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Developing an efficient photocatalyst for CO2 reduction is appealing. Here, the authors report a core-shell c-TiO2@a-TiO2-x(OH)y heterostructure with surface frustrated Lewis pairs on amorphous shells which enables a new genre of chemical reactivity.
The UCLA Ribonomics group reports that the nuclear export efficiency of innate immune mRNAs varies over a hundred-fold range such that for many genes only a small fraction of the newly synthesized premRNA reaches the cytoplasm. They show that nuclear export and cytoplasmic decay rates are correlated thereby ensuring similar expression levels of short-lived and long-lived mRNAs.
IL6 expression in the bone marrow is associated with reduced survival in paediatric AML. Here, the authors used RNA-seq to identify treatment resistance-associated co-occurring inflammatory signalling in leukemic cells.
Halo-structured nuclei are examples of many-body open quantum system. Here the authors use a complete kinematics measurement and find an elastic breakup of proton halo nucleus 8B.
Future optical devices, e.g., for AR and VR, will require sophisticated flat metaoptics with unique optical functionalities. The authors demonstrate a metaobjective based on electrically switchable metallic polymer metalenses, whose optical states and focal length is adjustable via CMOS compatible voltages.
Clear electronic transport signatures of topological nodal-line semimetals have been lacking due to their complex electronic structure and the presence of topologically trivial states. Kim et al. demonstrate that the quantum transport response in slightly hole-doped SrAs3 is dominated by nodal-line fermions.
Here, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. Interleukin-11 secreted by the bone acts as a hormone to regulate fat metabolism, in addition to having an autocrine-paracrine effect on bone itself.
The human genome harbors more than 4.5 million transposable element (TE)-derived insertions, the result of recurrent waves of invasion and internal propagation. Here they show that TEs belonging to evolutionarily recent subfamilies go on to regulate later stages of human embryonic development, notably conditioning the expression of genes involved in gastrulation and early organogenesis.
The authors present GhostKnockoff, a method for genome-wide association studies which can be applied to enhance existing and future studies to identify functional variants with weaker statistical effects that might be missed by conventional association tests.
Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target: the protein–protein interaction (PPI) of GIT1/β-Pix.
Iron is an essential mineral in plant physiology. YS1 transporter imports iron–phytosiderophore complex (Fe(III)–DMA) from the soil. Here, the authors describe the cryo-EM structures of barley YS1 in complex with substrate, and a synthetic substrate analog.
The modelling of BVOC chemistry strongly affects how doubling of BVOC emissions affects climate. Lower oxidant depletion with state-of-science chemistry leads to 43% smaller positive forcing from smaller methane increases and cloud albedo decreases.
The authors demonstrate on-the-fly reconfigurable optical trapping of organic polariton condensates which are delocalised over a macroscopic distance from the excitation region, holding great potential for future work on polaritonic lattice physics.
Zinc finger (ZF) arrays are programmable DNA-binding proteins. Here the authors report ZF-DddA-derived cytosine base editors (DdCBEs) and optimise their architectures to improve targeting; they apply these variants in vitro and in vivo to mitochondrial base editing and show higher editing than ZF deaminases.
Spatial transcriptomics analyses can be affected by noise and spatial correlation across tissue locations. Here, the authors develop SpatialPCA, a spatially-aware dimensionality reduction method that explicitly models spatial correlation structures, and show its application to the analysis of healthy and tumour tissues.
Using single-molecule visualization and manipulation, Chang et al. show that the eukaryotic Smc5/6 complex preferentially binds to and stabilizes ssDNA-dsDNA junctions, which could serve as the molecular basis for its diverse roles in genome maintenance.
Population-based studies can provide information on the safety of COVID-19 vaccines. Here the authors report the rates of thrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in Catalonia, Spain and compare them with the background (expected) rates in the general population.
Magnetite is rarely present on the Moon. Here the authors report the magnetite formed by eutectic reaction during the impact process in Chang’E-5 lunar soil, and the potential contribution of this magnetite formation to magnetic anomalies on the Moon.
Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
Multiple state-of-the-art analyses of immune cells in 117 blood, 117 cerebrospinal fluid, 13 choroid plexus and 13 brain parenchyma samples reveal differential characteristics of immune cells in different body compartments and different diseases.