Gaszton Vizsnyiczai et al.

Microengineered 3D motors powered by bacteria and driven by light

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  • Article | | open

    MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes.

    • Yassine Sassi
    • , Petros Avramopoulos
    • , Deepak Ramanujam
    • , Laurenz Grüter
    • , Stanislas Werfel
    • , Simon Giosele
    • , Andreas-David Brunner
    • , Dena Esfandyari
    • , Aikaterini S. Papadopoulou
    • , Bart De Strooper
    • , Norbert Hübner
    • , Regalla Kumarswamy
    • , Thomas Thum
    • , Xiaoke Yin
    • , Manuel Mayr
    • , Bernhard Laggerbauer
    •  & Stefan Engelhardt
  • Article | | open

    Expanding the scope of materials for spin caloritronics enhances the opportunity to achieve more energy efficient memory and sensor devices. Here the authors report the tunnel magneto-Seebeck effects in magnetic tunnel junctions with Co2FeAl and Co2FeSi Heusler compounds.

    • Alexander Boehnke
    • , Ulrike Martens
    • , Christian Sterwerf
    • , Alessia Niesen
    • , Torsten Huebner
    • , Marvin von der Ehe
    • , Markus Meinert
    • , Timo Kuschel
    • , Andy Thomas
    • , Christian Heiliger
    • , Markus Münzenberg
    •  & Günter Reiss
  • Article | | open

    The mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift with puberty onset.

    • Bhupinder Pal
    • , Yunshun Chen
    • , François Vaillant
    • , Paul Jamieson
    • , Lavinia Gordon
    • , Anne C. Rios
    • , Stephen Wilcox
    • , Naiyang Fu
    • , Kevin He Liu
    • , Felicity C. Jackling
    • , Melissa J. Davis
    • , Geoffrey J. Lindeman
    • , Gordon K. Smyth
    •  & Jane E. Visvader
  • Article | | open

    CRISPR-Cas9 systems are being continually improved to enhance specificity and improve functionality. Here the authors design hybrid DNA-RNA guide and tracr molecules to direct Cas9 nuclease activity with reduced off-target effects.

    • Fernando Orden Rueda
    • , Michal Bista
    • , Matthew D. Newton
    • , Anne U. Goeppert
    • , M. Emanuela Cuomo
    • , Euan Gordon
    • , Felix Kröner
    • , Jon A. Read
    • , Jonathan D. Wrigley
    • , David Rueda
    •  & Benjamin J. M. Taylor
  • Article | | open

    The mechanisms behind deformation of multiphase solids are elusive. Here, the authors use X-rays and simulations to show that the same mechanisms causing rocks to fold occur at the micrometer scale in dual-metal lamellas of Ag/Cu and Al/Cu under high-pressure torsion, leading to vortices formation.

    • Mohsen Pouryazdan
    • , Boris J. P. Kaus
    • , Alexander Rack
    • , Alexey Ershov
    •  & Horst Hahn
  • Article | | open

    In Streptococcus pneumoniae, competence for genetic transformation is accompanied by a pause in growth. Here, Bergé et al. show that this pause is linked to the cell cycle via at least two pathways that impair peptidoglycan synthesis and preserve genomic integrity during transformation.

    • Matthieu J. Bergé
    • , Chryslène Mercy
    • , Isabelle Mortier-Barrière
    • , Michael S. VanNieuwenhze
    • , Yves V. Brun
    • , Christophe Grangeasse
    • , Patrice Polard
    •  & Nathalie Campo

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