• Archive: Biotechnology

    • Biotechnology 2007 Research Highlights

      • Prenatal diagnosis: Detection without invasion

        Dangsheng Li

        Published online: 19 December 2007 | doi:10.1038/nchina.2007.274

        Original article citation:

        Lo, Y. M. D. et al. Plasma placental RNA allelic ratio permits non-invasive prenatal chromosomal aneuploidy detection. Nature Med. 13, 218–223 (2007).

      • Biological nanotubes: Putting viruses into shape

        Anne Pichon

        Published online: 12 December 2007 | doi:10.1038/nchina.2007.264

        Original article citation:

        Xu, Y. et al. DNA-templated CMV viral capsid proteins assemble into nanotubes. Chem. Commun. doi: 10.1039/b715299j (2007).

      • Ultraviolet response: A sunscreen for plants

        Wei Zeng

        Published online: 05 December 2007 | doi:10.1038/nchina.2007.257

        Original article citation:

        Zhao, J. et al. SAD2, an importin beta-like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking. Plant Cell doi: 10.1105/tpc.106.048900 (2007).

      • Cryopreservation: Electrically frozen Open !

        Tim Reid

        Published online: 05 December 2007 | doi:10.1038/nchina.2007.259

        Original article citation:

        Sun, W., Xu, X., Zhang, H. & Xu, C. Effects of dipole polarization of water molecules on ice formation under an electrostatic field. Cryobiol. doi: 10.1016/j.cryobiol.2007.10.173 (2007).

      • Fungal insecticides: Now come with an extra sting

        Felix Cheung

        Published online: 28 November 2007 | doi:10.1038/nchina.2007.251

        Original article citation:

        Wang, C. & St Leger, R. J. A scorpion neurotoxin increases the potency of a fungal insecticide. Nature Biotechnol. doi: 10.1038/nbt1357 (2007).

      • Bipedal nanomotors: Asymmetry locked in

        Wei Zeng

        Published online: 28 November 2007 | doi:10.1038/nchina.2007.252

        Original article citation:

        Wang, Z. Synergic mechanism and fabrication target for bipedal nanomotors. PNAS 104, 17921–17926 (2007).

      • Pest control: Plant defence

        Felix Cheung

        Published online: 21 November 2007 | doi:10.1038/nchina.2007.243

        Original article citation:

        Mao, Y. B. et al. Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. Nature Biotechnol. doi: 10.1038/nbt1352 (2007).

      • Antifungal proteins: The nutty killer

        Felix Cheung

        Published online: 14 November 2007 | doi:10.1038/nchina.2007.239

        Original article citation:

        Wang, S., Shao, B., Rao, P., Lee, Y. & Ye, X. Hypotin, a novel antipathogenic and antiproliferative protein from peanuts with a sequence similar to those of chitinase precursors. J. Agric. Food Chem. doi: 10.1021/jf071540j (2007).

      • Blood lipid levels: The power of Chinese yams Open !

        Tim Reid

        Published online: 14 November 2007 | doi:10.1038/nchina.2007.240

        Original article citation:

        Wang, S., Yu, J., Liu, H. & Chen, W. Characterization and preliminary lipid-lowering evaluation of starch from Chinese yam. Food Chem. doi: 10.1016/j.foodchem.2007.10.059 (2007).

      • Nanochannels: Driven by charges

        Wei Zeng

        Published online: 14 November 2007 | doi:10.1038/nchina.2007.242

        Original article citation:

        Gong, X. et al. A charge-driven molecular water pump. Nature Nanotech. doi: 10.1038/nnano.2007.320 (2007).

      • Lipid degradation: Freezing and thawing Open !

        Wei Zeng

        Published online: 07 November 2007 | doi:10.1038/nchina.2007.235

        Original article citation:

        Li, W. et al. Differential degradation of extraplastidic and plastidic lipids during freezing and post-freezing recovery in Arabidopsis thaliana. J. Biol. Chem. doi: 10.1074/jbc.M706692200 (2007).

      • Histone methylation: Take it away

        Wei Zeng

        Published online: 31 October 2007 | doi:10.1038/nchina.2007.230

        Original article citation:

        Xiang, Y. et al. JMJD3 is a histone H3K27 demethylase. Cell Res. 17, 850–857 (2007).

      • Protein structure: Let's swap

        Wei Zeng

        Published online: 17 October 2007 | doi:10.1038/nchina.2007.218

        Original article citation:

        Wu, J. et al. Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins. J. Biol. Chem. doi: 10.1074/jbc.M703826200 (2007).

      • Carbon nanotubes: Becoming a brighter fighter

        Felix Cheung

        Published online: 12 September 2007 | doi:10.1038/nchina.2007.187

        Original article citation:

        Jia, N. et al. Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes. Nano Lett. doi: 10.1021/nl071114c (2007).

      • Drug delivery: Wet or dry

        Felix Cheung

        Published online: 12 September 2007 | doi:10.1038/nchina.2007.188

        Original article citation:

        Xia, F. et al. Multiresponsive surfaces change between superhydrophilicity and superhydrophobicity. Adv. Mater. doi: 10.1002/adma.200602334 (2007).

      • DNA analysis: Under the heat

        Wei Zeng

        Published online: 29 August 2007 | doi:10.1038/nchina.2007.174

        Original article citation:

        Zhang, H. D. et al. DNA mutation detection with chip-based temperature gradient capillary electrophoresis using a slantwise radiative heating system. Lab Chip doi: 10.1039/b701649b (2007).

      • Antibody mimetics: Smaller but better

        Felix Cheung

        Published online: 29 August 2007 | doi:10.1038/nchina.2007.176

        Original article citation:

        Qiu, X. Q., Wang, H., Cai, B., Wang, L. L. & Yue, S. T. Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting. Nature Biotechnol. 25, 921–929 (2007).

      • Prenatal diagnostics: Finding the extra copy

        Wei Zeng

        Published online: 22 August 2007 | doi:10.1038/nchina.2007.170

        Original article citation:

        Lo, D. Y. M. et al. Digital PCR for the molecular detection of fetal chromosomal aneuploidy. PNAS 104, 13116–13121 (2007).

      • Sensors: A snappy detector Open !

        Anne Pichon

        Published online: 08 August 2007 | doi:10.1038/nchina.2007.154

        Original article citation:

        Li, B., Du, Y., Wei, H. & Dong, S. Reusable, label-free electrochemical aptasensor for sensitive detection of small molecules. Chem. Commun. doi: 10.1039/b707057h (2007).

      • Water-quality management: A speedy sensor

        Tim Reid

        Published online: 08 August 2007 | doi:10.1038/nchina.2007.157

        Original article citation:

        Xin, L., Wang, X., Guo, G., Wang, X. & Chen, X. An optical biosensing film for biochemical oxygen demand determination in seawater with an automatic flow sampling system. Meas. Sci. Technol. 18, 2878–2884 (2007).

      • Protein structure: From loops to hoops Open !

        Hongfei Wang

        Published online: 11 July 2007 | doi:10.1038/nchina.2007.133

        Original article citation:

        Ye, M. et al. IR spectroscopic discrimination between the loop and alpha-helices and determination of the loop diffusion kinetics by T-jump time-resolved IR spectroscopy for cytochrome c. Biophys. J. doi: 10.1529/biophysj.107.106799 (2007).

      • Fluorescent probes: A ball with two spikes

        Wei Zeng

        Published online: 04 July 2007 | doi:10.1038/nchina.2007.125

        Original article citation:

        Wu, C. et al. Hybrid silica-nanocrystal-organic dye superstructures as post-encoding fluorescent probes. Angew. Chem. Int. Edn doi: 10.1002/anie.200700847 (2007).

      • Artificial vitreous: Plastic eye surgery Open !

        Wei Zeng

        Published online: 20 June 2007 | doi:10.1038/nchina.2007.115

        Original article citation:

        Gao, Q. et al. A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve. Eye doi: 10.1038/sj.eye.6702875 (2007).

      • Nanochannels: Switchable membrane Open !

        Felix Cheung

        Published online: 06 June 2007 | doi:10.1038/nchina.2007.96

        Original article citation:

        Mao, Y., Chang, S., Yang, S., Ouyang, Q. & Jiang, L. Tunable non-equilibrium gating of flexible DNA nanochannels in response to transport flux. Nature Nanotech. doi: 10.1038/nnano.2007.148 (2007).

      • Carbon nanohorns: Miniature drug dealers

        Tim Reid

        Published online: 09 May 2007 | doi:10.1038/nchina.2007.76

        Original article citation:

        Fan, X. B., Tan, J., Zhang, G. L. & Zhang F. B. Isolation of carbon nanohorn assemblies and their potential for intracellular delivery. Nanotechnol. 18, 195103 (2007).

      • Quantum dots: Cell illuminators Open !

        Tim Reid

        Published online: 09 May 2007 | doi:10.1038/nchina.2007.78

        Original article citation:

        Li, H., Wang, X., Gao, Z. & He, Z. Gemini surfactant for fluorescent and stable quantum dots in solution. Nanotechnol. 18, 205603 (2007).

      • Practical pharmacology: Getting under the skin Open !

        Kaspar Mossman

        Published online: 31 January 2007 | doi:10.1038/nchina.2007.070131-1

        Original article citation:

        Chen, Y. et al. Transdermal protein delivery by a coadministered peptide identified via phage display. Nature Biotech. 24, 455–460 (2006).

      • Environmental detoxification: Green clean-up by root therapy

        Kaspar Mossman

        Published online: 18 January 2007 | doi:10.1038/nchina.2007.070118-19

        Original article citation:

        Wang, G.-D. et al. Ex planta phytoremediation of trichlorophenol and phenolic allelochemicals via an engineered secretory laccase. Nature Biotechnol. 22, 893–897 (2004).

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