Formamidopyrimidine residues are damaged purines that retain the same Watson-Crick hydrogen-bonding face found in the parent nucleobase, yet these lesions are mutagenic. Crystallographic evidence suggests molecular mechanisms by which these lesions 'mispair' to generate mutations during DNA replication.
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Gates, K. FaPy lesions and DNA mutations. Nat Chem Biol 9, 412–414 (2013). https://doi.org/10.1038/nchembio.1274
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DOI: https://doi.org/10.1038/nchembio.1274
