Alasdair H. Fikouras et al.

Non-obstructive intracellular nanolasers

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  • Article | | open

    The impacts of climate change on summer carbon cycling in the northern hemisphere remain poorly resolved. Here the authors use atmospheric CO2 records from Point Barrow (Alaska) to show that summer CO2 drawdown is significantly negatively correlated with terrestrial temperature north of 50°N between 1979–2012.

    • Tao Wang
    • , Dan Liu
    • , Shilong Piao
    • , Yilong Wang
    • , Xiaoyi Wang
    • , Hui Guo
    • , Xu Lian
    • , John F Burkhart
    • , Philippe Ciais
    • , Mengtian Huang
    • , Ivan Janssens
    • , Yue Li
    • , Yongwen Liu
    • , Josep Peñuelas
    • , Shushi Peng
    • , Hui Yang
    • , Yitong Yao
    • , Yi Yin
    •  & Yutong Zhao
  • Article | | open

    The causes of Mid-Pleistocene Transition global cooling 1 million years ago are still unknown. Here, the authors find the subarctic North Pacific became stratified during these glaciations due to closure of the Bering Strait, which would have removed CO2 from the atmosphere and caused global cooling.

    • Sev Kender
    • , Ana Christina Ravelo
    • , Savannah Worne
    • , George E. A. Swann
    • , Melanie J. Leng
    • , Hirofumi Asahi
    • , Julia Becker
    • , Henrieka Detlef
    • , Ivano W. Aiello
    • , Dyke Andreasen
    •  & Ian R. Hall
  • Article | | open

    Weaker ferritic/matensitic steels rather than stronger austenitic steels are usually candidates for nuclear reactors since they do not easily swell under irradiation. Here, the authors make an ultrastrong lanthanum-doped nanocrystalline austenitic steel that is thermally stable and radiation-tolerant.

    • Congcong Du
    • , Shenbao Jin
    • , Yuan Fang
    • , Jin Li
    • , Shenyang Hu
    • , Tingting Yang
    • , Ying Zhang
    • , Jianyu Huang
    • , Gang Sha
    • , Yugang Wang
    • , Zhongxia Shang
    • , Xinghang Zhang
    • , Baoru Sun
    • , Shengwei Xin
    •  & Tongde Shen
  • Article | | open

    The impacts of climate change on summer carbon cycling in the northern hemisphere remain poorly resolved. Here the authors use atmospheric CO2 records from Point Barrow (Alaska) to show that summer CO2 drawdown is significantly negatively correlated with terrestrial temperature north of 50°N between 1979–2012.

    • Tao Wang
    • , Dan Liu
    • , Shilong Piao
    • , Yilong Wang
    • , Xiaoyi Wang
    • , Hui Guo
    • , Xu Lian
    • , John F Burkhart
    • , Philippe Ciais
    • , Mengtian Huang
    • , Ivan Janssens
    • , Yue Li
    • , Yongwen Liu
    • , Josep Peñuelas
    • , Shushi Peng
    • , Hui Yang
    • , Yitong Yao
    • , Yi Yin
    •  & Yutong Zhao
  • Article | | open

    The causes of Mid-Pleistocene Transition global cooling 1 million years ago are still unknown. Here, the authors find the subarctic North Pacific became stratified during these glaciations due to closure of the Bering Strait, which would have removed CO2 from the atmosphere and caused global cooling.

    • Sev Kender
    • , Ana Christina Ravelo
    • , Savannah Worne
    • , George E. A. Swann
    • , Melanie J. Leng
    • , Hirofumi Asahi
    • , Julia Becker
    • , Henrieka Detlef
    • , Ivano W. Aiello
    • , Dyke Andreasen
    •  & Ian R. Hall
  • Article | | open

    Credibility of long-term projection in quantitative models is continuously under debate and they rely on validation to prove projection accuracy. Here the authors investigated the views on the validation approaches and they show that empirical data plays an important role in the validation practice in all main areas of sustainability science.

    • Sibel Eker
    • , Elena Rovenskaya
    • , Michael Obersteiner
    •  & Simon Langan
  • Article | | open

    The impacts of climate change on summer carbon cycling in the northern hemisphere remain poorly resolved. Here the authors use atmospheric CO2 records from Point Barrow (Alaska) to show that summer CO2 drawdown is significantly negatively correlated with terrestrial temperature north of 50°N between 1979–2012.

    • Tao Wang
    • , Dan Liu
    • , Shilong Piao
    • , Yilong Wang
    • , Xiaoyi Wang
    • , Hui Guo
    • , Xu Lian
    • , John F Burkhart
    • , Philippe Ciais
    • , Mengtian Huang
    • , Ivan Janssens
    • , Yue Li
    • , Yongwen Liu
    • , Josep Peñuelas
    • , Shushi Peng
    • , Hui Yang
    • , Yitong Yao
    • , Yi Yin
    •  & Yutong Zhao
  • Article | | open

    How DNA repair proteins locate their target sites on DNA is still a matter of debate. Here the authors characterize by single-molecule fluorescence imaging the modes of scanning adopted by bacterial endonuclease V as it moves along linear DNA tracks.

    • Arash Ahmadi
    • , Ida Rosnes
    • , Pernille Blicher
    • , Robin Diekmann
    • , Mark Schüttpelz
    • , Kyrre Glette
    • , Jim Tørresen
    • , Magnar Bjørås
    • , Bjørn Dalhus
    •  & Alexander D. Rowe
  • Article | | open

    Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.

    • Michael C. Schmid
    • , Samia Q. Khan
    • , Megan M. Kaneda
    • , Paulina Pathria
    • , Ryan Shepard
    • , Tiani L. Louis
    • , Sudarshan Anand
    • , Gyunghwi Woo
    • , Chris Leem
    • , M. Hafeez Faridi
    • , Terese Geraghty
    • , Anugraha Rajagopalan
    • , Seema Gupta
    • , Mansoor Ahmed
    • , Roberto I. Vazquez-Padron
    • , David A. Cheresh
    • , Vineet Gupta
    •  & Judith A. Varner
  • Article | | open

    Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.

    • Michael C. Schmid
    • , Samia Q. Khan
    • , Megan M. Kaneda
    • , Paulina Pathria
    • , Ryan Shepard
    • , Tiani L. Louis
    • , Sudarshan Anand
    • , Gyunghwi Woo
    • , Chris Leem
    • , M. Hafeez Faridi
    • , Terese Geraghty
    • , Anugraha Rajagopalan
    • , Seema Gupta
    • , Mansoor Ahmed
    • , Roberto I. Vazquez-Padron
    • , David A. Cheresh
    • , Vineet Gupta
    •  & Judith A. Varner
  • Article | | open

    SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.

    • Konstantinos Tzelepis
    • , Etienne De Braekeleer
    • , Demetrios Aspris
    • , Isaia Barbieri
    • , M. S. Vijayabaskar
    • , Wen-Hsin Liu
    • , Malgorzata Gozdecka
    • , Emmanouil Metzakopian
    • , Hamish D. Toop
    • , Monika Dudek
    • , Samuel C. Robson
    • , Francisco Hermida-Prado
    • , Yu Hsuen Yang
    • , Roya Babaei-Jadidi
    • , Dimitrios A. Garyfallos
    • , Hannes Ponstingl
    • , Joao M. L. Dias
    • , Paolo Gallipoli
    • , Michael Seiler
    • , Silvia Buonamici
    • , Binje Vick
    • , Andrew J. Bannister
    • , Roland Rad
    • , Rab K. Prinjha
    • , John C. Marioni
    • , Brian Huntly
    • , Jennifer Batson
    • , Jonathan C. Morris
    • , Cristina Pina
    • , Allan Bradley
    • , Irmela Jeremias
    • , David O. Bates
    • , Kosuke Yusa
    • , Tony Kouzarides
    •  & George S. Vassiliou

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