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Nature Communications is an open access journal that publishes high-quality research in biology, physics, chemistry, Earth sciences, and all related areas.

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  • Article | | open

    Identifying gene subsets affecting disease phenotypes from transcriptome data is challenge. Here, the authors develop a method that combines transcriptional data with disease ordinal clinical measurements to discover a sphingolipid metabolism regulator involving in Huntington’s disease progression.

    • Leila Pirhaji
    • , Pamela Milani
    • , Simona Dalin
    • , Brook T. Wassie
    • , Denise E. Dunn
    • , Robert J. Fenster
    • , Julian Avila-Pacheco
    • , Paul Greengard
    • , Clary B. Clish
    • , Myriam Heiman
    • , Donald C. Lo
    •  & Ernest Fraenkel
  • Article | | open

    Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease. Here, Wray and colleagues identify association of the GPX3-TNIP1 locus with ALS using cross-ethnic meta-analyses.

    • Beben Benyamin
    • , Ji He
    • , Qiongyi Zhao
    • , Jacob Gratten
    • , Fleur Garton
    • , Paul J. Leo
    • , Zhijun Liu
    • , Marie Mangelsdorf
    • , Ammar Al-Chalabi
    • , Lisa Anderson
    • , Timothy J. Butler
    • , Lu Chen
    • , Xiang-Ding Chen
    • , Katie Cremin
    • , Hong-Weng Deng
    • , Matthew Devine
    • , Janette Edson
    • , Jennifer A. Fifita
    • , Sarah Furlong
    • , Ying-Ying Han
    • , Jessica Harris
    • , Anjali K. Henders
    • , Rosalind L. Jeffree
    • , Zi-Bing Jin
    • , Zhongshan Li
    • , Ting Li
    • , Mengmeng Li
    • , Yong Lin
    • , Xiaolu Liu
    • , Mhairi Marshall
    • , Emily P. McCann
    • , Bryan J. Mowry
    • , Shyuan T. Ngo
    • , Roger Pamphlett
    • , Shu Ran
    • , David C. Reutens
    • , Dominic B. Rowe
    • , Perminder Sachdev
    • , Sonia Shah
    • , Sharon Song
    • , Li-Jun Tan
    • , Lu Tang
    • , Leonard H. Berg
    • , Wouter Rheenen
    • , Jan H. Veldink
    • , Robyn H. Wallace
    • , Lawrie Wheeler
    • , Kelly L. Williams
    • , Jinyu Wu
    • , Xin Wu
    • , Jian Yang
    • , Weihua Yue
    • , Zong-Hong Zhang
    • , Dai Zhang
    • , Peter G. Noakes
    • , Ian P. Blair
    • , Robert D. Henderson
    • , Pamela A. McCombe
    • , Peter M. Visscher
    • , Huji Xu
    • , Perry F. Bartlett
    • , Matthew A. Brown
    • , Naomi R. Wray
    •  & Dongsheng Fan
  • Article | | open

    Anthracenols with multiple chiral centres are common motifs in natural products. Here, the authors show a highly stereoselective photoenolization/Diels–Alder methodology involving a key Lewis acid reagent enabling the efficient construction of a family of anthracenol derivatives with quaternary centers.

    • Baochao Yang
    • , Kuaikuai Lin
    • , Yingbo Shi
    •  & Shuanhu Gao
  • Article | | open

    Strain engineering is an essential tool for modifying local electronic properties in silicon-based electronics. Here, Ahn et al. demonstrate control of biaxial strain in two-dimensional materials based on the growth substrate, enabling more complex low-dimensional electronics.

    • Geun Ho Ahn
    • , Matin Amani
    • , Haider Rasool
    • , Der-Hsien Lien
    • , James P. Mastandrea
    • , Joel W. Ager III
    • , Madan Dubey
    • , Daryl C. Chrzan
    • , Andrew M. Minor
    •  & Ali Javey
  • Article | | open

    Post-translational modifications can affect antibody function in health and disease, but identification of all variants is difficult using existing technologies. Here the authors develop a microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs can be used as biomarkers for rheumatoid arthritis.

    • Jing-Rong Wang
    • , Wei-Na Gao
    • , Rudolf Grimm
    • , Shibo Jiang
    • , Yong Liang
    • , Hua Ye
    • , Zhan-Guo Li
    • , Lee-Fong Yau
    • , Hao Huang
    • , Ju Liu
    • , Min Jiang
    • , Qiong Meng
    • , Tian-Tian Tong
    • , Hai-Hui Huang
    • , Stephanie Lee
    • , Xing Zeng
    • , Liang Liu
    •  & Zhi-Hong Jiang

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