Browse Articles

  • Article
    | Open Access

    STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.

    • Lívia H. Yamashiro
    • , Stephen C. Wilson
    • , Huntly M. Morrison
    • , Vasiliki Karalis
    • , Jing-Yi J. Chung
    • , Katherine J. Chen
    • , Helen S. Bateup
    • , Moriah L. Szpara
    • , Angus Y. Lee
    • , Jeffery S. Cox
    •  & Russell E. Vance
  • Article
    | Open Access

    Designing energy efficient and scalable artificial networks for neuromorphic computing remains a challenge. Here, the authors demonstrate online learning in a monolithically integrated 4 × 4 fully memristive neural network consisting of volatile NbOx memristor neurons and nonvolatile TaOx memristor synapses.

    • Qingxi Duan
    • , Zhaokun Jing
    • , Xiaolong Zou
    • , Yanghao Wang
    • , Ke Yang
    • , Teng Zhang
    • , Si Wu
    • , Ru Huang
    •  & Yuchao Yang
  • Article
    | Open Access

    Roads are widespread and can impact ecological communities. Cooke et al. use data for 75 bird species across Great Britain to show that common species are disproportionately abundant near roads, whereas rarer, smaller-bodied and migrant species are more likely to be negatively associated with roads.

    • Sophia C. Cooke
    • , Andrew Balmford
    • , Paul F. Donald
    • , Stuart E. Newson
    •  & Alison Johnston
  • Article
    | Open Access

    Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.

    • Hana Hanzlikova
    • , Evgeniia Prokhorova
    • , Katerina Krejcikova
    • , Zuzana Cihlarova
    • , Ilona Kalasova
    • , Jan Kubovciak
    • , Jana Sachova
    • , Richard Hailstone
    • , Jan Brazina
    • , Shereen Ghosh
    • , Sebahattin Cirak
    • , Joseph G. Gleeson
    • , Ivan Ahel
    •  & Keith W. Caldecott
  • Article
    | Open Access

    Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anaphase spindle migration and oocyte division asymmetry by controlling spindle length.

    • Zhe Wei
    • , Jessica Greaney
    • , Wei-Guo Nicholas Loh
    •  & Hayden Anthony Homer
  • Article
    | Open Access

    Immunoglobulin (Ig) rearrangement and translocation information are usually obtained by targeted sequencing of the respective loci. Here, the authors present the IgCaller algorithm, which extracts Ig heavy and light chain genetic properties from short-read whole-genome sequencing results to provide a feasible alternative to direct sequencing.

    • Ferran Nadeu
    • , Rut Mas-de-les-Valls
    • , Alba Navarro
    • , Romina Royo
    • , Silvia Martín
    • , Neus Villamor
    • , Helena Suárez-Cisneros
    • , Rosó Mares
    • , Junyan Lu
    • , Anna Enjuanes
    • , Alfredo Rivas-Delgado
    • , Marta Aymerich
    • , Tycho Baumann
    • , Dolors Colomer
    • , Julio Delgado
    • , Ryan D. Morin
    • , Thorsten Zenz
    • , Xose S. Puente
    • , Peter J. Campbell
    • , Sílvia Beà
    • , Francesco Maura
    •  & Elías Campo
  • Article
    | Open Access

    Strong mitigation of anthropogenic emissions is necessary, but it is not clear how fast these efforts would lead to temperature changes. Here, the authors find that there is a substantial delay between reductions of emissions and a detectable change in surface temperature for a number of climate forcers.

    • B. H. Samset
    • , J. S. Fuglestvedt
    •  & M. T. Lund
  • Article
    | Open Access

    Efficient radiation monitoring ensures safety in nuclear power, but beta-ray scintillators should be developed for use near a highly radioactive and hot reactor. Here, the authors report a two-dimensional halide perovskite-based beta-ray scintillator with high irradiation hardness and thermotolerance.

    • Dejian Yu
    • , Peng Wang
    • , Fei Cao
    • , Yu Gu
    • , Jiaxin Liu
    • , Zeyao Han
    • , Bo Huang
    • , Yousheng Zou
    • , Xiaobao Xu
    •  & Haibo Zeng
  • Article
    | Open Access

    Previous attempts to combine expansion microscopy (ExM) and single molecule localisation microscopy (SMLM) have proved challenging. Here the authors show that post-labelling Ex-SMLM improves labelling efficiency, reduces linkage error, and preserves ultrastructural details.

    • Fabian U. Zwettler
    • , Sebastian Reinhard
    • , Davide Gambarotto
    • , Toby D. M. Bell
    • , Virginie Hamel
    • , Paul Guichard
    •  & Markus Sauer
  • Review Article
    | Open Access

    The lack of scalable, high-quality insulators is a major problem hindering the progress on electronic devices built from 2D materials. Here, the authors review the current state-of-the-art and the future prospects of suitable insulators for 2D technologies.

    • Yury Yu. Illarionov
    • , Theresia Knobloch
    • , Markus Jech
    • , Mario Lanza
    • , Deji Akinwande
    • , Mikhail I. Vexler
    • , Thomas Mueller
    • , Max C. Lemme
    • , Gianluca Fiori
    • , Frank Schwierz
    •  & Tibor Grasser
  • Article
    | Open Access

    Omecamtiv mecarbil is a small molecule effector under clinical trial for the treatment of systolic heart failure. Here the authors define the molecular mechanisms of its inotropic action and find it can increase the efficiency of contraction in muscle fibres when the orthophosphate concentration rises with the beat frequency.

    • Serena Governali
    • , Marco Caremani
    • , Cristina Gallart
    • , Irene Pertici
    • , Ger Stienen
    • , Gabriella Piazzesi
    • , Coen Ottenheijm
    • , Vincenzo Lombardi
    •  & Marco Linari
  • Article
    | Open Access

    G-quadruplex (G4) forming sequences are highly enriched in the human genome and function as important regulators of diverse range of biological processes. Here the authors show that while G4 structures on template strand block transcription, folding on the non-template strand enhances transcription by means of successive R-loop formation.

    • Chun-Ying Lee
    • , Christina McNerney
    • , Kevin Ma
    • , Walter Zhao
    • , Ashley Wang
    •  & Sua Myong
  • Article
    | Open Access

    Structural genomic variation can fuel evolution. Here, authors present genome data from seven Corvus species and unearth structural variants that vary between incipient crow species in Europe, with implications for premating isolation involving plumage patterning.

    • Matthias H. Weissensteiner
    • , Ignas Bunikis
    • , Ana Catalán
    • , Kees-Jan Francoijs
    • , Ulrich Knief
    • , Wieland Heim
    • , Valentina Peona
    • , Saurabh D. Pophaly
    • , Fritz J. Sedlazeck
    • , Alexander Suh
    • , Vera M. Warmuth
    •  & Jochen B. W. Wolf
  • Article
    | Open Access

    Circadian activity modulation in the suprachiasmatic nucleus (SCN) is a network-level emergent property that requires neuropeptide VIP signaling, yet the precise cellular mechanisms are unknown. Patton et al. show that cells expressing VIP or its receptor VPAC2 together determine these emergent properties of the SCN.

    • Andrew P. Patton
    • , Mathew D. Edwards
    • , Nicola J. Smyllie
    • , Ryan Hamnett
    • , Johanna E. Chesham
    • , Marco Brancaccio
    • , Elizabeth S. Maywood
    •  & Michael H. Hastings
  • Article
    | Open Access

    Sepsis is a difficult to treat condition. Here, the authors present a telodendrimer nanotrap that captures inflammator mediators to improve survival in combination with antibiotic treatment.

    • Changying Shi
    • , Xiaojing Wang
    • , Lili Wang
    • , Qinghe Meng
    • , Dandan Guo
    • , Li Chen
    • , Matthew Dai
    • , Guirong Wang
    • , Robert Cooney
    •  & Juntao Luo
  • Article
    | Open Access

    The cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase B EmbB involved in mycobacterial cell wall biosynthesis provides insights into the substrate binding and reaction mechanism. Mapping of the ethambutol resistance associated mutations onto the structure suggests the location of the drug binding site.

    • Yong Zi Tan
    • , José Rodrigues
    • , James E. Keener
    • , Ruixiang Blake Zheng
    • , Richard Brunton
    • , Brian Kloss
    • , Sabrina I. Giacometti
    • , Ana L. Rosário
    • , Lei Zhang
    • , Michael Niederweis
    • , Oliver B. Clarke
    • , Todd L. Lowary
    • , Michael T. Marty
    • , Margarida Archer
    • , Clinton S. Potter
    • , Bridget Carragher
    •  & Filippo Mancia
  • Article
    | Open Access

    Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase, and displays pronounced activity against pathogenic fungi of the order Mucorales.

    • Yue Fu
    • , David Estoppey
    • , Silvio Roggo
    • , Dominik Pistorius
    • , Florian Fuchs
    • , Christian Studer
    • , Ashraf S. Ibrahim
    • , Thomas Aust
    • , Frederic Grandjean
    • , Manuel Mihalic
    • , Klaus Memmert
    • , Vivian Prindle
    • , Etienne Richard
    • , Ralph Riedl
    • , Sven Schuierer
    • , Eric Weber
    • , Jürg Hunziker
    • , Frank Petersen
    • , Jianshi Tao
    •  & Dominic Hoepfner
  • Article
    | Open Access

    The Central Atlantic Magmatic Province is the most aerially extensive magmatic event in Earth’s history, yet few constraints exist on the volumes of intrusions at depth. Here, the authors find limited intrusive volumes beneath the South Georgia Rift, consistent with modest potential mantle temperatures (<1500 °C) related to syn-rift decompression melting.

    • R. E. Marzen
    • , D. J. Shillington
    • , D. Lizarralde
    • , J. H. Knapp
    • , D. M. Heffner
    • , J. K. Davis
    •  & S. H. Harder
  • Article
    | Open Access

    The Pan-Cancer Analysis of Whole Genomes project generated a vast array of data. In this article, the authors describe five different online resources to enable readers to explore and visualize the data.

    • Mary J. Goldman
    • , Junjun Zhang
    • , Nuno A. Fonseca
    • , Isidro Cortés-Ciriano
    • , Qian Xiang
    • , Brian Craft
    • , Elena Piñeiro-Yáñez
    • , Brian D. O’Connor
    • , Wojciech Bazant
    • , Elisabet Barrera
    • , Alfonso Muñoz-Pomer
    • , Robert Petryszak
    • , Anja Füllgrabe
    • , Fatima Al-Shahrour
    • , Maria Keays
    • , David Haussler
    • , John N. Weinstein
    • , Wolfgang Huber
    • , Alfonso Valencia
    • , Peter J. Park
    • , Irene Papatheodorou
    • , Jingchun Zhu
    • , Vincent Ferretti
    •  & Miguel Vazquez
  • Article
    | Open Access

    Acute kidney injury is a major health problem amongst hospitalized patients. Here the authors provide a comprehensive characterization of enhancer and super-enhancer elements, and the transcription factor motifs associated with these elements in response to kidney injury in vivo; providing insight into the regulation of kidney repair.

    • Julia Wilflingseder
    • , Michaela Willi
    • , Hye Kyung Lee
    • , Hannes Olauson
    • , Jakub Jankowski
    • , Takaharu Ichimura
    • , Reinhold Erben
    • , M. Todd Valerius
    • , Lothar Hennighausen
    •  & Joseph V. Bonventre
  • Article
    | Open Access

    Monomethylmercury is a toxin that humans can be exposed to after consumption of seafood in which it has bioaccumulated. Here the authors show that amphipods in the deepest point of the global ocean contain monomethylmercury with surface origins, suggesting rapid sinking of this toxin on particles.

    • Ruoyu Sun
    • , Jingjing Yuan
    • , Jeroen E. Sonke
    • , Yanxu Zhang
    • , Tong Zhang
    • , Wang Zheng
    • , Shun Chen
    • , Mei Meng
    • , Jiubin Chen
    • , Yi Liu
    • , Xiaotong Peng
    •  & Congqiang Liu
  • Article
    | Open Access

    SWI/SNF remodelers alter histone-DNA interactions and are important for regulating chromatin architecture and gene expression. Here, the authors present the cryo-EM structure of a nucleosome-free Swi/Snf complex from Saccharomyces cerevisiae and discuss the assembly and function of SWI/SNF remodelers.

    • Chengcheng Wang
    • , Zhouyan Guo
    • , Xiechao Zhan
    • , Fenghua Yang
    • , Mingxuan Wu
    •  & Xiaofeng Zhang
  • Article
    | Open Access

    The polyhedral skeletal electron pair theory (PESPT), also known as Wade-Mingos’ rules, defines a relationship between skeletal bonding electron pairs and structure of clusters. Here the authors report the synthesis, structure and computational studies of planar C2B4R4 carboranes that do not adhere to PESPT.

    • Wei Lu
    • , Dinh Cao Huan Do
    •  & Rei Kinjo
  • Article
    | Open Access

    SARS-CoV-2 is causing a global pandemic in which the implementation of serology can support decision making in different scenarios. Here, the authors compare the outcome of eight commercially available assays to virus neutralization and discuss their use in diagnostics and exposure assessment of SARS-CoV-2.

    • Corine H. GeurtsvanKessel
    • , Nisreen M. A. Okba
    • , Zsofia Igloi
    • , Susanne Bogers
    • , Carmen W. E. Embregts
    • , Brigitta M. Laksono
    • , Lonneke Leijten
    • , Casper Rokx
    • , Bart Rijnders
    • , Janette Rahamat-Langendoen
    • , Johannes P. C. van den Akker
    • , Jeroen J. A. van Kampen
    • , Annemiek A. van der Eijk
    • , Rob S. van Binnendijk
    • , Bart Haagmans
    •  & Marion Koopmans
  • Article
    | Open Access

    Chinese chestnut is widely cultivated for nut production and harbors value as a genetic resource for restoration of American and European chestnut trees destroyed by chestnut blight. Here, the authors reveal the genomic basis of homoploid hybrid speciation within Castanea spp. and find the nonrandom distribution of reproductive barrier loci based on a high-quality reference genome.

    • Yongshuai Sun
    • , Zhiqiang Lu
    • , Xingfu Zhu
    •  & Hui Ma
  • Article
    | Open Access

    The authors here report tensile properties of polycrystalline methane hydrate at the micron scale by applying a contactless, thermos-induced stress to a tenuous shell of hydrate grown in a thin glass capillary. The results suggest that the cohesive strength of methane hydrate in marine settings may be an order of magnitude less than currently thought.

    • Dyhia Atig
    • , Daniel Broseta
    • , Jean-Michel Pereira
    •  & Ross Brown
  • Article
    | Open Access

    Despite evidence that astrocytes mediate sleep-dependent function, the involved signaling mechanisms are unknown. The authors show that astrocytic Ca2+ signalling exhibits distinct features across the sleep-wake cycle and ablation of this Ca2+ signalling pathway impairs slow wave sleep.

    • Laura Bojarskaite
    • , Daniel M. Bjørnstad
    • , Klas H. Pettersen
    • , Céline Cunen
    • , Gudmund Horn Hermansen
    • , Knut Sindre Åbjørsbråten
    • , Anna R. Chambers
    • , Rolf Sprengel
    • , Koen Vervaeke
    • , Wannan Tang
    • , Rune Enger
    •  & Erlend A. Nagelhus
  • Article
    | Open Access

    In vitro models of the human mammary gland have struggled to mimic the 3D morphogenic processes that occur in vivo. Here the authors develop a 3D microfluidic platform of a vascularized human mammary duct that simulates diverse morphogenic transitions and paracrine crosstalk.

    • Matthew L. Kutys
    • , William J. Polacheck
    • , Michaela K. Welch
    • , Keith A. Gagnon
    • , Thijs Koorman
    • , Sudong Kim
    • , Linqing Li
    • , Andrea I. McClatchey
    •  & Christopher S. Chen
  • Article
    | Open Access

    The authors demonstrate a two-dimensional optomechanical crystal cavity which traps a phonon mode within a phononic bandgap while yielding large thermal conductivity to the environment. High quantum cooperativity at millikelvin temperatures is realized, suitable for quantum coherent control.

    • Hengjiang Ren
    • , Matthew H. Matheny
    • , Gregory S. MacCabe
    • , Jie Luo
    • , Hannes Pfeifer
    • , Mohammad Mirhosseini
    •  & Oskar Painter
  • Article
    | Open Access

    Designing flexible and transparent electrodes for high-performance optoelectronic devices remains a challenge. Here, the authors presented conductive and flexible dielectric-metal-dielectric multi-layers electrodes based on Cu-doped Ag film (thickness of 6.5 nm) with 100.3% relative transmittance.

    • Chengang Ji
    • , Dong Liu
    • , Cheng Zhang
    •  & L. Jay Guo
  • Article
    | Open Access

    Ion migration can induce overshoot of luminance in normal 3D perovskite light-emitting diode devices and results in reduced lifetime. Here Kim et al. show that the ion migration and overshoot can be suppressed in 3D/2D hybrid perovskites, leading to 21 times longer operational lifetime.

    • Hobeom Kim
    • , Joo Sung Kim
    • , Jung-Min Heo
    • , Mingyuan Pei
    • , In-Hyeok Park
    • , Zhun Liu
    • , Hyung Joong Yun
    • , Min-Ho Park
    • , Su-Hun Jeong
    • , Young-Hoon Kim
    • , Jin-Woo Park
    • , Emad Oveisi
    • , Satyawan Nagane
    • , Aditya Sadhanala
    • , Lijun Zhang
    • , Jin Jung Kweon
    • , Sung Keun Lee
    • , Hoichang Yang
    • , Hyun Myung Jang
    • , Richard H. Friend
    • , Kian Ping Loh
    • , Mohammad Khaja Nazeeruddin
    • , Nam-Gyu Park
    •  & Tae-Woo Lee
  • Article
    | Open Access

    CD4+ T cells contain a T-bethigh memory-phenotype (MP) population with innate-like functions. Here the authors characterize the requirements for their differentiation at homeostasis and identify a function for IL-12 that is tonically produced by type 1 dendritic cells in an MyD88- and CD40-dependent, but foreign PAMP-independent manner.

    • Takeshi Kawabe
    • , Jaeu Yi
    • , Akihisa Kawajiri
    • , Kerry Hilligan
    • , Difeng Fang
    • , Naoto Ishii
    • , Hidehiro Yamane
    • , Jinfang Zhu
    • , Dragana Jankovic
    • , Kwang Soon Kim
    • , Giorgio Trinchieri
    •  & Alan Sher
  • Article
    | Open Access

    Water oxidation catalysis may provide the electrons needed for sustainable fuel production, but catalysts often degrade under working conditions. Here, authors introduce soluble species into perovskites to exert positive ion leaching effects for enhancing perovskite stability and activity.

    • Daqin Guan
    • , Gihun Ryu
    • , Zhiwei Hu
    • , Jing Zhou
    • , Chung-Li Dong
    • , Yu-Cheng Huang
    • , Kaifeng Zhang
    • , Yijun Zhong
    • , Alexander C. Komarek
    • , Ming Zhu
    • , Xinhao Wu
    • , Chih-Wen Pao
    • , Chung-Kai Chang
    • , Hong-Ji Lin
    • , Chien-Te Chen
    • , Wei Zhou
    •  & Zongping Shao
  • Article
    | Open Access

    The association between blood pressure (BP) and migraine is poorly understood. Here, the authors explore this relationship using summary-level GWAS data for BP and migraine. Cross-trait meta-analysis reveals shared loci between BP and migraine, while Mendelian randomization suggests that diastolic BP specifically plays a key role in migraine susceptibility.

    • Yanjun Guo
    • , Pamela M. Rist
    • , Iyas Daghlas
    • , Franco Giulianini
    • , Padhraig Gormley
    • , Verneri Anttila
    • , Bendik S. Winsvold
    • , Priit Palta
    • , Tonu Esko
    • , Tune H. Pers
    • , Kai-How Farh
    • , Ester Cuenca-Leon
    • , Mikko Muona
    • , Nicholas A. Furlotte
    • , Tobias Kurth
    • , Andres Ingason
    • , George McMahon
    • , Lannie Ligthart
    • , Gisela M. Terwindt
    • , Mikko Kallela
    • , Tobias M. Freilinger
    • , Caroline Ran
    • , Scott G. Gordon
    • , Anine H. Stam
    • , Stacy Steinberg
    • , Guntram Borck
    • , Markku Koiranen
    • , Lydia Quaye
    • , Hieab H. H. Adams
    • , Terho Lehtimäki
    • , Antti-Pekka Sarin
    • , Juho Wedenoja
    • , David A. Hinds
    • , Julie E. Buring
    • , Markus Schürks
    • , Paul M. Ridker
    • , Maria Gudlaug Hrafnsdottir
    • , Hreinn Stefansson
    • , Susan M. Ring
    • , Jouke-Jan Hottenga
    • , Brenda W. J. H. Penninx
    • , Markus Färkkilä
    • , Ville Artto
    • , Mari Kaunisto
    • , Salli Vepsäläinen
    • , Rainer Malik
    • , Andrew C. Heath
    • , Pamela A. F. Madden
    • , Nicholas G. Martin
    • , Grant W. Montgomery
    • , Mitja Kurki
    • , Mart Kals
    • , Reedik Mägi
    • , Kalle Pärn
    • , Eija Hämäläinen
    • , Hailiang Huang
    • , Andrea E. Byrnes
    • , Lude Franke
    • , Jie Huang
    • , Evie Stergiakouli
    • , Phil H. Lee
    • , Cynthia Sandor
    • , Caleb Webber
    • , Zameel Cader
    • , Bertram Muller-Myhsok
    • , Stefan Schreiber
    • , Thomas Meitinger
    • , Johan G. Eriksson
    • , Veikko Salomaa
    • , Kauko Heikkilä
    • , Elizabeth Loehrer
    • , Andre G. Uitterlinden
    • , Albert Hofman
    • , Cornelia M. van Duijn
    • , Lynn Cherkas
    • , Linda M. Pedersen
    • , Audun Stubhaug
    • , Christopher S. Nielsen
    • , Minna Männikkö
    • , Evelin Mihailov
    • , Lili Milani
    • , Hartmut Göbel
    • , Ann-Louise Esserlind
    • , Anne Francke Christensen
    • , Thomas Folkmann Hansen
    • , Thomas Werge
    • , Jaakko Kaprio
    • , Arpo J. Aromaa
    • , Olli Raitakari
    • , M. Arfan Ikram
    • , Tim Spector
    • , Marjo-Riitta Järvelin
    • , Andres Metspalu
    • , Christian Kubisch
    • , David P. Strachan
    • , Michel D. Ferrari
    • , Andrea C. Belin
    • , Martin Dichgans
    • , Maija Wessman
    • , Arn M. J. M. van den Maagdenberg
    • , John-Anker Zwart
    • , Dorret I. Boomsma
    • , George Davey Smith
    • , Kari Stefansson
    • , Nicholas Eriksson
    • , Mark J. Daly
    • , Benjamin M. Neale
    • , Jes Olesen
    • , Daniel I. Chasman
    • , Dale R. Nyholt
    • , Aarno Palotie
    • , Michelle Agee
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , David A. Hinds
    • , Karen E. Huber
    • , Aaron Kleinman
    • , Nadia K. Litterman
    • , Jennifer C. McCreight
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Tobias Kurth
    •  & Daniel I. Chasman
  • Article
    | Open Access

    With the rise in polymer consumption, energy efficient techniques for polymer processing become more important. Using poly(ethylene oxide) aqueous solutions, the authors show that flow can causes a change of polymer solubility resulting in polymer crystallisation at ambient conditions.

    • Gary J. Dunderdale
    • , Sarah J. Davidson
    • , Anthony J. Ryan
    •  & Oleksandr O. Mykhaylyk
  • Article
    | Open Access

    COVID-19 is a serious pandemic threat to public health, but insights on the pathophysiological and immunological conditions are only emerging. Here the authors use multi-color flow cytometry to characterize CD4+ and CD8+ T cells in peripheral blood from 39 COVID-19 patients in Italy to report altered T cell activation, function and polarization.

    • Sara De Biasi
    • , Marianna Meschiari
    • , Lara Gibellini
    • , Caterina Bellinazzi
    • , Rebecca Borella
    • , Lucia Fidanza
    • , Licia Gozzi
    • , Anna Iannone
    • , Domenico Lo Tartaro
    • , Marco Mattioli
    • , Annamaria Paolini
    • , Marianna Menozzi
    • , Jovana Milić
    • , Giacomo Franceschi
    • , Riccardo Fantini
    • , Roberto Tonelli
    • , Marco Sita
    • , Mario Sarti
    • , Tommaso Trenti
    • , Lucio Brugioni
    • , Luca Cicchetti
    • , Fabio Facchinetti
    • , Antonello Pietrangelo
    • , Enrico Clini
    • , Massimo Girardis
    • , Giovanni Guaraldi
    • , Cristina Mussini
    •  & Andrea Cossarizza
  • Article
    | Open Access

    Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line.

    • Daisuke Doi
    • , Hiroaki Magotani
    • , Tetsuhiro Kikuchi
    • , Megumi Ikeda
    • , Satoe Hiramatsu
    • , Kenji Yoshida
    • , Naoki Amano
    • , Masaki Nomura
    • , Masafumi Umekage
    • , Asuka Morizane
    •  & Jun Takahashi