Allergic reactions to otherwise innocuous substances involve a complex interplay of molecular interactions—some strong, some weak. This study reveals a key role for low-affinity antibodies and thus a possible point of weakness that may be exploited for therapeutic intervention.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Handlogten, M.W., Kiziltepe, T., Serezani, A.P., Kaplan, M.H. & Bilgicer, B. Nat. Chem. Biol. 9, 789–795 (2013).
Gould, H.J. & Sutton, B.J. Nat. Rev. Immunol. 8, 205–217 (2008).
Hunt, J. et al. J. Biol. Chem. 287, 17459–17470 (2012).
Metzger, H., Eglite, S., Haleem-Smith, H., Reischl, I. & Torigoe, C. Mol. Immunol. 38, 1207–1211 (2002).
Posner, R.G. et al. Org. Lett. 9, 3551–3554 (2007).
Sil, D., Lee, J.B., Luo, D., Holowka, D. & Baird, B. ACS Chem. Biol. 2, 674–684 (2007).
Andrews, N.L. et al. Immunity 31, 469–479 (2009).
Rajagopalan, K. et al. Proc. Natl. Acad. Sci. USA 93, 6019–6024 (1996).
Handlogten, M.W., Kiziltepe, T., Moustakas, D.T. & Bilgicer, B. Chem. Biol. 18, 1179–1188 (2011).
Christensen, L.H., Holm, J., Lund, G., Riise, E. & Lund, K. J. Allergy Clin. Immunol. 122, 298–304 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Sutton, B. Allergy's Achilles' heel?. Nat Chem Biol 9, 757–759 (2013). https://doi.org/10.1038/nchembio.1390
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.1390
