• Archive: Genetics

    • Genetics 2008 Research Highlights

      • Ophthalmology: New clues in sight

        Jasmine Farsarakis

        Published online: 17 December 2008 | doi:10.1038/nchina.2008.295

        Original article citation:

        Ji, Y. et al. Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber hereditary optic neuropathy in Chinese families with the m.11778right arrowA mutation. Am. J. Hum. Genet. doi:10.1016/j.ajhg.2008.11.002 (2008).

      • Rice genetics: Discolouring factor

        Jane Qiu

        Published online: 17 December 2008 | doi:10.1038/nchina.2008.296

        Original article citation:

        Yu, Y. et al. Independent losses of function in a polyphenol oxidase in rice: Differentiation in grain discoloration between subspecies and the role of positive selection under domestication. Plant Cell doi:10.1105/tpc.108.060426 (2008).

      • Human genome: A Han Chinese deciphered Open !

        Felix Cheung

        Published online: 12 November 2008 | doi:10.1038/nchina.2008.266

        Original article citation:

        Wang, J. et al. The diploid genome sequence of an Asian individual. Nature doi:10.1038/nature07484 (2008).

      • MicroRNAs: Cancer 'fingerprints' Open !

        Jasmine Farsarakis

        Published online: 29 October 2008 | doi:10.1038/nchina.2008.251

        Original article citation:

        Chen, X. et al. Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18, 997–1006 (2008).

      • Rice genetics: Better buds

        Felix Cheung

        Published online: 29 October 2008 | doi:10.1038/nchina.2008.252

        Original article citation:

        Jin, J. et al. Genetic control of rice plant architecture under domestication. Nature Genet. doi: 10.1038/ng.247 (2008).

      • Human genetics: Mapping differences

        Jane Qiu

        Published online: 29 October 2008 | doi:10.1038/nchina.2008.253

        Original article citation:

        Xu, S. & Jin, L. A genome-wide analysis of admixture in Uyghurs and a high-density admixture map for disease-gene discovery. Am. J. Human Genet. 83, 322–336 (2008).

      • Rice genetics: Good harvest Open !

        Felix Cheung

        Published online: 22 October 2008 | doi:10.1038/nchina.2008.245

        Original article citation:

        Wang, E. et al. Control of rice grain-filling and yield by a gene with a potential signature of domestication. Nature Genet. doi: 10.1038/ng.220 (2008).

      • Rice genetics: Erection problems

        Felix Cheung

        Published online: 22 October 2008 | doi:10.1038/nchina.2008.246

        Original article citation:

        Tan, L. et al. Control of a key transition from prostrate to erect growth in rice domestication. Nature Genet. doi: 10.1038/ng.197 (2008).

      • Chinese history: Mixed mausoleum makers Open !

        Tim Reid

        Published online: 22 October 2008 | doi:10.1038/nchina.2008.248

        Original article citation:

        Xu, Z. et al. Mitochondrial DNA evidence for a diversified origin of workers building mausoleum for first Emperor of China. PLoS ONE 3, e3275 (2008).

      • Intestinal stem cells: In search of self-renewal

        Felix Cheung

        Published online: 15 October 2008 | doi:10.1038/nchina.2008.239

        Original article citation:

        Lin, G., Xu, N. & Xi, R. Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature doi: 10.1038/nature07329 (2008).

      • Cancer biology: Consequences of changes

        Jane Qiu

        Published online: 08 October 2008 | doi:10.1038/nchina.2008.233

        Original article citation:

        Sun, T. et al. Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer. Cancer Res. 68, 7025–7034 (2008).

      • Rice genetics: Flowering switch

        Jane Qiu

        Published online: 08 October 2008 | doi:10.1038/nchina.2008.234

        Original article citation:

        Wu, C. et al. RID1, encoding a Cys2/His2–type zinc finger transcription factor, acts as a master switch from vegetative to floral development in rice. Proc. Natl Acad. Sci. USA 105, 12915–12920 (2008).

      • MicroRNA: Fingerprinting diseases

        Jane Qiu

        Published online: 01 October 2008 | doi:10.1038/nchina.2008.229

        Original article citation:

        Chen, X. et al. Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. doi: 10.1038/cr.2008.282 (2008).

      • Agricultural sciences: Good neighbours

        Jane Qiu

        Published online: 01 October 2008 | doi:10.1038/nchina.2008.230

        Original article citation:

        Wu, K. M., Lu, Y. H., Feng, H. Q., Jiang, Y. Y. & Zhao, J. Z. Suppression of cotton bollworm in multiple crops in China in areas with Bt toxin-containing cotton. Science 321, 1676–1678 (2008).

      • Hydrobiology: Out of air, but not out of action Open !

        Jane Qiu

        Published online: 17 September 2008 | doi:10.1038/nchina.2008.218

        Original article citation:

        Wang, D., Zhong, X. P., Qiao Z. X. & Gui, J. F. Inductive transcription and protective role of fish heme oxygenase-1 under hypoxic stress. J. Exp. Biol. 211, 2700–2706 (2008).

      • Gene expression: Cluster spotting

        Jane Qiu

        Published online: 27 August 2008 | doi:10.1038/nchina.2008.200

        Original article citation:

        Zhang, J., Li, J. & Deng, H. Class-specific correlations of gene expressions: Identification and their effects on clustering analyses. Am. J. Human Genet. 83, 269–277 (2008).

      • Hybrid rice: Reproductive barrier

        Jane Qiu

        Published online: 20 August 2008 | doi:10.1038/nchina.2008.193

        Original article citation:

        Chen, J. et al. A triallelic system of S5 is a major regulator of the reproductive barrier and compatibility of indica–japonica hybrids in rice. Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0804761105 (2008).

      • Eukaryotes: Changes enclosed Open !

        Jasmine Farsarakis

        Published online: 13 August 2008 | doi:10.1038/nchina.2008.186

        Original article citation:

        Tian, D. et al. Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes. Nature doi: 10.1038/nature07175 (2008).

      • Coronary cataract: Blindin' crystallin

        Felix Cheung

        Published online: 06 August 2008 | doi:10.1038/nchina.2008.179

        Original article citation:

        Lou, D. et al. A novel mutation in CRYBB2 responsible for inherited coronary cataract. Eye doi: 10.1038/eye.2008.222 (2008).

      • Aquaculture: Solely female

        Tim Reid

        Published online: 06 August 2008 | doi:10.1038/nchina.2008.183

        Original article citation:

        Chen, S. L. et al. Molecular marker-assisted sex control in half-smooth tongue sole (Cynoglossus semilaevis). Aquaculture doi: 10.1016/j.aquaculture.2008.07.015 (2008).

      • Cancer gene therapy: One stone, two birds

        Jasmine Farsarakis

        Published online: 30 July 2008 | doi:10.1038/nchina.2008.174

        Original article citation:

        Gan, Y. et al. Adenovirus-mediated HCCS1 overexpression elicits a potent antitumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo. Cancer Gene Ther. doi: 10.1038/cgt.2008.52 (2008).

      • Lung cancer: Micro markers

        Jasmine Farsarakis

        Published online: 23 July 2008 | doi:10.1038/nchina.2008.167

        Original article citation:

        Hu, J. et al. Genetic variants of miRNA sequences and non-small cell lung cancer survival. J. Clin. Invest. 118, 2600–2608 (2008).

      • Gene discovery: Hidden treasures

        John Fox

        Published online: 25 June 2008 | doi:10.1038/nchina.2008.145

        Original article citation:

        Xue, C., Li, F. & Li, F. Finding noncoding RNA transcripts from low abundance expressed sequence tags. Cell Res. 18, 695–700 (2008).

      • Disease genes: Finding the culprits Open !

        Tim Reid

        Published online: 28 May 2008 | doi:10.1038/nchina.2008.124

        Original article citation:

        Wu, X., Jiang, R., Zhang, M. Q. & Li, S. Network-based global inference of human disease genes. Mol. Sys. Biol. 4, 189 (2008).

      • Genetics: Productivity booster Open !

        Jane Qiu

        Published online: 21 May 2008 | doi:10.1038/nchina.2008.115

        Original article citation:

        Xue, W. et al. Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice. Nature Genet. doi: 10.1038/ng.143 (2008).

      • Epigenetics: Blooming time

        Jane Qiu

        Published online: 14 May 2008 | doi:10.1038/nchina.2008.110

        Original article citation:

        Zhai, J. et al. Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genet. 4, e1000056 (2008).

      • Transgenic plants: Spread control

        Wei Zeng

        Published online: 16 April 2008 | doi:10.1038/nchina.2008.87

        Original article citation:

        Lin, C. et al. A built-in strategy for containment of transgenic plants: Creation of selectively terminable transgenic rice. PLoS ONE 3, e1818 (2008).

      • Rice genome: Sifting through the family history

        Wei Zeng

        Published online: 26 March 2008 | doi:10.1038/nchina.2008.69

        Original article citation:

        Zou, X. H. et al. Analysis of 142 genes resolves the rapid diversification of the rice genus. Genome Biol. doi: 10.1186/gb-2008-9-3-r49 (2008).

      • Gut microbiota: Scanning the belly Open !

        Wei Zeng

        Published online: 05 March 2008 | doi:10.1038/nchina.2008.47

        Original article citation:

        Li, M. et al. Symbiotic gut microbes modulate human metabolic phenotypes. PNAS 105, 2117–2122 (2008).

      • Gene evolution: History repeats itself

        Wei Zeng

        Published online: 06 February 2008 | doi:10.1038/nchina.2008.26

        Original article citation:

        Yang, S. et al. Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila. PLoS Genet. doi: 10.1371/journal.pgen.0040003.eor (2008).

      • Brain evolution: What makes it bigger

        Wei Zeng

        Published online: 06 February 2008 | doi:10.1038/nchina.2008.27

        Original article citation:

        Wang, J. K., Li, Y. & Su, B. A common SNP of MCPH1 is associated with cranial volume variation in Chinese population. Hum. Mol. Genet. doi: 10.1093/hmg/ddn021 (2008).

      • Behavioural disorder: In search of hyperactive genes Open !

        Wei Zeng

        Published online: 30 January 2008 | doi:10.1038/nchina.2008.21

        Original article citation:

        Guan, L. et al. A high-density single-nucleotide polymorphism screen of 23 candidate genes in attention deficit hyperactivity disorder: Suggesting multiple susceptibility genes among Chinese Han population. Mol. Psychiatry doi: 10.1038/sj.mp.4002139 (2008).

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