• Archive: Clinical medicine

    • Clinical medicine 2007 Research Highlights

      • Cardiac arrhythmias: MicroRNA beating the heart

        John Fox

        Published online: 19 December 2007 | doi:10.1038/nchina.2007.282

        Original article citation:

        Yang, B. et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nature Med. 13, 486–491 (2007).

      • Sexually transmitted diseases: High-risk behaviour on the Internet Open !

        Felix Cheung

        Published online: 12 December 2007 | doi:10.1038/nchina.2007.262

        Original article citation:

        Zhang, D. et al. Internet use and risk behaviours: An online survey of visitors to three gay websites in China. Sexually Transmitted Inf. 83, 571–576 (2007).

      • Neurological diseases: Screening for treatments

        John Fox

        Published online: 05 December 2007 | doi:10.1038/nchina.2007.255

        Original article citation:

        Zhang, L. et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. PNAS 104, 19023–19028 (2007).

      • Avian influenza: Bird flu virus sticks in the throat

        John Fox

        Published online: 28 November 2007 | doi:10.1038/nchina.2007.254

        Original article citation:

        Nicholls, J. M. et al. Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nature Med. 13, 147–149 (2007).

      • Soy proteins: Helping your blood vessels

        Felix Cheung

        Published online: 07 November 2007 | doi:10.1038/nchina.2007.232

        Original article citation:

        Chan, Y. H. et al. Isoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burden. Am. J. Clin. Nutr. 86, 938–945 (2007).

      • Improved detection: Filtering chronic kidney disease

        John Fox

        Published online: 07 November 2007 | doi:10.1038/nchina.2007.233

        Original article citation:

        Ma, Y. C. et al. Improved GFR estimation by combined creatinine and cystatin C measurements. Kidney Int. doi: 10.1038/sj.ki.5002566 (2007).

      • Remyelination: For the price of a gene

        Felix Cheung

        Published online: 17 October 2007 | doi:10.1038/nchina.2007.214

        Original article citation:

        Mi, S. et al. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nature Med. 13, 1228–1233 (2007).

      • Avian flu: Beyond respiration

        Felix Cheung

        Published online: 10 October 2007 | doi:10.1038/nchina.2007.210

        Original article citation:

        Gu, J. et al. H5N1 infection of the respiratory tract and beyond: A molecular pathology study. Lancet 370, 1137–1145 (2007).

      • Colon cancer : The link with heart disease Open !

        John Fox

        Published online: 10 October 2007 | doi:10.1038/nchina.2007.212

        Original article citation:

        Chan, A. O. O. et al. Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease. JAMA 298, 1412–1419 (2007).

      • Fish-oil supplements: Healthy hearts

        John Fox

        Published online: 03 October 2007 | doi:10.1038/nchina.2007.203

        Original article citation:

        Wang, S. et al. Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients. Eur. J. Clin. Nutr. doi: 10.1038/sj.ejcn.1602886 (2007).

      • Antioxidants: Try some ginseng

        Tim Reid

        Published online: 03 October 2007 | doi:10.1038/nchina.2007.204

        Original article citation:

        Luo, D. & Fang, B. Structural identification of Ginseng polysaccharides and testing of their antioxidant activities. Carbohydr. Polym. doi: 10.1016/j.carbpol.2007.09.006 (2007).

      • Stem-cell transplantation: Cut risks to the bone

        John Fox

        Published online: 19 September 2007 | doi:10.1038/nchina.2007.189

        Original article citation:

        Cheuk, D. K. L. et al. Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation. Bone Marrow Transplant. doi: 10.1038/sj.bmt.1705835 (2007).

      • Prostate cancer: A receptive warning

        John Fox

        Published online: 22 August 2007 | doi:10.1038/nchina.2007.166

        Original article citation:

        Zhou, T., Xu, C., He, M. & Sun, Y. Upregulation of erythropoietin receptor in human prostate carcinoma and high-grade prostatic intraepithelial neoplasia. Prostate Cancer Prostatic Dis. doi: 10.1038/sj.pcan.4500995 (2007).

      • Autoimmune disease: A balanced approach Open !

        John Fox

        Published online: 25 July 2007 | doi:10.1038/nchina.2007.144

        Original article citation:

        Shi, Y. et al. Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nature Immunol. doi: 10.1038/ni1489 (2007).

      • Angiogenesis: The healing power of ginseng

        Felix Cheung

        Published online: 25 July 2007 | doi:10.1038/nchina.2007.147

        Original article citation:

        Leung, K. W. et al. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br. J. Pharmacol. doi: 10.1038/sj.bjp.0707359 (2007).

      • Psoriasis: The guilty gene

        Tim Reid

        Published online: 20 June 2007 | doi:10.1038/nchina.2007.113

        Original article citation:

        Zhang, X. J. et al. Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. J. Invest. Dermatol. doi: 10.1038/sj.jid.5700896 (2007).

      • Artificial vitreous: Plastic eye surgery Open !

        Wei Zeng

        Published online: 20 June 2007 | doi:10.1038/nchina.2007.115

        Original article citation:

        Gao, Q. et al. A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve. Eye doi: 10.1038/sj.eye.6702875 (2007).

      • Hepatitis B: Aiming at new targets

        John Fox

        Published online: 13 June 2007 | doi:10.1038/nchina.2007.106

        Original article citation:

        Ding, X. R., Yang, J., Sun, D. C., Lou, S. K. & Wang, S. Q. Whole genome expression profiling of hepatitis B virus-transfected cell line reveals the potential targets of anti-HBV drugs. Pharmacogenom. J. doi: 10.1038/sj.tpj.6500459 (2007).

      • Liver transplantation: Stemming donor rejection

        John Fox

        Published online: 13 June 2007 | doi:10.1038/nchina.2007.107

        Original article citation:

        Yue, Y. et al. Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration. Molecular Therapy doi: 10.1038/sj.mt.6300202 (2007).

      • Erectile dysfunction: Not too heavy, not too light

        John Fox

        Published online: 30 May 2007 | doi:10.1038/nchina.2007.94

        Original article citation:

        Cheng, J. Y. W. & Ng, E. M. L. Body mass index, physical activity and erectile dysfunction: An U-shaped relationship from population-based study. Int. J. Obes. doi: 10.1038/sj.ijo.0803639 (2007).

      • Hypertension: Losing inhibition Open !

        John Fox

        Published online: 23 May 2007 | doi:10.1038/nchina.2007.84

        Original article citation:

        Fan, X. et al. Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of captopril in women. Clin. Pharmacol. Ther. (2007).

      • Cancer: Deadly insert

        Jim Casey

        Published online: 09 May 2007 | doi:10.1038/nchina.2007.75

        Original article citation:

        Sun, T. et al. A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nature Genet. 39, 605–613 (2007).

      • Carbon nanohorns: Miniature drug dealers

        Tim Reid

        Published online: 09 May 2007 | doi:10.1038/nchina.2007.76

        Original article citation:

        Fan, X. B., Tan, J., Zhang, G. L. & Zhang F. B. Isolation of carbon nanohorn assemblies and their potential for intracellular delivery. Nanotechnol. 18, 195103 (2007).

      • Sexually transmitted diseases: Fatal attraction

        Tim Reid

        Published online: 09 May 2007 | doi:10.1038/nchina.2007.77

        Original article citation:

        Chen, F. & Li, C. Transmission of sexually transmitted disease in complex network of the Penna model. J. Stat. Mech. P04006 (2007).

      • Cystic fibrosis: Sperm failure

        Tim Reid

        Published online: 11 April 2007 | doi:10.1038/nchina.2007.42

        Original article citation:

        Wang, X. F. et al. Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Nature Cell Biol. 5 902–906 (2003).

      • Liver cancer: Improved survival

        Jim Casey

        Published online: 04 April 2007 | doi:10.1038/nchina.2007.27

        Original article citation:

        Lo, C. M. et al. Randomized controlled trial of transarterial Lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 35, 1164–1171 (2002).

      • Lupus nephritis: New drug — less toxic

        Jim Casey

        Published online: 04 April 2007 | doi:10.1038/nchina.2007.28

        Original article citation:

        Chan, T. M. et al. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. N. Engl. J. Med. 343, 1156–1162 (2000).

      • Atrial fibrillation: A hearty mutation

        Jim Casey

        Published online: 04 April 2007 | doi:10.1038/nchina.2007.29

        Original article citation:

        Chen, Y. H. et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299, 251–254 (2003).

      • Stomach ulcers: Blood stopper

        Jim Casey

        Published online: 04 April 2007 | doi:10.1038/nchina.2007.30

        Original article citation:

        Lau, J. Y. W. et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N. Engl. J. Med. 343, 310–316 (2000).

      • Schistosoma genome: The third helminth Open !

        Kaspar Mossman

        Published online: 04 April 2007 | doi:10.1038/nchina.2007.32

        Original article citation:

        Han, Zeguang et al. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nature Genet. 35, 139–147 (2003).

      • Cancer: A suppressor suppressed

        Jim Casey

        Published online: 28 February 2007 | doi:10.1038/nchina.2007.15

        Original article citation:

        Lo, K.-W. et al. High Frequency of Promoter Hypermethylation of RASSF1A in Nasopharyngeal Carcinoma. Cancer Res. 61, 3877–3881 (2001).

      • SARS: Bat reservoir for virus?

        Jim Casey

        Published online: 28 February 2007 | doi:10.1038/nchina.2007.16

        Original article citation:

        Lau, S. K. et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc. Natl Acad. Sci.USA 102, 14040–14045 (2005).

      • Bird flu: A cytokine storm?

        Jim Casey

        Published online: 28 February 2007 | doi:10.1038/nchina.2007.17

        Original article citation:

        Chan, M. C. W. et al. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir. Res. 6, 135 (2005).

      • SARS: Host unknown

        Jim Casey

        Published online: 28 February 2007 | doi:10.1038/nchina.2007.18

        Original article citation:

        Song, H.-D. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc. Natl Acad. Sci. USA 102, 2430–2435 (2005).

      • Heart failure: Pacemaking it better

        John Fox

        Published online: 28 February 2007 | doi:10.1038/nchina.2007.19

        Original article citation:

        Yu, C.-M. et al. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation 105, 438–445 (2002).

      • Heart failure: Doppler imaging best

        John Fox

        Published online: 28 February 2007 | doi:10.1038/nchina.2007.20

        Original article citation:

        Yu, C.-M. et al. Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and nonischemic heart failure after cardiac resynchronization therapy. Circulation 110, 66–73 (2004).

      • Pneumonia: A new coronavirus

        John Fox

        Published online: 28 February 2007 | doi:10.1038/nchina.2007.21

        Original article citation:

        Woo, P. C. et al. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79, 884–895 (2006).

      • Aspirin resistance: Patients risk cell death

        John Fox

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-11

        Original article citation:

        Chen, W.H. , Lee, P. Y. , Ng, W. , Tse, H. F. & Lau, C. P. Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment. J. Am. Coll. Cardiol. 43, 1122–1126 (2004).

      • Case study: Bowel blood loss

        Jim Casey

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-14

        Original article citation:

        Chan, A. O. & Lai, K. C. A patient with long-standing iron-deficient anemia. Nature Clin. Pract. Gastroenterol. Hepatol. 3, 112–116 (2006).

      • Cancer research: The kindness of strangers

        Jim Casey

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-21

        Original article citation:

        Wei, Y. Q. et al. Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nature Med. 6, 1160–1166 (2000).

      • Case study: Lymph-node tumours

        Jim Casey

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-35

        Original article citation:

        Liu, J. et al. COX2-related multicentric mixed-type Castleman's disease in a young man. Nature Clin. Pract. Oncol. 2, 370–375 (2005).

      • Kidney disease: Slowing progression with allopurinol

        Rachael Williams

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-4

        Original article citation:

        Siu, Y.-P. et al. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am. J. Kidney Dis. 47, 51–59 (2006).

      • Cholesterol therapy: Stable reception

        Jim Casey

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-44

        Original article citation:

        Kong, W. J. et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Med. 10, 1344–1351 (2004).

      • Advanced renal disease: Safe and effective benazepril

        John Fox

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-6

        Original article citation:

        Hou, F. F. et al. Efficacy and safety of Benazepril for advanced chronic renal insufficiency. N. Engl. J. Med. 354, 131–40 (2006).

      • Virus detection: Catch SARS early

        Dangsheng Li

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-9

        Original article citation:

        Poon, L. L. et al. A one step quantitative RT-PCR for detection of SARS coronavirus with an internal control for PCR inhibitors. J. Clin. Virol. 30, 214–217 (2004).

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