• Archive: Biotechnology

    • Biotechnology 2008 Research Highlights

      • DNA hydrogels: Fishy fluorescence Open !

        Felix Cheung

        Published online: 17 December 2008 | doi:110.1038/nchina.2008.297

        Original article citation:

        Tang, H. et al. Fluorescent DNA–poly(phenylenevinylene) hybrid hydrogels for monitoring drug release. Chem. Commun. doi:10.1039/b817788k (2008).

      • DNA hybridization: Base by base

        Vicki Cleave

        Published online: 10 December 2008 | doi:10.1038/nchina.2008.287

        Original article citation:

        Chen, X., Zhou, Y., Qu, P. & Zhao, X. S. Base-by-Base dynamics in DNA hybridization probed by fluorescence correlation spectroscopy. J. Am. Chem. Soc. doi:10.1021/ja804628x (2008).

      • Photonic crystals: Labelled spheres

        Vicki Cleave

        Published online: 10 December 2008 | doi:10.1038/nchina.2008.288

        Original article citation:

        Zhao, Y. J. et al. Encoded porous beads for label-free multiplex detection of tumor markers. Adv. Mater. doi:10.1002/adma.200802339 (2008).

      • Stem cell: Supporting factors

        Felix Cheung

        Published online: 19 November 2008 | doi:10.1038/nchina.2008.269

        Original article citation:

        Zhao, Y. et al. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3, 475–479 (2008).

      • Human genome: A Han Chinese deciphered Open !

        Felix Cheung

        Published online: 12 November 2008 | doi:10.1038/nchina.2008.266

        Original article citation:

        Wang, J. et al. The diploid genome sequence of an Asian individual. Nature doi:10.1038/nature07484 (2008).

      • Antimicrobial peptides: Venom defence

        Felix Cheung

        Published online: 05 November 2008 | doi:10.1038/nchina.2008.259

        Original article citation:

        Wang, Y. et al. Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. PLoS One 3, e3217 (2008).

      • Agricultural sciences: Good neighbours

        Jane Qiu

        Published online: 01 October 2008 | doi:10.1038/nchina.2008.230

        Original article citation:

        Wu, K. M., Lu, Y. H., Feng, H. Q., Jiang, Y. Y. & Zhao, J. Z. Suppression of cotton bollworm in multiple crops in China in areas with Bt toxin-containing cotton. Science 321, 1676–1678 (2008).

      • Antibiotic biosynthesis: From genes to enzymes

        Jasmine Farsarakis

        Published online: 20 August 2008 | doi:10.1038/nchina.2008.196

        Original article citation:

        Zhao, Q. et al. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type 1 polyketide synthase for naphthoate biosynthesis. Chem. Biol. 15, 693–705 (2008).

      • Antibiotic synthesis: Fine adjustments

        John Fox

        Published online: 16 July 2008 | doi:10.1038/nchina.2008.165

        Original article citation:

        Zhou, Y. et al. Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex. Chem. Biol. 15, 629–638 (2008).

      • Antibiotic synthesis: Last but not least Open !

        Jasmine Farsarakis

        Published online: 09 July 2008 | doi:10.1038/nchina.2008.157

        Original article citation:

        Liu, T., Lin, X., Zhou, X., Deng, Z. & Cane, D. E. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem. Biol. 15, 449–458 (2008).

      • Cell-surface analysis: Competing carbohydrates

        Anne Pichon

        Published online: 04 June 2008 | doi:10.1038/nchina.2008.125

        Original article citation:

        Ding, L., Cheng, W., Wang, X., Ding, S. & Ju, H. Carbohydrate monolayer strategy for electrochemical assay of cell surface carbohydrate. J. Am. Chem. Soc. doi: 10.1021/ja801468b (2008).

      • Electrochemical DNA sensors: Turn on the signal Open !

        Anne Pichon

        Published online: 21 May 2008 | doi:10.1038/nchina.2008.113

        Original article citation:

        Liu, G. et al. An enzyme-based E-DNA sensor for sequence-specific detection of femtomolar DNA targets. J. Am. Chem. Soc. doi: 10.1021/ja800554t (2008).

      • Transgenic plants: Spread control

        Wei Zeng

        Published online: 16 April 2008 | doi:10.1038/nchina.2008.87

        Original article citation:

        Lin, C. et al. A built-in strategy for containment of transgenic plants: Creation of selectively terminable transgenic rice. PLoS ONE 3, e1818 (2008).

      • Immunotherapy: Better treatment for tuberculosis

        John Fox

        Published online: 12 March 2008 | doi:10.1038/nchina.2008.52

        Original article citation:

        Yu, D. H., Hu, X. D. & Cai, H. Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and MPT-83. Gene Ther. doi: 10.1038/gt.2008.13 (2008).

      • Vascular system: Build your own blood vessels

        Felix Cheung

        Published online: 05 March 2008 | doi:10.1038/nchina.2008.48

        Original article citation:

        Xu, W., Wang, X., Yan, Y. & Zhang, R. Rapid prototyping of polyurethane for the creation of vascular systems. J. Bioactive Compatible Polym. 23, 103–113 (2008).

      • Crop biocontrols: Dodging the rotten tomatoes Open !

        Tim Reid

        Published online: 05 March 2008 | doi:10.1038/nchina.2008.50

        Original article citation:

        Wang, Y. et al. Biocontrol of Alternaria Alternata on cherry tomato fruit by use of marine yeast Rhodosporidium paludigenum Fell & Tallman. Int. J. Food Microbiol. doi: 10.1016/j.ijfoodmicro.2008.02.002 (2008).

      • Rice yield: Blight fight

        Tim Reid

        Published online: 20 February 2008 | doi:10.1038/nchina.2008.34

        Original article citation:

        Ji, G. H., Wei, L. F., He, Y. Q., Wu, Y. P. & Bai, X. H. Biological control of rice bacterial blight by Lysobacter antibioticus strain 13-1. Biol. Control doi: 10.1016/j.biocontrol.2008.01.004 (2008).

      • Chemotherapy: Improved packaging, improved performance

        Jasmine Farsarakis

        Published online: 06 February 2008 | doi:10.1038/nchina.2008.25

        Original article citation:

        Tang, N. et al. Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin. J. Natl Cancer Inst. 99, 1004–1015 (2007).

      • Fluorescent probes: A bright encoding strategy

        Anne Pichon

        Published online: 10 January 2008 | doi:10.1038/nchina.2008.1

        Original article citation:

        Wu, C. et al. Fluorescent core–shell silica nanoparticles as tunable precursors: Towards encoding and multifunctional nanoprobes. Chem. Commun. doi: 10.1039/b717038f (2007).

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