• Archive: Genetics

    • Genetics 2009 Research Highlights

      • Genomics: The greatest thing since sliced cucumber Open !

        Felix Cheung

        Published online: 11 November 2009 | doi:10.1038/nchina.2009.219

        Original article citation:

        Huang, S. et al. The genome of the cucumber, Cucumis sativus L. Nature Genet. doi:10.1038/ng.475 (2009).

      • Immunology: Decoding multiple sclerosis Open !

        Felix Cheung

        Published online: 28 October 2009 | doi:10.1038/nchina.2009.208

        Original article citation:

        Du, C. et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nature Immunol. doi:10.1038/ni.1798 (2009).

      • Dermatology: Newly discovered lupus loci Open !

        Felix Cheung

        Published online: 28 October 2009 | doi:10.1038/nchina.2009.210

        Original article citation:

        Han, J. W. et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nature Genet. doi:10.1038/ng.472 (2009).

      • Neurology: Memory unlocked

        Felix Cheung

        Published online: 14 October 2009 | doi:10.1038/nchina.2009.202

        Original article citation:

        Zhou, S. J. et al. Preferential enhancement of working memory in mice lacking adenosine A2A receptors. Brain Res. doi:10.1016/j.brainres.2009.09.082 (2009).

      • Genomics: Silkworm secrets Open !

        Felix Cheung

        Published online: 16 September 2009 | doi:10.1038/nchina.2009.183

        Original article citation:

        Xia, Q. et al. Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science doi:10.1126/science.1176620 (2009).

      • Cardiology: Heart therapy Open !

        Felix Cheung

        Published online: 02 September 2009 | doi:10.1038/nchina.2009.174

        Original article citation:

        Ding, L. et al. Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction. Circulation doi:10.1161/CIRCULATIONAHA.109.870725 (2009).

      • Genomics: Mere differences

        Felix Cheung

        Published online: 02 September 2009 | doi:10.1038/nchina.2009.175

        Original article citation:

        Han, Y. et al. Centromere repositioning in cucurbit species: Implication of the genomic impact from centromere activation and inactivation. Proc. Natl Acad. Sci. doi:10.1073/pnas.0904833106 (2009).

      • Medical genetics: Key to longevity Open !

        Felix Cheung

        Published online: 19 August 2009 | doi:10.1038/nchina.2009.166

        Original article citation:

        Cai, X. Y. et al. Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. PLoS ONE 4, e6423 (2009).

      • Genomics: Parasitic flatworms deciphered

        Felix Cheung

        Published online: 29 July 2009 | doi:10.1038/nchina.2009.154

        Original article citation:

        Zhou, Y. et al. The Schistosoma japonicum genome reveals features of host–parasite interplay. Nature doi:10.1038/nature08140 (2009).

      • Infectious diseases: Swine flu origin unwrapped Open !

        Felix Cheung

        Published online: 24 June 2009 | doi:10.1038/nchina.2009.133

        Original article citation:

        Smith, G. J. D. et al. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature doi:10.1038/nature08182 (2009).

      • Sequencing technology: Snappy snippets Open !

        Felix Cheung

        Published online: 17 June 2009 | doi:10.1038/nchina.2009.129

        Original article citation:

        Li, R. et al. SNP detection for massively parallel whole-genome resequencing. Genome Res. doi:10.1101/gr.088013.108 (2009).

      • Metabolism: Goose liver tells a big fat story

        Felix Cheung

        Published online: 27 May 2009 | doi:10.1038/nchina.2009.115

        Original article citation:

        Han, C. et al. The role of insulin and glucose in goose primary hepatocyte triglyceride accumulation. J. Exp. Biol. 212, 1553–1558 (2009).

      • Oncology: Stress factors Open !

        Felix Cheung

        Published online: 20 May 2009 | doi:10.1038/nchina.2009.113

        Original article citation:

        Shi, H. et al. Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. Am. J. Hum. Genet. 84, 534–541 (2009).

      • Extremophile biology: Shrimp shield

        Felix Cheung

        Published online: 13 May 2009 | doi:10.1038/nchina.2009.95

        Original article citation:

        Liu, Y. L., Zhao, Y., Dai, Z. M., Chen, H. M. & Yang, W. J. Formation of diapause cyst shell in brine shrimp, Artemia parthenogenetica and its resistance role toward environmental stresses. J. Biol. Chem. doi:10.1074/jbc.M109.004051 (2009).

      • Rice genetics: On the roll

        Felix Cheung

        Published online: 29 April 2009 | doi:10.1038/nchina.2009.87

        Original article citation:

        Zhang, G. H., Xu, Q., Zhu, X. D., Qian, Q. and Xue, H. W. SHALLOT-LIKE1 is a KANADI transcription factor that modulates rice leaf rolling by regulating leaf abaxial cell development. Plant Cell doi:10.1105/tpc.108.061457 (2009).

      • Plant physiology: Environmental regulations

        Tim Reid

        Published online: 15 April 2009 | doi:10.1038/nchina.2009.75

        Original article citation:

        Bu, Q. et al. The Arabidopsis RING finger E3 ligase RHA2a is a novel positive regulator of ABA signaling during seed germination and early seedling development. Plant Physiol. doi:10.1104/pp.109.135269 (2009).

      • Rice genetics: Know grain, know gain Open !

        Felix Cheung

        Published online: 01 April 2009 | doi:10.1038/nchina.2009.64

        Original article citation:

        Huang, X. et al. Natural variation at the DEP1 locus enhances grain yield in rice. Nature Genet. doi:10.1038/ng.352 (2009).

      • Genomics: A fishing exercise

        Jane Qiu

        Published online: 25 March 2009 | doi:10.1038/nchina.2009.55

        Original article citation:

        Guo, M. et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. doi:10.1101/gr.086595.108 (2009).

      • MicroRNA detection: Spot the difference

        Tim Reid

        Published online: 18 March 2009 | doi:10.1038/nchina.2009.49

        Original article citation:

        Cheng, Y. et al. Highly sensitive determination of microRNA using target-primed and branched rolling-circle amplification. Angew. Chem. Int. Ed. doi:10.1002/anie.200805665 (2009).

      • Congenital disorders: Mutation fingered Open !

        Felix Cheung

        Published online: 11 March 2009 | doi:10.1038/nchina.2009.47

        Original article citation:

        Gao, B. et al. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature doi:10.1038/nature07862 (2009).

      • Oncology: Cancer connection

        Felix Cheung

        Published online: 25 February 2009 | doi:10.1038/nchina.2009.31

        Original article citation:

        Gong, Y. et al. Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers. Oncogene doi:10.1038/onc.2008.503 (2009).

      • Dermatology: Hair for you too! Open !

        Felix Cheung

        Published online: 11 February 2009 | doi:10.1038/nchina.2009.21

        Original article citation:

        Wen, Y. et al. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nature Genet. doi:10.1038/ng.276 (2009).

      • Dermatology: New markers for psoriasis

        Felix Cheung

        Published online: 11 February 2009 | doi:10.1038/nchina.2009.22

        Original article citation:

        Zhang, X. J. et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nature Genet. doi:10.1038/ng.310 (2009).

      • Spermiogenesis: Heads or tails

        Felix Cheung

        Published online: 04 February 2009 | doi:10.1038/nchina.2009.14

        Original article citation:

        Zhou, J. et al. RIM-BP3 is a manchette-associated protein essential for spermiogenesis. Development 136, 373–382 (2009).

      • Rice genetics: Transcriptome mapped

        Felix Cheung

        Published online: 21 January 2009 | doi:10.1038/nchina.2009.10

        Original article citation:

        Jiao, Y. et al. A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies. Nature Genet. doi:10.1038/ng.282 (2009).

      • Neurodegenerative diseases: Root of spasm

        Jane Qiu

        Published online: 14 January 2009 | doi:10.1038/nchina.2009.2

        Original article citation:

        Lin, P. et al. A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42). Am. J. Hum. Gen. 83, 752–759 (2008).

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