Browse Articles

  • Article | | open

    Striatal GABAergic interneurons regulate the influence of cortical inputs on striatal projection neurons through feedforward inhibition. Here, the authors report that this inhibition is mediated mainly by PV interneurons in the dorsolateral striatum and SOM interneurons in the dorsomedial striatum.

    • Elodie Fino
    • , Marie Vandecasteele
    • , Sylvie Perez
    • , Frédéric Saudou
    •  & Laurent Venance
  • Article | | open

    Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin.

    • Tomislav Čaval
    • , Weihua Tian
    • , Zhang Yang
    • , Henrik Clausen
    •  & Albert J. R. Heck
  • Article | | open

    The exact mechanism of momentum conversion from light to an object has varied descriptions in the literature and experimental verifications are difficult. Here the authors do an in-depth experimental and numerical study of the momentum dynamics of elastic waves in a dielectric mirror hit by a pulsed laser beam.

    • Tomaž Požar
    • , Jernej Laloš
    • , Aleš Babnik
    • , Rok Petkovšek
    • , Max Bethune-Waddell
    • , Kenneth J. Chau
    • , Gustavo V. B. Lukasievicz
    •  & Nelson G. C. Astrath
  • Article | | open

    Here, with the state-of-the-state electron microscope, the authors report three-dimensional atomic-scale observation of LiNi0.5Mn1.5O4 from various directions, revealing unprecedented insight into the evolution of both atomic and electronic structures during delithiation.

    • Yue Gong
    • , Yuyang Chen
    • , Qinghua Zhang
    • , Fanqi Meng
    • , Jin-An Shi
    • , Xinyu Liu
    • , Xiaozhi Liu
    • , Jienan Zhang
    • , Hao Wang
    • , Jiangyong Wang
    • , Qian Yu
    • , Ze Zhang
    • , Qiang Xu
    • , Ruijuan Xiao
    • , Yong-Sheng Hu
    • , Lin Gu
    • , Hong Li
    • , Xuejie Huang
    •  & Liquan Chen
  • Article | | open

    Circular photocurrents emerge in atomically thin transition metal dichalcogenides as a result of circular photogalvanic and photon drag effects. Here, the authors identify two different circular photocurrent contributions in monolater MoSe2, dominant at different voltages and with different dependence on illumination wavelength and incidence angles.

    • Jorge Quereda
    • , Talieh S. Ghiasi
    • , Jhih-Shih You
    • , Jeroen van den Brink
    • , Bart J. van Wees
    •  & Caspar H. van der Wal
  • Article | | open

    Currently, gut microbiome profiling largely relies on next-generation sequencing, which is slow and expensive. Here, the authors develop a low-cost, paper-based synthetic biology platform that allows species-specific quantification of bacterial mRNAs and clinically relevant host biomarkers.

    • Melissa K. Takahashi
    • , Xiao Tan
    • , Aaron J. Dy
    • , Dana Braff
    • , Reid T. Akana
    • , Yoshikazu Furuta
    • , Nina Donghia
    • , Ashwin Ananthakrishnan
    •  & James J. Collins
  • Review Article | | open

    Active matter systems are made up of self-driven components which extract energy from their surroundings to generate mechanical work. Here the authors review the subfield of active nematics and provide a comparison between theoretical findings and the corresponding experimental realisations.

    • Amin Doostmohammadi
    • , Jordi Ignés-Mullol
    • , Julia M. Yeomans
    •  & Francesc Sagués
  • Article | | open

    Controlling the polarization state in ferroeletric materials is a prerequisite for their application. Here an approach is presented to optically manipulate the polarization of ferroelectric BaTiO3 by exploiting photogenerated carriers at the interface with a two-dimensional semiconducting MoS2 film.

    • Tao Li
    • , Alexey Lipatov
    • , Haidong Lu
    • , Hyungwoo Lee
    • , Jung-Woo Lee
    • , Engin Torun
    • , Ludger Wirtz
    • , Chang-Beom Eom
    • , Jorge Íñiguez
    • , Alexander Sinitskii
    •  & Alexei Gruverman
  • Article | | open

    Manipulation of paramagnetic microparticles can be exploited for drug delivery. Here the authors manipulate a swarm of such particles and control its shape with a magnetic field so that it can elongate reversibly, split into smaller swarms and thus be guided through a maze with multiple parallel channels.

    • Jiangfan Yu
    • , Ben Wang
    • , Xingzhou Du
    • , Qianqian Wang
    •  & Li Zhang
  • Article | | open

    Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.

    • Mathieu Daynac
    • , Malek Chouchane
    • , Hannah Y. Collins
    • , Nicole E. Murphy
    • , Noemi Andor
    • , Jianqin Niu
    • , Stephen P. J. Fancy
    • , William B. Stallcup
    •  & Claudia K. Petritsch
  • Article | | open

    The fossil taxon Propotto was originally identified as a primate, but is currently widely interpreted as a bat. Here, the authors identify Propotto as a stem chiromyiform lemur and, based on phylogenetic analysis, suggest two independent lemur colonizations of Madagascar.

    • Gregg F. Gunnell
    • , Doug M. Boyer
    • , Anthony R. Friscia
    • , Steven Heritage
    • , Fredrick Kyalo Manthi
    • , Ellen R. Miller
    • , Hesham M. Sallam
    • , Nancy B. Simmons
    • , Nancy J. Stevens
    •  & Erik R. Seiffert
  • Article | | open

    Dynamin-like proteins (DLPs) such as the mitofusins form homotypic and heterotypic oligomers that bridge and fuse opposing membranes. Here, Liu, Noel and Low present the crystal structure of a bacterial DLP heterotypic pair, providing insights into the mechanism behind long-range binding of opposing membranes.

    • Jiwei Liu
    • , Jeffrey K. Noel
    •  & Harry H. Low
  • Article | | open

    Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.

    • Nigel Turner
    • , Xin Ying Lim
    • , Hamish D. Toop
    • , Brenna Osborne
    • , Amanda E. Brandon
    • , Elysha N. Taylor
    • , Corrine E. Fiveash
    • , Hemna Govindaraju
    • , Jonathan D. Teo
    • , Holly P. McEwen
    • , Timothy A. Couttas
    • , Stephen M. Butler
    • , Abhirup Das
    • , Greg M. Kowalski
    • , Clinton R. Bruce
    • , Kyle L. Hoehn
    • , Thomas Fath
    • , Carsten Schmitz-Peiffer
    • , Gregory J. Cooney
    • , Magdalene K. Montgomery
    • , Jonathan C. Morris
    •  & Anthony S. Don
  • Article | | open

    The Late Chalcolithic material culture in the southern Levant has unique attributes that suggest spread of people or culture. Here, the authors use genome-wide ancient DNA data from 22 individuals from a Chalcolithic site and show evidence of complex population movements and turnovers.

    • Éadaoin Harney
    • , Hila May
    • , Dina Shalem
    • , Nadin Rohland
    • , Swapan Mallick
    • , Iosif Lazaridis
    • , Rachel Sarig
    • , Kristin Stewardson
    • , Susanne Nordenfelt
    • , Nick Patterson
    • , Israel Hershkovitz
    •  & David Reich
  • Article | | open

    Large mechanocaloric effects are disclosed in lithium-ion superionic conductors at room temperature. These occur in the absence of any structural phase transition, which is beneficial from a practical point of view, and are related to stress-induced variations in the ionic conductivity.

    • Arun K. Sagotra
    • , Dewei Chu
    •  & Claudio Cazorla
  • Article | | open

    Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.

    • Zhenzhen Wang
    • , Yan Zhang
    • , Enguo Ju
    • , Zhen Liu
    • , Fangfang Cao
    • , Zhaowei Chen
    • , Jinsong Ren
    •  & Xiaogang Qu
  • Article | | open

    How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.

    • Franziska Zosel
    • , Davide Mercadante
    • , Daniel Nettels
    •  & Benjamin Schuler
  • Article | | open

    Here, the authors perform spectroscopic investigations of individual Formamidinium lead iodide nanocrystals, demonstrate single-photon emission and unravel the mechanisms of carrier–phonon interactions. These results will guide the development of next-generation devices for photovoltaics and quantum technologies.

    • Ming Fu
    • , Philippe Tamarat
    • , Jean-Baptiste Trebbia
    • , Maryna I. Bodnarchuk
    • , Maksym V. Kovalenko
    • , Jacky Even
    •  & Brahim Lounis
  • Article | | open

    SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.

    • Peixin Song
    • , Nan Zheng
    • , Yong Liu
    • , Chen Tian
    • , Xilin Wu
    • , Xiaohua Ma
    • , Deyan Chen
    • , Xue Zou
    • , Guiyang Wang
    • , Huanru Wang
    • , Yongyang Zhang
    • , Sufang Lu
    • , Chao Wu
    •  & Zhiwei Wu
  • Review Article | | open

    Accelerated global warming in the Arctic might have profound impacts on mid-latitude weather particularly in winter, although the evidence for an effect also in summer is also growing. Here Coumou et al. show that these interactions could lead to more persistent hot-dry extremes in mid-latitudes.

    • D. Coumou
    • , G. Di Capua
    • , S. Vavrus
    • , L. Wang
    •  & S. Wang
  • Article | | open

    Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.

    • Florian Wimmers
    • , Nikita Subedi
    • , Nicole van Buuringen
    • , Daan Heister
    • , Judith Vivié
    • , Inge Beeren-Reinieren
    • , Rob Woestenenk
    • , Harry Dolstra
    • , Aigars Piruska
    • , Joannes F. M. Jacobs
    • , Alexander van Oudenaarden
    • , Carl G. Figdor
    • , Wilhelm T. S. Huck
    • , I. Jolanda M. de Vries
    •  & Jurjen Tel
  • Article | | open

    In general the computational requirements for simulating quantum systems scale exponentially but in some cases it is possible to formulate more efficient schemes. Here the authors present an efficient approach to calculate non-Markovian quantum dynamics using matrix product operator methods.

    • A. Strathearn
    • , P. Kirton
    • , D. Kilda
    • , J. Keeling
    •  & B. W. Lovett