Archive: Cell & molecular biology
Cell & molecular biology 2007 Research Highlights
Plant signalling: A new receptor
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.273
Original article citation:
et al. A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science 315, 1712–1716 (2007).
Top of pagePrenatal diagnosis: Detection without invasion
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.274
Original article citation:
et al. Plasma placental RNA allelic ratio permits non-invasive prenatal chromosomal aneuploidy detection. Nature Med. 13, 218–223 (2007).
Top of pageHormone signalling: Regulating progesterone-receptor degradation
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.275
Original article citation:
et al. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin–proteasome. EMBO J. 26, 1831–1842 (2007).
Top of pageApoptosis: Death effector domain goes nuclear
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.276
Original article citation:
Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism. EMBO J. 26, 1068–1080 (2007).
Top of pageBacterial effectors: Armed with a novel enzyme
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.277
Original article citation:
et al. The phosphothreonine lyase activity of a bacterial type III effector family. Science 315, 1000–1003 (2007).
Top of pageDNA repair: Finding a surprising partner this content is Open !
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.278
Original article citation:
et al. Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. Cell Research 17, 100–116 (2007).
Top of pageHost defence: Bringing viral RNA to elimination
Dangsheng Li
Published online: 19 December 2007 | doi:10.1038/nchina.2007.279
Original article citation:
The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. PNAS 104, 151–156 (2007).
Top of pageProtein-coupled-receptor signalling: Regulation of gene expression
Jasmine Farsarakis
Published online: 19 December 2007 | doi:10.1038/nchina.2007.283
Original article citation:
et al. A nuclear function of
Top of page
-arrestin1 in GPCR signaling: Regulation of histone acetylation and gene transcription. Cell 123, 833–847 (2005).Ultraviolet response: A sunscreen for plants
Wei Zeng
Published online: 05 December 2007 | doi:10.1038/nchina.2007.257
Original article citation:
et al. SAD2, an importin
Top of page-like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking. Plant Cell doi: 10.1105/tpc.106.048900 (2007).Biolabelling: From visible to visible
Tim Reid
Published online: 05 December 2007 | doi:10.1038/nchina.2007.260
Original article citation:
et al. Luminescent europium nanoparticles with a wide excitation range from UV to visible light for biolabeling and time-gated luminescence bioimaging. Chem. Commun. doi: 10.1039/b715054g (2007).
Top of pageSARS coronavirus: An insight into its mechanism of action
Jasmine Farsarakis
Published online: 21 November 2007 | doi:10.1038/nchina.2007.244
Original article citation:
et al. Mutation of Gly11 on the dimer interface results in the complete crystallographic dimer dissociation of SARS-CoV 3CLpro: Crystal structure with molecular dynamics simulations. J. Biol. Chem. doi: 10.1074/jbc.M705240200 (2007).
Top of pageAutoimmune diseases: Finding a natural treatment
Felix Cheung
Published online: 07 November 2007 | doi:10.1038/nchina.2007.231
Original article citation:
et al. Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J. Immunol. 179, 5958–5965 (2007).
Top of pageLipid degradation: Freezing and thawing this content is Open !
Wei Zeng
Published online: 07 November 2007 | doi:10.1038/nchina.2007.235
Original article citation:
et al. Differential degradation of extraplastidic and plastidic lipids during freezing and post-freezing recovery in Arabidopsis thaliana. J. Biol. Chem. doi: 10.1074/jbc.M706692200 (2007).
Top of pageSeed treatment: Laser-protected wheat
Tim Reid
Published online: 31 October 2007 | doi:10.1038/nchina.2007.227
Original article citation:
Effects of CO2 laser pretreatment on drought stress resistance in wheat. J. Photochem. Photobiol. B doi: 10.1016/j.jphotobiol.2007.09.014 (2007).
Top of pageProtein interaction: PICK1 PDZ domain
Jasmine Farsarakis
Published online: 31 October 2007 | doi:10.1038/nchina.2007.228
Original article citation:
et al. Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J. doi: 10.1038/sj.emboj.7601860 (2007).
Top of pageHistone methylation: Take it away
Wei Zeng
Published online: 31 October 2007 | doi:10.1038/nchina.2007.230
Original article citation:
et al. JMJD3 is a histone H3K27 demethylase. Cell Res. 17, 850–857 (2007).
Top of pageMetabolic pathways: Insulin sensitivity
Jasmine Farsarakis
Published online: 24 October 2007 | doi:10.1038/nchina.2007.222
Original article citation:
et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6, 307–319 (2007).
Top of pageDNA chemistry: Sulphur degradation
Felix Cheung
Published online: 24 October 2007 | doi:10.1038/nchina.2007.223
Original article citation:
et al. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chem. Bio. doi: 10.1038/nchembio.2007.39 (2007).
Top of pagesiRNA silencing: Rice dicer this content is Open !
Wei Zeng
Published online: 24 October 2007 | doi:10.1038/nchina.2007.224
Original article citation:
et al. Oryza sativa dicer-like4 reveals a key role for small interfering RNA silencing in plant development. Plant Cell doi: 10.1105/tpc.107.052209 (2007).
Top of pageEndometrial cancer: Driven by hormones
Felix Cheung
Published online: 10 October 2007 | doi:10.1038/nchina.2007.209
Original article citation:
et al. Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin. Cell Res. doi: 10.1038/cr.2007.79 (2007).
Top of pageNon-viral gene transfer: HPhA carries the day
Wei Zeng
Published online: 03 October 2007 | doi:10.1038/nchina.2007.206
Original article citation:
et al. An archaeal histone-like protein mediates efficient p53 gene transfer and facilitates its anti-cancer effect in vitro and in vivo. Cancer Gene Ther. doi: 10.1038/sj.cgt.7701086 (2007).
Top of pageCell death: The dark side of IGF-1R
Dangsheng Li
Published online: 26 September 2007 | doi:10.1038/nchina.2007.197
Original article citation:
A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop. J. Cell Biol. 178, 995–1007 (2007).
Top of pageGadd45a regulation: Keep in touch
Felix Cheung
Published online: 19 September 2007 | doi:10.1038/nchina.2007.193
Original article citation:
et al. Gadd45a regulates
Top of page
-catenin distribution and maintains cell–cell adhesion/contact. Oncogene doi: 10.1038/sj.onc.1210469 (2007). Raf regulation: Location matters
Dangsheng Li
Published online: 12 September 2007 | doi:10.1038/nchina.2007.184
Original article citation:
et al. Spatial regulation of Raf kinase signaling by RKTG. PNAS 104, 14348–14353 (2007).
Top of pageOlfactory system: Mice on the scent this content is Open !
Wei Zeng
Published online: 05 September 2007 | doi:10.1038/nchina.2007.181
Original article citation:
et al. Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science 317, 953–957 (2007).
Top of pageGlucose metabolism: Manner, memory and morphine
Tim Reid
Published online: 29 August 2007 | doi:10.1038/nchina.2007.173
Original article citation:
et al. Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment. Cell Res. 17, 689–700 (2007).
Top of pagePlant pathogens: Two loops, one defence this content is Open !
Wei Zeng
Published online: 29 August 2007 | doi:10.1038/nchina.2007.175
Original article citation:
et al. The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature doi: 10.1038/nature06109 (2007).
Top of pageAntibody mimetics: Smaller but better
Felix Cheung
Published online: 29 August 2007 | doi:10.1038/nchina.2007.176
Original article citation:
Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting. Nature Biotechnol. 25, 921–929 (2007).
Top of pageCholesterol synthesis: Regulation by destruction this content is Open !
Dangsheng Li
Published online: 22 August 2007 | doi:10.1038/nchina.2007.169
Original article citation:
et al. Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. Cell Met. doi: 10.1016/j.cmet.2007.07.002 (2007).
Top of pagePrenatal diagnostics: Finding the extra copy
Wei Zeng
Published online: 22 August 2007 | doi:10.1038/nchina.2007.170
Original article citation:
et al. Digital PCR for the molecular detection of fetal chromosomal aneuploidy. PNAS 104, 13116–13121 (2007).
Top of pageArsenic pollution: Know your onions
Tim Reid
Published online: 15 August 2007 | doi:10.1038/nchina.2007.162
Original article citation:
Genotoxicity of arsenic evaluated by Allium-root micronucleus assay. Sci. Total Environ. 383, 232–236 (2007).
Top of pageLeukocytes: Sticky cells
Felix Cheung
Published online: 08 August 2007 | doi:10.1038/nchina.2007.151
Original article citation:
et al. P-selectin primes leukocyte integrin activation during inflammation. Nature Immunol. doi: 10.1038/ni1491 (2007).
Top of pageProtein structure: Totally hooked
Wei Zeng
Published online: 08 August 2007 | doi:10.1038/nchina.2007.152
Original article citation:
et al. The multifunctional human p100 protein 'hooks' methylated ligands. Nature Struct. Mol. Biol. doi: 10.1038/nsmb1269 (2007).
Top of pageATP release: How it all started
Wei Zeng
Published online: 08 August 2007 | doi:10.1038/nchina.2007.153
Original article citation:
et al. Regulated ATP release from astrocytes through lysosome exocytosis. Nature Cell Biol. doi: 10.1038/ncb1620 (2007).
Top of pageAngiogenesis: The healing power of ginseng
Felix Cheung
Published online: 25 July 2007 | doi:10.1038/nchina.2007.147
Original article citation:
et al. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen
Top of page receptor. Br. J. Pharmacol. doi: 10.1038/sj.bjp.0707359 (2007). Food chemistry: Secrets of the Jinhua ham this content is Open !
Tim Reid
Published online: 18 July 2007 | doi:10.1038/nchina.2007.142
Original article citation:
Biochemical changes during processing of traditional Jinhua ham. Meat Science 77, 114–120 (2007).
Top of pageNF-
B regulation: Partners in crime Dangsheng Li
Published online: 18 July 2007 | doi:10.1038/nchina.2007.143
Original article citation:
et al. UXT is a novel and essential cofactor in the NF-
Top of page
B transcriptional enhanceosome. J. Cell Biol. doi: 10.1083/jcb.200611081 (2007). Axon differentiation: Dishevelled neurons
Wei Zeng
Published online: 27 June 2007 | doi:10.1038/nchina.2007.119
Original article citation:
et al. Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nature Cell Biol. doi: 10.1038/ncb1603 (2007).
Top of pageGastric cancer: Belly phases
Wei Zeng
Published online: 20 June 2007 | doi:10.1038/nchina.2007.111
Original article citation:
et al. Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer. Oncogene doi: 10.1038/sj.onc.1210538 (2007).
Top of pageDiabetes: Infectious tolerance
Jim Casey
Published online: 20 June 2007 | doi:10.1038/nchina.2007.114
Original article citation:
et al. Foxp3-expressing CD4+T cells under the control of IFN-g promoter prevent diabetes in NOD mice. Mol. Ther. doi: 10.1038/sj.mt.6300208 (2007).
Top of pageLeukaemia: White blood arsenal this content is Open !
Wei Zeng
Published online: 30 May 2007 | doi:10.1038/nchina.2007.93
Original article citation:
et al. Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase C
Top of page
. Leukemia doi: 10.1038/sj.leu.2404735 (2007). DNA sequencing: Keeping in line
Tim Reid
Published online: 23 May 2007 | doi:10.1038/nchina.2007.88
Original article citation:
et al. Single-base resolution and long-coverage sequencing based on single-molecule nanomanipulation. Nanotechnol. 18, 225101 (2007).
Top of pageCarbon nanohorns: Miniature drug dealers
Tim Reid
Published online: 09 May 2007 | doi:10.1038/nchina.2007.76
Original article citation:
, , & Isolation of carbon nanohorn assemblies and their potential for intracellular delivery. Nanotechnol. 18, 195103 (2007).
Top of pageQuantum dots: Cell illuminators this content is Open !
Tim Reid
Published online: 09 May 2007 | doi:10.1038/nchina.2007.78
Original article citation:
, , & Gemini surfactant for fluorescent and stable quantum dots in solution. Nanotechnol. 18, 205603 (2007).
Top of pageTumour growth: Tax evasion this content is Open !
Tim Reid
Published online: 25 April 2007 | doi:10.1038/nchina.2007.53
Original article citation:
The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication. Nature Cell Biol. 8, 717–724 (2006).
Top of pageCell death: Outside in this content is Open !
Tim Reid
Published online: 18 April 2007 | doi:10.1038/nchina.2007.48
Original article citation:
et al. Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis. EMBO J. 24, 766–778 (2005).
Top of pageBacterial evolution: Good housekeeping this content is Open !
Tim Reid
Published online: 18 April 2007 | doi:10.1038/nchina.2007.49
Original article citation:
et al. Leucyl-tRNA synthetase from the ancestral bacterium Aquifex aeolicus contains relics of synthetase evolution. EMBO J. 24, 1430–1439 (2005).
Top of pageMacromolecular complex: Powered by sunlight
Kaspar Mossman
Published online: 11 April 2007 | doi:10.1038/nchina.2007.36
Original article citation:
et al. Crystal structure of spinach major light-harvesting complex at 2.72 Å resolution. Nature 428, 287–292 (2004).
Top of pageEffects of tamoxifen: A two-edged sword this content is Open !
Kaspar Mossman
Published online: 11 April 2007 | doi:10.1038/nchina.2007.39
Original article citation:
et al. Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature 438, 981–987 (2005).
Top of pageCystic fibrosis: Sperm failure
Tim Reid
Published online: 11 April 2007 | doi:10.1038/nchina.2007.42
Original article citation:
et al. Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Nature Cell Biol. 5 902–906 (2003).
Top of pageNerve growth: Nervous twitch
Tim Reid
Published online: 11 April 2007 | doi:10.1038/nchina.2007.45
Original article citation:
et al. Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nature Cell Biol. 5, 38–45 (2003).
Top of pageSkin cancer: Cell-lateral damage
Tim Reid
Published online: 11 April 2007 | doi:10.1038/nchina.2007.46
Original article citation:
, , , &
Top of page-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-B activation. The EMBO J. 24, 4237–4246 (2005).Neural development: The neuron turns this content is Open !
Kaspar Mossman
Published online: 04 April 2007 | doi:10.1038/nchina.2007.33
Original article citation:
& . Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature 434, 894–898 (2005).
Top of pageSARS virus: A channel for escape this content is Open !
Dangsheng Li
Published online: 28 February 2007 | doi:10.1038/nchina.2007.12
Original article citation:
et al. Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release. Proc. Natl Acad. Sci. 103, 12540–12545 (2006).
Top of pageTight junctions: How to stick cells together
Dangsheng Li
Published online: 28 February 2007 | doi:10.1038/nchina.2007.13
Original article citation:
et al. Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J. 25, 5058–5070 (2006).
Top of pageCancer: A suppressor suppressed
Jim Casey
Published online: 28 February 2007 | doi:10.1038/nchina.2007.15
Original article citation:
et al. High Frequency of Promoter Hypermethylation of RASSF1A in Nasopharyngeal Carcinoma. Cancer Res. 61, 3877–3881 (2001).
Top of pageBird flu: A cytokine storm?
Jim Casey
Published online: 28 February 2007 | doi:10.1038/nchina.2007.17
Original article citation:
et al. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir. Res. 6, 135 (2005).
Top of pagePneumonia: A new coronavirus
John Fox
Published online: 28 February 2007 | doi:10.1038/nchina.2007.21
Original article citation:
et al. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79, 884–895 (2006).
Top of pageCellular signalling pathways: Axin as a scaffold this content is Open !
Dangsheng Li
Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-2
Original article citation:
et al. Axin is a scaffold protein in TGF-
Top of page signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25, 1646–1658 (2006).Vascular proliferation: A novel regulator
Dangsheng Li
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-10
Original article citation:
et al. Dysregulation of HSG triggers vascular proliferative disorders. Nature Cell Biol. 6, 872–883 (2004).
Top of pageInnate immunity: SIKE suppresses anti-viral responses
Dangsheng Li
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-12
Original article citation:
et al. SIKE is an IKK /TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 24, 4018–4028 (2005).
Top of pageSupramolecular structure: March to the scaffold
Kaspar Mossman
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-16
Original article citation:
, , , & The tetrameric L27 domain complex as an organization platform for supramolecular assemblies. Nature Struct. Mol. Biol. 11, 475–480 (2004).
Top of pageProtein domains: X11 swallows its tail
Kaspar Mossman
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-18
Original article citation:
et al. Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. Nature Struct. Mol. Biol. 12, 722–728 (2005).
Top of pageNeuron growth: Cellular body sculpture
Marie-Therese Heemels
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-2
Original article citation:
et al. Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3β and its upstream regulators. Cell 120, 123–135 (2005).
Top of pageThe SARS coronavirus: Channelling RNA
Kaspar Mossman
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-24
Original article citation:
et al. Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamer. Nature Struct. Mol. Biol. 12, 980–986 (2005).
Top of pageTumor suppressors: Axin helps p53
Dangsheng Li
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-36
Original article citation:
et al. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23, 4583–4594 (2004).
Top of pageProtein structure: Split domains get together
Dangsheng Li
Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-37
Original article citation:
et al. Structure of the split PH domain and distinct lipid-binding properties of the PH–PDZ supramodule of
Top of page
-syntrophin. EMBO J. 24, 3985–3995 (2005).DNA methylation: Working together
Jasmine Farsarakis
Published online: 10 January 2007 | doi:10.1038/nchina.2007.284
Original article citation:
et al. Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol. Cell Biol. 27, 8748–8759 (2007).
Top of pageBreast cancer: Destroying bad seeds this content is Open !
Wei Zeng
Published online: 10 January 2007 | doi:10.1038/nchina.2007.289
Original article citation:
et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131, 1109–1123 (2007).
Top of page
- Breadcrumb trail
- Home
- Subject archive
- Cell & molecular biology 2007
Main navigation
NPG Journals
by Subject Area
Chemistry
Clinical Practice & Research
Earth & Environment
Life sciences
Physical sciences
by A - Z Index
Extra navigation
Local version
This is the international version of Nature China, if you are based in China we offer a Chinese mirror site.
ADVERTISEMENT
- Nature China
- EISSN: 1751-5793
- Banner image by Prof. Huang Wei, Director of the Center for Art Design, Graduate School at Shenzhen, Tsinghua University
