Archive: Genetics
Genetics 2007 Research Highlights
Drug addiction: The ultimate gene list this content is Open !
John Fox
Published online: 19 December 2007 | doi:10.1038/nchina.2007.272
Original article citation:
Genes and (common) pathways underlying addiction revealed by combining and analyzing candidate gene lists from multiple technology platforms. PLoS Comput. Biol. doi: 10.1371/journal.pcbi.0040002 (2007).
Top of pagePrenatal diagnosis: Detection without invasion
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.274
Original article citation:
et al. Plasma placental RNA allelic ratio permits non-invasive prenatal chromosomal aneuploidy detection. Nature Med. 13, 218–223 (2007).
Top of pageGenetic interaction: What entropy tells
Wei Zeng
Published online: 21 November 2007 | doi:10.1038/nchina.2007.245
Original article citation:
et al. Exploration of gene–gene interaction effects using entropy-based methods. Eur. J. Human Genet. doi: 10.1038/sj.ejhg.5201921 (2007).
Top of pageBovine pneumonia: Tracing the culprits
Tim Reid
Published online: 21 November 2007 | doi:10.1038/nchina.2007.247
Original article citation:
et al. Strains of Mycoplasma mycoides subsp. mycoides small colony type isolated in China between 1953 and 1960 show close similarity to strains of the Africa/Australia cluster. Vet. J. doi: 10.1016/j.tvjl.2007.08.021 (2007).
Top of pageDNA chemistry: Sulphur degradation
Felix Cheung
Published online: 24 October 2007 | doi:10.1038/nchina.2007.223
Original article citation:
et al. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chem. Bio. doi: 10.1038/nchembio.2007.39 (2007).
Top of pageRemyelination: For the price of a gene
Felix Cheung
Published online: 17 October 2007 | doi:10.1038/nchina.2007.214
Original article citation:
et al. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nature Med. 13, 1228–1233 (2007).
Top of pageGadd45a regulation: Keep in touch
Felix Cheung
Published online: 19 September 2007 | doi:10.1038/nchina.2007.193
Original article citation:
et al. Gadd45a regulates
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-catenin distribution and maintains cell–cell adhesion/contact. Oncogene doi: 10.1038/sj.onc.1210469 (2007). DNA analysis: Under the heat
Wei Zeng
Published online: 29 August 2007 | doi:10.1038/nchina.2007.174
Original article citation:
et al. DNA mutation detection with chip-based temperature gradient capillary electrophoresis using a slantwise radiative heating system. Lab Chip doi: 10.1039/b701649b (2007).
Top of pagePrenatal diagnostics: Finding the extra copy
Wei Zeng
Published online: 22 August 2007 | doi:10.1038/nchina.2007.170
Original article citation:
et al. Digital PCR for the molecular detection of fetal chromosomal aneuploidy. PNAS 104, 13116–13121 (2007).
Top of pageArsenic pollution: Know your onions
Tim Reid
Published online: 15 August 2007 | doi:10.1038/nchina.2007.162
Original article citation:
Genotoxicity of arsenic evaluated by Allium-root micronucleus assay. Sci. Total Environ. 383, 232–236 (2007).
Top of pageProtein structure: Totally hooked
Wei Zeng
Published online: 08 August 2007 | doi:10.1038/nchina.2007.152
Original article citation:
et al. The multifunctional human p100 protein 'hooks' methylated ligands. Nature Struct. Mol. Biol. doi: 10.1038/nsmb1269 (2007).
Top of pageAutoimmune disease: A balanced approach this content is Open !
John Fox
Published online: 25 July 2007 | doi:10.1038/nchina.2007.144
Original article citation:
et al. Critical regulation of CD4+ T cell survival and autoimmunity by
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-arrestin 1. Nature Immunol. doi: 10.1038/ni1489 (2007). Angiogenesis: The healing power of ginseng
Felix Cheung
Published online: 25 July 2007 | doi:10.1038/nchina.2007.147
Original article citation:
et al. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen
Top of page receptor. Br. J. Pharmacol. doi: 10.1038/sj.bjp.0707359 (2007). Papaya ringspot virus: Coat variations
Wei Zeng
Published online: 25 July 2007 | doi:10.1038/nchina.2007.148
Original article citation:
Variation in the coat protein gene of papaya ringspot virus isolates from multiple locations of China. J. Integr. Plant Bio. 49, 1062–1069 (2007).
Top of pageDecision making: Small brains fly high
Wei Zeng
Published online: 18 July 2007 | doi:10.1038/nchina.2007.138
Original article citation:
Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila. Science 316, 1901–1904 (2007).
Top of pageGastric cancer: Belly phases
Wei Zeng
Published online: 20 June 2007 | doi:10.1038/nchina.2007.111
Original article citation:
et al. Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer. Oncogene doi: 10.1038/sj.onc.1210538 (2007).
Top of pagePsoriasis: The guilty gene
Tim Reid
Published online: 20 June 2007 | doi:10.1038/nchina.2007.113
Original article citation:
et al. Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. J. Invest. Dermatol. doi: 10.1038/sj.jid.5700896 (2007).
Top of pageDiabetes: Infectious tolerance
Jim Casey
Published online: 20 June 2007 | doi:10.1038/nchina.2007.114
Original article citation:
et al. Foxp3-expressing CD4+T cells under the control of IFN-g promoter prevent diabetes in NOD mice. Mol. Ther. doi: 10.1038/sj.mt.6300208 (2007).
Top of pageHepatitis B: Aiming at new targets
John Fox
Published online: 13 June 2007 | doi:10.1038/nchina.2007.106
Original article citation:
Whole genome expression profiling of hepatitis B virus-transfected cell line reveals the potential targets of anti-HBV drugs. Pharmacogenom. J. doi: 10.1038/sj.tpj.6500459 (2007).
Top of pageLiver transplantation: Stemming donor rejection
John Fox
Published online: 13 June 2007 | doi:10.1038/nchina.2007.107
Original article citation:
et al. Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration. Molecular Therapy doi: 10.1038/sj.mt.6300202 (2007).
Top of pageGut microbiota: A stomach copy this content is Open !
Wei Zeng
Published online: 06 June 2007 | doi:10.1038/nchina.2007.100
Original article citation:
et al. Inter-species transplantation of gut microbiota from human to pigs. ISME J. doi: 10.1038/ismej.2007.23 (2007).
Top of pageNanochannels: Switchable membrane this content is Open !
Felix Cheung
Published online: 06 June 2007 | doi:10.1038/nchina.2007.96
Original article citation:
Tunable non-equilibrium gating of flexible DNA nanochannels in response to transport flux. Nature Nanotech. doi: 10.1038/nnano.2007.148 (2007).
Top of pageHypertension: Losing inhibition this content is Open !
John Fox
Published online: 23 May 2007 | doi:10.1038/nchina.2007.84
Original article citation:
et al. Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of captopril in women. Clin. Pharmacol. Ther. (2007).
Top of pageDNA sequencing: Keeping in line
Tim Reid
Published online: 23 May 2007 | doi:10.1038/nchina.2007.88
Original article citation:
et al. Single-base resolution and long-coverage sequencing based on single-molecule nanomanipulation. Nanotechnol. 18, 225101 (2007).
Top of pageRice yield: Bumper crop?
Jim Casey
Published online: 09 May 2007 | doi:10.1038/nchina.2007.74
Original article citation:
, , , & A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase. Nature Genet. 39, 623–630 (2007).
Top of pageCancer: Deadly insert
Jim Casey
Published online: 09 May 2007 | doi:10.1038/nchina.2007.75
Original article citation:
et al. A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nature Genet. 39, 605–613 (2007).
Top of pageSexually transmitted diseases: Fatal attraction
Tim Reid
Published online: 09 May 2007 | doi:10.1038/nchina.2007.77
Original article citation:
& Transmission of sexually transmitted disease in complex network of the Penna model. J. Stat. Mech. P04006 (2007).
Top of pagePlant growth: Wide rice this content is Open !
Tim Reid
Published online: 25 April 2007 | doi:10.1038/nchina.2007.54
Original article citation:
et al. Control of tillering in rice. Nature 422, 618–621 (2003).
Top of pageBacterial evolution: Good housekeeping this content is Open !
Tim Reid
Published online: 18 April 2007 | doi:10.1038/nchina.2007.49
Original article citation:
et al. Leucyl-tRNA synthetase from the ancestral bacterium Aquifex aeolicus contains relics of synthetase evolution. EMBO J. 24, 1430–1439 (2005).
Top of pageGenetic linkage: Cancer detectives
Kaspar Mossman
Published online: 11 April 2007 | doi:10.1038/nchina.2007.34
Original article citation:
et al. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nature Genet. 31, 395–399 (2002).
Top of pageGenetic mapping: Rice — chromosome 4
Kaspar Mossman
Published online: 11 April 2007 | doi:10.1038/nchina.2007.35
Original article citation:
et al. Sequence and analysis of rice chromosome 4. Nature 420, 316–320 (2002).
Top of pageRice traits: A salty tale this content is Open !
Kaspar Mossman
Published online: 11 April 2007 | doi:10.1038/nchina.2007.37
Original article citation:
et al. A rice quantitative trait locus for salt tolerance encodes a sodium transporter. Nature Genet. 37, 1141–1146 (2005).
Top of pageWhole-genome sequencing: Corkscrew killer
Kaspar Mossman
Published online: 11 April 2007 | doi:10.1038/nchina.2007.38
Original article citation:
et al. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422, 888–893 (2003).
Top of pageCystic fibrosis: Sperm failure
Tim Reid
Published online: 11 April 2007 | doi:10.1038/nchina.2007.42
Original article citation:
et al. Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Nature Cell Biol. 5 902–906 (2003).
Top of pageAtrial fibrillation: A hearty mutation
Jim Casey
Published online: 04 April 2007 | doi:10.1038/nchina.2007.29
Original article citation:
et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299, 251–254 (2003).
Top of pageHuman development: Dominant defect
Kaspar Mossman
Published online: 04 April 2007 | doi:10.1038/nchina.2007.31
Original article citation:
et al. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nature Genet. 28, 386–388 (2001).
Top of pageCancer: A suppressor suppressed
Jim Casey
Published online: 28 February 2007 | doi:10.1038/nchina.2007.15
Original article citation:
et al. High Frequency of Promoter Hypermethylation of RASSF1A in Nasopharyngeal Carcinoma. Cancer Res. 61, 3877–3881 (2001).
Top of pageSARS: Bat reservoir for virus?
Jim Casey
Published online: 28 February 2007 | doi:10.1038/nchina.2007.16
Original article citation:
et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc. Natl Acad. Sci.USA 102, 14040–14045 (2005).
Top of pageSARS: Host unknown
Jim Casey
Published online: 28 February 2007 | doi:10.1038/nchina.2007.18
Original article citation:
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc. Natl Acad. Sci. USA 102, 2430–2435 (2005).
Top of pagePneumonia: A new coronavirus
John Fox
Published online: 28 February 2007 | doi:10.1038/nchina.2007.21
Original article citation:
et al. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79, 884–895 (2006).
Top of pageHan genetics: Men move south
Lucy Heady
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-48
Original article citation:
et al. Genetic evidence supports demic diffusion of Han culture. Nature 431, 302–305 (2004).
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