Browse Articles

  • Article | | open

    There has been recent controversy over the validity of commonly-used software packages for functional MRI (fMRI) data analysis. Here, the authors compare the performance of three leading packages (AFNI, FSL, SPM) in terms of temporal autocorrelation modeling, a key statistical step in fMRI analysis.

    • Wiktor Olszowy
    • , John Aston
    • , Catarina Rua
    •  & Guy B. Williams
  • Article | | open

    TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. Here the authors study the role of sTREM2 in a mouse model of Alzheimer’s disease, and find it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.

    • Li Zhong
    • , Ying Xu
    • , Rengong Zhuo
    • , Tingting Wang
    • , Kai Wang
    • , Ruizhi Huang
    • , Daxin Wang
    • , Yue Gao
    • , Yifei Zhu
    • , Xuan Sheng
    • , Kai Chen
    • , Na Wang
    • , Lin Zhu
    • , Dan Can
    • , Yuka Marten
    • , Mitsuru Shinohara
    • , Chia-Chen Liu
    • , Dan Du
    • , Hao Sun
    • , Lei Wen
    • , Huaxi Xu
    • , Guojun Bu
    •  & Xiao-Fen Chen
  • Article | | open

    Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.

    • Laura Siles
    • , Chiara Ninfali
    • , Marlies Cortés
    • , Douglas S. Darling
    •  & Antonio Postigo
  • Article | | open

    Given the potential for increasingly common and intense tropical storms, it is important to understand their effects on island forest communities. Here, the authors show that Hurricane María’s strength and rainfall had larger effects on tree mortality than other less severe storms, and that large trees and species with low-density wood were most susceptible.

    • María Uriarte
    • , Jill Thompson
    •  & Jess K. Zimmerman
  • Article | | open

    TonB-dependent transporters (TBDTs) are outer membrane proteins that import nutrients and bacteriocins in bacteria. Here, Gómez-Santos et al. show that a TBDT is required for secretion of a protease in Myxococcus xanthus, suggesting that some TBDTs may be involved in protein secretion.

    • Nuria Gómez-Santos
    • , Timo Glatter
    • , Ralf Koebnik
    • , Magdalena Anna Świątek-Połatyńska
    •  & Lotte Søgaard-Andersen
  • Article | | open

    Cornstarch and water is a mixture that solidifies under impact. The authors find that ordinary sand behaves in a similar way when coated with a thin layer of viscoelastic polymer, suggesting a potential route for designing materials which respond dramatically to fast deformations.

    • David Z. Chen
    • , Hu Zheng
    • , Dong Wang
    •  & Robert P. Behringer
  • Article | | open

    Females are choosy about their mates, which should erode genetic diversity but in practice does not. Here, selection and genomic resequencing of Drosophila supports the hypothesis that this paradox can be explained by sexually selected traits reflecting genetic variation in condition.

    • Robert J. Dugand
    • , Joseph L. Tomkins
    •  & W. Jason Kennington
  • Article | | open

    FGF signaling through ERK is known to promote the differentiation of embryonic stem cells (ES cells). Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK signaling and the promotion of self-renewal.

    • Ya-Pu Li
    • , Fei-Fei Duan
    • , Yu-Ting Zhao
    • , Kai-Li Gu
    • , Le-Qi Liao
    • , Huai-Bin Su
    • , Jing Hao
    • , Kun Zhang
    • , Na Yang
    •  & Yangming Wang
  • Article | | open

    The mathematical structure of quantum measurements and the Born rule are usually imposed as axioms; here, the authors show instead that they are the only possible measurement postulates, if we require that arbitrary partitioning of systems does not change the theory’s predictions.

    • Lluís Masanes
    • , Thomas D. Galley
    •  & Markus P. Müller
  • Article | | open

    While single-atom catalysts (SACs) have attracted a lot of interest, the nature of the active sites in SACs remains elusive. Here the authors elucidate that depositing single atoms via high temperature synthesis leads to improved reducibility of lattice oxygen on CeO2 yielding low temperature reactivity of Pt catalysts in CO oxidation.

    • Xavier Isidro Pereira-Hernández
    • , Andrew DeLaRiva
    • , Valery Muravev
    • , Deepak Kunwar
    • , Haifeng Xiong
    • , Berlin Sudduth
    • , Mark Engelhard
    • , Libor Kovarik
    • , Emiel J. M. Hensen
    • , Yong Wang
    •  & Abhaya K. Datye
  • Article | | open

    The authors use polyacrylamide grafted graphene oxide as a molecular brush to coat the commercial polypropylene separator. The bilayer design combines lithiophilicity chemistry and high mechanical strength, rendering high performance Li metal anodes and offering a strategy for the design of separators.

    • Chuanfa Li
    • , Shaohong Liu
    • , Chenguang Shi
    • , Ganghao Liang
    • , Zhitao Lu
    • , Ruowen Fu
    •  & Dingcai Wu
  • Article | | open

    The early evolution of the deuterostomes is not well resolved. Here, Topper and colleagues investigate the early Cambrian metazoan Yanjiahella biscarpa, concluding that it is a stem echinoderm, is among the oldest known deuterstomes, and supports an ancestral enteropneust body plan in hemichordates.

    • Timothy P. Topper
    • , Junfeng Guo
    • , Sébastien Clausen
    • , Christian B. Skovsted
    •  & Zhifei Zhang
  • Article | | open

    Methods to diagnose malaria are of interest but can be costly or not sensitive enough to detect low levels of parasitemia. Here the authors report an ultrasensitive method by using hemozoin (a biomarker of all Plasmodium species) to catalyse the polymerization of N-isopropylacrylamide.

    • Omar Rifaie-Graham
    • , Jonas Pollard
    • , Samuel Raccio
    • , Sandor Balog
    • , Sebastian Rusch
    • , María Andrea Hernández-Castañeda
    • , Pierre-Yves Mantel
    • , Hans-Peter Beck
    •  & Nico Bruns
  • Article | | open

    Convolutional Neural Networks (CNNs) have reached human-level benchmarks in classifying images, but they can be “fooled” by adversarial examples that elicit bizarre misclassifications from machines. Here, the authors show how humans can anticipate which objects CNNs will see in adversarial images.

    • Zhenglong Zhou
    •  & Chaz Firestone
  • Article | | open

    The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.

    • Yun Zhao
    • , Rachid Zagani
    • , Sung-Moo Park
    • , Naohiro Yoshida
    • , Pankaj Shah
    •  & Hans-Christian Reinecker
  • Article | | open

    While water-splitting electrocatalysts enable energy storage in carbon-neutral fuels, a recent challenge has been the discovery and understanding of catalyst active sites. Here, authors find domain boundaries in MoS2 materials to present high-activity, stable, and scalable sites for H2 evolution.

    • Jianqi Zhu
    • , Zhi-Chang Wang
    • , Huijia Dai
    • , Qinqin Wang
    • , Rong Yang
    • , Hua Yu
    • , Mengzhou Liao
    • , Jing Zhang
    • , Wei Chen
    • , Zheng Wei
    • , Na Li
    • , Luojun Du
    • , Dongxia Shi
    • , Wenlong Wang
    • , Lixin Zhang
    • , Ying Jiang
    •  & Guangyu Zhang
  • Article | | open

    A desired product cannot be obtained at higher concentration than its equilibrium concentration when isomerases are used for biotransformation. Here, the authors engineer in vivo oxidoreductive reactions in yeast to overcome the equilibrium limitation of in vitro isomerases-based tagatose production.

    • Jing-Jing Liu
    • , Guo-Chang Zhang
    • , Suryang Kwak
    • , Eun Joong Oh
    • , Eun Ju Yun
    • , Kulika Chomvong
    • , Jamie H. D. Cate
    •  & Yong-Su Jin
  • Article | | open

    The search for environmentally friendly, lead-free primary explosives continues to be important for both military and civil applications. Here the authors synthesize an organic fused-ring initiating substance that possesses many of the attributes necessary for commercial application.

    • Mucong Deng
    • , Yongan Feng
    • , Wenquan Zhang
    • , Xiujuan Qi
    •  & Qinghua Zhang
  • Article | | open

    BCL6 corepressor (BCOR) is recurrently mutated in acute myeloid leukaemia and myelodysplastic syndrome. Here, the authors use mouse models to show the mechanism of how inactivation of BCOR in haematopoietic stem cells contributes to the development of leukaemia.

    • Madison J. Kelly
    • , Joan So
    • , Amy J. Rogers
    • , Gareth Gregory
    • , Jason Li
    • , Magnus Zethoven
    • , Micah D. Gearhart
    • , Vivian J. Bardwell
    • , Ricky W. Johnstone
    • , Stephin J. Vervoort
    •  & Lev M. Kats
  • Article | | open

    Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer. Here, the authors show MPM is heterogeneously composed of epithelioid and sarcomatoid components and their proportions associate with prognosis and could inform therapeutic strategies.

    • Yuna Blum
    • , Clément Meiller
    • , Lisa Quetel
    • , Nabila Elarouci
    • , Mira Ayadi
    • , Danisa Tashtanbaeva
    • , Lucile Armenoult
    • , François Montagne
    • , Robin Tranchant
    • , Annie Renier
    • , Leanne de Koning
    • , Marie-Christine Copin
    • , Paul Hofman
    • , Véronique Hofman
    • , Henri Porte
    • , Françoise Le Pimpec-Barthes
    • , Jessica Zucman-Rossi
    • , Marie-Claude Jaurand
    • , Aurélien de Reyniès
    •  & Didier Jean
  • Article | | open

    Artificial cells need to be supplied with ATP as they lack internal systems of energy generation. Here the authors reconstruct ATP synthase and bacteriorhodopsins for light-driven ATP generation, powering transcription and translation.

    • Samuel Berhanu
    • , Takuya Ueda
    •  & Yutetsu Kuruma
  • Article | | open

    The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.

    • Seung Jae Jeong
    • , Shinhye Park
    • , Loi T. Nguyen
    • , Jungwon Hwang
    • , Eun-Young Lee
    • , Hoi-Khoanh Giong
    • , Jeong-Soo Lee
    • , Ina Yoon
    • , Ji-Hyun Lee
    • , Jong Hyun Kim
    • , Hoi Kyoung Kim
    • , Doyeun Kim
    • , Won Suk Yang
    • , Seon-Young Kim
    • , Chan Yong Lee
    • , Kweon Yu
    • , Nahum Sonenberg
    • , Myung Hee Kim
    •  & Sunghoon Kim
  • Article | | open

    G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Here authors use native ion mobility mass spectrometry to monitor small molecule binding events to GIRK2 and shed light on the selectivity of GIRK2 towards PIPs.

    • Yang Liu
    • , Catherine E. LoCaste
    • , Wen Liu
    • , Michael L. Poltash
    • , David H. Russell
    •  & Arthur Laganowsky
  • Article | | open

    Measuring metabolic fluxes in cellular compartments is a challenge. Here, the authors introduce an approach to infer fluxes in mitochondria and cytosol, and find that IDH1 is the major producer of cytosolic citrate in HeLa cells and that in SDH- deficient cells citrate synthase functions in reverse.

    • Won Dong Lee
    • , Dzmitry Mukha
    • , Elina Aizenshtein
    •  & Tomer Shlomi
  • Article | | open

    Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics.

    • Ira W. Deveson
    • , Bindu Swapna Madala
    • , James Blackburn
    • , Chris Barker
    • , Ted Wong
    • , Kirston M. Barton
    • , Martin A. Smith
    • , D. Neil Watkins
    •  & Tim R. Mercer
  • Article | | open

    The effect of plant biodiversity on microbial function has been tested in limited studies and is likely to be context-dependent. In this meta-analysis of 106 prior studies comparing plant monocultures to mixtures, the authors find that plant diversity increases microbial biomass and respiration rates, an effect moderated by stand age.

    • Chen Chen
    • , Han Y. H. Chen
    • , Xinli Chen
    •  & Zhiqun Huang
  • Article | | open

    Loading guests inside the pre-existing pores of nanoporous hosts remains challenging. Here, the authors introduce a rational route for incorporation of guest compounds into an arbitrary nanoporous host, enabling the investigation of multiple host-guest systems with surprising functionalities.

    • Tiesheng Wang
    • , Lijun Gao
    • , Jingwei Hou
    • , Servann J. A. Herou
    • , James T. Griffiths
    • , Weiwei Li
    • , Jinhu Dong
    • , Song Gao
    • , Maria-Magdalena Titirici
    • , R. Vasant Kumar
    • , Anthony K. Cheetham
    • , Xinhe Bao
    • , Qiang Fu
    •  & Stoyan K. Smoukov
  • Article | | open

    Here the authors show that Aedes mosquitoes can acquire ZIKV by breeding in contaminated aquatic systems, and that these infected mosquitoes can transmit ZIKV to susceptible mice. This suggests that human urine containing aquatic environments could contribute to ZIKV transmission.

    • Senyan Du
    • , Yang Liu
    • , Jianying Liu
    • , Jie Zhao
    • , Clara Champagne
    • , Liangqin Tong
    • , Renli Zhang
    • , Fuchun Zhang
    • , Cheng-Feng Qin
    • , Ping Ma
    • , Chun-Hong Chen
    • , Guodong Liang
    • , Qiyong Liu
    • , Pei-Yong Shi
    • , Bernard Cazelles
    • , Penghua Wang
    • , Huaiyu Tian
    •  & Gong Cheng
  • Article | | open

    Removal of SO2 from flue gas is of prime importance to avoid its poisoning of CO2-seperating agents. Here, the authors demonstrate that two fluorinated metal–organic frameworks selectively remove SO2 from synthetic flue gas and can sense SO2 with p.p.m.-level detection using quartz crystal microbalance transducers.

    • M. R. Tchalala
    • , P. M. Bhatt
    • , K. N. Chappanda
    • , S. R. Tavares
    • , K. Adil
    • , Y. Belmabkhout
    • , A. Shkurenko
    • , A. Cadiau
    • , N. Heymans
    • , G. De Weireld
    • , G. Maurin
    • , K. N. Salama
    •  & M. Eddaoudi
  • Article | | open

    The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expression

    • Margarita C. Dinamarca
    • , Adi Raveh
    • , Andy Schneider
    • , Thorsten Fritzius
    • , Simon Früh
    • , Pascal D. Rem
    • , Michal Stawarski
    • , Txomin Lalanne
    • , Rostislav Turecek
    • , Myeongjeong Choo
    • , Valérie Besseyrias
    • , Wolfgang Bildl
    • , Detlef Bentrop
    • , Matthias Staufenbiel
    • , Martin Gassmann
    • , Bernd Fakler
    • , Jochen Schwenk
    •  & Bernhard Bettler
  • Article | | open

    The therapeutic efficacy of adoptive T cell transfer is limited by their ability to infiltrate solid tumours. Here, the authors show that loading the tumor penetrating cyclic peptide iRGD on the cell surface of T cells enhances their ability to penetrate the tumour, resulting in enhanced efficacy in a mouse model of gastric cancer.

    • Naiqing Ding
    • , Zhengyun Zou
    • , Huizi Sha
    • , Shu Su
    • , Hanqing Qian
    • , Fanyan Meng
    • , Fangjun Chen
    • , Shiyao Du
    • , Shujuan Zhou
    • , Hong Chen
    • , Lianru Zhang
    • , Ju Yang
    • , Jia Wei
    •  & Baorui Liu
  • Article | | open

    SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects the extracellular matrix to lipid metabolism.

    • Rebecca Bertolio
    • , Francesco Napoletano
    • , Miguel Mano
    • , Sebastian Maurer-Stroh
    • , Marco Fantuz
    • , Alessandro Zannini
    • , Silvio Bicciato
    • , Giovanni Sorrentino
    •  & Giannino Del Sal
  • Article | | open

    The spins of nitrogen vacancy centres have been shown to be sensitive, high-temperature quantum probes of magnetic fields but the usual readout scheme fails above 550 K. Here the authors demonstrate coherent control and sensing up to 1000 K by using fast temperature control to reach the conditions for readout.

    • Gang-Qin Liu
    • , Xi Feng
    • , Ning Wang
    • , Quan Li
    •  & Ren-Bao Liu
  • Article | | open

    Single-atom catalysts have been studied for CO oxidation, but experimental in situ investigations are limited. Here, the authors use a suite of in situ/operando spectroscopy to identify key intermediates and define design principles to enhance the CO oxidation activity of atomically dispersed Rh on heteropoly acids.

    • Max J. Hülsey
    • , Bin Zhang
    • , Zhirui Ma
    • , Hiroyuki Asakura
    • , David A. Do
    • , Wei Chen
    • , Tsunehiro Tanaka
    • , Peng Zhang
    • , Zili Wu
    •  & Ning Yan
  • Article | | open

    Medial entorhinal cortex (MEC) is involved in memory processes that entail the replay of sequential firing of hippocampal place cells during rest periods and during behaviour. Here, the authors show that MEC lesioned animals show intact replay after an epoch of rats running on a linear track, while replay during the behavioral epoch is reduced.

    • Alireza Chenani
    • , Marta Sabariego
    • , Magdalene I. Schlesiger
    • , Jill K. Leutgeb
    • , Stefan Leutgeb
    •  & Christian Leibold
  • Article | | open

    The performance of solid oxide fuel cells relies on oxygen exchange kinetics, which can limit oxygen reduction at the cathode. Here the authors use ab initio methods to model oxygen exchange in a representative cathode material to better understand the active molecular mechanism toward optimized design.

    • Yipeng Cao
    • , Milind J. Gadre
    • , Anh T. Ngo
    • , Stuart B. Adler
    •  & Dane D. Morgan
  • Article | | open

    Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryonic stem cells.

    • Parysatis Sachs
    • , Dong Ding
    • , Philipp Bergmaier
    • , Boris Lamp
    • , Christina Schlagheck
    • , Florian Finkernagel
    • , Andrea Nist
    • , Thorsten Stiewe
    •  & Jacqueline E. Mermoud
  • Perspective | | open

    The primary causes of dramatic variations in volcanic flux and composition along strike in subduction zones remain largely unknown. Here we use a promising new approach to show that along-strike volcanic variability in the Quaternary Cascades Arc is primarily due to variations in the flux of basalt into the base of the crust, rather than crustal magma storage.

    • C. B. Till
    • , A. J. R. Kent
    • , G. A. Abers
    • , H. A. Janiszewski
    • , J. B. Gaherty
    •  & B. W. Pitcher
  • Article | | open

    Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.

    • Hiroaki Saito
    • , Andreas Gasser
    • , Simona Bolamperti
    • , Miki Maeda
    • , Levi Matthies
    • , Katharina Jähn
    • , Courtney L. Long
    • , Hartmut Schlüter
    • , Marcel Kwiatkowski
    • , Vaibhav Saini
    • , Paola Divieti Pajevic
    • , Teresita Bellido
    • , Andre J. van Wijnen
    • , Khalid S. Mohammad
    • , Theresa A. Guise
    • , Hanna Taipaleenmäki
    •  & Eric Hesse
  • Article | | open

    Extracellular electron uptake (EEU) is the ability of microbes to take up electrons from solid-phase conductive substances such as metal oxides. Here, Guzman et al. show that electrons enter the photosynthetic electron transport chain and are used for CO2 fixation during EEU in a phototrophic bacterium.

    • Michael S. Guzman
    • , Karthikeyan Rengasamy
    • , Michael M. Binkley
    • , Clive Jones
    • , Tahina Onina Ranaivoarisoa
    • , Rajesh Singh
    • , David A. Fike
    • , J. Mark Meacham
    •  & Arpita Bose
  • Article | | open

    Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.

    • Ei-Wen Yang
    • , Jae Hoon Bahn
    • , Esther Yun-Hua Hsiao
    • , Boon Xin Tan
    • , Yiwei Sun
    • , Ting Fu
    • , Bo Zhou
    • , Eric L. Van Nostrand
    • , Gabriel A. Pratt
    • , Peter Freese
    • , Xintao Wei
    • , Giovanni Quinones-Valdez
    • , Alexander E. Urban
    • , Brenton R. Graveley
    • , Christopher B. Burge
    • , Gene W. Yeo
    •  & Xinshu Xiao
  • Article | | open

    Photon acceleration, which can be used to generate tunable high harmonic radiation, typically requires high-intensity lasers and long propagation distances. Here, Shcherbakov et al. show efficient photon acceleration at low power input power from a semiconductor metasurface, less than a micron thin.

    • Maxim R. Shcherbakov
    • , Kevin Werner
    • , Zhiyuan Fan
    • , Noah Talisa
    • , Enam Chowdhury
    •  & Gennady Shvets
  • Article | | open

    Nonlinear structured illumination microscopy is a super-resolution technique that is challenging to extend to 3 dimensions. The authors obtain super-resolution image information in 3D from a 2D scan by exploiting orthogonal speckle illumination patterns and compressed sensing of the sparse fluorescence.

    • M. Pascucci
    • , S. Ganesan
    • , A. Tripathi
    • , O. Katz
    • , V. Emiliani
    •  & M. Guillon
  • Article | | open

    Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired resistance to chemotherapy in LPS.

    • Ye Chen
    • , Liang Xu
    • , Anand Mayakonda
    • , Mo-Li Huang
    • , Deepika Kanojia
    • , Tuan Zea Tan
    • , Pushkar Dakle
    • , Ruby Yu-Tong Lin
    • , Xin-Yu Ke
    • , Jonathan W. Said
    • , Jianxiang Chen
    • , Sigal Gery
    • , Ling-Wen Ding
    • , Yan-Yi Jiang
    • , Angela Pang
    • , Mark Edward Puhaindran
    • , Boon Cher Goh
    •  & H. Phillip Koeffler
  • Article | | open

    Continuous continental rift zones evolve from enigmatic interactions between individual propagating rift segments. Here, the authors document progressive focusing of tectonic and magmatic activity caused by interactions between the Kenyan and Ethiopian rift segments of the East African Rift.

    • Giacomo Corti
    • , Raffaello Cioni
    • , Zara Franceschini
    • , Federico Sani
    • , Stéphane Scaillet
    • , Paola Molin
    • , Ilaria Isola
    • , Francesco Mazzarini
    • , Sascha Brune
    • , Derek Keir
    • , Asfaw Erbello
    • , Ameha Muluneh
    • , Finnigan Illsley-Kemp
    •  & Anne Glerum
  • Article | | open

    The role of macroautophagy in neuronal processes mediating brain maintenance remains enigmatic. Authors show here that impairing autophagy within the major learning related brain center of Drosophila, and not other regions, triggered a form of presynaptic metaplasticity that was invariably connected to the absence of the specific component of aversive olfactory memory, which normally only declines in the course of aging process

    • Anuradha Bhukel
    • , Christine Brigitte Beuschel
    • , Marta Maglione
    • , Martin Lehmann
    • , Gabor Juhász
    • , Frank Madeo
    •  & Stephan J. Sigrist
  • Article | | open

    Constructing artificial ion channels to mimic biological process is highly demanded but currently artificial ion channels lack robustness. Here the authors report a robust NO-regulated artificial nanochannel based on a spiro ring opening−closing reaction strategy.

    • Yao Sun
    • , Sen Chen
    • , Xiaoya Chen
    • , Yuling Xu
    • , Siyun Zhang
    • , Qingying Ouyang
    • , Guangfu Yang
    •  & Haibing Li
  • Article | | open

    The mechanisms underlying the success or failure of fecal microbiota transplantation (FMT) are unclear. Here, Wang et al. use a mouse model of FMT to show that fluorescent D-amino acids can be used to track the transplanted microbiota in the recipient animals.

    • Wei Wang
    • , Liyuan Lin
    • , Yahui Du
    • , Yanling Song
    • , Xiaoman Peng
    • , Xing Chen
    •  & Chaoyong James Yang