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Immunology

Evolving superkines for selectivity

Combinatorial protein engineering based on structural data and the differential expression of alternate second receptor chains for interleukin-4 (IL-4) is used to modify and tune cellular specificity on primary human cells.

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Figure 1: Hypothetical influence of relative receptor expressions on the activity of engineered cytokines.

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Correspondence to Sachdev S Sidhu.

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The authors declare no competing financial interests.

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Miersch, S., Sidhu, S. Evolving superkines for selectivity. Nat Chem Biol 8, 955–956 (2012). https://doi.org/10.1038/nchembio.1119

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