• Featured this month

    • January 2007

      • Biotechnology

        • Practical pharmacology: Getting under the skin Open !

          Kaspar Mossman

          Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-1

          Original article citation:

          Chen, Y. et al. Transdermal protein delivery by a coadministered peptide identified via phage display. Nature Biotech. 24, 455–460 (2006).

        • Environmental detoxification: Green clean-up by root therapy

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-19

          Original article citation:

          Wang, G.-D. et al. Ex planta phytoremediation of trichlorophenol and phenolic allelochemicals via an engineered secretory laccase. Nature Biotechnol. 22, 893–897 (2004).

      • Cell & molecular biology

        • Cellular signalling pathways: Axin as a scaffold Open !

          Dangsheng Li

          Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-2

          Original article citation:

          Liu, W. et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25, 1646–1658 (2006).

        • Vascular proliferation: A novel regulator

          Dangsheng Li

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-10

          Original article citation:

          Chen, K.-H. et al. Dysregulation of HSG triggers vascular proliferative disorders. Nature Cell Biol. 6, 872–883 (2004).

        • Innate immunity: SIKE suppresses anti-viral responses

          Dangsheng Li

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-12

          Original article citation:

          Huang, J. et al. SIKE is an IKK /TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 24, 4018–4028 (2005).

        • Supramolecular structure: March to the scaffold

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-16

          Original article citation:

          Feng, W., Long, J.-F., Fan, J.-S., Suetake, T. & Zhang, M. The tetrameric L27 domain complex as an organization platform for supramolecular assemblies. Nature Struct. Mol. Biol. 11, 475–480 (2004).

        • Protein domains: X11 swallows its tail

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-18

          Original article citation:

          Long, J.-F. et al. Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. Nature Struct. Mol. Biol. 12, 722–728 (2005).

        • Neuron growth: Cellular body sculpture

          Marie-Therese Heemels

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-2

          Original article citation:

          Jiang, H. et al. Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3β and its upstream regulators. Cell 120, 123–135 (2005).

        • The SARS coronavirus: Channelling RNA

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-24

          Original article citation:

          Zhai, Y. J. et al. Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamer. Nature Struct. Mol. Biol. 12, 980–986 (2005).

        • Tumor suppressors: Axin helps p53

          Dangsheng Li

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-36

          Original article citation:

          Rui, Y. et al. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23, 4583–4594 (2004).

        • Protein structure: Split domains get together

          Dangsheng Li

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-37

          Original article citation:

          Yan, J. et al. Structure of the split PH domain and distinct lipid-binding properties of the PH–PDZ supramodule of alpha-syntrophin. EMBO J. 24, 3985–3995 (2005).

      • Chemistry

        • Catalysis: Mirror, mirror, who's the most selective? Open !

          Kaspar Mossman

          Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-3

          Original article citation:

          Tang, Z. et al. A Highly Efficient Organocatalyst for Direct Aldol Reactions of Ketones with Aldedydes. J. Am. Chem. Soc. 125, 9285–9289 (2005).

        • Chiral selectivity: Baylis-Hillman reactions

          Magdalena Helmer

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-3

          Original article citation:

          Shi, M. , Chen, L. H. & Li, C. Q. Chiral phosphine lewis bases catalyzed asymmetric aza-Baylis-Hiliman reaction of N-sulfonated imines with activated olefins. J. Am. Chem. Soc. 127, 3790–3800 (2005).

        • Organometallic chemistry: Two to tango

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-8

          Original article citation:

          Tao, J., Tong, M.-L. &  Chen, X.-M. Hydrothermal synthesis and crystal structures of three-dimensional co-ordination frameworks constructed with mixed terephthalate (tp) and 4,4'-bipyridine (4,4'-bipy) ligands: [M(tp)(4,4'-bipy)] (M = CoII, CdII or ZnII). J. Chem. Soc. Dalton Trans. 3669–3674 (2000).

      • Clinical medicine

        • Aspirin resistance: Patients risk cell death

          John Fox

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-11

          Original article citation:

          Chen, W.H. , Lee, P. Y. , Ng, W. , Tse, H. F. & Lau, C. P. Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment. J. Am. Coll. Cardiol. 43, 1122–1126 (2004).

        • Case study: Bowel blood loss

          Jim Casey

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-14

          Original article citation:

          Chan, A. O. & Lai, K. C. A patient with long-standing iron-deficient anemia. Nature Clin. Pract. Gastroenterol. Hepatol. 3, 112–116 (2006).

        • Cancer research: The kindness of strangers

          Jim Casey

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-21

          Original article citation:

          Wei, Y. Q. et al. Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nature Med. 6, 1160–1166 (2000).

        • Case study: Lymph-node tumours

          Jim Casey

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-35

          Original article citation:

          Liu, J. et al. COX2-related multicentric mixed-type Castleman's disease in a young man. Nature Clin. Pract. Oncol. 2, 370–375 (2005).

        • Kidney disease: Slowing progression with allopurinol

          Rachael Williams

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-4

          Original article citation:

          Siu, Y.-P. et al. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am. J. Kidney Dis. 47, 51–59 (2006).

        • Cholesterol therapy: Stable reception

          Jim Casey

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-44

          Original article citation:

          Kong, W. J. et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Med. 10, 1344–1351 (2004).

        • Advanced renal disease: Safe and effective benazepril

          John Fox

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-6

          Original article citation:

          Hou, F. F. et al. Efficacy and safety of Benazepril for advanced chronic renal insufficiency. N. Engl. J. Med. 354, 131–40 (2006).

        • Virus detection: Catch SARS early

          Dangsheng Li

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-9

          Original article citation:

          Poon, L. L. et al. A one step quantitative RT-PCR for detection of SARS coronavirus with an internal control for PCR inhibitors. J. Clin. Virol. 30, 214–217 (2004).

      • Developmental biology

      • Earth & environment

        • Atmospheric mercury: How clean is the air you breathe? Open !

          Nicki Stevens

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-1

          Original article citation:

          Feng, X. B. et al. Total gaseous mercury emissions from soil in Guiyang, Guizhou, China. J. Geophys. Res. Atmos. 110, D14306 (2005).

        • Plate tectonics: Journeys to the deep

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-32

          Original article citation:

          Ye, K., Cong, B. & Ye, D. The possible subduction of continental material to depths greater than 200 km. Nature 407, 734–736 (2000).

        • Desertification: Dusty deposits show their age

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-33

          Original article citation:

          Guo, Z. T. et al. Onset of Asian desertification by 22 Myr ago inferred from loess deposits in China. Nature 416, 159–163 (2002).

      • Ecology & evolution

        • Ancient fishes: A real bonehead Open !

          Kaspar Mossman

          Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-6

          Original article citation:

          Zhu, M., Yu, X., Wang, W., Zhao, W. & Jia, L. A primitive fish provides key characters bearing on deep osteichthyan phylogeny. Nature 441, 77–80 (2006).

        • Fossilized behaviour: Let sleeping dragons lie

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-20

          Original article citation:

          Xu, X. & Norell, M. A. A new troodontid dinosaur from China with avian-like sleeping posture. Nature 431, 838–841 (2004).

        • Early oviraptorosaurs: Rare as hen's teeth

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-23

          Original article citation:

          Xu, X. et al. An unusual oviraptorosaurian dinosaur from China. Nature 419, 291–293 (2002).

        • Biodiversity: The more the merrier

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-29

          Original article citation:

          Bai, Y., Han, X., Wu, J., Chen, Z. & Li, L. Ecosystem stability and compensatory effects in the Inner Mongolia grassland. Nature 431, 181–184 (2004).

        • Primates: An eye for a good meal

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-30

          Original article citation:

          Dominy, N. J. & Lucas, P. W. Ecological importance of trichromatic vision to primates. Nature 410, 363–366 (2001).

        • Early humans: Race across Asia

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-34

          Original article citation:

          Zhu, R. X. et al. New evidence on the earliest human presence at high northern latitudes in northeast Asia. Nature 431, 559–562 (2004).

        • Cretaceous lampreys: A sucker for blood

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-38

          Original article citation:

          Chang, M.-M., Zhang, J. & Miao, D. A lamprey from the Cretaceous Jehol biota of China. Nature 441, 972–974 (2006).

        • Fossil embryos: Arrested development

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-39

          Original article citation:

          Dong, X.-P., Donoghue, P. C. J., Cheng, H. & Liu, J.-B. Fossil embryos from the Middle and Late Cambrian period of Hunan, south China. Nature 427, 237–240 (2004).

        • Cambrian fossils: Dwellers of the primordial ooze

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-40

          Original article citation:

          Shu, D.-G. et al. Primitive deuterostomes from the Chengjiang Lagerstätte. Nature 414, 419–424 (2001).

        • Cambrian fossils: Stationary bodies

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-41

          Original article citation:

          Shu, D.-G., Conway Morris, S., Han, J., Zhang, Z.-F. & Liu, J.-N. Ancestral echinoderms from the Chengjiang deposits of China. Nature 430, 422–428 (2002).

        • Population change: Antarctic archive of penguin poop

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-42

          Original article citation:

          Sun, L., Xie, Z. & Zhao, J. Palaeoecology: A 3,000-year record of penguin populations. Nature 407, 858 (2000).

        • Cambrian tunicates: Stuck on you

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-43

          Original article citation:

          Shu, D.-G., Chen, L., Han, J. & Zhang, X.-L. An Early Cambrian tunicate from China. Nature 411, 472–473 (2001).

        • Bodyplan evolution: The migrating nostril

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-45

          Original article citation:

          Zhu, M. & Ahlberg, P. E. The origin of the internal nostril of tetrapods. Nature 432, 94–97 (2004).

        • Dromaeosaurs: Smallest non-avian dinosaur

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-46

          Original article citation:

          Xu, X., Zhou, Z. & Wang, X. The smallest known non-avian theropod dinosaur. Nature 408, 705–708 (2000).

        • Palaeoichthyology: Fish out of water

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-50

          Original article citation:

          Zhu, M. & Yu, X. A primitive fish close to the common ancestor of tetrapods and lungfish. Nature 418, 767–770 (2002).

        • Paleornithology: Telling tails

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-51

          Original article citation:

          Zhou, Z. & Zhang, F. A long-tailed, seed-eating bird from the Early Cretaceous of China. Nature 418, 405–409 (2002).

        • Early amphibians: Four legs good

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-52

          Original article citation:

          Zhu, M. , Ahlberg, P. E. , Zhao, W. & Jia, L. Palaeontology: First Devonian tetrapod from Asia. Nature 420, 760–761 (2002).

        • Bird-like dinosaurs: Two wings good, four wings better

          Kaspar Mossman

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.071118-22

          Original article citation:

          Xu, X. et al. Four-winged dinosaurs from China. Nature 421, 335–340 (2003).

      • Genetics

        • Han genetics: Men move south

          Lucy Heady

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-48

          Original article citation:

          Wen, B. et al. Genetic evidence supports demic diffusion of Han culture. Nature 431, 302–305 (2004).

      • Materials

        • Planar C60 arrays: The new order

          Lucy Heady

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-25

          Original article citation:

          Hou, J. G. et al. Surface science: Topology of two-dimensional C60 domains. Nature 409, 304–305 (2001).

        • Mechanical properties: Stretchy silk reveals disorder

          Lucy Heady

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-26

          Original article citation:

          Liu, Y. Shao Z. & Vollrath, F. Relationships between supercontraction and mechanical properties of spider silk. Nature Mater. 4, 901–905 (2005).

        • Carbon nanotubes: As long as a piece of string

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-31

          Original article citation:

          Jiang, K., Li, Q. & Fan, S. Nanotechnology: Spinning continuous carbon nanotube yarns. Nature 419, 801 (2002).

        • Nanotechnology: Make your own diamond

          Lucy Heady

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-47

          Original article citation:

          Lifshitz, Y. et al. Nanostructure: Epitaxial diamond polytypes on silicon. Nature 412, 404 (2001).

        • Nanotubes: Tiny tubes reach the limit

          Lucy Heady

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-49

          Original article citation:

          Wang, N., Tang, Z. K., Li, G. D. & Chen, J. S. Materials science: Single-walled 4 Å carbon nanotube arrays. Nature 408, 50–51 (2000).

        • Integrated photonics: A nanoscale army

          Joerg Heber

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-5

          Original article citation:

          Jie, J. et al. Synthesis and optical properties of well-aligned ZnO nanorod array on an undoped ZnO film. Appl. Phys. Lett. 86, 031909 (2005).

        • Nanomaterials: Stretching the limits

          Tim Reid

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-7

          Original article citation:

          Lu, L. et al. Superplastic extensibility of nanocrystalline copper at room temperature. Science 287, 1463–1466 (2000).

      • Neuroscience

        • Dyslexia in Chinese: Thinking in tongues Open !

          Kaspar Mossman

          Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-4

          Original article citation:

          Siok, W. T. et al. Biological abnormality of impaired reading is constrained by culture. Nature 431, 71–76 (2004).

      • Space & astronomy

        • Earth's magnetosphere: Outstanding in the field Open !

          Tim Reid

          Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-5

          Original article citation:

          Xiao, C. J. et al. In situ evidence for the structure of the magnetic null in a 3D reconnection event in the Earth's magnetotail. Nature Phys. 2, 478–483 (2006).

        • Gamma-ray bursts: When two become one

          Paul Hanlon

          Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-27

          Original article citation:

          Dai, Z. G., Wang, X. Y., Wu, X. F. & Zhang, B. X-ray Flares from Postmerger Millisecond Pulsars. Science 311, 1127–1129 (2006).

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