Browse Articles

  • Article | | open

    The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to explore pore-formation in molecular detail.

    • Anaïs Menny
    • , Marina Serna
    • , Courtney M. Boyd
    • , Scott Gardner
    • , Agnel Praveen Joseph
    • , B. Paul Morgan
    • , Maya Topf
    • , Nicholas J. Brooks
    •  & Doryen Bubeck
  • Article | | open

    Hardware implementation of spiking neural networks holds promise for high energy efficient brain-inspired computing. Here, Prezioso et al. realize the detection of synchrony in a demo circuit composed of 20 metal-oxide memristor synapses connected to a leaky-integrate-and-fire silicon neuron.

    • M. Prezioso
    • , M. R. Mahmoodi
    • , F. Merrikh Bayat
    • , H. Nili
    • , H. Kim
    • , A. Vincent
    •  & D. B. Strukov
  • Article | | open

    In gene regulation, diversification at the transcriptome 3′end is linked to differentiation and dedifferentiation. Here, the authors discover extensive transcriptome 3′end-alterations in neuroblastoma, regulated by PCF11, and provide an interactive data repository of transcriptome-wide alternative polyadenylation.

    • Anton Ogorodnikov
    • , Michal Levin
    • , Surendra Tattikota
    • , Sergey Tokalov
    • , Mainul Hoque
    • , Denise Scherzinger
    • , Federico Marini
    • , Ansgar Poetsch
    • , Harald Binder
    • , Stephan Macher-Göppinger
    • , Hans Christian Probst
    • , Bin Tian
    • , Michael Schaefer
    • , Karl J. Lackner
    • , Frank Westermann
    •  & Sven Danckwardt
  • Article | | open

    The need for cheap water-splitting materials in order to scale-up and commercialize solar-to-fuel technologies is urgent, but there are still few candidate materials. Here, authors integrate layered double hydroxides with graphdiyne as high-performance overall water-splitting electrocatalysts.

    • Lan Hui
    • , Yurui Xue
    • , Bolong Huang
    • , Huidi Yu
    • , Chao Zhang
    • , Danyan Zhang
    • , Dianzeng Jia
    • , Yingjie Zhao
    • , Yongjun Li
    • , Huibiao Liu
    •  & Yuliang Li
  • Article | | open

    To realize the potential of resistive RAM crossbar arrays as platforms for neuromorphic computing, reduced network-level energy consumption must be achieved. Here, the authors use a hardware/software co-design approach to realize reduced energy consumption during network training for the network.

    • Yuhan Shi
    • , Leon Nguyen
    • , Sangheon Oh
    • , Xin Liu
    • , Foroozan Koushan
    • , John R. Jameson
    •  & Duygu Kuzum
  • Article | | open

    Inherent or acquired resistance to treatment of glioblastoma (GBM) is nearly universal. Here, the authors introduce a platform to identify synergistic drug combinations for patient-specific treatment of GBM based on gene expression signatures and small molecule perturbation-response profiles.

    • Vasileios Stathias
    • , Anna M. Jermakowicz
    • , Marie E. Maloof
    • , Michele Forlin
    • , Winston Walters
    • , Robert K. Suter
    • , Michael A. Durante
    • , Sion L. Williams
    • , J. William Harbour
    • , Claude-Henry Volmar
    • , Nicholas J. Lyons
    • , Claes Wahlestedt
    • , Regina M. Graham
    • , Michael E. Ivan
    • , Ricardo J. Komotar
    • , Jann N. Sarkaria
    • , Aravind Subramanian
    • , Todd R. Golub
    • , Stephan C. Schürer
    •  & Nagi G. Ayad
  • Article | | open

    The flammability and toxicity of the currently used electrolytes are the concerns that must be addressed. Here the authors show a non-fluorinated and non-toxic ionomeric aqueous gel electrolyte called water-in-ionomer that allows an enlargement of electrochemical stability window and design of environmentally friendly battery cell chemistries.

    • Xin He
    • , Bo Yan
    • , Xin Zhang
    • , Zigeng Liu
    • , Dominic Bresser
    • , Jun Wang
    • , Rui Wang
    • , Xia Cao
    • , Yixi Su
    • , Hao Jia
    • , Clare P. Grey
    • , Henrich Frielinghaus
    • , Donald G. Truhlar
    • , Martin Winter
    • , Jie Li
    •  & Elie Paillard
  • Article | | open

    Metabolism is frequently dysregulated in cancer. Here, the authors conduct a pan-cancer analysis of The Cancer Genome Atlas to determine significant metabolic pathway alterations, highlight master metabolic transcriptional regulators, and predict patient response to metabolism targeted-therapeutics

    • S. R. Rosario
    • , M. D. Long
    • , H. C. Affronti
    • , A. M. Rowsam
    • , K. H. Eng
    •  & D. J. Smiraglia
  • Article | | open

    Cubic crystalline single networks of large open-space lattices are ubiquitous in nature. Here the authors show that the topology of the circumferential bilayer of polymer cubosomes differentiates between two non-intersecting pore networks embedded in the cubic mesophase by sealing one channel network at the interface.

    • Yunju La
    • , Jeongeun Song
    • , Moon Gon Jeong
    • , Arah Cho
    • , Seon-Mi Jin
    • , Eunji Lee
    •  & Kyoung Taek Kim
  • Article | | open

    Biogenesis and function of miRNAs in somatic cells is well characterized, but their role in the germline has not been established. Here the authors identify and characterize Drosha independent and dependent miRNAs during C. elegans oogenesis, revealing their roles in meiotic progression and oocyte development.

    • Amanda L. Minogue
    • , Michael R. Tackett
    • , Elnaz Atabakhsh
    • , Genesis Tejada
    •  & Swathi Arur
  • Article | | open

    Significant improvements in numerical methods for quantum systems often come from finding new ways of representing quantum states that can be optimized and simulated more efficiently. Here the authors demonstrate a method to calculate exact neural network representations of many-body ground states.

    • Giuseppe Carleo
    • , Yusuke Nomura
    •  & Masatoshi Imada
  • Article | | open

    The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus venous identity of endothelial cells lining them.

    • Bart Weijts
    • , Edgar Gutierrez
    • , Semion K. Saikin
    • , Ararat J. Ablooglu
    • , David Traver
    • , Alex Groisman
    •  & Eugene Tkachenko
  • Article | | open

    Alphaviruses are enveloped RNA viruses that contain several human pathogens. Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket factor.

    • Lihong Chen
    • , Ming Wang
    • , Dongjie Zhu
    • , Zhenzhao Sun
    • , Jun Ma
    • , Jinglin Wang
    • , Lingfei Kong
    • , Shida Wang
    • , Zaisi Liu
    • , Lili Wei
    • , Yuwen He
    • , Jingfei Wang
    •  & Xinzheng Zhang
  • Article | | open

    SRY and its target SOX9 are known key determinants in testis development. Here the authors by studying duplications and deletions upstream of SOX9 from patient samples with disorders of sex development (DSD) reveal enhancers for SOX9 critical for human sex development and DSD.

    • Brittany Croft
    • , Thomas Ohnesorg
    • , Jacky Hewitt
    • , Josephine Bowles
    • , Alexander Quinn
    • , Jacqueline Tan
    • , Vincent Corbin
    • , Emanuele Pelosi
    • , Jocelyn van den Bergen
    • , Rajini Sreenivasan
    • , Ingrid Knarston
    • , Gorjana Robevska
    • , Dung Chi Vu
    • , John Hutson
    • , Vincent Harley
    • , Katie Ayers
    • , Peter Koopman
    •  & Andrew Sinclair
  • Article | | open

    Cyclic polymers can be usually accessed by ring-expansion and ring-closure approaches. Here, the authors report an alternative blocking-cyclization technique which enables the tunable synthesis of multicyclic polymers via commercial Ru-based Grubbs catalysts and conventional ring-opening metathesis polymerisation.

    • Jie Chen
    • , Hongfei Li
    • , Hengchen Zhang
    • , Xiaojuan Liao
    • , Huijing Han
    • , Lidong Zhang
    • , Ruyi Sun
    •  & Meiran Xie
  • Article | | open

    The plant trans-Golgi network comprises functionally distinct subcompartments. Here Renna et al. show that the TGNap1 protein acts in microtubule-dependent biogenesis, tracking and function of a TGN subset, highlighting diversification within the plant TGN.

    • Luciana Renna
    • , Giovanni Stefano
    • , Erin Slabaugh
    • , Clarissa Wormsbaecher
    • , Alan Sulpizio
    • , Krzysztof Zienkiewicz
    •  & Federica Brandizzi
  • Article | | open

    Chiroptical sensing in complex mixtures remains a challenging task. Here, the authors report an efficient coumarin probe for chiroptical click chirality sensing of absolute configuration, concentration and enantiomeric excess of several compound classes. The method can be directly applied to crude asymmetric reaction mixtures.

    • F. Yushra Thanzeel
    • , Kaluvu Balaraman
    •  & Christian Wolf
  • Article | | open

    Interventions in metabolic networks can improve microbes for chemical production. Here, the authors develop a tool to identify metabolic valves that can decouple growth and production to systematically improve the rate and yield of biochemical production processes.

    • Naveen Venayak
    • , Axel von Kamp
    • , Steffen Klamt
    •  & Radhakrishnan Mahadevan
  • Article | | open

    Methods to silence broadband noise and shield large volumes are lacking. Here, the authors show theoretically and experimentally that acoustic bianisotropic materials, with non-zero strain to momentum coupling, lead to effective sound barriers with excellent efficiency in terms of attenuation, bandwidth, and shielded volume.

    • Bogdan-Ioan Popa
    • , Yuxin Zhai
    •  & Hyung-Suk Kwon
  • Article | | open

    While nanocarrier-based drug delivery is a promising therapeutic approach, in situ characterization of drug nanocarriers in blood remains difficult. Here, the authors demonstrate how the fluorescence correlation spectroscopy can be used to directly characterize drug nanocarriers in flowing blood.

    • Inka Negwer
    • , Andreas Best
    • , Meike Schinnerer
    • , Olga Schäfer
    • , Leon Capeloa
    • , Manfred Wagner
    • , Manfred Schmidt
    • , Volker Mailänder
    • , Mark Helm
    • , Matthias Barz
    • , Hans-Jürgen Butt
    •  & Kaloian Koynov
  • Article | | open

    Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppression via mechanisms involving NF-kB/OX40L signalling.

    • Song Chen
    • , Lijun Fang
    • , Wei Guo
    • , Yushan Zhou
    • , Gang Yu
    • , Wenwen Li
    • , Kui Dong
    • , Jingru Liu
    • , Yuechen Luo
    • , Bing Wang
    • , Zhonglong Li
    • , Chunxiao Zhao
    • , Zhina Sun
    • , Yue Shen
    • , Qibing Leng
    • , Dongming Zhou
    • , Zhongchao Han
    • , Huifang Huang
    • , He Ren
    • , Guogang Xu
    •  & Xiaoming Feng
  • Article | | open

    Schizophrenia (SCZ) risk is influenced by genetic and environmental factors. Here, the authors develop a statistical method for analyzing gene-by-environment effects in SCZ risk across Denmark with fine spatial resolution.

    • Chun Chieh Fan
    • , John J. McGrath
    • , Vivek Appadurai
    • , Alfonso Buil
    • , Michael J. Gandal
    • , Andrew J. Schork
    • , Preben Bo Mortensen
    • , Esben Agerbo
    • , Sandy A. Geschwind
    • , Daniel Geschwind
    • , Thomas Werge
    • , Wesley K. Thompson
    •  & Carsten Bøcker Pedersen
  • Article | | open

    During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and inflammatory cytokine production.

    • Sean Matthew McCauley
    • , Kyusik Kim
    • , Anetta Nowosielska
    • , Ann Dauphin
    • , Leonid Yurkovetskiy
    • , William Edward Diehl
    •  & Jeremy Luban
  • Article | | open

    Human skin constructs hold potential for regenerative medicine, but the incorporation of hair follicles into such constructs is a challenge. Here, the authors use 3D printed molds to pattern hair follicle cell types in a physiological organization, and achieve human hair growth on the back of a mouse.

    • Hasan Erbil Abaci
    • , Abigail Coffman
    • , Yanne Doucet
    • , James Chen
    • , Joanna Jacków
    • , Etienne Wang
    • , Zongyou Guo
    • , Jung U. Shin
    • , Colin A. Jahoda
    •  & Angela M. Christiano
  • Article | | open

    Predicting plastic deformation in crystals remains challenging owing to the nonlinear nature of stochastic avalanches involved, which resemble the critical phenomena. Salmenjoki et al. use machine learning to predict plastic deformation and show that it works better for those under large strains.

    • Henri Salmenjoki
    • , Mikko J. Alava
    •  & Lasse Laurson
  • Article | | open

    Hybrid halide perovskite single crystals show excellent optoelectronic properties but their small size and large thickness limit their application. Herein Liu et al. grow large area ultrathin flexible crystalline membrane of layered perovskite and demonstrate high detectivity in the flexible photosensors.

    • Yucheng Liu
    • , Yunxia Zhang
    • , Zhou Yang
    • , Haochen Ye
    • , Jiangshan Feng
    • , Zhuo Xu
    • , Xu Zhang
    • , Rahim Munir
    • , Jia Liu
    • , Ping Zuo
    • , Qingxian Li
    • , Mingxin Hu
    • , Lina Meng
    • , Kang Wang
    • , Detlef-M. Smilgies
    • , Guangtao Zhao
    • , Hua Xu
    • , Zupei Yang
    • , Aram Amassian
    • , Jiawei Li
    • , Kui Zhao
    •  & Shengzhong(Frank) Liu
  • Article | | open

    IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliary role.

    • Linh T. Vuong
    • , Carlo Iomini
    • , Sophie Balmer
    • , Davide Esposito
    • , Stuart A. Aaronson
    •  & Marek Mlodzik
  • Article | | open

    Shaping particle beams generated from laser-plasma accelerators is challenging. Here the authors demonstrate an all-optical method to structure the accelerated proton beam by modulating and imprinting the spatial laser profile onto the proton beam.

    • Lieselotte Obst-Huebl
    • , Tim Ziegler
    • , Florian-Emanuel Brack
    • , João Branco
    • , Michael Bussmann
    • , Thomas E. Cowan
    • , Chandra B. Curry
    • , Frederico Fiuza
    • , Marco Garten
    • , Maxence Gauthier
    • , Sebastian Göde
    • , Siegfried H. Glenzer
    • , Axel Huebl
    • , Arie Irman
    • , Jongjin B. Kim
    • , Thomas Kluge
    • , Stephan D. Kraft
    • , Florian Kroll
    • , Josefine Metzkes-Ng
    • , Richard Pausch
    • , Irene Prencipe
    • , Martin Rehwald
    • , Christian Roedel
    • , Hans-Peter Schlenvoigt
    • , Ulrich Schramm
    •  & Karl Zeil
  • Article | | open

    The mechanisms underlying the regenerative capacity of the liver are not fully understood. Here, the authors show that the acute regenerative response to liver injury in mice is regulated by the communication involving the vagus nerve, macrophages, and hepatocytes, leading to hepatic FoxM1 activation and promotion of overall survival.

    • Tomohito Izumi
    • , Junta Imai
    • , Junpei Yamamoto
    • , Yohei Kawana
    • , Akira Endo
    • , Hiroto Sugawara
    • , Masato Kohata
    • , Yoichiro Asai
    • , Kei Takahashi
    • , Shinjiro Kodama
    • , Keizo Kaneko
    • , Junhong Gao
    • , Kenji Uno
    • , Shojiro Sawada
    • , Vladimir V. Kalinichenko
    • , Yasushi Ishigaki
    • , Tetsuya Yamada
    •  & Hideki Katagiri
  • Article | | open

    Viruses are potential vectors for horizontal gene transfer. Here, studying viral infection of sugar beet plants, the authors report the generation of virus-host circular DNA hybrids and provide a picture of the initial steps in virus-mediated horizontal transfer of chromosomal DNA between plant species.

    • Marco Catoni
    • , Emanuela Noris
    • , Anna Maria Vaira
    • , Thomas Jonesman
    • , Slavica Matić
    • , Reihaneh Soleimani
    • , Seyed Ali Akbar Behjatnia
    • , Nestor Vinals
    • , Jerzy Paszkowski
    •  & Gian Paolo Accotto
  • Article | | open

    Ring-opening polymerizations of α-amino acid N-carboxyanhydrides to form polypeptides are usually sensitive to moisture, slow and can undergo side reactions. Here the authors use lithium hexamethyldisilazide to initiate α-amino acid N-carboxyanhydride polymerizations that is very fast and can be conducted in an open vessel.

    • Yueming Wu
    • , Danfeng Zhang
    • , Pengcheng Ma
    • , Ruiyi Zhou
    • , Lei Hua
    •  & Runhui Liu
  • Article | | open

    Bone marrow-derived epithelial cells can be recruited to sites of chronic inflammation. Here, the authors using allogenic bone marrow transplantation in a multistage murine cutaneous carcinogenesis model show that bone marrow-derived epithelial cells and hair follicle stem cells are recruited to cutaneous neoplasms during tumor promotion of carcinogen-exposed skin and bone marrow.

    • Heuijoon Park
    • , Sonali Lad
    • , Kelsey Boland
    • , Kelly Johnson
    • , Nyssa Readio
    • , Guangchun Jin
    • , Samuel Asfaha
    • , Kelly S. Patterson
    • , Ashok Singh
    • , Xiangdong Yang
    • , Douglas Londono
    • , Anupama Singh
    • , Carol Trempus
    • , Derek Gordon
    • , Timothy C. Wang
    •  & Rebecca J. Morris
  • Article | | open

    Optogenetics is a promising alternative approach for restoration of neuromuscular function. Here the authors establish a closed-loop functional optogenetic stimulation for the control of limb joint angle in murine models, which demonstrates improved control and less fatigue than electrical stimulation systems.

    • Shriya S. Srinivasan
    • , Benjamin E. Maimon
    • , Maurizio Diaz
    • , Hyungeun Song
    •  & Hugh M. Herr
  • Article | | open

    Previous descriptions of the charge-transfer absorptions in organic solar cells only involve the charge transfer state and the ground state. Here Chen et al. underline that a third state, i.e., the local absorbing state on the donor and/or acceptor, needs to be considered.

    • Xian-Kai Chen
    • , Veaceslav Coropceanu
    •  & Jean-Luc Brédas
  • Article | | open

    Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.

    • Carlo C. Campa
    • , Rangel L. Silva
    • , Jean P. Margaria
    • , Tracey Pirali
    • , Matheus S. Mattos
    • , Lucas R. Kraemer
    • , Diego C. Reis
    • , Giorgio Grosa
    • , Francesca Copperi
    • , Eduardo M. Dalmarco
    • , Roberto C. P. Lima-Júnior
    • , Silvio Aprile
    • , Valentina Sala
    • , Federica Dal Bello
    • , Douglas Silva Prado
    • , Jose Carlos Alves-Filho
    • , Claudio Medana
    • , Geovanni D. Cassali
    • , Gian Cesare Tron
    • , Mauro M. Teixeira
    • , Elisa Ciraolo
    • , Remo C. Russo
    •  & Emilio Hirsch
  • Article | | open

    Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.

    • Christos Petridis
    • , Alexander A. Navarini
    • , Nick Dand
    • , Jake Saklatvala
    • , David Baudry
    • , Michael Duckworth
    • , Michael H. Allen
    • , Charles J. Curtis
    • , Sang Hyuck Lee
    • , A. David Burden
    • , Alison Layton
    • , Veronique Bataille
    • , Andrew E. Pink
    • , Anton Alexandroff
    • , Alex Anstey
    • , Jaskiran Azad
    • , Omar Aziz
    • , Nigel Burrows
    • , Aamir Butt
    • , Peter Cartwright
    • , Anna Chapman
    • , Timothy H. Clayton
    • , Sandeep Cliff
    • , Tim Cutler
    • , Brigid Daly
    • , Amrit Darvay
    • , Claudia DeGiovanni
    • , Anthony Downs
    • , Colm Dwyer
    • , John English
    • , Adam Ferguson
    • , Colin Fleming
    • , Elizabeth Fraser-Andrews
    • , Mark Goodfield
    • , Clive E. Grattan
    • , Hartmut Hempel
    • , Sue Hood
    • , Bronwyn Hughes
    • , Evmorfia Ladoyanni
    • , Calum Lyon
    • , Ali Mahmud
    • , Moshin Malik
    • , Eleanor Mallon
    • , Simon Meggitt
    • , Andrew Messenger
    • , Yaaseen Moosa
    • , Stephanie Munn
    • , Anthony Ormerod
    • , Deepak Rallan
    • , Janet Ross
    • , Ingrid Salvary
    • , Rachel Wachsmuth
    • , Shyamal Wahie
    • , Shernaz Walton
    • , Sarah Walsh
    • , Diane Williamson
    • , Carolyn Willis
    • , Isabelle Carlavan
    • , Johannes J. Voegel
    • , Timothy D. Spector
    • , Richard C. Trembath
    • , John A. McGrath
    • , Catherine H. Smith
    • , Jonathan N. Barker
    •  & Michael A. Simpson
  • Article | | open

    Locations in the ocean where CO2 naturally seeps from the seafloor can be used to infer potential responses to ocean acidification. Here the authors explore the functional composition of benthic communities along a natural CO2 gradient, showing a loss of functional diversity at high-CO2 sites.

    • Nuria Teixidó
    • , Maria Cristina Gambi
    • , Valeriano Parravacini
    • , Kristy Kroeker
    • , Fiorenza Micheli
    • , Sebastien Villéger
    •  & Enric Ballesteros
  • Article | | open

    Permafrost thaw poses a serious threat to the sustainable development of Arctic communities. Here the authors show that most fundamental Arctic infrastructure and population will be at high hazard risk, even if the Paris Agreement target is achieved.

    • Jan Hjort
    • , Olli Karjalainen
    • , Juha Aalto
    • , Sebastian Westermann
    • , Vladimir E. Romanovsky
    • , Frederick E. Nelson
    • , Bernd Etzelmüller
    •  & Miska Luoto
  • Article | | open

    Short-lived natural bromocarbons, which contribute to ozone depletion in the atmosphere, are believed to be produced through light-driven processes, mainly in oceans. Here the authors present bromocarbon measurements in snow, sea ice, and air during polar winter that show an unexpected source of bromine to the polar atmosphere during periods of no sunlight.

    • Katarina Abrahamsson
    • , Anna Granfors
    • , Martin Ahnoff
    • , Carlos A. Cuevas
    •  & Alfonso Saiz-Lopez