain parental cell fate and is later required for establishment of the cell lineages.

    • Hai-Tong Fang
    • , Chadi A. EL Farran
    • , Qiao Rui Xing
    • , Li-Feng Zhang
    • , Hu Li
    • , Bing Lim
    •  & Yuin-Han Loh
  • Article | | open

    The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.

    • Srinath C. Sampath
    • , Srihari C. Sampath
    • , Andrew T. V. Ho
    • , Stéphane Y. Corbel
    • , Joshua D. Millstone
    • , John Lamb
    • , John Walker
    • , Bernd Kinzel
    • , Christian Schmedt
    •  & Helen M. Blau