• Archive: Cell & molecular biology

    • Cell & molecular biology 2009 Research Highlights

      • Haematopoiesis: First blood

        Felix Cheung

        Published online: 18 November 2009 | doi:10.1038/nchina.2009.220

        Original article citation:

        Yue, R. et al. beta-Arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 139, 535–546 (2009).

      • Immunology: Negative two Open !

        Felix Cheung

        Published online: 11 November 2009 | doi:10.1038/nchina.2009.216

        Original article citation:

        You, F. et al. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nature Immunol. doi:10.1038/ni.1815 (2009).

      • Immunology: Decoding multiple sclerosis Open !

        Felix Cheung

        Published online: 28 October 2009 | doi:10.1038/nchina.2009.208

        Original article citation:

        Du, C. et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nature Immunol. doi:10.1038/ni.1798 (2009).

      • Cell death: Killer's fate Open !

        Felix Cheung

        Published online: 21 October 2009 | doi:10.1038/nchina.2009.204

        Original article citation:

        Wang, S. et al. Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death. Cell Res. doi:10.1038/cr.2009.114 (2009).

      • Immunology: Negative seven

        Felix Cheung

        Published online: 07 October 2009 | doi:10.1038/nchina.2009.196

        Original article citation:

        Jia, Y. et al. Negative regulation of MAVS-mediated innate immune response by PSMA7. J. Immunol. doi:10.4049/jimmunol.0901646 (2009).

      • Stem cells: Skin treatment for your liver

        Felix Cheung

        Published online: 30 September 2009 | doi:10.1038/nchina.2009.188

        Original article citation:

        Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. doi:10.1038/cr.2009.107 (2009)

      • Immunology: A protein with a rigorous role

        Felix Cheung

        Published online: 23 September 2009 | doi:10.1038/nchina.2009.184

        Original article citation:

        Kong, L. et al. An essential role for RIG-I in Toll-like receptor-stimulated phagocytosis. Cell Host Microbe 6, 150–161 (2009).

      • Cancer biology: Bringing breast cancer to an end

        Felix Cheung

        Published online: 16 September 2009 | doi:10.1038/nchina.2009.180

        Original article citation:

        Wang, Y. et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 138, 660–672 (2009).

      • Cell biology: To arrest or not to arrest Open !

        Felix Cheung

        Published online: 02 September 2009 | doi:10.1038/nchina.2009.172

        Original article citation:

        Li, Q. et al. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biol. doi:10.1038/ncb1927 (2009).

      • Molecular biology: Lock and load Open !

        Felix Cheung

        Published online: 26 August 2009 | doi:10.1038/nchina.2009.168

        Original article citation:

        Yu, C. et al. Myosin VI undergoes cargo-mediated dimerization. Cell 138, 537–548, (2009).

      • Neurobiology: The mediators Open !

        Felix Cheung

        Published online: 12 August 2009 | doi:10.1038/nchina.2009.161

        Original article citation:

        Tong, X. P. et al. Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration. J. Cell Biol. 186, 113–128 (2009).

      • Plant defence: Death and resistance

        Felix Cheung

        Published online: 05 August 2009 | doi:10.1038/nchina.2009.156

        Original article citation:

        Gao, M. et al. Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe 6, 34–44 (2009).

      • Cellular neuroscience: The site of initiation Open !

        Felix Cheung

        Published online: 05 August 2009 | doi:10.1038/nchina.2009.158

        Original article citation:

        Hu, W. et al. Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation. Nature Neurosci. doi:10.1038/nn.2359 (2009).

      • Structural biology: Bacterial tricks unmasked

        Felix Cheung

        Published online: 29 July 2009 | doi:10.1038/nchina.2009.151

        Original article citation:

        Huang, Z. et al. Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics. Nature Struct. Mol. Biol. doi:10.1038/nsmb.1647 (2009).

      • Plant development: Split ends Open !

        Felix Cheung

        Published online: 01 July 2009 | doi:10.1038/nchina.2009.136

        Original article citation:

        Sun, S. Y. et al. OsHAL3 mediates a new pathway in the light-regulated growth of rice. Nature Cell Biol. doi:10.1038/ncb1892 (2009).

      • Cell death: From apoptosis to necrosis

        Felix Cheung

        Published online: 24 June 2009 | doi:10.1038/nchina.2009.130

        Original article citation:

        Zhang, D. W. et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science doi:10.1126/science.1172308 (2009).

      • Structural biology: The amino acid antiporter

        Felix Cheung

        Published online: 24 June 2009 | doi:10.1038/nchina.2009.131

        Original article citation:

        Gao, X. et al. Structure and mechanism of an amino acid antiporter. Science doi:10.1126/science.1173654 (2009).

      • Cellular dynamics: One more tip on microtubules

        Felix Cheung

        Published online: 17 June 2009 | doi:10.1038/nchina.2009.126

        Original article citation:

        Jiang, K. et al. TIP150 interacts with and targets MCAK at the microtubule plus ends. EMBO Rep. doi:10.1038/embor.2009.94 (2009).

      • Cell migration: Two steps at a time

        Felix Cheung

        Published online: 17 June 2009 | doi:10.1038/nchina.2009.127

        Original article citation:

        Shan, Y. et al. Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. PLoS Biol. 7, e1000116 (2009).

      • Immunology: Boost one way, but not the other Open !

        Felix Cheung

        Published online: 10 June 2009 | doi:10.1038/nchina.2009.122

        Original article citation:

        Wang, C., et al. The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon. Nature Immunol. doi:10.1038/ni.1742 (2009).

      • Autophagy: A new way to fight cancer

        Felix Cheung

        Published online: 03 June 2009 | doi:10.1038/nchina.2009.118

        Original article citation:

        Shen, S. et al. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. J. Cell Biol. 185, 629–639 (2009).

      • Structural biology: The autoinhibitory switch

        Felix Cheung

        Published online: 03 June 2009 | doi:10.1038/nchina.2009.119

        Original article citation:

        Chen, L. et al. Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature doi:10.1038/nature08075

      • Extremophile biology: Shrimp shield

        Felix Cheung

        Published online: 13 May 2009 | doi:10.1038/nchina.2009.95

        Original article citation:

        Liu, Y. L., Zhao, Y., Dai, Z. M., Chen, H. M. & Yang, W. J. Formation of diapause cyst shell in brine shrimp, Artemia parthenogenetica and its resistance role toward environmental stresses. J. Biol. Chem. doi:10.1074/jbc.M109.004051 (2009).

      • Genome biology: Maintenance on a shoestring Open !

        Felix Cheung

        Published online: 06 May 2009 | doi:10.1038/nchina.2009.91

        Original article citation:

        Meng, F. L. et al. Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. EMBO J. doi:10.1038/emboj.2009.92 (2009).

      • Apoptosis: Negative regulator exposed

        Felix Cheung

        Published online: 29 April 2009 | doi:10.1038/nchina.2009.85

        Original article citation:

        Tian, C. et al. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nature Cell Biol. doi:10.1038/ncb1864 (2009).

      • Cancer biology: Brain stopper Open !

        Felix Cheung

        Published online: 22 April 2009 | doi:10.1038/nchina.2009.80

        Original article citation:

        Zhao, S. et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 324, 261–265 (2009).

      • Cancer biology: Survival run

        Jane Qiu

        Published online: 22 April 2009 | doi:10.1038/nchina.2009.81

        Original article citation:

        Zheng, C. et al. E2F1 induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res. 69, 2324–2331 (2009).

      • Plant physiology: Environmental regulations

        Tim Reid

        Published online: 15 April 2009 | doi:10.1038/nchina.2009.75

        Original article citation:

        Bu, Q. et al. The Arabidopsis RING finger E3 ligase RHA2a is a novel positive regulator of ABA signaling during seed germination and early seedling development. Plant Physiol. doi:10.1104/pp.109.135269 (2009).

      • Neurobiology: The road to tolerance

        Jane Qiu

        Published online: 15 April 2009 | doi:10.1038/nchina.2009.78

        Original article citation:

        Xie, W. Y. et al. Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. J. Neurosci. 29, 3551–3564 (2009).

      • Neurobiology: Pinpointing pain

        Jane Qiu

        Published online: 08 April 2009 | doi:10.1038/nchina.2009.71

        Original article citation:

        Cao, H., et al. Activation of extracellular signal-regulated kinase in the anterior cingulated cortex contributes to the induction and expression of affective pain. J. Neurosci. 29, 3307–3321 (2009)

      • Neurobiology: Smart filter Open !

        Felix Cheung

        Published online: 08 April 2009 | doi:10.1038/nchina.2009.72

        Original article citation:

        Song, A. H. et al. A selective filter for cytoplasmic transport at the axon initial segment. Cell doi:10.1016/j.cell.2009.01.016 (2009).

      • Immunology: Defence control

        Jane Qiu

        Published online: 01 April 2009 | doi:10.1038/nchina.2009.61

        Original article citation:

        Zhong, B. et al. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity doi:10.1016/j.immuni.2009.01.008 (2009).

      • Genomics: A fishing exercise

        Jane Qiu

        Published online: 25 March 2009 | doi:10.1038/nchina.2009.55

        Original article citation:

        Guo, M. et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. doi:10.1101/gr.086595.108 (2009).

      • Botany: External affairs

        Jane Qiu

        Published online: 18 March 2009 | doi:10.1038/nchina.2009.50

        Original article citation:

        Wang, Q. et al. Calmodulin binds to extracellular sites on the plasma membrane of plant cells and elicits a rise in intracellular calcium concentration. J. Biol. Chem. doi:10.1074/jbc.M808028200 (2009).

      • Microbiology: A bacterium's superbowl

        Felix Cheung

        Published online: 18 March 2009 | doi:10.1038/nchina.2009.51

        Original article citation:

        Shen, Q. T. et al. Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0811780106 (2009).

      • Cancer biology: Path of resistance

        Jane Qiu

        Published online: 11 March 2009 | doi:10.1038/nchina.2009.43

        Original article citation:

        Wang, J. X., Li, Q. & Li, P. F. Apoptosis repressor with caspase recruitment domain contributes to chemotherapy resistance by abolishing mitochondrial fission mediated by dynamin-related protein-1. Cancer Res. 69, 492–500 (2009).

      • Oncology: Cancer connection

        Felix Cheung

        Published online: 25 February 2009 | doi:10.1038/nchina.2009.31

        Original article citation:

        Gong, Y. et al. Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers. Oncogene doi:10.1038/onc.2008.503 (2009).

      • Structural biology: New clues on bird flu Open !

        Felix Cheung

        Published online: 25 February 2009 | doi:10.1038/nchina.2009.32

        Original article citation:

        Yuan, P. et al. Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site. Nature doi:10.1038/nature07720 (2009).

      • Cellular development: Selective demise Open !

        Jane Qiu

        Published online: 18 February 2009 | doi:10.1038/nchina.2009.25

        Original article citation:

        Zhang, Y. et al. SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell 136, 308–321 (2009).

      • Lipid metabolism: Fat wrap

        Jane Qiu

        Published online: 18 February 2009 | doi:10.1038/nchina.2009.26

        Original article citation:

        Ye, J. et al. Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoportein B. Cell Met. 9, 177–190 (2009).

      • Chemical biology: On neutral ground

        Felix Cheung

        Published online: 18 February 2009 | doi:10.1038/nchina.2009.27

        Original article citation:

        Tang, B. et al. A near-infrared neutral pH fluorescent probe for monitoring minor pH changes: Imaging in living HepG2 and HL-7702 cells. J. Am. Chem. Soc. doi:10.1021/ja809149g (2009).

      • Neural development: Don't get too excited

        Jane Qiu

        Published online: 11 February 2009 | doi:10.1038/nchina.2009.23

        Original article citation:

        Peng, Y. R. et al. Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron 61, 71–84 (2009).

      • Diabetes: The rise of resistance Open !

        Felix Cheung

        Published online: 04 February 2009 | doi:10.1038/nchina.2009.13

        Original article citation:

        Luan, B. et al. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature doi:10.1038/nature07617 (2009).

      • Rice genetics: Transcriptome mapped

        Felix Cheung

        Published online: 21 January 2009 | doi:10.1038/nchina.2009.10

        Original article citation:

        Jiao, Y. et al. A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies. Nature Genet. doi:10.1038/ng.282 (2009).

      • Sexually transmitted diseases: Yin–yang action

        Jane Qiu

        Published online: 21 January 2009 | doi:10.1038/nchina.2009.7

        Original article citation:

        Huang, Z. et al. Structural basis for activation and inhibition of the secreted Chlamydia protease CPAF. Cell Host Microbe 4, 529–542 (2008).

      • Cell migration: Follow the flickers Open !

        Felix Cheung

        Published online: 14 January 2009 | doi:10.1038/nchina.2009.1

        Original article citation:

        Wei, C. et al. Calcium flickers steer cell migration. Nature doi:10.1038/nature07577 (2008).

      • Structural biology: Cavity immunity

        Felix Cheung

        Published online: 07 January 2009 | doi:10.1038/nchina.2008.300

        Original article citation:

        Zhang, X. et al. Crystal structure of TIPE2 provides insights into immune homeostasis. Nature Struct. Mol. Biol. doi:10.1038/nsmb.1522 (2008).

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