Toshiya Ando et al.

Genetic basis for colour patterns of ladybird beetles

Latest Research

Physical Sciences

  • Article | | open

    Gradient-based hybrid quantum-classical algorithms are often initialised with random, unstructured guesses. Here, the authors show that this approach will fail in the long run, due to the exponentially-small probability of finding a large enough gradient along any direction.

    • Jarrod R. McClean
    • , Sergio Boixo
    • , Vadim N. Smelyanskiy
    • , Ryan Babbush
    •  & Hartmut Neven
  • Article | | open

    Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.

    • Ting Zhou
    • , Tae Wan Kim
    • , Chi Nok Chong
    • , Lei Tan
    • , Sadaf Amin
    • , Zohreh Sadat Badieyan
    • , Suranjit Mukherjee
    • , Zaniar Ghazizadeh
    • , Hui Zeng
    • , Min Guo
    • , Miguel Crespo
    • , Tuo Zhang
    • , Reyn Kenyon
    • , Christopher L. Robinson
    • , Effie Apostolou
    • , Hui Wang
    • , Jenny Zhaoying Xiang
    • , Todd Evans
    • , Lorenz Studer
    •  & Shuibing Chen
  • Article | | open

    Irradiating iron introduces defects such as interstitial dislocation loops, whose exact formation mechanism remains unclear. Here, the authors use large scale molecular dynamics simulations to reveal a punch out mechanism that can directly create < 100 > interstitial dislocation loops.

    • Qing Peng
    • , Fanjiang Meng
    • , Yizhong Yang
    • , Chenyang Lu
    • , Huiqiu Deng
    • , Lumin Wang
    • , Suvranu De
    •  & Fei Gao

Earth and environmental sciences

  • Article | | open

    Water based inks used for water-jet rewritable paper (WJRP) are an environmental friendly alternative to conventional printing, but black colour in WJRP could not be realized so far. Here the authors demonstrate black as well as other colour WJRP based on binary systems containing less-sensitive acidochromic dyes and mild proton donors.

    • Guan Xi
    • , Lan Sheng
    • , Jiahui Du
    • , Jinyan Zhang
    • , Minjie Li
    • , Hongze Wang
    • , Yufei Ma
    •  & Sean Xiao-An Zhang
  • Article | | open

    A challenge for mutualists is that partner cue reliability is often low. Here, the authors show that though fruit brightness is weakly predictive of nutritional content, the diets of birds (e.g. migrants vs. residents) are structured by fruit brightness in alignment with expected nutritional needs.

    • Jörg Albrecht
    • , Jonas Hagge
    • , Dana G. Schabo
    • , H. Martin Schaefer
    •  & Nina Farwig
  • Article | | open

    The Paris Agreement includes bottom-up pledges and top-down warming threshold. Under this setting where countries effectively choose their own fairness principle, this article assesses the global warming implied by each Nationally Determined Contribution to inform the future ratcheting-up process.

    • Yann Robiou du Pont
    •  & Malte Meinshausen

Biological sciences

  • Article | | open

    Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy.

    • Wei-Chien Yuan
    • , Brian Pepe-Mooney
    • , Giorgio G. Galli
    • , Michael T. Dill
    • , Hai-Tsang Huang
    • , Mingfeng Hao
    • , Yumeng Wang
    • , Han Liang
    • , Raffaele A. Calogero
    •  & Fernando D. Camargo
  • Article | | open

    DNA2 encodes a 5′ flap DNA endonuclease involved in replication and DNA double strand break processing. Here the authors by using a conditional degron system together with electron microscopy characterize the role played by Dna2 and Pif1 helicase during unperturbed DNA replication in S. cerevisiae.

    • Silvia Emma Rossi
    • , Marco Foiani
    •  & Michele Giannattasio
  • Article | | open

    Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.

    • Ting Zhou
    • , Tae Wan Kim
    • , Chi Nok Chong
    • , Lei Tan
    • , Sadaf Amin
    • , Zohreh Sadat Badieyan
    • , Suranjit Mukherjee
    • , Zaniar Ghazizadeh
    • , Hui Zeng
    • , Min Guo
    • , Miguel Crespo
    • , Tuo Zhang
    • , Reyn Kenyon
    • , Christopher L. Robinson
    • , Effie Apostolou
    • , Hui Wang
    • , Jenny Zhaoying Xiang
    • , Todd Evans
    • , Lorenz Studer
    •  & Shuibing Chen

Health sciences

  • Article | | open

    Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy.

    • Wei-Chien Yuan
    • , Brian Pepe-Mooney
    • , Giorgio G. Galli
    • , Michael T. Dill
    • , Hai-Tsang Huang
    • , Mingfeng Hao
    • , Yumeng Wang
    • , Han Liang
    • , Raffaele A. Calogero
    •  & Fernando D. Camargo
  • Article | | open

    Little is known about developmental set points of immune responses, especially in humans. Here the authors show that the metabolic state of monocytes isolated from prematurely born infants underlies attenuated responsiveness to fungal infection via selective control of protein translation.

    • Bernard Kan
    • , Christina Michalski
    • , Helen Fu
    • , Hilda H. T. Au
    • , Kelsey Lee
    • , Elizabeth A. Marchant
    • , Maye F. Cheng
    • , Emily Anderson-Baucum
    • , Michal Aharoni-Simon
    • , Peter Tilley
    • , Raghavendra G. Mirmira
    • , Colin J. Ross
    • , Dan S. Luciani
    • , Eric Jan
    •  & Pascal M. Lavoie
  • Article | | open

    The AR-V7 isoform is associated with anti-androgen drug resistance in prostate cancer. Here, the authors show that AR-V7 protein stability is regulated by HSP70/STUB1 complex-mediated proteostasis which confers drug resistance in late stage prostate cancer. Inhibition of HSP70 re-sensitizes resistant cells to enzalutamide therapy.

    • Chengfei Liu
    • , Wei Lou
    • , Joy C. Yang
    • , Liangren Liu
    • , Cameron M. Armstrong
    • , Alan P. Lombard
    • , Ruining Zhao
    • , Onika D. V. Noel
    • , Clifford G. Tepper
    • , Hong-Wu Chen
    • , Marc Dall’Era
    • , Christopher P. Evans
    •  & Allen C. Gao

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