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Protein dynamics

Bridging the gap

Detailed biophysical and biochemical studies provide an exquisite example of how conformational flexibility controls the interaction between an intrinsically disordered protein and its numerous binding partners.

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Figure 1: Schematic showing the subdomains of the kinase inhibitory domain of p21.

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Correspondence to Gary W Daughdrill.

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Daughdrill, G. Bridging the gap. Nat Chem Biol 7, 193–194 (2011). https://doi.org/10.1038/nchembio.544

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