Browse Articles

  • Article | | open

    Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.

    • Minh Binh Nguyen
    • , Idan Cohen
    • , Vinod Kumar
    • , Zijian Xu
    • , Carmit Bar
    • , Katherine L. Dauber-Decker
    • , Pai-Chi Tsai
    • , Pauline Marangoni
    • , Ophir D. Klein
    • , Ya-Chieh Hsu
    • , Ting Chen
    • , Marja L. Mikkola
    •  & Elena Ezhkova
  • Article | | open

    While the architecture of vertebrate nuclear pore complexes (NPCs) is well understood, the extent of its evolutionary conservation is still unclear. Here, the authors analyze the in situ architecture of an algal NPC, revealing distinct structural features that provide insights into NPC evolution.

    • Shyamal Mosalaganti
    • , Jan Kosinski
    • , Sahradha Albert
    • , Miroslava Schaffer
    • , Daniela Strenkert
    • , Patrice A. Salomé
    • , Sabeeha S. Merchant
    • , Jürgen M. Plitzko
    • , Wolfgang Baumeister
    • , Benjamin D. Engel
    •  & Martin Beck
  • Article | | open

    Sex-specific meiotic crossover (CO) landscapes have been identified in multiple species. Here, the authors show that male and female meioses in maize have similar CO landscapes, and differences between COs in the two sexes only exists in their location relative to transcription start sites and some chromatin marks.

    • Penny M. A. Kianian
    • , Minghui Wang
    • , Kristin Simons
    • , Farhad Ghavami
    • , Yan He
    • , Stefanie Dukowic-Schulze
    • , Anitha Sundararajan
    • , Qi Sun
    • , Jaroslaw Pillardy
    • , Joann Mudge
    • , Changbin Chen
    • , Shahryar F. Kianian
    •  & Wojciech P. Pawlowski
  • Article | | open

    Geminiviruses are an important plant pathogen that causes large food crop losses globally. Here the authors describe a high resolution cryo-EM structure of the Ageratum yellow vein virus and reveal the molecular details of how a single capsid protein sequence can adopt the different conformations needed to build that geminate capsid.

    • Emma L. Hesketh
    • , Keith Saunders
    • , Chloe Fisher
    • , Joran Potze
    • , John Stanley
    • , George P. Lomonossoff
    •  & Neil A. Ranson
  • Article | | open

    The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection.

    • Navid Madani
    • , Amy M. Princiotto
    • , Linh Mach
    • , Shilei Ding
    • , Jérémie Prevost
    • , Jonathan Richard
    • , Bhavna Hora
    • , Laura Sutherland
    • , Connie A. Zhao
    • , Brandon P. Conn
    • , Todd Bradley
    • , M. Anthony Moody
    • , Bruno Melillo
    • , Andrés Finzi
    • , Barton F. Haynes
    • , Amos B. Smith III
    • , Sampa Santra
    •  & Joseph Sodroski
  • Article | | open

    Extreme sea levels are a flood risk along the world’s coastlines. Here the authors carry out probabilistic projections of extreme sea levels and show that for the present century coastal flood hazards will increase significantly along most of the global coastlines.

    • Michalis I. Vousdoukas
    • , Lorenzo Mentaschi
    • , Evangelos Voukouvalas
    • , Martin Verlaan
    • , Svetlana Jevrejeva
    • , Luke P. Jackson
    •  & Luc Feyen
  • Article | | open

    Rhinovirus (RV) infections can trigger acute exacerbations of respiratory diseases. Here, Niespodziana et al. develop a PreDicta chip that identifies the culprit RV strain from small blood samples and show that RV-A and RV-C strains are associated with most severe symptoms.

    • Katarzyna Niespodziana
    • , Katarina Stenberg-Hammar
    • , Spyridon Megremis
    • , Clarissa R. Cabauatan
    • , Kamila Napora-Wijata
    • , Phyllis C. Vacal
    • , Daniela Gallerano
    • , Christian Lupinek
    • , Daniel Ebner
    • , Thomas Schlederer
    • , Christian Harwanegg
    • , Cilla Söderhäll
    • , Marianne van Hage
    • , Gunilla Hedlin
    • , Nikolaos G. Papadopoulos
    •  & Rudolf Valenta
  • Article | | open

    Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival signaling.

    • Lijian Shao
    • , Jianhui Chang
    • , Wei Feng
    • , Xiaoyan Wang
    • , Elizabeth A. Williamson
    • , Ying Li
    • , Amir Schajnovitz
    • , David Scadden
    • , Luke J. Mortensen
    • , Charles P. Lin
    • , Linheng Li
    • , Ariel Paulson
    • , James Downing
    • , Daohong Zhou
    •  & Robert A. Hromas
  • Article | | open

    Coupling superconductors to mesoscopic systems leads to unusual effects that could be exploited in new devices including topological quantum computers. Here the authors present a double quantum dot with a Yu–Shiba–Rusinov ground state arising from the interplay of Coulomb interactions and superconductivity.

    • K. Grove-Rasmussen
    • , G. Steffensen
    • , A. Jellinggaard
    • , M. H. Madsen
    • , R. Žitko
    • , J. Paaske
    •  & J. Nygård
  • Article | | open

    Thioplatensimycin (thioPTM) and thioplatencin (thioPTN) are recently discovered thiocarboxylic acid congeners of the antibacterial compounds PTM and PTN. Here, the authors identify a thioacid cassette encoding PtmA3 and PtmU4 that are responsible for carboxylate activation and sulfur transfer, respectively.

    • Liao-Bin Dong
    • , Jeffrey D. Rudolf
    • , Dingding Kang
    • , Nan Wang
    • , Cyndi Qixin He
    • , Youchao Deng
    • , Yong Huang
    • , K. N. Houk
    • , Yanwen Duan
    •  & Ben Shen
  • Article | | open

    Soft tissue tumors in infants encompass an overlapping spectrum of diseases posing unique diagnostic and clinical challenges. Here, the authors investigate the genetic basis of cryptogenic congenital mesoblastic nephroma and infantile fibrosarcoma lacking the canonical NTRK3-ETV6 fusion gene, and identify therapeutically tractable intragenic rearrangements in EGFR and BRAF.

    • Jenny Wegert
    • , Christian Vokuhl
    • , Grace Collord
    • , Martin Del Castillo Velasco-Herrera
    • , Sarah J. Farndon
    • , Charlotte Guzzo
    • , Mette Jorgensen
    • , John Anderson
    • , Olga Slater
    • , Catriona Duncan
    • , Sabrina Bausenwein
    • , Heike Streitenberger
    • , Barbara Ziegler
    • , Rhoikos Furtwängler
    • , Norbert Graf
    • , Michael R. Stratton
    • , Peter J. Campbell
    • , David TW Jones
    • , Christian Koelsche
    • , Stefan M. Pfister
    • , William Mifsud
    • , Neil Sebire
    • , Monika Sparber-Sauer
    • , Ewa Koscielniak
    • , Andreas Rosenwald
    • , Manfred Gessler
    •  & Sam Behjati
  • Article | | open

    Chordoid glioma is a slow growing diencephalic tumor whose mutational landscape is poorly characterized. Here, the authors perform whole-exome and RNA-sequencing and find that 15 of 16 chordoid glioma cases studied harbor the same PRKCA mutation which results in enhanced proliferation.

    • Shai Rosenberg
    • , Iva Simeonova
    • , Franck Bielle
    • , Maite Verreault
    • , Bertille Bance
    • , Isabelle Le Roux
    • , Mailys Daniau
    • , Arun Nadaradjane
    • , Vincent Gleize
    • , Sophie Paris
    • , Yannick Marie
    • , Marine Giry
    • , Marc Polivka
    • , Dominique Figarella-Branger
    • , Marie-Hélène Aubriot-Lorton
    • , Chiara Villa
    • , Alexandre Vasiljevic
    • , Emmanuèle Lechapt-Zalcman
    • , Michel Kalamarides
    • , Ariane Sharif
    • , Karima Mokhtari
    • , Stefano Maria Pagnotta
    • , Antonio Iavarone
    • , Anna Lasorella
    • , Emmanuelle Huillard
    •  & Marc Sanson
  • Article | | open

    Twinning has been experimentally seen in high-entropy alloys, but understanding how it operates remains a challenge. Here, the authors show that twinning can be a primary deformation mechanism in three well-known medium- and high-entropy alloys that have unstable face-centered cubic lattices.

    • Shuo Huang
    • , He Huang
    • , Wei Li
    • , Dongyoo Kim
    • , Song Lu
    • , Xiaoqing Li
    • , Erik Holmström
    • , Se Kyun Kwon
    •  & Levente Vitos
  • Article | | open

    Macroscopically large supercrystals are very difficult to assemble from metallic nanoparticles. Here, the authors use a binary solvent diffusion method to form sub-millimeter gold nanoparticle supercrystals with rare hcp symmetry, and discover that they exhibit facet-dependent optical properties.

    • Kaifu Bian
    • , Hattie Schunk
    • , Dongmei Ye
    • , Austin Hwang
    • , Ting Shan Luk
    • , Ruipeng Li
    • , Zhongwu Wang
    •  & Hongyou Fan
  • Article | | open

    Gold nanoclusters are known to grow stepwise from gold-thiolate monomers and oligomers. Here, the authors find that the evolution of silver nanoclusters differs completely from that of gold: rather than following a bottom-up pathway, the clusters evolve from similarly-sized Ag-thiolate cluster intermediates.

    • Yitao Cao
    • , Jiahao Guo
    • , Run Shi
    • , Geoffrey I. N. Waterhouse
    • , Jinheng Pan
    • , Zhenxia Du
    • , Qiaofeng Yao
    • , Li-Zhu Wu
    • , Chen-Ho Tung
    • , Jianping Xie
    •  & Tierui Zhang
  • Article | | open

    In layered inorganic materials lattice distortions can couple to break inversion symmetry and drive improper ferroelectricity, but in perovskites, symmetry prohibits such an effect. Here, the authors use group-theoretical analysis to provide crystal engineering design principles for improper ferroelectricity in molecular perovskites.

    • Hanna L. B. Boström
    • , Mark S. Senn
    •  & Andrew L. Goodwin
  • Article | | open

    Electrodeposition provides a facile fabrication means for electrochemical devices but weak substrate-deposit interactions cause poor performance. Here, authors utilize anion insertion within graphitic layers to improve the material interfaces and construct highly active O2-evolving electrocatalysts.

    • Zhenhua Yan
    • , Hongming Sun
    • , Xiang Chen
    • , Huanhuan Liu
    • , Yaran Zhao
    • , Haixia Li
    • , Wei Xie
    • , Fangyi Cheng
    •  & Jun Chen
  • Article | | open

    Estrogen receptor alpha (ERα) plays critical roles in the etiology and treatment of breast cancer. Here the authors synthesize benzopyrans with variable side chains to identify antiestrogenic compounds and characterize OP-1074, a compound that exhibits pure antiestrogenic activity by inducing the degradation of ERα and possesses greater potency than tamoxifen or fulvestrant in a xenograft model.

    • S. W. Fanning
    • , L. Hodges-Gallagher
    • , D. C. Myles
    • , R. Sun
    • , C. E. Fowler
    • , I. N. Plant
    • , B. D. Green
    • , C. L. Harmon
    • , G. L. Greene
    •  & P. J. Kushner
  • Review Article | | open

    Understudied in the Antarctic system are the subsurface interfaces between ice-sheet, ocean and geological substrate. Here, the authors review our understanding of these components and propose new avenues of holistic dynamic modeling to achieve a unified understanding of past, present and future polar climate.

    • Florence Colloni
    • , Laura De Santis
    • , Christine S. Siddoway
    • , Andrea Bergamasco
    • , Nicholas R. Golledge
    • , Gerrit Lohmann
    • , Sandra Passchier
    •  & Martin J. Siegert
  • Article | | open

    Existing methods to extract structural information from single-molecule scattering measurements require large number of photons per image. Here the authors discuss a method to reconstruct the structure of a molecule from X-ray scattering data by using only three photons per image.

    • Benjamin von Ardenne
    • , Martin Mechelke
    •  & Helmut Grubmüller
  • Article | | open

    Post-diagnostic use of cholera vaccine can improve the prognosis in patients with colorectal cancer suggesting cholera toxin might have an antineoplastic effect. Here the authors perform a nationwide population-based study and report an association between cholera vaccine administration and reduction in prostate cancer mortality.

    • Jianguang Ji
    • , Jan Sundquist
    •  & Kristina Sundquist
  • Article | | open

    Sub-nano clusters with atomic precision provide a compelling platform for bridging heterogeneous and homogeneous catalysis, but their synthesis remains a great challenge. Here, the authors report a precursor-preselected wet-chemistry strategy to synthesize highly dispersed Fe2 clusters supported on mesoporous carbon nitride.

    • Shubo Tian
    • , Qiang Fu
    • , Wenxing Chen
    • , Quanchen Feng
    • , Zheng Chen
    • , Jian Zhang
    • , Weng-Chon Cheong
    • , Rong Yu
    • , Lin Gu
    • , Juncai Dong
    • , Jun Luo
    • , Chen Chen
    • , Qing Peng
    • , Claudia Draxl
    • , Dingsheng Wang
    •  & Yadong Li
  • Article | | open

    The recently introduced glass and liquid states of metal–organic frameworks (MOFs) provide opportunities to design and explore new properties for this class of material. Here, the authors show that a MOF liquid can be blended with another MOF component to produce domain-structured MOF glasses with single, tailorable glass transitions.

    • Louis Longley
    • , Sean M. Collins
    • , Chao Zhou
    • , Glen J. Smales
    • , Sarah E. Norman
    • , Nick J. Brownbill
    • , Christopher W. Ashling
    • , Philip A. Chater
    • , Robert Tovey
    • , Carola-Bibiane Schönlieb
    • , Thomas F. Headen
    • , Nicholas J. Terrill
    • , Yuanzheng Yue
    • , Andrew J. Smith
    • , Frédéric Blanc
    • , David A. Keen
    • , Paul A. Midgley
    •  & Thomas D. Bennett