Browse Articles

  • Article | | open

    Earthquakes frequently occur in the brittle-ductile transition near the base of the seismogenic zone. Using shear experiments on calcite faults, here the authors show that microscale cavitation plays a role in controlling the brittle-ductile transition, and in nucleating earthquakes at the base of the seismogenic zone.

    • Berend A. Verberne
    • , Jianye Chen
    • , André R. Niemeijer
    • , Johannes H. P. de Bresser
    • , Gillian M. Pennock
    • , Martyn R. Drury
    •  & Christopher J. Spiers
  • Article | | open

    Isotope tracer administration for probing metabolism in vivo is important to assess metabolic functions in a relevant physiological setting. Here, the authors report a non-invasive method of administering 13C6- glucose to mouse models via liquid diet feeding to achieve deep metabolic network coverage.

    • Ramon C. Sun
    • , Teresa W.-M. Fan
    • , Pan Deng
    • , Richard M. Higashi
    • , Andrew N. Lane
    • , Anh-Thu Le
    • , Timothy L. Scott
    • , Qiushi Sun
    • , Marc O. Warmoes
    •  & Ye Yang
  • Article | | open

    Genetic variance can influence breast cancer prognosis. Here, the authors conduct a meta-analysis to explore genetic variance linked to breast cancer in young women, identifying a prognostic association with germline variation of ADAMTSL1.

    • Latha Kadalayil
    • , Sofia Khan
    • , Heli Nevanlinna
    • , Peter A. Fasching
    • , Fergus J. Couch
    • , John L. Hopper
    • , Jianjun Liu
    • , Tom Maishman
    • , Lorraine Durcan
    • , Sue Gerty
    • , Carl Blomqvist
    • , Brigitte Rack
    • , Wolfgang Janni
    • , Andrew Collins
    • , Diana Eccles
    •  & William Tapper
  • Article | | open

    Coherent coupling in soft matter, controlled by nanoscale morphology, plays an important role in charge generation and recombination in optoelectronics. Eder et al. show how to reversibly switch between H- and J-type coupling in conjugated polymer aggregates, leading to tunable photoluminescence.

    • Theresa Eder
    • , Thomas Stangl
    • , Max Gmelch
    • , Klaas Remmerssen
    • , Dirk Laux
    • , Sigurd Höger
    • , John M. Lupton
    •  & Jan Vogelsang
  • Article | | open

    STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.

    • Sophia Maschalidi
    • , Paula Nunes-Hasler
    • , Clarissa R Nascimento
    • , Ignacio Sallent
    • , Valérie Lannoy
    • , Meriem Garfa-Traore
    • , Nicolas Cagnard
    • , Fernando E. Sepulveda
    • , Pablo Vargas
    • , Ana-Maria Lennon-Duménil
    • , Peter van Endert
    • , Thierry Capiod
    • , Nicolas Demaurex
    • , Guillaume Darrasse-Jèze
    •  & Bénédicte Manoury
  • Article | | open

    The biosynthetic pathway of fusidane-type antibiotics, such as helvolic acid, is largely undiscovered. Here, the authors investigate the biosynthesis of helvolic acid, thereby determining the sequence of the enzymatic reactions involved in the process and the intermediates formed.

    • Jian-Ming Lv
    • , Dan Hu
    • , Hao Gao
    • , Tetsuo Kushiro
    • , Takayoshi Awakawa
    • , Guo-Dong Chen
    • , Chuan-Xi Wang
    • , Ikuro Abe
    •  & Xin-Sheng Yao
  • Article | | open

    During the maternal-to-zygotic transition there is degradation of maternal proteins via the ubiquitin-proteasome system (UPS). Here, the authors show that in the embryo the maternally inherited epigenetic factor DPPA3/Stella/PGC7 is cleavage by the UPS and controls intracellular trafficking.

    • Seung-Wook Shin
    • , Edgar John Vogt
    • , Maria Jimenez-Movilla
    • , Boris Baibakov
    •  & Jurrien Dean
  • Article | | open

    The dynamic control of light emission from quantum dots is generally controlled via optical or electrical pumping. Here, Lu et al. electrically control the local density of states around a quantum dot to modulate its visible light emission properties.

    • Yu-Jung Lu
    • , Ruzan Sokhoyan
    • , Wen-Hui Cheng
    • , Ghazaleh Kafaie Shirmanesh
    • , Artur R. Davoyan
    • , Ragip A. Pala
    • , Krishnan Thyagarajan
    •  & Harry A. Atwater
  • Article | | open

    PARP1 recruitment to DNA lesions is critical for DNA damage repair but how DNA damage induces PARP1 redistribution is largely unknown. Here, the authors provide evidence that PARP1 redistribution and DNA repair in tumor cells depend on the formation of a HSF1–PARP13–PARP1 complex.

    • Mitsuaki Fujimoto
    • , Ryosuke Takii
    • , Eiichi Takaki
    • , Arpit Katiyar
    • , Ryuichiro Nakato
    • , Katsuhiko Shirahige
    •  & Akira Nakai
  • Article | | open

    Ash1 is an H3K36 methyltransferase, Trithorax group protein and is critical in antagonizing Polycomb silencing. Here, the authors purify the Drosophila Ash1 complex and identify Mrg15 and Nurf55 as subunits, finding that Mrg15 is recruited by Ash1 and reinforces Ash1 activity.

    • Chang Huang
    • , Fu Yang
    • , Zhuqiang Zhang
    • , Jing Zhang
    • , Gaihong Cai
    • , Lin Li
    • , Yong Zheng
    • , She Chen
    • , Rongwen Xi
    •  & Bing Zhu
  • Article | | open

    Unlike chimpanzees and gorillas, bonobos have not been found infected by malaria parasites in the wild. Here, Liu et al. report more thorough survey and sequencing results showing that bonobos host malaria parasites, including a yet-unknown species, but only in the eastern-most part of their range.

    • Weimin Liu
    • , Scott Sherrill-Mix
    • , Gerald H. Learn
    • , Erik J. Scully
    • , Yingying Li
    • , Alexa N. Avitto
    • , Dorothy E. Loy
    • , Abigail P. Lauder
    • , Sesh A. Sundararaman
    • , Lindsey J. Plenderleith
    • , Jean-Bosco N. Ndjango
    • , Alexander V. Georgiev
    • , Steve Ahuka-Mundeke
    • , Martine Peeters
    • , Paco Bertolani
    • , Jef Dupain
    • , Cintia Garai
    • , John A. Hart
    • , Terese B. Hart
    • , George M. Shaw
    • , Paul M. Sharp
    •  & Beatrice H. Hahn
  • Article | | open

    Mulitidrug and toxic compound extrusion (MATE) family transporters export xenobiotics and some plant MATE transporters are involved in secondary metabolite transport. Here, the authors present the structure of the Arabidopsis thaliana MATE transporter AtDTX14 and propose a model for eukaryotic MATE transport mechanism.

    • Hirotake Miyauchi
    • , Satomi Moriyama
    • , Tsukasa Kusakizako
    • , Kaoru Kumazaki
    • , Takanori Nakane
    • , Keitaro Yamashita
    • , Kunio Hirata
    • , Naoshi Dohmae
    • , Tomohiro Nishizawa
    • , Koichi Ito
    • , Takaaki Miyaji
    • , Yoshinori Moriyama
    • , Ryuichiro Ishitani
    •  & Osamu Nureki
  • Article | | open

    NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recruitment.

    • Federica Fusella
    • , Laura Seclì
    • , Elena Busso
    • , Anna Krepelova
    • , Enrico Moiso
    • , Stefania Rocca
    • , Laura Conti
    • , Laura Annaratone
    • , Cristina Rubinetto
    • , Maurizia Mello-Grand
    • , Vijay Singh
    • , Giovanna Chiorino
    • , Lorenzo Silengo
    • , Fiorella Altruda
    • , Emilia Turco
    • , Alessandro Morotti
    • , Salvatore Oliviero
    • , Isabella Castellano
    • , Federica Cavallo
    • , Paolo Provero
    • , Guido Tarone
    •  & Mara Brancaccio
  • Article | | open

    Semimetals with the band structure exhibiting Dirac and Weyl crossings can show special electronic and magnetic properties. Here the authors explore the electronic properties of the type-II Weyl semimetals, MoP2 and WP2 with robust Weyl points which display very high magnetoresistance and conductivity.

    • Nitesh Kumar
    • , Yan Sun
    • , Nan Xu
    • , Kaustuv Manna
    • , Mengyu Yao
    • , Vicky Süss
    • , Inge Leermakers
    • , Olga Young
    • , Tobias Förster
    • , Marcus Schmidt
    • , Horst Borrmann
    • , Binghai Yan
    • , Uli Zeitler
    • , Ming Shi
    • , Claudia Felser
    •  & Chandra Shekhar
  • Article | | open

    Understanding and accurate prediction of human mobility is of increasing importance, but a universal framework is lacking. Here, the authors develop a unified model that accurately predicts both individual and population mobility and scaling behaviors on diverse spatial scales.

    • Xiao-Yong Yan
    • , Wen-Xu Wang
    • , Zi-You Gao
    •  & Ying-Cheng Lai
  • Article | | open

    Anti-Stokes luminescence - the emission of photons with higher energy than those absorbed – in nanomaterials is widely used for optoelectronic applications. Here the authors observe it in degenerately doped bulk InP and GaAs, indicating it as a more general property of direct bandgap semiconductors.

    • K. Mergenthaler
    • , N. Anttu
    • , N. Vainorius
    • , M. Aghaeipour
    • , S. Lehmann
    • , M. T. Borgström
    • , L. Samuelson
    •  & M.-E. Pistol
  • Article | | open

    Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membranes.

    • Sicai Zhang
    • , Ronnie P.-A. Berntsson
    • , William H. Tepp
    • , Liang Tao
    • , Eric A. Johnson
    • , Pål Stenmark
    •  & Min Dong
  • Article | | open

    MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes.

    • Yassine Sassi
    • , Petros Avramopoulos
    • , Deepak Ramanujam
    • , Laurenz Grüter
    • , Stanislas Werfel
    • , Simon Giosele
    • , Andreas-David Brunner
    • , Dena Esfandyari
    • , Aikaterini S. Papadopoulou
    • , Bart De Strooper
    • , Norbert Hübner
    • , Regalla Kumarswamy
    • , Thomas Thum
    • , Xiaoke Yin
    • , Manuel Mayr
    • , Bernhard Laggerbauer
    •  & Stefan Engelhardt
  • Article | | open

    Expanding the scope of materials for spin caloritronics enhances the opportunity to achieve more energy efficient memory and sensor devices. Here the authors report the tunnel magneto-Seebeck effects in magnetic tunnel junctions with Co2FeAl and Co2FeSi Heusler compounds.

    • Alexander Boehnke
    • , Ulrike Martens
    • , Christian Sterwerf
    • , Alessia Niesen
    • , Torsten Huebner
    • , Marvin von der Ehe
    • , Markus Meinert
    • , Timo Kuschel
    • , Andy Thomas
    • , Christian Heiliger
    • , Markus Münzenberg
    •  & Günter Reiss
  • Article | | open

    The mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift with puberty onset.

    • Bhupinder Pal
    • , Yunshun Chen
    • , François Vaillant
    • , Paul Jamieson
    • , Lavinia Gordon
    • , Anne C. Rios
    • , Stephen Wilcox
    • , Naiyang Fu
    • , Kevin He Liu
    • , Felicity C. Jackling
    • , Melissa J. Davis
    • , Geoffrey J. Lindeman
    • , Gordon K. Smyth
    •  & Jane E. Visvader
  • Article | | open

    CRISPR-Cas9 systems are being continually improved to enhance specificity and improve functionality. Here the authors design hybrid DNA-RNA guide and tracr molecules to direct Cas9 nuclease activity with reduced off-target effects.

    • Fernando Orden Rueda
    • , Michal Bista
    • , Matthew D. Newton
    • , Anne U. Goeppert
    • , M. Emanuela Cuomo
    • , Euan Gordon
    • , Felix Kröner
    • , Jon A. Read
    • , Jonathan D. Wrigley
    • , David Rueda
    •  & Benjamin J. M. Taylor
  • Article | | open

    The mechanisms behind deformation of multiphase solids are elusive. Here, the authors use X-rays and simulations to show that the same mechanisms causing rocks to fold occur at the micrometer scale in dual-metal lamellas of Ag/Cu and Al/Cu under high-pressure torsion, leading to vortices formation.

    • Mohsen Pouryazdan
    • , Boris J. P. Kaus
    • , Alexander Rack
    • , Alexey Ershov
    •  & Horst Hahn
  • Article | | open

    In Streptococcus pneumoniae, competence for genetic transformation is accompanied by a pause in growth. Here, Bergé et al. show that this pause is linked to the cell cycle via at least two pathways that impair peptidoglycan synthesis and preserve genomic integrity during transformation.

    • Matthieu J. Bergé
    • , Chryslène Mercy
    • , Isabelle Mortier-Barrière
    • , Michael S. VanNieuwenhze
    • , Yves V. Brun
    • , Christophe Grangeasse
    • , Patrice Polard
    •  & Nathalie Campo